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The map label for this gene is mutT [H]

Identifier: 54294495

GI number: 54294495

Start: 1742163

End: 1742567

Strand: Reverse

Name: mutT [H]

Synonym: lpl1564

Alternate gene names: 54294495

Gene position: 1742567-1742163 (Counterclockwise)

Preceding gene: 54294496

Following gene: 54294494

Centisome position: 52.08

GC content: 37.04

Gene sequence:

>405_bases
GTGAAAGTAGCAGTTGCTATCATTATCGATGAAAAACAGCGTATACTAATTACCCAACGTCCTTTTCATGTCGCACATGG
GGGACTTTGGGAGTTTCCTGGCGGAAAATTGGAGCCTCATGAATCTCCAGAGGATGCTTTGGTTCGAGAGATTAGGGAGG
AGTTAGGTATAATTGTAAATGAATATCGTTTTCTGGGGTATGTCGATTATGACTATCCAGATAAACACATACAATTAATT
ATTTTTATGGTGACTCGTTTTACAGGCAACCCTTTATGTCAGGAAGGACAGCTCAATATGAAGTGGGTAAAAAAAGAGGA
ATTAAATATTAATGATTTCCCTAAAGCAAATCATGCGGTTTTCGATTTAATTGATATCCCTGAACTTCAATATCAAGCTT
TATAA

Upstream 100 bases:

>100_bases
AAACGCAAACTTTTAGACGACAAGAAAAGAAAATTGGCCGTAATGATCCTTGCCCCTGTGGCTCAGGTAAAAAATATAAA
GCCTGTCATGGAAGCCTCGT

Downstream 100 bases:

>100_bases
ATGTGCGAATAATCTAAAGTTTGAAGCTAGGACATCATATTTAATTGCTATGCACAAAATAAACTCCCTGTTTAGATGAT
ATTATAACAGATCAGTTGTC

Product: Mutator protein MutT

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MKVAVAIIIDEKQRILITQRPFHVAHGGLWEFPGGKLEPHESPEDALVREIREELGIIVNEYRFLGYVDYDYPDKHIQLI
IFMVTRFTGNPLCQEGQLNMKWVKKEELNINDFPKANHAVFDLIDIPELQYQAL

Sequences:

>Translated_134_residues
MKVAVAIIIDEKQRILITQRPFHVAHGGLWEFPGGKLEPHESPEDALVREIREELGIIVNEYRFLGYVDYDYPDKHIQLI
IFMVTRFTGNPLCQEGQLNMKWVKKEELNINDFPKANHAVFDLIDIPELQYQAL
>Mature_134_residues
MKVAVAIIIDEKQRILITQRPFHVAHGGLWEFPGGKLEPHESPEDALVREIREELGIIVNEYRFLGYVDYDYPDKHIQLI
IFMVTRFTGNPLCQEGQLNMKWVKKEELNINDFPKANHAVFDLIDIPELQYQAL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=120, Percent_Identity=40.8333333333333, Blast_Score=97, Evalue=5e-22,
Organism=Escherichia coli, GI1788056, Length=103, Percent_Identity=40.7766990291262, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 15631; Mature: 15631

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAVAIIIDEKQRILITQRPFHVAHGGLWEFPGGKLEPHESPEDALVREIREELGIIVN
CEEEEEEEECCCCEEEEEECCEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCEEEE
EYRFLGYVDYDYPDKHIQLIIFMVTRFTGNPLCQEGQLNMKWVKKEELNINDFPKANHAV
CEEEEEEECCCCCCHHHEEHEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEE
FDLIDIPELQYQAL
EEEECCCCCEEECC
>Mature Secondary Structure
MKVAVAIIIDEKQRILITQRPFHVAHGGLWEFPGGKLEPHESPEDALVREIREELGIIVN
CEEEEEEEECCCCEEEEEECCEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCEEEE
EYRFLGYVDYDYPDKHIQLIIFMVTRFTGNPLCQEGQLNMKWVKKEELNINDFPKANHAV
CEEEEEEECCCCCCHHHEEHEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEE
FDLIDIPELQYQAL
EEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3033442; 1630901; 9278503; 2841285; 8202364; 3288626; 1851162; 1309939; 7578113; 9063868 [H]