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The map label for this gene is bla [H]

Identifier: 54294337

GI number: 54294337

Start: 1568104

End: 1568904

Strand: Direct

Name: bla [H]

Synonym: lpl1405

Alternate gene names: 54294337

Gene position: 1568104-1568904 (Clockwise)

Preceding gene: 54294336

Following gene: 54294339

Centisome position: 46.87

GC content: 38.83

Gene sequence:

>801_bases
ATGAAGAAAATCATTATATTTTTGTGCACAGGATTATTATTTTGCGTTTCTACTTGGGCTCAAGGCACCTGTTTTTTAGC
AAAAGAAAATCAAACTGTTTTAAAACGTGAGGGCAATGATTGCGATCAACGCTATTCGCCAGCATCAACTTTTAAAATTG
CCCTTAGCCTCATGGGCTTTGATTCTGGAATACTAAAGGATGAGTTGCATCCTGAATGGCCATACAAAAAAGAATATGAA
CTTTATCTGAATGTATGGAAGTACCCTCAAAACCCGCATACCTGGATCAGAGACTCCTGTGTTTGGTATTCACAGGCATT
AACTCGGCAATTGGGCATGAAACGGTTTAAAGGGTATGTCGACGCATTTCACTACGGTAATCAGGATGTTTCGGGAGACA
GAGGTCAAAATAACGGCTTAACCAATGCCTGGCTTTCCAGCTCACTTTCTATCTCACCCGCAGAGCAAATTCAATTTCTA
CAAAAAATAATCTATAAGAAACTGCCGGTGAGTCAAAAAGCTTATACCATAACTAAAAATATCATGTACATCCAGGAGTT
GCCTGGAGGGTGGAAGCTTTATGGAAAAACAGGAACTGGTCGACAGTTAACAAAAGATAAAAGTCAAAAATTGCCTTTGC
AACATGGATGGTTCGTAGGTTGGATTGAGAAGGATGAGCGTGTAATTACCTTTGCAAAGCATATTGCAGACAGTAAAGAG
AATAACACTTTTGCCAGTTTTAGAGCGAAAAATGATGCTCTGATTCAATTGTTTAACCTGATTAATGAGCTGGAGAAATA
A

Upstream 100 bases:

>100_bases
CCGGTATTCCGAAATGTCGCAATGGATGCTCTGAGCAGTGCAAATCGATAACTAGCTTATGGGTTTGCATATCCATATAT
TCAAAAATGTTGAGGTTGTT

Downstream 100 bases:

>100_bases
TCCAAAAGATGGCCGGTTCAGTGTTTTCTGATCCGGCTATCTAATTCTCTGAATTATAATCACTGGTTGTTAATTTCGCA
TTTTAGTTTGGAAGCTTGTT

Product: hypothetical protein

Products: NA

Alternate protein names: Penicillinase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKKIIIFLCTGLLFCVSTWAQGTCFLAKENQTVLKREGNDCDQRYSPASTFKIALSLMGFDSGILKDELHPEWPYKKEYE
LYLNVWKYPQNPHTWIRDSCVWYSQALTRQLGMKRFKGYVDAFHYGNQDVSGDRGQNNGLTNAWLSSSLSISPAEQIQFL
QKIIYKKLPVSQKAYTITKNIMYIQELPGGWKLYGKTGTGRQLTKDKSQKLPLQHGWFVGWIEKDERVITFAKHIADSKE
NNTFASFRAKNDALIQLFNLINELEK

Sequences:

>Translated_266_residues
MKKIIIFLCTGLLFCVSTWAQGTCFLAKENQTVLKREGNDCDQRYSPASTFKIALSLMGFDSGILKDELHPEWPYKKEYE
LYLNVWKYPQNPHTWIRDSCVWYSQALTRQLGMKRFKGYVDAFHYGNQDVSGDRGQNNGLTNAWLSSSLSISPAEQIQFL
QKIIYKKLPVSQKAYTITKNIMYIQELPGGWKLYGKTGTGRQLTKDKSQKLPLQHGWFVGWIEKDERVITFAKHIADSKE
NNTFASFRAKNDALIQLFNLINELEK
>Mature_266_residues
MKKIIIFLCTGLLFCVSTWAQGTCFLAKENQTVLKREGNDCDQRYSPASTFKIALSLMGFDSGILKDELHPEWPYKKEYE
LYLNVWKYPQNPHTWIRDSCVWYSQALTRQLGMKRFKGYVDAFHYGNQDVSGDRGQNNGLTNAWLSSSLSISPAEQIQFL
QKIIYKKLPVSQKAYTITKNIMYIQELPGGWKLYGKTGTGRQLTKDKSQKLPLQHGWFVGWIEKDERVITFAKHIADSKE
NNTFASFRAKNDALIQLFNLINELEK

Specific function: Has a broad substrate profile, hydrolyzes amoxicillin, ticarcillin, cephalothin, ceftazidime, cefotaxime, and aztreonam, but not imipenem or cephamycins [H]

COG id: COG2602

COG function: function code V; Beta-lactamase class D

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-D beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR002137
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 30743; Mature: 30743

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00337 BETA_LACTAMASE_D

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIIIFLCTGLLFCVSTWAQGTCFLAKENQTVLKREGNDCDQRYSPASTFKIALSLMGF
CCEEEHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCHHHHCCCHHHHHHHHHHHCC
DSGILKDELHPEWPYKKEYELYLNVWKYPQNPHTWIRDSCVWYSQALTRQLGMKRFKGYV
CCCCHHCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DAFHYGNQDVSGDRGQNNGLTNAWLSSSLSISPAEQIQFLQKIIYKKLPVSQKAYTITKN
HHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEHHHH
IMYIQELPGGWKLYGKTGTGRQLTKDKSQKLPLQHGWFVGWIEKDERVITFAKHIADSKE
EEEEEECCCCEEEEECCCCCCCCCCCHHHCCCCCCCCEEEEEECCCHHHHHHHHHCCCCC
NNTFASFRAKNDALIQLFNLINELEK
CCCEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIIIFLCTGLLFCVSTWAQGTCFLAKENQTVLKREGNDCDQRYSPASTFKIALSLMGF
CCEEEHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCHHHHCCCHHHHHHHHHHHCC
DSGILKDELHPEWPYKKEYELYLNVWKYPQNPHTWIRDSCVWYSQALTRQLGMKRFKGYV
CCCCHHCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DAFHYGNQDVSGDRGQNNGLTNAWLSSSLSISPAEQIQFLQKIIYKKLPVSQKAYTITKN
HHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEHHHH
IMYIQELPGGWKLYGKTGTGRQLTKDKSQKLPLQHGWFVGWIEKDERVITFAKHIADSKE
EEEEEECCCCEEEEECCCCCCCCCCCHHHCCCCCCCCEEEEEECCCHHHHHHHHHCCCCC
NNTFASFRAKNDALIQLFNLINELEK
CCCEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9333046 [H]