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The map label for this gene is pdhA [H]

Identifier: 54294399

GI number: 54294399

Start: 1637356

End: 1638429

Strand: Reverse

Name: pdhA [H]

Synonym: lpl1468

Alternate gene names: 54294399

Gene position: 1638429-1637356 (Counterclockwise)

Preceding gene: 54294403

Following gene: 54294398

Centisome position: 48.97

GC content: 40.41

Gene sequence:

>1074_bases
ATGACAACTGTTGCTCAATTTGAAATAACATACACACAATACCTGAATGAACAAGGTAAATTGGTCGCTGAATTACCTCC
ATTCGCAGATAATCAATCCATACTTAAAGAATTGTATAAAATCATGGTACTCACCCGTACTTTTGATAAAAAAGCAATTG
CATTACAAAGAACAGGGAAAATGGGAACCTATGCGCCAATTAATGGCCAGGAAGCTATTTCGACTGCAATTGGACATGCT
CTTAAACCTGAAGATGTACTTGTCCCTTATTACAGAGATTATGCTGCTCAATTTCAGAGAGGCGTTAAAATGTCAGAGAT
ACTCGCCTTTTGGGGCGGGGATGAGCGAGGAAGTCATTATTCTAATAATGCCGAAGATTTACCTATTTGTGTCCCAATTG
CATCTCAATGTTTACATGCCGCAGGAGTCGCATTTGCCTTCAAATACAAAAACCAATCAAGAGTAGCTGTGGTATGTATT
GGAGAAGGAGGCACTTCAGAAGGTGATTTTTACGAAGCCATGAATGTGGCTGGGGCATGGAAGTTACCAGTGGTCTTCGT
AGTAAATAATAACAAATGGGCGATCTCTGTGCCTATAGAAAAACAAACTGGCTCACAAACAATAGCCCAAAAAGCGATTG
CTGCTGGTTTTTCTGGCGTTCAAATAGACGGTAATGATATTTTTGCTGCAAGACAGGTTATAGGGGATGCTATTGAAAAG
GCTCGTCAAGGTGGTGGACCTACTCTAATCGAAGCCTTAACCTATCGCTTGTGCGACCATACAACGGCTGATGATGCAAC
ACGCTATCAGCCTTCTCATGAAGTAGAGGGGGCAAAAGCCAAAGAGCCTATTGTTCGTTTTAAACACTATTTAATGCAAC
AAAATATTTGGACATCTGAGGATGAAGAAAAGCTGGTTATAGAATGCAGTGAAACGGTGGAAAAAGCAGTAGAGGAATAT
TTGAATACCAAACCTCAGCCTGTTAGCAGCATTTTTGATTATCATTATGCAGAATTACCAGAATATTTAATTGAACAACG
CGCAATAGCCATGGAGGAGTATTCTCATGCCTGA

Upstream 100 bases:

>100_bases
AAAAACGTATATTTTTATCTCGGGTTCCTATTAATTTACTGGTTTTTAAATTAATTTGTGAGTATCCTATGCCAACGCGT
TGTTGACAAGGAGCCATGTA

Downstream 100 bases:

>100_bases
TATTACTTTAGTTGAAGCTGTTACTCAGGCTTTGGCGTATGAGTTAGCTCATGATGAAAATGTAGTAGTCTTTGGCGAGG
ATGTTGGTAAAAATGGTGGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MTTVAQFEITYTQYLNEQGKLVAELPPFADNQSILKELYKIMVLTRTFDKKAIALQRTGKMGTYAPINGQEAISTAIGHA
LKPEDVLVPYYRDYAAQFQRGVKMSEILAFWGGDERGSHYSNNAEDLPICVPIASQCLHAAGVAFAFKYKNQSRVAVVCI
GEGGTSEGDFYEAMNVAGAWKLPVVFVVNNNKWAISVPIEKQTGSQTIAQKAIAAGFSGVQIDGNDIFAARQVIGDAIEK
ARQGGGPTLIEALTYRLCDHTTADDATRYQPSHEVEGAKAKEPIVRFKHYLMQQNIWTSEDEEKLVIECSETVEKAVEEY
LNTKPQPVSSIFDYHYAELPEYLIEQRAIAMEEYSHA

Sequences:

>Translated_357_residues
MTTVAQFEITYTQYLNEQGKLVAELPPFADNQSILKELYKIMVLTRTFDKKAIALQRTGKMGTYAPINGQEAISTAIGHA
LKPEDVLVPYYRDYAAQFQRGVKMSEILAFWGGDERGSHYSNNAEDLPICVPIASQCLHAAGVAFAFKYKNQSRVAVVCI
GEGGTSEGDFYEAMNVAGAWKLPVVFVVNNNKWAISVPIEKQTGSQTIAQKAIAAGFSGVQIDGNDIFAARQVIGDAIEK
ARQGGGPTLIEALTYRLCDHTTADDATRYQPSHEVEGAKAKEPIVRFKHYLMQQNIWTSEDEEKLVIECSETVEKAVEEY
LNTKPQPVSSIFDYHYAELPEYLIEQRAIAMEEYSHA
>Mature_356_residues
TTVAQFEITYTQYLNEQGKLVAELPPFADNQSILKELYKIMVLTRTFDKKAIALQRTGKMGTYAPINGQEAISTAIGHAL
KPEDVLVPYYRDYAAQFQRGVKMSEILAFWGGDERGSHYSNNAEDLPICVPIASQCLHAAGVAFAFKYKNQSRVAVVCIG
EGGTSEGDFYEAMNVAGAWKLPVVFVVNNNKWAISVPIEKQTGSQTIAQKAIAAGFSGVQIDGNDIFAARQVIGDAIEKA
RQGGGPTLIEALTYRLCDHTTADDATRYQPSHEVEGAKAKEPIVRFKHYLMQQNIWTSEDEEKLVIECSETVEKAVEEYL
NTKPQPVSSIFDYHYAELPEYLIEQRAIAMEEYSHA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=345, Percent_Identity=31.5942028985507, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI258645172, Length=345, Percent_Identity=31.5942028985507, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4505685, Length=330, Percent_Identity=25.4545454545455, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI291084742, Length=330, Percent_Identity=25.4545454545455, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI4885543, Length=342, Percent_Identity=25.4385964912281, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI291084744, Length=298, Percent_Identity=25.8389261744966, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI291084757, Length=307, Percent_Identity=23.7785016286645, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI86563355, Length=335, Percent_Identity=33.7313432835821, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI86563357, Length=335, Percent_Identity=33.7313432835821, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17536047, Length=318, Percent_Identity=26.7295597484277, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32564172, Length=318, Percent_Identity=26.7295597484277, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6321026, Length=306, Percent_Identity=27.1241830065359, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355903, Length=331, Percent_Identity=31.1178247734139, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24639748, Length=284, Percent_Identity=26.7605633802817, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24639744, Length=262, Percent_Identity=27.4809160305344, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28571106, Length=262, Percent_Identity=27.4809160305344, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24639740, Length=264, Percent_Identity=27.2727272727273, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24639746, Length=264, Percent_Identity=27.2727272727273, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39653; Mature: 39522

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVAQFEITYTQYLNEQGKLVAELPPFADNQSILKELYKIMVLTRTFDKKAIALQRTGK
CCCEEEEEEHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHECCCC
MGTYAPINGQEAISTAIGHALKPEDVLVPYYRDYAAQFQRGVKMSEILAFWGGDERGSHY
CCCCCCCCCHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCC
SNNAEDLPICVPIASQCLHAAGVAFAFKYKNQSRVAVVCIGEGGTSEGDFYEAMNVAGAW
CCCCCCCEEEHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHCCCCC
KLPVVFVVNNNKWAISVPIEKQTGSQTIAQKAIAAGFSGVQIDGNDIFAARQVIGDAIEK
CCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHH
ARQGGGPTLIEALTYRLCDHTTADDATRYQPSHEVEGAKAKEPIVRFKHYLMQQNIWTSE
HHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
DEEKLVIECSETVEKAVEEYLNTKPQPVSSIFDYHYAELPEYLIEQRAIAMEEYSHA
CCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTVAQFEITYTQYLNEQGKLVAELPPFADNQSILKELYKIMVLTRTFDKKAIALQRTGK
CCEEEEEEHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHECCCC
MGTYAPINGQEAISTAIGHALKPEDVLVPYYRDYAAQFQRGVKMSEILAFWGGDERGSHY
CCCCCCCCCHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCC
SNNAEDLPICVPIASQCLHAAGVAFAFKYKNQSRVAVVCIGEGGTSEGDFYEAMNVAGAW
CCCCCCCEEEHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHCCCCC
KLPVVFVVNNNKWAISVPIEKQTGSQTIAQKAIAAGFSGVQIDGNDIFAARQVIGDAIEK
CCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHH
ARQGGGPTLIEALTYRLCDHTTADDATRYQPSHEVEGAKAKEPIVRFKHYLMQQNIWTSE
HHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
DEEKLVIECSETVEKAVEEYLNTKPQPVSSIFDYHYAELPEYLIEQRAIAMEEYSHA
CCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA