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The map label for this gene is gltT [H]

Identifier: 54293861

GI number: 54293861

Start: 1028375

End: 1029655

Strand: Direct

Name: gltT [H]

Synonym: lpl0917

Alternate gene names: 54293861

Gene position: 1028375-1029655 (Clockwise)

Preceding gene: 54293860

Following gene: 54293866

Centisome position: 30.74

GC content: 37.16

Gene sequence:

>1281_bases
ATGTGTGCAGCACACCACCAAAAGAATAAATATATTTTTAGTACCCCACTAATTTATGCAGCGATGATTGGACTTGGGAT
AATAAGTGGATTATCCGATTTGCCTTTTTTAAAGGAAACAGGGCTTTTAATTTCTGATTTATTTATTAAATTGTTCAAGT
GCATTAGTTTACCAATTATTTCCTTGTCGATTATTGTAACTCTGGCAAACTATCAAACGGATAGTTTGATGAAAAGTGTA
TGGCAAAGAACAATTAAATATACTTTTGCTACAACTTTAGTTGCAGCATTAATCAGCTGTTTTTTATATATCTTGATTCA
TCCAAGCACTGTTCAAGTCAATTTGGATGCGGCGAACCCAAAGCCCACCAGCAGTTTGGGATATCTTGGCTATTTGAGTA
ACATAATACCGACTAATTTATTATCTCCATTCCTGGAGCAACAGGTTATGGGGGTATTGTTGCTTAGTATTGTTATTGGT
TTTGCTGTTCGTCAAATATCGGAGACAGAGCCACGGGAAACTATTATTCGATTTTTCCGCGGTGCTCATGGGATGTTTTT
AGTGATGACCAGATGGATAATTAAATTAATACCTTTGGGGTTATTCGGGTTCATTACTTCTACTGTAATTCAGTTGCGAT
CGGGTATGGATATTAAAGGGATAGGCCAATACTTGATGATTATTGTTTTAGCTAATTTGATACAAGGATTAGTCATTCTG
CCTTTATGGCTGAAATCAAATGGTATTAAACCATTCTCTTCGATGAGGGCAATGTTACCTGCGTTATCTGTTGCTTTTTT
TTCCAAGTCATCTGTCGGTACTTTGCCTGTTACAATGAATACTGTAGAGGCTAATTTAAAGGTTAACCCTCAAGTCAGTC
GTTTTGTTTTACCTTTATGCACAAGCATTAATATGAATGGATGTGCTGCATTTATTTTTGCCACAGTCATTTATCTTATG
CAAAGTCATGGCATCCAGGTTTCTTATGCTACTATGGGGATATGGGTTTTAGTATCAACAATTGCGGCAATAGGGAATGC
CGGCGTTCCTATGGGTTGCTTTTTCTTAAGCGTTAGTTTGCTCTCCAGTATGAATGTGCCTATCACGCTTATGGGAGTTA
TTCTTCCTTTCTATGGTTTGATTGATATGTTGGAAACTGCCTTAAACGTATGGTCTGATGCTTGTGTTACCAAGGTTGTT
AATGATAAAGCAGAAGGTGGTGATGGAGTGGTGGGCATTAGACCAAAAGAGCGTTCATTATTAAATGCCGAGTTAGGTTA
A

Upstream 100 bases:

>100_bases
TTATAATTCCTCATTGTTTAACTCCATATATCAAGACATCTGTTGTTGCTGCTAATCCTACTTTGCTTAAATAATTAATT
AATGTTTTAAGGATTCCGTT

Downstream 100 bases:

>100_bases
AGCCAGCAAATCTTCAAGCGCAAATGAGTGTAGCTTACATATAAGTCTCCAGAAAGTTTTTTTGAGACTTATATCTATGA
AATCAGTTTGTAATTTATAA

Product: hypothetical protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPIISLSIIVTLANYQTDSLMKSV
WQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANPKPTSSLGYLGYLSNIIPTNLLSPFLEQQVMGVLLLSIVIG
FAVRQISETEPRETIIRFFRGAHGMFLVMTRWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLMIIVLANLIQGLVIL
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQVSRFVLPLCTSINMNGCAAFIFATVIYLM
QSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSLLSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVV
NDKAEGGDGVVGIRPKERSLLNAELG

Sequences:

>Translated_426_residues
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPIISLSIIVTLANYQTDSLMKSV
WQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANPKPTSSLGYLGYLSNIIPTNLLSPFLEQQVMGVLLLSIVIG
FAVRQISETEPRETIIRFFRGAHGMFLVMTRWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLMIIVLANLIQGLVIL
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQVSRFVLPLCTSINMNGCAAFIFATVIYLM
QSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSLLSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVV
NDKAEGGDGVVGIRPKERSLLNAELG
>Mature_426_residues
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPIISLSIIVTLANYQTDSLMKSV
WQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANPKPTSSLGYLGYLSNIIPTNLLSPFLEQQVMGVLLLSIVIG
FAVRQISETEPRETIIRFFRGAHGMFLVMTRWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLMIIVLANLIQGLVIL
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQVSRFVLPLCTSINMNGCAAFIFATVIYLM
QSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSLLSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVV
NDKAEGGDGVVGIRPKERSLLNAELG

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468566, Length=267, Percent_Identity=27.7153558052434, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI223468564, Length=249, Percent_Identity=28.1124497991968, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI5032093, Length=270, Percent_Identity=27.7777777777778, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI21314632, Length=252, Percent_Identity=26.5873015873016, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI66773030, Length=376, Percent_Identity=23.6702127659574, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI40254478, Length=408, Percent_Identity=23.7745098039216, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI169790839, Length=247, Percent_Identity=25.9109311740891, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4827012, Length=279, Percent_Identity=24.3727598566308, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI194239697, Length=199, Percent_Identity=28.1407035175879, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI262359914, Length=183, Percent_Identity=25.1366120218579, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI301601644, Length=121, Percent_Identity=28.9256198347107, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790514, Length=366, Percent_Identity=24.3169398907104, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789473, Length=387, Percent_Identity=25.3229974160207, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788024, Length=368, Percent_Identity=25.2717391304348, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789947, Length=366, Percent_Identity=19.3989071038251, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983099, Length=404, Percent_Identity=25.990099009901, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=404, Percent_Identity=25.990099009901, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71996953, Length=416, Percent_Identity=25, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI193206505, Length=455, Percent_Identity=23.5164835164835, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17541374, Length=391, Percent_Identity=26.0869565217391, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17537407, Length=409, Percent_Identity=22.7383863080685, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193206654, Length=407, Percent_Identity=23.5872235872236, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583025, Length=394, Percent_Identity=22.8426395939086, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17137668, Length=394, Percent_Identity=22.8426395939086, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24583023, Length=394, Percent_Identity=22.8426395939086, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46386; Mature: 46386

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPII
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHH
SLSIIVTLANYQTDSLMKSVWQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
KPTSSLGYLGYLSNIIPTNLLSPFLEQQVMGVLLLSIVIGFAVRQISETEPRETIIRFFR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GAHGMFLVMTRWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLMIIVLANLIQGLVIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQVSRFVLPLC
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECEEECCHHHHHHHHHH
TSINMNGCAAFIFATVIYLMQSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSL
HCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVVNDKAEGGDGVVGIRPKERSL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHH
LNAELG
HCCCCC
>Mature Secondary Structure
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPII
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHH
SLSIIVTLANYQTDSLMKSVWQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
KPTSSLGYLGYLSNIIPTNLLSPFLEQQVMGVLLLSIVIGFAVRQISETEPRETIIRFFR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GAHGMFLVMTRWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLMIIVLANLIQGLVIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQVSRFVLPLC
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECEEECCHHHHHHHHHH
TSINMNGCAAFIFATVIYLMQSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSL
HCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVVNDKAEGGDGVVGIRPKERSL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHH
LNAELG
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]