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The map label for this gene is kmo [H]

Identifier: 54293867

GI number: 54293867

Start: 1036815

End: 1038164

Strand: Direct

Name: kmo [H]

Synonym: lpl0923

Alternate gene names: 54293867

Gene position: 1036815-1038164 (Clockwise)

Preceding gene: 54293866

Following gene: 54293868

Centisome position: 30.99

GC content: 36.59

Gene sequence:

>1350_bases
ATGAAGCACATTACCATAATTGGAGCCGGGTTAGCGGGAACTTTGTGTGGTTTATATCTTGCTAGAAGAGGCTATGAAGT
AGAGTTGTTTGAATCAAGACCAGACATTCGTAACAGTCCGACTGATTATGGCCGCTCCATTAATCTTGCTTTGTCGTGCA
GAGGAATTACTGCTTTAAAAGCAATGAACCTGTTAAGTGAAGTAAATAAAATTATGGTTCCAATGCGGGCAAGAGCTATT
CACGAAGCTAATGGCGAGATTCACTATCAACCATTTGGACGTCACATTGATGAATATATCAATGCTATTTCTCGTTCTGA
TCTCAATGCCTTGCTTTTAAATAAAGCGAAATTATGCCCTAACATTAAATTACACTTTAATATGAAATTGCACTCTCTTG
ATATTCATAATAAAAAAATTAAATTTGAAAATAAAAATGGTGATTTTGTTGAGGCCTCATACCATAGACTAATTGGAGCA
GATGGTGCGCCGTCTCATGTAAGGGATATGCTGAAAAATGAGGGGATAGTTAGTGCAAGCAGAGATTTTTTATCTCATGG
ATACAAGGAGCTTTCAATTAGCAAAAAACATACAAAAGGGATGGCTAGAGAGCATTTGCATTTATGGCCACGTGATTCGT
TTATGCTATTAGGTAACCCTAATCCTGACGATTCAATTACAGGTTCTTTGTTTTTAGCTAATGAAGGGAAAGACAGCTTT
GCTGAACTAAATAATGAAGAAAAATTACATTTATTTTTTAAAACACAGTTCCCGGATGCCTATGCAGCTATGCCAAATTT
GGTTCAAGAATTTTTTGGTAATCCTACTGGACATTTGAGTACTATCCAATGCTCACCCTGGTACTATAAAGACGAATGCT
TATTAATAGGTGATGCGGCACATGGGATAATTCCATTCTTTGGGCAAGGAATGAATAGCGCATTTGAAGATTGCCGTATT
CTTGATGAATTACTGGATGAATACCAAGACGACTGGTCGCGAGTGAACTCTGTTTTTTATGAACACAGAAAAGTGAATAC
CGATGCGATAGCAAAAATGTCTATGGATAATTATCATGAAATTCATTCGGACATAAGAAATCCAAAATTTATTTTACAAA
AGCAGATTGAACGGGAGCTCATGTTGCGATACCCGGAACATTATGTTTCCATGCATGTTTTGGTTATGTTTACCAATACC
CCTTATGCCAAGGCGATGGCAATAGGCGAGTTACAATCTGGCCTTTTAGAGCAAATTTGTTTCCCAATAACTGATATTAA
GGAGTTAAATTGGCAGGAAGTAGAGAAATTACTTAGCTTATATGACAAAAAATTGGCGAAAATTATTTGA

Upstream 100 bases:

>100_bases
GTTTTACTTTTATTCAAGCAATATATTGATTGAATTTGTGTATTTTTTAAGGAGATTCGGAATAGATGTCGTATTGATAT
AGAATGGGTTGGGAGGATAA

Downstream 100 bases:

>100_bases
TTTAATTTATGTCATTCATTTTAAATGAAATTTATAGTCAAAGTTTTGTCAGAAAAGATAGATTCAGGGACATTTTTTTG
TCGCTACCTGAGGCTTATTA

Product: hypothetical protein

Products: NA

Alternate protein names: Kynurenine 3-hydroxylase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAI
HEANGEIHYQPFGRHIDEYINAISRSDLNALLLNKAKLCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGA
DGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRI
LDELLDEYQDDWSRVNSVFYEHRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNT
PYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLSLYDKKLAKII

Sequences:

>Translated_449_residues
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAI
HEANGEIHYQPFGRHIDEYINAISRSDLNALLLNKAKLCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGA
DGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRI
LDELLDEYQDDWSRVNSVFYEHRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNT
PYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLSLYDKKLAKII
>Mature_449_residues
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAI
HEANGEIHYQPFGRHIDEYINAISRSDLNALLLNKAKLCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGA
DGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRI
LDELLDEYQDDWSRVNSVFYEHRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNT
PYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLSLYDKKLAKII

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily [H]

Homologues:

Organism=Homo sapiens, GI187960045, Length=423, Percent_Identity=36.6430260047281, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17562934, Length=443, Percent_Identity=31.8284424379233, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI212646493, Length=353, Percent_Identity=30.3116147308782, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI193208447, Length=310, Percent_Identity=30.3225806451613, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319372, Length=435, Percent_Identity=31.4942528735632, Blast_Score=202, Evalue=7e-53,
Organism=Drosophila melanogaster, GI28573964, Length=422, Percent_Identity=35.5450236966825, Blast_Score=246, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: =1.14.13.9 [H]

Molecular weight: Translated: 51335; Mature: 51335

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALK
CCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEEECCHHHHH
AMNLLSEVNKIMVPMRARAIHEANGEIHYQPFGRHIDEYINAISRSDLNALLLNKAKLCP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
NIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGADGAPSHVRDMLKNEGIVSAS
CEEEEEEEEEEEEECCCCEEEEECCCCCEEEHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
RDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
HHHHHCCCHHHCCCHHHHHHHHHHHCEECCCCCEEEECCCCCCCCCCEEEEEECCCCHHH
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAA
HHCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEECCCEEEEECCC
HGIIPFFGQGMNSAFEDCRILDELLDEYQDDWSRVNSVFYEHRKVNTDAIAKMSMDNYHE
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHH
IHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNTPYAKAMAIGELQSGLLEQIC
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
FPITDIKELNWQEVEKLLSLYDKKLAKII
CCCCCHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALK
CCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEEECCHHHHH
AMNLLSEVNKIMVPMRARAIHEANGEIHYQPFGRHIDEYINAISRSDLNALLLNKAKLCP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
NIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGADGAPSHVRDMLKNEGIVSAS
CEEEEEEEEEEEEECCCCEEEEECCCCCEEEHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
RDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
HHHHHCCCHHHCCCHHHHHHHHHHHCEECCCCCEEEECCCCCCCCCCEEEEEECCCCHHH
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAA
HHCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEECCCEEEEECCC
HGIIPFFGQGMNSAFEDCRILDELLDEYQDDWSRVNSVFYEHRKVNTDAIAKMSMDNYHE
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHH
IHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNTPYAKAMAIGELQSGLLEQIC
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
FPITDIKELNWQEVEKLLSLYDKKLAKII
CCCCCHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA