Click here to switch to the map view.

The map label for this gene is pdhB [H]

Identifier: 54294398

GI number: 54294398

Start: 1636389

End: 1637363

Strand: Reverse

Name: pdhB [H]

Synonym: lpl1467

Alternate gene names: 54294398

Gene position: 1637363-1636389 (Counterclockwise)

Preceding gene: 54294399

Following gene: 54294397

Centisome position: 48.94

GC content: 41.44

Gene sequence:

>975_bases
ATGCCTGATATTACTTTAGTTGAAGCTGTTACTCAGGCTTTGGCGTATGAGTTAGCTCATGATGAAAATGTAGTAGTCTT
TGGCGAGGATGTTGGTAAAAATGGTGGAGTATTTCGAGCTACTGTAGGTTTACAAGACAGATTCGGAGAAAATAGAGTTT
TTGATACTCCACTAGCAGAATCGATGATAGCTGGCCTTGCTGTAGGGATGTCTATTCAAGGCTTAAAACCTGTTGCTGAA
TTTCAATTCATGGGTTTTATTTATCCAGCCATGAATCAGATCATATCTCATGCAGCGCGTATGCGTAACAGAACCAGAGG
CCGCTTACATTGCCCTTTGGTTTATCGTGCTCCGTTTGGAGGTGGAATCAGAGCACCGGAGCATCATTCTGAAAGTACAG
AAGCATTATTTGCTCATATTCCGGGTTTGCAAGTGGTTATTCCCTCTTCTCCAAAACGCGCCTATGGCCTGTTGTTAGCA
GCTATACGTAACCCCGATCCCGTTATCTTTCTTGAACCAAAACGAATTTATCGATTGGTCAAACAACCTGTTCCAGATGA
TGGACAAGCCTTACCGTTAGGTAAATGTTTTACCCTGCAACAGGGAGATGATCTGACATTAATTAGCTGGGGAGCCAGTA
TGCATGAAACCTTGCAGGCAGCCAAACAATTAACTGATGAAGGTATTTCCTGCGATGTTATTGATGTAGCAACAATTAAG
CCTCTGGATATAGAAACTATATTAAGTTCTGTAGAAAAAACAGGGCGTTGCGTCGTAGTTCATGAAGGAGCAAAAACCTG
TGGAGTGGGTGCTGAAATATCGGCTCAAATTATGGAACATTGTATGGCAGATTTACTAGCTCCTGTGCAAAGAGTTACGG
GATATGATACGGTTATGCCTTATTTCCAACTTGAAAAACAGTACATACCTAGCATTGCACGTATTAAAAACACTGTTATG
AGTATAATGGAGTAA

Upstream 100 bases:

>100_bases
ACCAAACCTCAGCCTGTTAGCAGCATTTTTGATTATCATTATGCAGAATTACCAGAATATTTAATTGAACAACGCGCAAT
AGCCATGGAGGAGTATTCTC

Downstream 100 bases:

>100_bases
TAATGAATATTTTTAATCTACCCGATTTAGGTGAAGGTTTACCTGACGCTGAAATTCATGAATGGTTTGTTAAGGAAGGC
GACACAGTTAAAGCAGATCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MPDITLVEAVTQALAYELAHDENVVVFGEDVGKNGGVFRATVGLQDRFGENRVFDTPLAESMIAGLAVGMSIQGLKPVAE
FQFMGFIYPAMNQIISHAARMRNRTRGRLHCPLVYRAPFGGGIRAPEHHSESTEALFAHIPGLQVVIPSSPKRAYGLLLA
AIRNPDPVIFLEPKRIYRLVKQPVPDDGQALPLGKCFTLQQGDDLTLISWGASMHETLQAAKQLTDEGISCDVIDVATIK
PLDIETILSSVEKTGRCVVVHEGAKTCGVGAEISAQIMEHCMADLLAPVQRVTGYDTVMPYFQLEKQYIPSIARIKNTVM
SIME

Sequences:

>Translated_324_residues
MPDITLVEAVTQALAYELAHDENVVVFGEDVGKNGGVFRATVGLQDRFGENRVFDTPLAESMIAGLAVGMSIQGLKPVAE
FQFMGFIYPAMNQIISHAARMRNRTRGRLHCPLVYRAPFGGGIRAPEHHSESTEALFAHIPGLQVVIPSSPKRAYGLLLA
AIRNPDPVIFLEPKRIYRLVKQPVPDDGQALPLGKCFTLQQGDDLTLISWGASMHETLQAAKQLTDEGISCDVIDVATIK
PLDIETILSSVEKTGRCVVVHEGAKTCGVGAEISAQIMEHCMADLLAPVQRVTGYDTVMPYFQLEKQYIPSIARIKNTVM
SIME
>Mature_323_residues
PDITLVEAVTQALAYELAHDENVVVFGEDVGKNGGVFRATVGLQDRFGENRVFDTPLAESMIAGLAVGMSIQGLKPVAEF
QFMGFIYPAMNQIISHAARMRNRTRGRLHCPLVYRAPFGGGIRAPEHHSESTEALFAHIPGLQVVIPSSPKRAYGLLLAA
IRNPDPVIFLEPKRIYRLVKQPVPDDGQALPLGKCFTLQQGDDLTLISWGASMHETLQAAKQLTDEGISCDVIDVATIKP
LDIETILSSVEKTGRCVVVHEGAKTCGVGAEISAQIMEHCMADLLAPVQRVTGYDTVMPYFQLEKQYIPSIARIKNTVMS
IME

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=323, Percent_Identity=42.7244582043344, Blast_Score=274, Evalue=9e-74,
Organism=Homo sapiens, GI34101272, Length=323, Percent_Identity=42.7244582043344, Blast_Score=274, Evalue=9e-74,
Organism=Homo sapiens, GI156564403, Length=318, Percent_Identity=38.3647798742138, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI291084858, Length=318, Percent_Identity=37.1069182389937, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI133778974, Length=148, Percent_Identity=34.4594594594595, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17506935, Length=319, Percent_Identity=41.3793103448276, Blast_Score=248, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17538422, Length=321, Percent_Identity=39.2523364485981, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17539652, Length=229, Percent_Identity=28.82096069869, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=337, Percent_Identity=36.4985163204748, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI160714828, Length=323, Percent_Identity=41.4860681114551, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI160714832, Length=323, Percent_Identity=41.4860681114551, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI21358145, Length=325, Percent_Identity=38.1538461538462, Blast_Score=227, Evalue=9e-60,
Organism=Drosophila melanogaster, GI24650940, Length=325, Percent_Identity=38.1538461538462, Blast_Score=227, Evalue=9e-60,
Organism=Drosophila melanogaster, GI24650943, Length=95, Percent_Identity=40, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650945, Length=95, Percent_Identity=40, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35413; Mature: 35281

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDITLVEAVTQALAYELAHDENVVVFGEDVGKNGGVFRATVGLQDRFGENRVFDTPLAE
CCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECHHHHCCCCCCCCCHHHH
SMIAGLAVGMSIQGLKPVAEFQFMGFIYPAMNQIISHAARMRNRTRGRLHCPLVYRAPFG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEECCCC
GGIRAPEHHSESTEALFAHIPGLQVVIPSSPKRAYGLLLAAIRNPDPVIFLEPKRIYRLV
CCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECHHHHHHHH
KQPVPDDGQALPLGKCFTLQQGDDLTLISWGASMHETLQAAKQLTDEGISCDVIDVATIK
HCCCCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
PLDIETILSSVEKTGRCVVVHEGAKTCGVGAEISAQIMEHCMADLLAPVQRVTGYDTVMP
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
YFQLEKQYIPSIARIKNTVMSIME
HHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDITLVEAVTQALAYELAHDENVVVFGEDVGKNGGVFRATVGLQDRFGENRVFDTPLAE
CCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECHHHHCCCCCCCCCHHHH
SMIAGLAVGMSIQGLKPVAEFQFMGFIYPAMNQIISHAARMRNRTRGRLHCPLVYRAPFG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEECCCC
GGIRAPEHHSESTEALFAHIPGLQVVIPSSPKRAYGLLLAAIRNPDPVIFLEPKRIYRLV
CCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECHHHHHHHH
KQPVPDDGQALPLGKCFTLQQGDDLTLISWGASMHETLQAAKQLTDEGISCDVIDVATIK
HCCCCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
PLDIETILSSVEKTGRCVVVHEGAKTCGVGAEISAQIMEHCMADLLAPVQRVTGYDTVMP
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
YFQLEKQYIPSIARIKNTVMSIME
HHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]