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The map label for this gene is helC [H]

Identifier: 54293985

GI number: 54293985

Start: 1171293

End: 1172543

Strand: Direct

Name: helC [H]

Synonym: lpl1044

Alternate gene names: 54293985

Gene position: 1171293-1172543 (Clockwise)

Preceding gene: 54293982

Following gene: 54293986

Centisome position: 35.01

GC content: 46.12

Gene sequence:

>1251_bases
ATGCGTTATTTTTCACGTCTCGTCATTTTCATGATGATGTACTTCGTTGTTTGCGAAGTACTGTCGGCTACCCCCTTTAC
TTTTAAACAGGCTTTGGACACGGCTTATCGAAATAATCCTGAATTGCAAGCCGAAATGGACAAAGCAAGGGCCATGCGGG
GTTACTTTATTCAAAGTGGCCTTTATCCCAATCCGCAACTGACTTTAACGGCGGAGAATTTCGGTGGCTCTGGCGCCTAC
TCCAGTTATGAATCTGCGGAAACCACGTTTTCAGTCACTCAGCCGATTCCTTTAGGCCATCGACTTCAGTATTTGAAAAA
AGCAACCTATGCAGACTATCTGGCGTCTCTTGCCAGCATCAGAGTTCAGCAAACAGCGCTGTATATGGCTGTGGGTGTGG
CTTATGTGGATGCGCTATACGCCGGTCAATGGCATCAAGTGACCAAAAAACTGACTCGACTGAATCAGGATATTGTGGTG
GCTATTGAGCGCCGGGTTAAGGCAGGTGCTGGGGCAGAGCTGGATTTGCGATTGGCGCAAGTACGATTGGGCGAGGCCAA
AATCCAGGAAAATAAAGCAGCACGGGACGCTTTGTTGCAGCGAGCCAAGCTTGCGCGCTTGTTAGGTGATGGGTTAAGAG
TGGATAGGCCTTTGGTGGATAAAGGGTTACCAGGTGTTTCAGTCAATTGGACTGAATTAGTAAAAAAATTACCGCAAAGC
CCTCAGTTACTGCAAATGCAACTGCAATTACAAGCCAAGCGCAAGACGATTACCGCTGTTAAAAAATCCGTTTGGCCGGA
TTTAAACATTCAATTGGGAGGTCGTCATTTTTCTGATGACGGCAGTAATGCGGCCGTTATGTCAGCTTTTGCAGAAGTGC
CAGTATATAATCGAAATCAAGGCAAAATCATGACAGCAGAAGCGCAATACACCCAGACGGCCCATGAATTTCAAGGAACG
CGTCTTGATGTGCGTCAAAGTGTCTATGCGGCCTTTTTACAAGCCCAGCAAAACCACTATGAAGCCAGTTTAGTTACGGA
TTCCTTATTGCCGTTGGCACGTAAAGCGATAAAACTGGCTCAAGAGGGCTATCAAATGGGACGTTACACGTACATTGAAT
TATCAACCGCACTCAATTCTTTGTATGAAGAAGAGCGGCATTACCAGCAGGCTCATGCCGATTATCATAAAGCCTTAATT
CAGATGACAGGACTTTTAGGACTGGATAATTCTAAGGAGGAGAGCAAATGA

Upstream 100 bases:

>100_bases
ATCAGATTGTCTTGATTTTAGCAATAGGGTGTATCAAGACACGAAATCAAGGTACAATGAAACAATAAGGTTTGACATGG
ATTTTCTTAAAAGGTAAGGA

Downstream 100 bases:

>100_bases
CATTCCTAAAGCCATTTAAGCCATCCATTCTGCTTCTTATTCTTTGGTTCGTTATGGGGGTTTTTTCCTGGGCAGGGGAG
GGCTCTCATGCTATGGAAGA

Product: HelC protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MRYFSRLVIFMMMYFVVCEVLSATPFTFKQALDTAYRNNPELQAEMDKARAMRGYFIQSGLYPNPQLTLTAENFGGSGAY
SSYESAETTFSVTQPIPLGHRLQYLKKATYADYLASLASIRVQQTALYMAVGVAYVDALYAGQWHQVTKKLTRLNQDIVV
AIERRVKAGAGAELDLRLAQVRLGEAKIQENKAARDALLQRAKLARLLGDGLRVDRPLVDKGLPGVSVNWTELVKKLPQS
PQLLQMQLQLQAKRKTITAVKKSVWPDLNIQLGGRHFSDDGSNAAVMSAFAEVPVYNRNQGKIMTAEAQYTQTAHEFQGT
RLDVRQSVYAAFLQAQQNHYEASLVTDSLLPLARKAIKLAQEGYQMGRYTYIELSTALNSLYEEERHYQQAHADYHKALI
QMTGLLGLDNSKEESK

Sequences:

>Translated_416_residues
MRYFSRLVIFMMMYFVVCEVLSATPFTFKQALDTAYRNNPELQAEMDKARAMRGYFIQSGLYPNPQLTLTAENFGGSGAY
SSYESAETTFSVTQPIPLGHRLQYLKKATYADYLASLASIRVQQTALYMAVGVAYVDALYAGQWHQVTKKLTRLNQDIVV
AIERRVKAGAGAELDLRLAQVRLGEAKIQENKAARDALLQRAKLARLLGDGLRVDRPLVDKGLPGVSVNWTELVKKLPQS
PQLLQMQLQLQAKRKTITAVKKSVWPDLNIQLGGRHFSDDGSNAAVMSAFAEVPVYNRNQGKIMTAEAQYTQTAHEFQGT
RLDVRQSVYAAFLQAQQNHYEASLVTDSLLPLARKAIKLAQEGYQMGRYTYIELSTALNSLYEEERHYQQAHADYHKALI
QMTGLLGLDNSKEESK
>Mature_416_residues
MRYFSRLVIFMMMYFVVCEVLSATPFTFKQALDTAYRNNPELQAEMDKARAMRGYFIQSGLYPNPQLTLTAENFGGSGAY
SSYESAETTFSVTQPIPLGHRLQYLKKATYADYLASLASIRVQQTALYMAVGVAYVDALYAGQWHQVTKKLTRLNQDIVV
AIERRVKAGAGAELDLRLAQVRLGEAKIQENKAARDALLQRAKLARLLGDGLRVDRPLVDKGLPGVSVNWTELVKKLPQS
PQLLQMQLQLQAKRKTITAVKKSVWPDLNIQLGGRHFSDDGSNAAVMSAFAEVPVYNRNQGKIMTAEAQYTQTAHEFQGT
RLDVRQSVYAAFLQAQQNHYEASLVTDSLLPLARKAIKLAQEGYQMGRYTYIELSTALNSLYEEERHYQQAHADYHKALI
QMTGLLGLDNSKEESK

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 46723; Mature: 46723

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYFSRLVIFMMMYFVVCEVLSATPFTFKQALDTAYRNNPELQAEMDKARAMRGYFIQSG
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
LYPNPQLTLTAENFGGSGAYSSYESAETTFSVTQPIPLGHRLQYLKKATYADYLASLASI
CCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
RVQQTALYMAVGVAYVDALYAGQWHQVTKKLTRLNQDIVVAIERRVKAGAGAELDLRLAQ
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEHHHHH
VRLGEAKIQENKAARDALLQRAKLARLLGDGLRVDRPLVDKGLPGVSVNWTELVKKLPQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCHHHHHHHCCCC
PQLLQMQLQLQAKRKTITAVKKSVWPDLNIQLGGRHFSDDGSNAAVMSAFAEVPVYNRNQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCCCCCCHHHHHHHHHCCCEECCC
GKIMTAEAQYTQTAHEFQGTRLDVRQSVYAAFLQAQQNHYEASLVTDSLLPLARKAIKLA
CCEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QEGYQMGRYTYIELSTALNSLYEEERHYQQAHADYHKALIQMTGLLGLDNSKEESK
HHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRYFSRLVIFMMMYFVVCEVLSATPFTFKQALDTAYRNNPELQAEMDKARAMRGYFIQSG
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
LYPNPQLTLTAENFGGSGAYSSYESAETTFSVTQPIPLGHRLQYLKKATYADYLASLASI
CCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
RVQQTALYMAVGVAYVDALYAGQWHQVTKKLTRLNQDIVVAIERRVKAGAGAELDLRLAQ
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEHHHHH
VRLGEAKIQENKAARDALLQRAKLARLLGDGLRVDRPLVDKGLPGVSVNWTELVKKLPQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCHHHHHHHCCCC
PQLLQMQLQLQAKRKTITAVKKSVWPDLNIQLGGRHFSDDGSNAAVMSAFAEVPVYNRNQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCCCCCCHHHHHHHHHCCCEECCC
GKIMTAEAQYTQTAHEFQGTRLDVRQSVYAAFLQAQQNHYEASLVTDSLLPLARKAIKLA
CCEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QEGYQMGRYTYIELSTALNSLYEEERHYQQAHADYHKALIQMTGLLGLDNSKEESK
HHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]