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The map label for this gene is wecA [H]

Identifier: 54293746

GI number: 54293746

Start: 905831

End: 906832

Strand: Direct

Name: wecA [H]

Synonym: lpl0799

Alternate gene names: 54293746

Gene position: 905831-906832 (Clockwise)

Preceding gene: 54293745

Following gene: 54293748

Centisome position: 27.07

GC content: 29.44

Gene sequence:

>1002_bases
ATGAATATAATACTTAATGTATTTTTAATATTTATCTCAGCAATTTTGACTAAATTATTTGCCTTGTTTGCGCAGCATAC
AAAATTGATTGATATTCCAAATGAAAGAAATTTACACTCCAGACCTACAGTCCGAGGAGGAGGGCTTGTCTTTATTGGTC
TTAGTTTATTTTGTTGGTTTTTTATTTGTAACTCACAATTTTTTTTAACATTGGATCAATTCATTTTTTCGATAGCTATT
ATTTTCATAGCAACTATAAGTTTTATAGATGATTTTTATAATTTGTCAGTTAAAATTCGATTCTTTTTTCAATGTCTGAT
TGCATTCCTGATAGTTATATTTATATTGCCTTCCCAATTGGATTTTGGTTTATTTCTATTTGAAAACACCTATTTAATTG
CTTTTTTTCTATTTTTTGCAGTTATTTGGGCAATTAATCATTTTAATTTCATGGATGGGCTTGATGGTTTTTGCGCTTCC
CAAGCGATTTTTTTGTTAGCCGCATATGCGTTGTTTTTCAACTCAGCAGGTTCATTAATTTATCAAGATTTTTGCCTGAT
TCTTATTTCTAGTTTAGCAGGGTTTTTAATTTTTAATTTCCCACCAGCCAAGATATTTATGGGAGATGTAGGGAGCGCCT
CCTTAGGATTAATTACTTTTTTCATAGCAATCATTGCTCAAAAGAATTATCAAATTCCAATTCTATATTGGTTTATCCTG
AACTCATTATTTCTTTTCGATTCTACGGTGACTTTAATTCGAAGAATTATAAATCGTGAAAAATGGTTTAGCCCTCATAA
AAAGCACGCTTACCAGAGATTAAAGCAATTGGGTATTAACTCGAGGTTTATTTTATTAGGCCAAATGTTATTAAATTGCA
GTTTTTTATCAATTATTCTATTGCATCGGATAATTGGTTTTAATCTCAATTATCTCATGTTGCTCCAGCTAATTTGTTTA
TTATTCCTATACGTAATAGTAGAAAAAAAATATCCCATGTAA

Upstream 100 bases:

>100_bases
TCTTTAGAAGTAAGTAATAAGAAAATTAAATCTCAATTAGGGTGGACACCACCAGTTAGTTCTGTTGAAGGATTAGAAAA
GACGGTAAAATGGTATCAAA

Downstream 100 bases:

>100_bases
CTGTAACCCCCCCATATTCAGTGGCATCCTAAATTAGAGTTCATTGGCTGATTTTTTGCCAGATATTCCCACGGCGTTAA
ATCATTTAGTGAATCATGGG

Product: alpha-N-acetylglucosaminyltransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MNIILNVFLIFISAILTKLFALFAQHTKLIDIPNERNLHSRPTVRGGGLVFIGLSLFCWFFICNSQFFLTLDQFIFSIAI
IFIATISFIDDFYNLSVKIRFFFQCLIAFLIVIFILPSQLDFGLFLFENTYLIAFFLFFAVIWAINHFNFMDGLDGFCAS
QAIFLLAAYALFFNSAGSLIYQDFCLILISSLAGFLIFNFPPAKIFMGDVGSASLGLITFFIAIIAQKNYQIPILYWFIL
NSLFLFDSTVTLIRRIINREKWFSPHKKHAYQRLKQLGINSRFILLGQMLLNCSFLSIILLHRIIGFNLNYLMLLQLICL
LFLYVIVEKKYPM

Sequences:

>Translated_333_residues
MNIILNVFLIFISAILTKLFALFAQHTKLIDIPNERNLHSRPTVRGGGLVFIGLSLFCWFFICNSQFFLTLDQFIFSIAI
IFIATISFIDDFYNLSVKIRFFFQCLIAFLIVIFILPSQLDFGLFLFENTYLIAFFLFFAVIWAINHFNFMDGLDGFCAS
QAIFLLAAYALFFNSAGSLIYQDFCLILISSLAGFLIFNFPPAKIFMGDVGSASLGLITFFIAIIAQKNYQIPILYWFIL
NSLFLFDSTVTLIRRIINREKWFSPHKKHAYQRLKQLGINSRFILLGQMLLNCSFLSIILLHRIIGFNLNYLMLLQLICL
LFLYVIVEKKYPM
>Mature_333_residues
MNIILNVFLIFISAILTKLFALFAQHTKLIDIPNERNLHSRPTVRGGGLVFIGLSLFCWFFICNSQFFLTLDQFIFSIAI
IFIATISFIDDFYNLSVKIRFFFQCLIAFLIVIFILPSQLDFGLFLFENTYLIAFFLFFAVIWAINHFNFMDGLDGFCAS
QAIFLLAAYALFFNSAGSLIYQDFCLILISSLAGFLIFNFPPAKIFMGDVGSASLGLITFFIAIIAQKNYQIPILYWFIL
NSLFLFDSTVTLIRRIINREKWFSPHKKHAYQRLKQLGINSRFILLGQMLLNCSFLSIILLHRIIGFNLNYLMLLQLICL
LFLYVIVEKKYPM

Specific function: Catalyzes the formation of undecaprenyl-PP-N- acetylglucosamine. Involved in the synthesis of anionic cell-wall polymers as it mediates the initiation of the linkage unit formation that appears to be common to the two types of teichoic acids attached to t

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=277, Percent_Identity=25.9927797833935, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715
- InterPro:   IPR018480 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 38548; Mature: 38548

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILNVFLIFISAILTKLFALFAQHTKLIDIPNERNLHSRPTVRGGGLVFIGLSLFCWF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FICNSQFFLTLDQFIFSIAIIFIATISFIDDFYNLSVKIRFFFQCLIAFLIVIFILPSQL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DFGLFLFENTYLIAFFLFFAVIWAINHFNFMDGLDGFCASQAIFLLAAYALFFNSAGSLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHH
YQDFCLILISSLAGFLIFNFPPAKIFMGDVGSASLGLITFFIAIIAQKNYQIPILYWFIL
HHHHHHHHHHHHHHHHEECCCCHHEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NSLFLFDSTVTLIRRIINREKWFSPHKKHAYQRLKQLGINSRFILLGQMLLNCSFLSIIL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LHRIIGFNLNYLMLLQLICLLFLYVIVEKKYPM
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIILNVFLIFISAILTKLFALFAQHTKLIDIPNERNLHSRPTVRGGGLVFIGLSLFCWF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FICNSQFFLTLDQFIFSIAIIFIATISFIDDFYNLSVKIRFFFQCLIAFLIVIFILPSQL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DFGLFLFENTYLIAFFLFFAVIWAINHFNFMDGLDGFCASQAIFLLAAYALFFNSAGSLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHH
YQDFCLILISSLAGFLIFNFPPAKIFMGDVGSASLGLITFFIAIIAQKNYQIPILYWFIL
HHHHHHHHHHHHHHHHEECCCCHHEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHH
NSLFLFDSTVTLIRRIINREKWFSPHKKHAYQRLKQLGINSRFILLGQMLLNCSFLSIIL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LHRIIGFNLNYLMLLQLICLLFLYVIVEKKYPM
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12101296; 9384377 [H]