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The map label for this gene is era [H]

Identifier: 54293917

GI number: 54293917

Start: 1092714

End: 1093649

Strand: Direct

Name: era [H]

Synonym: lpl0973

Alternate gene names: 54293917

Gene position: 1092714-1093649 (Clockwise)

Preceding gene: 54293913

Following gene: 54293918

Centisome position: 32.66

GC content: 36.22

Gene sequence:

>936_bases
ATGACATGGCTGTTAGAATGTTTTAAAAATAAACAGGAATCAAGATTAATGAGTAGTTATTGTGGTTATATTGCTTTAGT
TGGCAGGCCAAATGTTGGCAAATCAACCTTATTAAATCGTATTTTACAGCAAAAATTAAGTATTACCTCGAGAAAACCAC
AAACCACGCGCCATAGTATTTTAGGAATCCGTACAGAAGATGAATTTCAGTTTGTTTATGTAGATACTCCTGGTATTCAT
CAGGGTAATGCGAAAGCAATTAATCGCATGATGAATAAAACTGCGATTAGTGTACTACGTGACGTGGATGTGATTGCCTT
TCTAGTTGATGGAACGCATTGGAAAGACGAAGATGAGTATGTGCTGAATTTAATCAAACAAGCTAAAGTTCCTTGCATCC
TGGTAGTTAACAAAGTTGACAAGATAACTGATAAAACACAACTTTTGCCCTGGATAGAGCAAATAAGTCAGCGATATCAA
TTTGCAGCCATTATTCCTTTGTCGGCGAAAACTGGTTTGCAGGTGGATGAATTGGAAGGCAAATTAAAGACTTATTTGCC
AGAAGGACCACATTTGTTCCCTGATGATCAATTCACCGATCGGTCTACAAAATTTTTATGTGCTGAATTGCTCCGTGAAA
AAATTTTCCGCTTTTGTGGACAAGAATTGCCTTATTCAGTAACAGTAGATATCGAATCATTTAAGGATGAGGGAAATTTA
ATTCGTATTCATGCCTTGATTTTAGTAGACAAGGATAATCACAAGCGCATGATCATTGGTGATAAAGGCCAAAAATTAAA
AGAAATGGCAACTAATGCCCGTTTGGACATGGAAAAAATGCTAGATAAAAAGGTTTTTTTACAATGTTGGTGTAAAGTGA
AATCAGGCTGGTCAGATGATGAGAGAATACTGAAGCAATTGGGATATGACCAGTAA

Upstream 100 bases:

>100_bases
CAAAATCGTTTAATTTAATGCCATTAACGCACAGGGTACTCGAATTGGAACAGAAATAGCAAGTCTATTTAATGAAAAAT
TTGGTATCTCTGGAAGTTTT

Downstream 100 bases:

>100_bases
ATCGCTGAGTGCTTGGGTAATTCATAAGCAATGGTCTGGAGATACCAGTGCCAGACTAAAGCTTTTTACTAGGGAACTGG
GATTAATTAATTGCTTGTGC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTWLLECFKNKQESRLMSSYCGYIALVGRPNVGKSTLLNRILQQKLSITSRKPQTTRHSILGIRTEDEFQFVYVDTPGIH
QGNAKAINRMMNKTAISVLRDVDVIAFLVDGTHWKDEDEYVLNLIKQAKVPCILVVNKVDKITDKTQLLPWIEQISQRYQ
FAAIIPLSAKTGLQVDELEGKLKTYLPEGPHLFPDDQFTDRSTKFLCAELLREKIFRFCGQELPYSVTVDIESFKDEGNL
IRIHALILVDKDNHKRMIIGDKGQKLKEMATNARLDMEKMLDKKVFLQCWCKVKSGWSDDERILKQLGYDQ

Sequences:

>Translated_311_residues
MTWLLECFKNKQESRLMSSYCGYIALVGRPNVGKSTLLNRILQQKLSITSRKPQTTRHSILGIRTEDEFQFVYVDTPGIH
QGNAKAINRMMNKTAISVLRDVDVIAFLVDGTHWKDEDEYVLNLIKQAKVPCILVVNKVDKITDKTQLLPWIEQISQRYQ
FAAIIPLSAKTGLQVDELEGKLKTYLPEGPHLFPDDQFTDRSTKFLCAELLREKIFRFCGQELPYSVTVDIESFKDEGNL
IRIHALILVDKDNHKRMIIGDKGQKLKEMATNARLDMEKMLDKKVFLQCWCKVKSGWSDDERILKQLGYDQ
>Mature_310_residues
TWLLECFKNKQESRLMSSYCGYIALVGRPNVGKSTLLNRILQQKLSITSRKPQTTRHSILGIRTEDEFQFVYVDTPGIHQ
GNAKAINRMMNKTAISVLRDVDVIAFLVDGTHWKDEDEYVLNLIKQAKVPCILVVNKVDKITDKTQLLPWIEQISQRYQF
AAIIPLSAKTGLQVDELEGKLKTYLPEGPHLFPDDQFTDRSTKFLCAELLREKIFRFCGQELPYSVTVDIESFKDEGNLI
RIHALILVDKDNHKRMIIGDKGQKLKEMATNARLDMEKMLDKKVFLQCWCKVKSGWSDDERILKQLGYDQ

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=308, Percent_Identity=25.974025974026, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1788919, Length=292, Percent_Identity=53.4246575342466, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI87082120, Length=153, Percent_Identity=28.7581699346405, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17532761, Length=191, Percent_Identity=27.7486910994764, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646434, Length=300, Percent_Identity=26.6666666666667, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 35885; Mature: 35754

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWLLECFKNKQESRLMSSYCGYIALVGRPNVGKSTLLNRILQQKLSITSRKPQTTRHSI
CCHHHHHHCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHE
LGIRTEDEFQFVYVDTPGIHQGNAKAINRMMNKTAISVLRDVDVIAFLVDGTHWKDEDEY
EEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHH
VLNLIKQAKVPCILVVNKVDKITDKTQLLPWIEQISQRYQFAAIIPLSAKTGLQVDELEG
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHCC
KLKTYLPEGPHLFPDDQFTDRSTKFLCAELLREKIFRFCGQELPYSVTVDIESFKDEGNL
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCE
IRIHALILVDKDNHKRMIIGDKGQKLKEMATNARLDMEKMLDKKVFLQCWCKVKSGWSDD
EEEEEEEEEECCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHH
ERILKQLGYDQ
HHHHHHCCCCC
>Mature Secondary Structure 
TWLLECFKNKQESRLMSSYCGYIALVGRPNVGKSTLLNRILQQKLSITSRKPQTTRHSI
CHHHHHHCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHE
LGIRTEDEFQFVYVDTPGIHQGNAKAINRMMNKTAISVLRDVDVIAFLVDGTHWKDEDEY
EEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHH
VLNLIKQAKVPCILVVNKVDKITDKTQLLPWIEQISQRYQFAAIIPLSAKTGLQVDELEG
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHCC
KLKTYLPEGPHLFPDDQFTDRSTKFLCAELLREKIFRFCGQELPYSVTVDIESFKDEGNL
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCE
IRIHALILVDKDNHKRMIIGDKGQKLKEMATNARLDMEKMLDKKVFLQCWCKVKSGWSDD
EEEEEEEEEECCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHH
ERILKQLGYDQ
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA