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The map label for this gene is penA [H]

Identifier: 54294336

GI number: 54294336

Start: 1566144

End: 1568054

Strand: Direct

Name: penA [H]

Synonym: lpl1404

Alternate gene names: 54294336

Gene position: 1566144-1568054 (Clockwise)

Preceding gene: 54294335

Following gene: 54294337

Centisome position: 46.81

GC content: 37.89

Gene sequence:

>1911_bases
ATGTTATTAATAGAAATTATATTGACTATTCATTGCCTGCTTCTTCTCAGTTCACTATTTATAGGGCGTACCTGGCTAGC
AAATAAACCATCTTTTAAATTGAAATTACTCCGTTTTTTATTGGCCAGTTGCATTATTTCACCAATAATAGTTCATTGTG
TAGACTCTGATCAAAAGCCTGAACGAAAAAACTATGTATCATTTGATGCTTTGCAACAATATGCAAAGCAACCCATATTT
AAAACAGAATCTTCAAAATTCAATCATGGATCGCCTTCTGCCTTTACATCAATGAATGTGAACTACTGTCAACTCTTAAG
CATGATGTTTTTTTTAATCGTCTTGTTTCGTAGTTATCACTTGTTATCAGGTTTAGGTCGCTTGAAATTGATGTTGACTG
AAGCAATCCCATATCGAACTTCCGGAAAATTAGTTATTAAGGTTTCTCACCACTGCCATGTTCCTTTCTCAATATTGCTA
TTTAATAAAGCCTACATCGTATTGCCAGTATCCATATTTTCTTCTTCAATGAATGTGAGGATTGCTATTGCTCATGAAGG
GCAACACCATCGTAATGGAGATTGTTCATGGGCCTATTTTATCGAAATCATACGCATTATCTTCTTTGGAAACCCGGGTG
TAACTCAATGGTTTCGTGTTTTAGCAGATTTACAAGAATTGTCGTGTGATGAAGTATTGGTTGGACATCAAAAAATTTCG
GCACATGACTATGGCCACTGTCTATTGCAAGTGGTAGAGGCAGTATCCCAATGCTCTCTGACATCTAACCGGGAAATTGC
ATGCACAGTGGGTATGGCTTTGAACAAAGAAAACGAAGACTGTAAATTTATAATAAGGAGAATTTCAATGCTAACTGCTT
ATTCACCCAATGCATCCAGACCTTTGCTATTAGGGATAGTCTTCGCAGGATTTTCTATCCTGTCTCCAATCTGCGTTGCC
TATTCAACAGCAGGATCTTTGACGAGTTCCAGGGCAAAAGAAGTTGATATTTCTCATTTAGATCCCAGAATGCAGCAGAT
TGCAGAGAAACAAATTACGACAGCCGTCAAACAATATCATGCAAAATCTGGAGTTATTGCAATAGCTGATCCCCAAACAG
GCAATATCATTGCATTTGCTGAATCAAGTAAAAATAAGGGGCTAGAGAGCTGGAAATCACGTATTTTTTCACCCGGATCT
ACTATAAAACCTTTTATTGCAGCAGCTGCAATCAACTCTGGGAATAGCTCTGAAACAAAAAATTATGATTGTCATTCACC
TTATTACATAGCAGGCAAAACATTTACAAATTATAATTCCAATGTTGAATCAGCTTCCTTGGCAGAAGCCATCGCAAAAT
CTATCAATGTATGCCTTATCAGAGTTTCTCAAGAGGCTGGGGTGTCTGTAATCCGTAAAAAGCTCACTGAATTTGGTTTT
GACACAAGCACTTGGTGGCAAGCAGATCGAAGTGATGGTTTACAACTAACAATGGCTGCACTTGGAGAGAATATCCCTGT
CACAATCGAATCGCTAATAAAATCTTATGCCATTCTTGCTAACAAAGGACATTCATTTGACAGAGGAAATAGTGCCATTA
TTTCAGAAACAACCTCTTACTCAATAAATCATATGCTTGAAAATGCTGTCACAAATGGCACTGGAAAACTCGCAGTTATT
CCTGGTGTTTCTGTAGCAGGTAAGACAGGAACTGTAATTGAAAATAATGATAAATATCTTGCTTTGTTTGCCGGGTATGT
GCCAGTTGATAATCCGCGTTATGTTGTATTAGTCGTGATTGAAGAGGGTTATTTCAGTAAAAATGGAAAGACATTAGTTT
CGGGAGGAGAATTGGCCGCACCGGTATTCCGAAATGTCGCAATGGATGCTCTGAGCAGTGCAAATCGATAA

Upstream 100 bases:

>100_bases
GACTTTTGTTAGCCAGAAAGTTACAGCATGATGACATTCAAGCCATTGAAGAAGCACTTAAACAATTAAACGCTGGTGAA
AAACAGCCAGAGGTGATGTA

Downstream 100 bases:

>100_bases
CTAGCTTATGGGTTTGCATATCCATATATTCAAAAATGTTGAGGTTGTTATGAAGAAAATCATTATATTTTTGTGCACAG
GATTATTATTTTGCGTTTCT

Product: hypothetical protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MLLIEIILTIHCLLLLSSLFIGRTWLANKPSFKLKLLRFLLASCIISPIIVHCVDSDQKPERKNYVSFDALQQYAKQPIF
KTESSKFNHGSPSAFTSMNVNYCQLLSMMFFLIVLFRSYHLLSGLGRLKLMLTEAIPYRTSGKLVIKVSHHCHVPFSILL
FNKAYIVLPVSIFSSSMNVRIAIAHEGQHHRNGDCSWAYFIEIIRIIFFGNPGVTQWFRVLADLQELSCDEVLVGHQKIS
AHDYGHCLLQVVEAVSQCSLTSNREIACTVGMALNKENEDCKFIIRRISMLTAYSPNASRPLLLGIVFAGFSILSPICVA
YSTAGSLTSSRAKEVDISHLDPRMQQIAEKQITTAVKQYHAKSGVIAIADPQTGNIIAFAESSKNKGLESWKSRIFSPGS
TIKPFIAAAAINSGNSSETKNYDCHSPYYIAGKTFTNYNSNVESASLAEAIAKSINVCLIRVSQEAGVSVIRKKLTEFGF
DTSTWWQADRSDGLQLTMAALGENIPVTIESLIKSYAILANKGHSFDRGNSAIISETTSYSINHMLENAVTNGTGKLAVI
PGVSVAGKTGTVIENNDKYLALFAGYVPVDNPRYVVLVVIEEGYFSKNGKTLVSGGELAAPVFRNVAMDALSSANR

Sequences:

>Translated_636_residues
MLLIEIILTIHCLLLLSSLFIGRTWLANKPSFKLKLLRFLLASCIISPIIVHCVDSDQKPERKNYVSFDALQQYAKQPIF
KTESSKFNHGSPSAFTSMNVNYCQLLSMMFFLIVLFRSYHLLSGLGRLKLMLTEAIPYRTSGKLVIKVSHHCHVPFSILL
FNKAYIVLPVSIFSSSMNVRIAIAHEGQHHRNGDCSWAYFIEIIRIIFFGNPGVTQWFRVLADLQELSCDEVLVGHQKIS
AHDYGHCLLQVVEAVSQCSLTSNREIACTVGMALNKENEDCKFIIRRISMLTAYSPNASRPLLLGIVFAGFSILSPICVA
YSTAGSLTSSRAKEVDISHLDPRMQQIAEKQITTAVKQYHAKSGVIAIADPQTGNIIAFAESSKNKGLESWKSRIFSPGS
TIKPFIAAAAINSGNSSETKNYDCHSPYYIAGKTFTNYNSNVESASLAEAIAKSINVCLIRVSQEAGVSVIRKKLTEFGF
DTSTWWQADRSDGLQLTMAALGENIPVTIESLIKSYAILANKGHSFDRGNSAIISETTSYSINHMLENAVTNGTGKLAVI
PGVSVAGKTGTVIENNDKYLALFAGYVPVDNPRYVVLVVIEEGYFSKNGKTLVSGGELAAPVFRNVAMDALSSANR
>Mature_636_residues
MLLIEIILTIHCLLLLSSLFIGRTWLANKPSFKLKLLRFLLASCIISPIIVHCVDSDQKPERKNYVSFDALQQYAKQPIF
KTESSKFNHGSPSAFTSMNVNYCQLLSMMFFLIVLFRSYHLLSGLGRLKLMLTEAIPYRTSGKLVIKVSHHCHVPFSILL
FNKAYIVLPVSIFSSSMNVRIAIAHEGQHHRNGDCSWAYFIEIIRIIFFGNPGVTQWFRVLADLQELSCDEVLVGHQKIS
AHDYGHCLLQVVEAVSQCSLTSNREIACTVGMALNKENEDCKFIIRRISMLTAYSPNASRPLLLGIVFAGFSILSPICVA
YSTAGSLTSSRAKEVDISHLDPRMQQIAEKQITTAVKQYHAKSGVIAIADPQTGNIIAFAESSKNKGLESWKSRIFSPGS
TIKPFIAAAAINSGNSSETKNYDCHSPYYIAGKTFTNYNSNVESASLAEAIAKSINVCLIRVSQEAGVSVIRKKLTEFGF
DTSTWWQADRSDGLQLTMAALGENIPVTIESLIKSYAILANKGHSFDRGNSAIISETTSYSINHMLENAVTNGTGKLAVI
PGVSVAGKTGTVIENNDKYLALFAGYVPVDNPRYVVLVVIEEGYFSKNGKTLVSGGELAAPVFRNVAMDALSSANR

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=345, Percent_Identity=25.2173913043478, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 69887; Mature: 69887

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIEIILTIHCLLLLSSLFIGRTWLANKPSFKLKLLRFLLASCIISPIIVHCVDSDQKP
CHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ERKNYVSFDALQQYAKQPIFKTESSKFNHGSPSAFTSMNVNYCQLLSMMFFLIVLFRSYH
CHHCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
LLSGLGRLKLMLTEAIPYRTSGKLVIKVSHHCHVPFSILLFNKAYIVLPVSIFSSSMNVR
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCEEEEEEHHHHCCCCCEE
IAIAHEGQHHRNGDCSWAYFIEIIRIIFFGNPGVTQWFRVLADLQELSCDEVLVGHQKIS
EEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCC
AHDYGHCLLQVVEAVSQCSLTSNREIACTVGMALNKENEDCKFIIRRISMLTAYSPNASR
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCC
PLLLGIVFAGFSILSPICVAYSTAGSLTSSRAKEVDISHLDPRMQQIAEKQITTAVKQYH
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHCCCHHHCCHHHHHHHHHHHHHHHHHHH
AKSGVIAIADPQTGNIIAFAESSKNKGLESWKSRIFSPGSTIKPFIAAAAINSGNSSETK
HCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHEECCCCCCCCC
NYDCHSPYYIAGKTFTNYNSNVESASLAEAIAKSINVCLIRVSQEAGVSVIRKKLTEFGF
CCCCCCCEEEECCEEECCCCCCCHHHHHHHHHHCCCEEEEEECHHCCHHHHHHHHHHHCC
DTSTWWQADRSDGLQLTMAALGENIPVTIESLIKSYAILANKGHSFDRGNSAIISETTSY
CCCHHCCCCCCCCCEEEHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHH
SINHMLENAVTNGTGKLAVIPGVSVAGKTGTVIENNDKYLALFAGYVPVDNPRYVVLVVI
HHHHHHHHHHCCCCCCEEEECCCEECCCCCCEEECCCCEEEEEECCCCCCCCCEEEEEEE
EEGYFSKNGKTLVSGGELAAPVFRNVAMDALSSANR
ECCEECCCCCEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLLIEIILTIHCLLLLSSLFIGRTWLANKPSFKLKLLRFLLASCIISPIIVHCVDSDQKP
CHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ERKNYVSFDALQQYAKQPIFKTESSKFNHGSPSAFTSMNVNYCQLLSMMFFLIVLFRSYH
CHHCCCCHHHHHHHHHCCCEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
LLSGLGRLKLMLTEAIPYRTSGKLVIKVSHHCHVPFSILLFNKAYIVLPVSIFSSSMNVR
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEECCEEEEEEHHHHCCCCCEE
IAIAHEGQHHRNGDCSWAYFIEIIRIIFFGNPGVTQWFRVLADLQELSCDEVLVGHQKIS
EEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCC
AHDYGHCLLQVVEAVSQCSLTSNREIACTVGMALNKENEDCKFIIRRISMLTAYSPNASR
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCC
PLLLGIVFAGFSILSPICVAYSTAGSLTSSRAKEVDISHLDPRMQQIAEKQITTAVKQYH
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHCCCHHHCCHHHHHHHHHHHHHHHHHHH
AKSGVIAIADPQTGNIIAFAESSKNKGLESWKSRIFSPGSTIKPFIAAAAINSGNSSETK
HCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHEECCCCCCCCC
NYDCHSPYYIAGKTFTNYNSNVESASLAEAIAKSINVCLIRVSQEAGVSVIRKKLTEFGF
CCCCCCCEEEECCEEECCCCCCCHHHHHHHHHHCCCEEEEEECHHCCHHHHHHHHHHHCC
DTSTWWQADRSDGLQLTMAALGENIPVTIESLIKSYAILANKGHSFDRGNSAIISETTSY
CCCHHCCCCCCCCCEEEHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHH
SINHMLENAVTNGTGKLAVIPGVSVAGKTGTVIENNDKYLALFAGYVPVDNPRYVVLVVI
HHHHHHHHHHCCCCCCEEEECCCEECCCCCCEEECCCCEEEEEECCCCCCCCCEEEEEEE
EEGYFSKNGKTLVSGGELAAPVFRNVAMDALSSANR
ECCEECCCCCEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]