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The map label for this gene is rmlC [H]

Identifier: 54293740

GI number: 54293740

Start: 899815

End: 900378

Strand: Direct

Name: rmlC [H]

Synonym: lpl0793

Alternate gene names: 54293740

Gene position: 899815-900378 (Clockwise)

Preceding gene: 54293739

Following gene: 54293741

Centisome position: 26.89

GC content: 36.35

Gene sequence:

>564_bases
ATGAATATAATAAATACTCAGATCGATGAACTTAAAATTATCGAACCCAAGATTTATGGTGATGAAAGAGGTTTTTTTTA
TGAATCTTTTCAAGCTAAACGATATGAAGAGTTATTAGGAATAACTGATCGTTTTGTACAAGATAATTTTTCAAGATCAC
AAAAAGGGGTGCTAAGAGGTCTGCATTATCAAAGTCAACAAACTCAGGGAAAACTGGTTTCAGTTTTAACTGGTGAAGTG
CTTGATGTTGCCGTGGATATTAGGTTAGGCTCTCCTACTTTTGGGCAATGGGTTGGAGTGATTCTTTCCGGAGAAAACAA
AAGGCAATTTTGGATTCCTAAAGGGTTTGCACATGGGTTTTATGTTTTGAGTGCTATGGCTGATTTCGCTTATAAATGTA
CCGACTATTATCATCCTGAAAGTGAGTTTTCCATTCATTATCTTGATCCGCAATTAGCGATTGATTGGCCATTAGGAGAG
CAGGTTCAATTGTCTCCAAAAGACGCTGCAGCCAAACCTTTAAGTTTAATAGATGCTGAACTTTTACCGAGATATCAAAC
CTAA

Upstream 100 bases:

>100_bases
AGGTAGCTTAATTATTTGTTCTAGTGAAAACTGGATACAGGTAGTAATAGATTTAAATATTAAGGAATTATAATTCTCTT
TTAAGAGTTTTAGTAACGAT

Downstream 100 bases:

>100_bases
ATGAAAATATTGGTTACAGGTGCTAATGGGCAAGTTGGTACCGAGATTATCAAGCGGTTTTCTTCTTCTGAGCATGAAGT
ATCTCCTTGTACCAGAGATA

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MNIINTQIDELKIIEPKIYGDERGFFYESFQAKRYEELLGITDRFVQDNFSRSQKGVLRGLHYQSQQTQGKLVSVLTGEV
LDVAVDIRLGSPTFGQWVGVILSGENKRQFWIPKGFAHGFYVLSAMADFAYKCTDYYHPESEFSIHYLDPQLAIDWPLGE
QVQLSPKDAAAKPLSLIDAELLPRYQT

Sequences:

>Translated_187_residues
MNIINTQIDELKIIEPKIYGDERGFFYESFQAKRYEELLGITDRFVQDNFSRSQKGVLRGLHYQSQQTQGKLVSVLTGEV
LDVAVDIRLGSPTFGQWVGVILSGENKRQFWIPKGFAHGFYVLSAMADFAYKCTDYYHPESEFSIHYLDPQLAIDWPLGE
QVQLSPKDAAAKPLSLIDAELLPRYQT
>Mature_187_residues
MNIINTQIDELKIIEPKIYGDERGFFYESFQAKRYEELLGITDRFVQDNFSRSQKGVLRGLHYQSQQTQGKLVSVLTGEV
LDVAVDIRLGSPTFGQWVGVILSGENKRQFWIPKGFAHGFYVLSAMADFAYKCTDYYHPESEFSIHYLDPQLAIDWPLGE
QVQLSPKDAAAKPLSLIDAELLPRYQT

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=169, Percent_Identity=57.9881656804734, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17550412, Length=156, Percent_Identity=50.6410256410256, Blast_Score=164, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 21372; Mature: 21372

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIINTQIDELKIIEPKIYGDERGFFYESFQAKRYEELLGITDRFVQDNFSRSQKGVLRG
CCCCCCCCCCEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LHYQSQQTQGKLVSVLTGEVLDVAVDIRLGSPTFGQWVGVILSGENKRQFWIPKGFAHGF
HCCCCCCCCCHHHHHHHCCEEEEEEEEEECCCCHHHEEEEEEECCCCCEEECCCCHHHHH
YVLSAMADFAYKCTDYYHPESEFSIHYLDPQLAIDWPLGEQVQLSPKDAAAKPLSLIDAE
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCEEECCCCCCCCCHHHHHHH
LLPRYQT
HCCCCCC
>Mature Secondary Structure
MNIINTQIDELKIIEPKIYGDERGFFYESFQAKRYEELLGITDRFVQDNFSRSQKGVLRG
CCCCCCCCCCEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LHYQSQQTQGKLVSVLTGEVLDVAVDIRLGSPTFGQWVGVILSGENKRQFWIPKGFAHGF
HCCCCCCCCCHHHHHHHCCEEEEEEEEEECCCCHHHEEEEEEECCCCCEEECCCCHHHHH
YVLSAMADFAYKCTDYYHPESEFSIHYLDPQLAIDWPLGEQVQLSPKDAAAKPLSLIDAE
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCEEECCCCCCCCCHHHHHHH
LLPRYQT
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609; 10802738 [H]