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The map label for this gene is hemL [H]

Identifier: 54294423

GI number: 54294423

Start: 1659227

End: 1660516

Strand: Direct

Name: hemL [H]

Synonym: lpl1492

Alternate gene names: 54294423

Gene position: 1659227-1660516 (Clockwise)

Preceding gene: 54294421

Following gene: 54294424

Centisome position: 49.59

GC content: 38.37

Gene sequence:

>1290_bases
ATGAGCCGTTCTTCAGATTTATTTCATAAAGCACAAACAATCATTCCCGGAGGTGTTAACTCACCGGTTCGAGCTTTCAA
AGGTGTTGGAGGTGAACCTGTTTTTTTCAAATCTGGCAAAGGTGCCTACCTGACGGATGTAGATGATAAACAATATATTG
ATTATGTTGGATCTTGGGGCCCACTTATCCTTGGACACTGCCATCCCAAAGTGATAGAAGCTGTGGATAATGTATTACAC
AGTGGTATGAGTTTTGGCGCCCCAACAGAACTGGAAATACAATTAGCTGAAAAAATTGCTTCCCTGATGCCATCAATAGA
AAAAATTCGCATGGTGAATTCAGGAACTGAAGCAACTATGACTGCAATTCGACTGGCGCGCGGATTCACTAATAAAAATA
AATTTATTAAATTTAACGGCTGTTATCATGGGCATAGCGATAGCTTATTAGTTAAAGCGGGATCTGGTTTGCTTACTCTC
GGAATTCCTTCAACTCCAGGCATTCCACAATGTATTACCGAACATACTTTAACGGCTGATTTTAATAACCTGGAACAAGT
TGCTCAACTCTTTGAAAAATATCCAAACGACATCGCTACTGTAATTTTGGAACCTGTTCCTGGCAATATGGGATTTATCC
TACCTAAGATAGAGTTTTTAAAAGGATTACGTGAGCTTTGCGATCAATATAATGCTTTGTTAATTTTTGATGAAGTAATG
ACTGGGTTTAGAGTTGGTTTACATGGTGCACAGGGCTTGTTTGGGATTAAACCTGATATCACAACACTTGGAAAAATCAT
AGGTGGTGGTATGCCTGTAGGTGCTTTAGGTGGTAAACGTGAAATTATGTCCTTTCTGGCGCCTGAAGGCCCTGTATATC
AGGCTGGTACTCTTTCAGGAAATCCATTGGCAATGGCCGCAGGTTTGGCTACTTTAAAAGAGATTGAAAAAATTAATTTT
TTTGAAGATTTAAGCAGTACGACTAATAAATTAACCGAGGCATTATCTGATGCGGCAGAAAACGCAAACATTCCACTTTT
TGCTGCATCATTGGGCGGAATGTTTGGATTTTGTTTTACAGATAAGAATAGTGTTGAAAATTATTTGGATGTTGCTTCCT
CGGATGAAGTTTTATTTAAGAAATTTTTTCATGCTATGCTTGCTCAAGGAGTATATTTTGCACCATCTATGTATGAAGCT
GGATTTGTCTCCAGTATGCATGGTGATTTGGAAATACAAAAAACATATGATGCTGCTGAATTGGTACTGAATCAATTAAA
ATCTGCCTGA

Upstream 100 bases:

>100_bases
AATATTTTAACATTTTTTGTATAATAAATTTCTGAAACATCTTGAATATTAAAAATAATAACTGATATTTGTCTAAAGTT
TATCATTTTTGGGATTTTCT

Downstream 100 bases:

>100_bases
TAGCAGAATTGTACCTTATTACCTTACGTTACTTAAATACAATCTTTAAAATCAGTATTTGGGTAATTAAGTTCATTAAA
GCGTCTAAATGTGATTGCAG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWGPLILGHCHPKVIEAVDNVLH
SGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTL
GIPSTPGIPQCITEHTLTADFNNLEQVAQLFEKYPNDIATVILEPVPGNMGFILPKIEFLKGLRELCDQYNALLIFDEVM
TGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSGNPLAMAAGLATLKEIEKINF
FEDLSSTTNKLTEALSDAAENANIPLFAASLGGMFGFCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEA
GFVSSMHGDLEIQKTYDAAELVLNQLKSA

Sequences:

>Translated_429_residues
MSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWGPLILGHCHPKVIEAVDNVLH
SGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTL
GIPSTPGIPQCITEHTLTADFNNLEQVAQLFEKYPNDIATVILEPVPGNMGFILPKIEFLKGLRELCDQYNALLIFDEVM
TGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSGNPLAMAAGLATLKEIEKINF
FEDLSSTTNKLTEALSDAAENANIPLFAASLGGMFGFCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEA
GFVSSMHGDLEIQKTYDAAELVLNQLKSA
>Mature_428_residues
SRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWGPLILGHCHPKVIEAVDNVLHS
GMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATMTAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTLG
IPSTPGIPQCITEHTLTADFNNLEQVAQLFEKYPNDIATVILEPVPGNMGFILPKIEFLKGLRELCDQYNALLIFDEVMT
GFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSGNPLAMAAGLATLKEIEKINFF
EDLSSTTNKLTEALSDAAENANIPLFAASLGGMFGFCFTDKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEAG
FVSSMHGDLEIQKTYDAAELVLNQLKSA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=309, Percent_Identity=31.7152103559871, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI13994255, Length=328, Percent_Identity=29.2682926829268, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI284507298, Length=226, Percent_Identity=31.4159292035398, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=58.9201877934272, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1789016, Length=356, Percent_Identity=31.1797752808989, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787560, Length=382, Percent_Identity=32.4607329842932, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1789759, Length=317, Percent_Identity=30.9148264984227, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI145693181, Length=299, Percent_Identity=34.7826086956522, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788044, Length=312, Percent_Identity=31.0897435897436, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786991, Length=336, Percent_Identity=28.8690476190476, Blast_Score=98, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=336, Percent_Identity=28.8690476190476, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=304, Percent_Identity=28.2894736842105, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=293, Percent_Identity=26.962457337884, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=355, Percent_Identity=25.9154929577465, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=307, Percent_Identity=29.3159609120521, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324432, Length=327, Percent_Identity=26.605504587156, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357415, Length=319, Percent_Identity=28.2131661442006, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46169; Mature: 46037

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWG
CCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECCCCCEEECCCCHHHHHHHCCCC
PLILGHCHPKVIEAVDNVLHSGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHH
TAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTLGIPSTPGIPQCITEHTLTAD
HHHHHHHCCCCCCCEEEEECEECCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHHHHCC
FNNLEQVAQLFEKYPNDIATVILEPVPGNMGFILPKIEFLKGLRELCDQYNALLIFDEVM
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEHHHH
TGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSG
HHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPLAMAAGLATLKEIEKINFFEDLSSTTNKLTEALSDAAENANIPLFAASLGGMFGFCFT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCEEEEEC
DKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEAGFVSSMHGDLEIQKTYDAAE
CCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHH
LVLNQLKSA
HHHHHHHCC
>Mature Secondary Structure 
SRSSDLFHKAQTIIPGGVNSPVRAFKGVGGEPVFFKSGKGAYLTDVDDKQYIDYVGSWG
CCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECCCCCEEECCCCHHHHHHHCCCC
PLILGHCHPKVIEAVDNVLHSGMSFGAPTELEIQLAEKIASLMPSIEKIRMVNSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHH
TAIRLARGFTNKNKFIKFNGCYHGHSDSLLVKAGSGLLTLGIPSTPGIPQCITEHTLTAD
HHHHHHHCCCCCCCEEEEECEECCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHHHHCC
FNNLEQVAQLFEKYPNDIATVILEPVPGNMGFILPKIEFLKGLRELCDQYNALLIFDEVM
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEEHHHH
TGFRVGLHGAQGLFGIKPDITTLGKIIGGGMPVGALGGKREIMSFLAPEGPVYQAGTLSG
HHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPLAMAAGLATLKEIEKINFFEDLSSTTNKLTEALSDAAENANIPLFAASLGGMFGFCFT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCEEEEEC
DKNSVENYLDVASSDEVLFKKFFHAMLAQGVYFAPSMYEAGFVSSMHGDLEIQKTYDAAE
CCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHH
LVLNQLKSA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA