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The map label for this gene is fabG [C]

Identifier: 54293807

GI number: 54293807

Start: 980765

End: 981613

Strand: Reverse

Name: fabG [C]

Synonym: lpl0863

Alternate gene names: 54293807

Gene position: 981613-980765 (Counterclockwise)

Preceding gene: 54293808

Following gene: 54293801

Centisome position: 29.34

GC content: 36.75

Gene sequence:

>849_bases
ATGAATGTAGTAATTATCACTGGTGCAGCAAGTGGCATTGGACATGCCTTAAGTCAAGTTTGTCTTGGCAATGGAAAAAC
TATAGTCATGGTTGATAAGAATCAGGACAAATTACATACAGAAGCCCAATCACTCATGACAAAATTTTCTCCTGAACATG
TTATTTGCTTTGACTGCGATGTAACCAAACCATCAGAAGTAGAACGACTTGCGGAATATTCCTGTAAACAACTAGGTCAG
GTAGACTGGATATTTAATAATGCTGGGATCATTGGCAATTTACTTCCTGCCTGGGAACTGCAAGAAAATGATATTAATCA
GGTAATGCAAGTGAATTTGCATGGGATGCTTAATATGATTCGCTCATTCATGCCTTATTTATTCAAACAGAATTTCCGTT
CTCATATTATCAACATGGCAAGCCTGTATGCCTTATGTACAGGCTCACAAATGGCCGCTTATTCCATGTCAAAACATGCC
GTATTAGCCTTATCCGAGTCATTATATTTTGATTTAAAACGCCTTAAAAAACCTGTAGATGTTTCTGTAGTATTTCCTTC
TTTTACAGATACCTCGTTATTAGCGAGTAGTGGGAAATTAAACCATTCCCCAATCCACAATCAATTAAATAACTTGTTAG
CACATTCTCGACCCGCCCTTGAAGTTGCAGAACATATAGTAAGGGAAGTTGAACACAAAAGATTTTATATATTGCCTGAT
AAAGAAGTTAAAGGATATTGTGAAGACAGAACCAAAGCCATACTGTTACAAGAAAATCCTCATCATAACAGCGTAGAGCA
ATTAATGTGTTCTTTATTAAAGCGCCAATCATCAGAGGCTAATCTGTAA

Upstream 100 bases:

>100_bases
TAAACAAAATGACCGAATTAAAAACTTTTTTTAACAAAGAGATTGGGGTTTTTCGTAAGTCCTGAAGAAGAGGGCATTAA
ACTTTTGTAAGGTAGTTTAT

Downstream 100 bases:

>100_bases
ATTGTGTCCGGCTTTCAAAACAGAATAGGTGTAATCAGGCTTATAATTCATGTGATCTTCCATGCTTTAACATTCATGTA
CTCATTACGAATCTAGGGAT

Product: hypothetical protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MNVVIITGAASGIGHALSQVCLGNGKTIVMVDKNQDKLHTEAQSLMTKFSPEHVICFDCDVTKPSEVERLAEYSCKQLGQ
VDWIFNNAGIIGNLLPAWELQENDINQVMQVNLHGMLNMIRSFMPYLFKQNFRSHIINMASLYALCTGSQMAAYSMSKHA
VLALSESLYFDLKRLKKPVDVSVVFPSFTDTSLLASSGKLNHSPIHNQLNNLLAHSRPALEVAEHIVREVEHKRFYILPD
KEVKGYCEDRTKAILLQENPHHNSVEQLMCSLLKRQSSEANL

Sequences:

>Translated_282_residues
MNVVIITGAASGIGHALSQVCLGNGKTIVMVDKNQDKLHTEAQSLMTKFSPEHVICFDCDVTKPSEVERLAEYSCKQLGQ
VDWIFNNAGIIGNLLPAWELQENDINQVMQVNLHGMLNMIRSFMPYLFKQNFRSHIINMASLYALCTGSQMAAYSMSKHA
VLALSESLYFDLKRLKKPVDVSVVFPSFTDTSLLASSGKLNHSPIHNQLNNLLAHSRPALEVAEHIVREVEHKRFYILPD
KEVKGYCEDRTKAILLQENPHHNSVEQLMCSLLKRQSSEANL
>Mature_282_residues
MNVVIITGAASGIGHALSQVCLGNGKTIVMVDKNQDKLHTEAQSLMTKFSPEHVICFDCDVTKPSEVERLAEYSCKQLGQ
VDWIFNNAGIIGNLLPAWELQENDINQVMQVNLHGMLNMIRSFMPYLFKQNFRSHIINMASLYALCTGSQMAAYSMSKHA
VLALSESLYFDLKRLKKPVDVSVVFPSFTDTSLLASSGKLNHSPIHNQLNNLLAHSRPALEVAEHIVREVEHKRFYILPD
KEVKGYCEDRTKAILLQENPHHNSVEQLMCSLLKRQSSEANL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI31542939, Length=196, Percent_Identity=28.0612244897959, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI40254992, Length=191, Percent_Identity=28.7958115183246, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI224922801, Length=167, Percent_Identity=29.3413173652695, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI310128830, Length=200, Percent_Identity=27, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI310115468, Length=200, Percent_Identity=27, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI20149619, Length=238, Percent_Identity=24.7899159663866, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4503817, Length=240, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI40807363, Length=239, Percent_Identity=26.3598326359833, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI25282469, Length=145, Percent_Identity=31.0344827586207, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=199, Percent_Identity=24.1206030150754, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=202, Percent_Identity=26.7326732673267, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193203117, Length=194, Percent_Identity=28.3505154639175, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=194, Percent_Identity=28.3505154639175, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=250, Percent_Identity=24.8, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=231, Percent_Identity=25.1082251082251, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=24.8704663212435, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=197, Percent_Identity=25.8883248730964, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=194, Percent_Identity=29.3814432989691, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=184, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=248, Percent_Identity=25.8064516129032, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281364892, Length=194, Percent_Identity=29.8969072164948, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24663911, Length=203, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI23397609, Length=192, Percent_Identity=28.6458333333333, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641232, Length=205, Percent_Identity=26.8292682926829, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI116007236, Length=201, Percent_Identity=26.3681592039801, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571387, Length=208, Percent_Identity=26.4423076923077, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355631, Length=232, Percent_Identity=26.2931034482759, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24581726, Length=170, Percent_Identity=25.2941176470588, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358495, Length=199, Percent_Identity=29.1457286432161, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639444, Length=197, Percent_Identity=25.8883248730964, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24644339, Length=199, Percent_Identity=29.1457286432161, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28571526, Length=192, Percent_Identity=27.6041666666667, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI116007234, Length=205, Percent_Identity=27.3170731707317, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI116007238, Length=190, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21357041, Length=196, Percent_Identity=26.530612244898, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665243, Length=251, Percent_Identity=26.2948207171315, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221331218, Length=254, Percent_Identity=26.3779527559055, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31680; Mature: 31680

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVVIITGAASGIGHALSQVCLGNGKTIVMVDKNQDKLHTEAQSLMTKFSPEHVICFDCD
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECC
VTKPSEVERLAEYSCKQLGQVDWIFNNAGIIGNLLPAWELQENDINQVMQVNLHGMLNMI
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RSFMPYLFKQNFRSHIINMASLYALCTGSQMAAYSMSKHAVLALSESLYFDLKRLKKPVD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
VSVVFPSFTDTSLLASSGKLNHSPIHNQLNNLLAHSRPALEVAEHIVREVEHKRFYILPD
EEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECC
KEVKGYCEDRTKAILLQENPHHNSVEQLMCSLLKRQSSEANL
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNVVIITGAASGIGHALSQVCLGNGKTIVMVDKNQDKLHTEAQSLMTKFSPEHVICFDCD
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECC
VTKPSEVERLAEYSCKQLGQVDWIFNNAGIIGNLLPAWELQENDINQVMQVNLHGMLNMI
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RSFMPYLFKQNFRSHIINMASLYALCTGSQMAAYSMSKHAVLALSESLYFDLKRLKKPVD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
VSVVFPSFTDTSLLASSGKLNHSPIHNQLNNLLAHSRPALEVAEHIVREVEHKRFYILPD
EEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECC
KEVKGYCEDRTKAILLQENPHHNSVEQLMCSLLKRQSSEANL
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA