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The map label for this gene is bioF [H]

Identifier: 54294486

GI number: 54294486

Start: 1731892

End: 1733037

Strand: Reverse

Name: bioF [H]

Synonym: lpl1555

Alternate gene names: 54294486

Gene position: 1733037-1731892 (Counterclockwise)

Preceding gene: 54294487

Following gene: 54294485

Centisome position: 51.8

GC content: 39.44

Gene sequence:

>1146_bases
ATGACTCTTAATATAAAAATTAATGAGTACACAGCACAGCTGCAAGAGCAAGGATTATTGCGTACAAGACAAATTTTAGA
AACGGATAAGATAGATTATATTCGATTTGACTCTAATGATTATTTGTCGCTCACAGAAGATAGGCGAATTGCTGAAGCCT
ATCAAAAGGGATATGAGTTGTATCCTTGTGGAAGTGGTGCTTCGATGGTTTTAAGTGGCTACCATAGTAGCCACCAAACC
CTTGAGAGGGCCTTTGCCGAAATGCTGCGAGTAGATGATTGTCTTTTATTTTCCTCTGGGTACTGTGCAAATTTGGCTGT
TACGGCCTTGCTTGGGCGTTTGGGAACACATTGTTTTATAGATAAAAGCGTTCATGCATCAATTTATGATGGGCTGGCTT
TGTCACGAGTAACCTACTCTCGTTACATACATAATGACATGAATGCTTTGCCTGCCTTGTTAAAATCTCATTTGGGCGAT
TCTGTTTTGATTACAGAAGGTATTTTTAGTATGAGTGGGCAGATAGCGCCTTTATCAACGATTAGTATGTTATGCAAAGA
GAATGGCTCTGAACTCTTTGTAGATGAAGCACATGCTTTTGGTGTGATGGGACCGCAAGGAATGGGCTCTGTGCCAGGCC
ATGGGCTGACACAGAATGAAGTTCCCTTGCGAGTTATTCCTTTTGGTAAGGCATTTGCTTCCCAGGGCGCAGTGGTTGTT
GGGCGGAAAGATTGGATACATGCTTTGTTGCAAACGGCACGTTCTTTTGTTTATTCAACTGCTATTAGTCCTGCTTTATG
CTATGGTTTGCTCAAAACATTGGAGATAATAGCAGCTGCTGACTCCAGAAGAGAAAAATTAAACCAATTAGTTGCTCAAT
TCAAAGAGTTAATAAATTCTTCGCCCTTAAATTGGCTGGATTCAGATACTCCAATTCAGCAATTAAGGTTAGGATGCCCT
CATAAGGCATTGCATTATGCCAGTGAACTGAAAAAAGATGGGATTTATTGCTCTGCTATCAGAGCTCCAACGGTAAATAG
TGCTTCTTCCGGTTTACGGATTATTATTAATTATAAGCATACTATTGAACAAATCATTGAGTTATTTAATAAATTGCACT
TAATACATGAATATTCATCTCGATAA

Upstream 100 bases:

>100_bases
TTCTGTGTTTATTGGCGATAAATTATTGACAGAAGATAATCCCCAGCGCTTCAAAGACAAAACTCTTTTTAACAAACTGG
GTTTGACTGAGATGGTATAA

Downstream 100 bases:

>100_bases
ACATGGGCAAGGAATGCCTTTGGTCCTATTTCATGGCTGGGGATTTGATAGCCAAATCTGGCAACCGATAATTCCTTACC
TCAAGCCTAAATATCAGATT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTLNIKINEYTAQLQEQGLLRTRQILETDKIDYIRFDSNDYLSLTEDRRIAEAYQKGYELYPCGSGASMVLSGYHSSHQT
LERAFAEMLRVDDCLLFSSGYCANLAVTALLGRLGTHCFIDKSVHASIYDGLALSRVTYSRYIHNDMNALPALLKSHLGD
SVLITEGIFSMSGQIAPLSTISMLCKENGSELFVDEAHAFGVMGPQGMGSVPGHGLTQNEVPLRVIPFGKAFASQGAVVV
GRKDWIHALLQTARSFVYSTAISPALCYGLLKTLEIIAAADSRREKLNQLVAQFKELINSSPLNWLDSDTPIQQLRLGCP
HKALHYASELKKDGIYCSAIRAPTVNSASSGLRIIINYKHTIEQIIELFNKLHLIHEYSSR

Sequences:

>Translated_381_residues
MTLNIKINEYTAQLQEQGLLRTRQILETDKIDYIRFDSNDYLSLTEDRRIAEAYQKGYELYPCGSGASMVLSGYHSSHQT
LERAFAEMLRVDDCLLFSSGYCANLAVTALLGRLGTHCFIDKSVHASIYDGLALSRVTYSRYIHNDMNALPALLKSHLGD
SVLITEGIFSMSGQIAPLSTISMLCKENGSELFVDEAHAFGVMGPQGMGSVPGHGLTQNEVPLRVIPFGKAFASQGAVVV
GRKDWIHALLQTARSFVYSTAISPALCYGLLKTLEIIAAADSRREKLNQLVAQFKELINSSPLNWLDSDTPIQQLRLGCP
HKALHYASELKKDGIYCSAIRAPTVNSASSGLRIIINYKHTIEQIIELFNKLHLIHEYSSR
>Mature_380_residues
TLNIKINEYTAQLQEQGLLRTRQILETDKIDYIRFDSNDYLSLTEDRRIAEAYQKGYELYPCGSGASMVLSGYHSSHQTL
ERAFAEMLRVDDCLLFSSGYCANLAVTALLGRLGTHCFIDKSVHASIYDGLALSRVTYSRYIHNDMNALPALLKSHLGDS
VLITEGIFSMSGQIAPLSTISMLCKENGSELFVDEAHAFGVMGPQGMGSVPGHGLTQNEVPLRVIPFGKAFASQGAVVVG
RKDWIHALLQTARSFVYSTAISPALCYGLLKTLEIIAAADSRREKLNQLVAQFKELINSSPLNWLDSDTPIQQLRLGCPH
KALHYASELKKDGIYCSAIRAPTVNSASSGLRIIINYKHTIEQIIELFNKLHLIHEYSSR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=379, Percent_Identity=25.8575197889182, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=27.2206303724928, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI83977442, Length=346, Percent_Identity=27.1676300578035, Blast_Score=121, Evalue=9e-28,
Organism=Homo sapiens, GI83977440, Length=346, Percent_Identity=27.1676300578035, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI83977444, Length=346, Percent_Identity=27.1676300578035, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4758668, Length=350, Percent_Identity=27.7142857142857, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI4502025, Length=341, Percent_Identity=29.0322580645161, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI40316939, Length=341, Percent_Identity=29.0322580645161, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI119220554, Length=326, Percent_Identity=26.0736196319018, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI5454084, Length=243, Percent_Identity=23.8683127572016, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786993, Length=351, Percent_Identity=37.8917378917379, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1790046, Length=375, Percent_Identity=30.1333333333333, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=397, Percent_Identity=27.9596977329975, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17560914, Length=323, Percent_Identity=27.8637770897833, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17560912, Length=323, Percent_Identity=27.8637770897833, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32566772, Length=353, Percent_Identity=25.7790368271955, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982617, Length=274, Percent_Identity=23.7226277372263, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=274, Percent_Identity=23.7226277372263, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=381, Percent_Identity=27.0341207349081, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323954, Length=292, Percent_Identity=26.7123287671233, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320267, Length=353, Percent_Identity=24.0793201133144, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24662918, Length=339, Percent_Identity=28.6135693215339, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=28.080229226361, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17136286, Length=229, Percent_Identity=32.3144104803493, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653280, Length=330, Percent_Identity=24.5454545454545, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653276, Length=330, Percent_Identity=24.5454545454545, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653278, Length=330, Percent_Identity=24.5454545454545, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42207; Mature: 42076

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNIKINEYTAQLQEQGLLRTRQILETDKIDYIRFDSNDYLSLTEDRRIAEAYQKGYEL
CEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCHHHHHHHHHHCCCEE
YPCGSGASMVLSGYHSSHQTLERAFAEMLRVDDCLLFSSGYCANLAVTALLGRLGTHCFI
EECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCEEE
DKSVHASIYDGLALSRVTYSRYIHNDMNALPALLKSHLGDSVLITEGIFSMSGQIAPLST
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCHHHH
ISMLCKENGSELFVDEAHAFGVMGPQGMGSVPGHGLTQNEVPLRVIPFGKAFASQGAVVV
HHHHHHCCCCEEEEECHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHCCCCEEE
GRKDWIHALLQTARSFVYSTAISPALCYGLLKTLEIIAAADSRREKLNQLVAQFKELINS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
SPLNWLDSDTPIQQLRLGCPHKALHYASELKKDGIYCSAIRAPTVNSASSGLRIIINYKH
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEECHH
TIEQIIELFNKLHLIHEYSSR
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLNIKINEYTAQLQEQGLLRTRQILETDKIDYIRFDSNDYLSLTEDRRIAEAYQKGYEL
EEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCHHHHHHHHHHCCCEE
YPCGSGASMVLSGYHSSHQTLERAFAEMLRVDDCLLFSSGYCANLAVTALLGRLGTHCFI
EECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCEEE
DKSVHASIYDGLALSRVTYSRYIHNDMNALPALLKSHLGDSVLITEGIFSMSGQIAPLST
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCHHHH
ISMLCKENGSELFVDEAHAFGVMGPQGMGSVPGHGLTQNEVPLRVIPFGKAFASQGAVVV
HHHHHHCCCCEEEEECHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHCCCCEEE
GRKDWIHALLQTARSFVYSTAISPALCYGLLKTLEIIAAADSRREKLNQLVAQFKELINS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
SPLNWLDSDTPIQQLRLGCPHKALHYASELKKDGIYCSAIRAPTVNSASSGLRIIINYKH
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEECHH
TIEQIIELFNKLHLIHEYSSR
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA