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The map label for this gene is folK [H]

Identifier: 54294418

GI number: 54294418

Start: 1655475

End: 1655900

Strand: Reverse

Name: folK [H]

Synonym: lpl1487

Alternate gene names: 54294418

Gene position: 1655900-1655475 (Counterclockwise)

Preceding gene: 54294419

Following gene: 54294417

Centisome position: 49.49

GC content: 34.74

Gene sequence:

>426_bases
ATGAATGTTTGCTATCTGAGCTTGGGATCGAATCAAAAAAATCCTGAGCGTCAAATAAGACAAGCCATTAAAGAAATCAA
ACAGATTCCATCAACATGCCTTATCAAGGTCTCTCGTTTATATTGGAATAAGGCCTGGGGCTTTGAAAATCAACAGGAAT
TTTGTAATGTTGTTATAGAGATACGAACTACTCTGTTACCCCATAAGCTCCTTAAGTGGTGCCAAAAAATAGAAAACAGG
CACCAGCGAGTCAGGAGAAAATTTTGGGGGCCAAGAACATTAGATATTGATATCATTTTATATGGTTATAGATTAATTCG
CACAAAAAACTTAATCGTTCCACATCCTTGTTTCCATTTACGAGATTTTGTTCTTGTTCCTCTAAGAGAATTAAACTCTA
ATTTAAAAATACCAAATTACACATAG

Upstream 100 bases:

>100_bases
TTCAAGTAGTCGATGATGTTGAAAAAAATAACATGGTAACTCAATTGGCTGCAACAACGCCCGGGCGGCCTAAAAAACGT
CGTAAACGGAAAGTAGCAAA

Downstream 100 bases:

>100_bases
AGATCATAATCTACTACACTATAACTTAATGATTCTATTTAAAATGAGGTTAACATGTATACAAATATTTTATTTGCCAC
AGATTTGTTAAATGAGCATA

Product: hypothetical protein

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MNVCYLSLGSNQKNPERQIRQAIKEIKQIPSTCLIKVSRLYWNKAWGFENQQEFCNVVIEIRTTLLPHKLLKWCQKIENR
HQRVRRKFWGPRTLDIDIILYGYRLIRTKNLIVPHPCFHLRDFVLVPLRELNSNLKIPNYT

Sequences:

>Translated_141_residues
MNVCYLSLGSNQKNPERQIRQAIKEIKQIPSTCLIKVSRLYWNKAWGFENQQEFCNVVIEIRTTLLPHKLLKWCQKIENR
HQRVRRKFWGPRTLDIDIILYGYRLIRTKNLIVPHPCFHLRDFVLVPLRELNSNLKIPNYT
>Mature_141_residues
MNVCYLSLGSNQKNPERQIRQAIKEIKQIPSTCLIKVSRLYWNKAWGFENQQEFCNVVIEIRTTLLPHKLLKWCQKIENR
HQRVRRKFWGPRTLDIDIILYGYRLIRTKNLIVPHPCFHLRDFVLVPLRELNSNLKIPNYT

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=140, Percent_Identity=38.5714285714286, Blast_Score=110, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=35.2941176470588, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 16970; Mature: 16970

Theoretical pI: Translated: 10.58; Mature: 10.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVCYLSLGSNQKNPERQIRQAIKEIKQIPSTCLIKVSRLYWNKAWGFENQQEFCNVVIE
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IRTTLLPHKLLKWCQKIENRHQRVRRKFWGPRTLDIDIILYGYRLIRTKNLIVPHPCFHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCCHHHH
RDFVLVPLRELNSNLKIPNYT
HHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNVCYLSLGSNQKNPERQIRQAIKEIKQIPSTCLIKVSRLYWNKAWGFENQQEFCNVVIE
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IRTTLLPHKLLKWCQKIENRHQRVRRKFWGPRTLDIDIILYGYRLIRTKNLIVPHPCFHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCCHHHH
RDFVLVPLRELNSNLKIPNYT
HHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]