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The map label for this gene is purK [H]

Identifier: 54293223

GI number: 54293223

Start: 301959

End: 303038

Strand: Reverse

Name: purK [H]

Synonym: lpl0271

Alternate gene names: 54293223

Gene position: 303038-301959 (Counterclockwise)

Preceding gene: 54293224

Following gene: 54293220

Centisome position: 9.06

GC content: 40.83

Gene sequence:

>1080_bases
ATGAAACTTGGTATTCTAGGTGGTGGTCAACTTGCAAGAATGTTGGCATTAGCAGCATATCCCCTAGGGATTAACACTGT
CTGCCTGGATCCCAGCCCTAACGCCTGTGCTGGTCAACTCACCAGGCTTATAGTCTCTGATTTTAATGATGAATTGGCTT
TAAAACAATTTTTGTCAGAAGTGGATTGCGTCACAATAGAAACCGAAAATATACCATTTTCTTGCGCCGAATTGGCTGCC
CAAATAAGGCCTTTCTATCCATCAACCCAAGCTTTGAAAATTACGCAAGACAGATTGTATGAAAAAAATTTTTTCAGAAC
TCTGAATATTCCTGTACCAGAATTTTTACCGGTTGAATCAGAAGATGAATTGATGCAGGCTATTTCAGTCATAGGAATGC
CTGCTGTGCTAAAAACAAGAAGGTTTGGCTATGATGGCAAGGGCCAATATGTTTTGCGAACCCAAGCTGATATTTCAAAA
AGTTGGGGCCTGTTAGGCAGCCAAGCTCTCATTCTTGAACAATTAATCTCCTTTGAAAGCGAATTTTCGTTAATTGCTGT
TCGTAATAAGAGTGGTGAAACAAGTTTCTACCCATTGATTAAAAATCATCACAGGAAGGGCATTTTACATTTCTCGGAAG
CCCCTGTTCATCAGGACACCTTACAACAAGAGGCACAAATTCATGCATTCAAAATTTTAGAAGCCCTGAATTATATTGGT
GTACTTACCATTGAGTTTTTTTATCAAGGCAACCAATTGATTGCGAATGAGATAGCACCACGCGTTCATAATTCTGGACA
CTGGACTATCGAGGGAGCACATACTAGCCAATTCGAAAATCATCTGCGCGCTCTTTTTGATTTGCCCTTGGGAAGCACTG
AAGTAAGCAGCTCTTGTTTTTTATTAAATTGCATTAGCAATCTCCTGCCATTGGAGCCCTGTTTATCGATCCCGGGCGTT
CATTATCACGCTTATGGAAAAGCACCCCGGCCAGATCGCAAGGTAGGTCATGTTACCCTTATCGATACTCATTTGGAACG
TTATGCAAAAAGTAAAGACTTACTGCTTGGCATTTCATGA

Upstream 100 bases:

>100_bases
TTGCTAATAAATATCCTGACATCCAAGCTGCCTTAAAACGCTATCGAGAACAACAAACACAAAAAGTGCTCGACAATCCA
AACCCTAAAGAGGAAAAGTC

Downstream 100 bases:

>100_bases
GTAGCCGATAGCTAGAAAGCGAGCAATAGGAGTCAGCGCACAATATTGTTCGCAATTTGGAAAGCTGAGCTTTGGATTCT
GTTTCCTACTGCTCATCCAC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPNACAGQLTRLIVSDFNDELALKQFLSEVDCVTIETENIPFSCAELAA
QIRPFYPSTQALKITQDRLYEKNFFRTLNIPVPEFLPVESEDELMQAISVIGMPAVLKTRRFGYDGKGQYVLRTQADISK
SWGLLGSQALILEQLISFESEFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQIHAFKILEALNYIG
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSSSCFLLNCISNLLPLEPCLSIPGV
HYHAYGKAPRPDRKVGHVTLIDTHLERYAKSKDLLLGIS

Sequences:

>Translated_359_residues
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPNACAGQLTRLIVSDFNDELALKQFLSEVDCVTIETENIPFSCAELAA
QIRPFYPSTQALKITQDRLYEKNFFRTLNIPVPEFLPVESEDELMQAISVIGMPAVLKTRRFGYDGKGQYVLRTQADISK
SWGLLGSQALILEQLISFESEFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQIHAFKILEALNYIG
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSSSCFLLNCISNLLPLEPCLSIPGV
HYHAYGKAPRPDRKVGHVTLIDTHLERYAKSKDLLLGIS
>Mature_359_residues
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPNACAGQLTRLIVSDFNDELALKQFLSEVDCVTIETENIPFSCAELAA
QIRPFYPSTQALKITQDRLYEKNFFRTLNIPVPEFLPVESEDELMQAISVIGMPAVLKTRRFGYDGKGQYVLRTQADISK
SWGLLGSQALILEQLISFESEFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQIHAFKILEALNYIG
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSSSCFLLNCISNLLPLEPCLSIPGV
HYHAYGKAPRPDRKVGHVTLIDTHLERYAKSKDLLLGIS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=360, Percent_Identity=35.5555555555556, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1788155, Length=303, Percent_Identity=26.4026402640264, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324702, Length=365, Percent_Identity=34.2465753424658, Blast_Score=199, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39974; Mature: 39974

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPNACAGQLTRLIVSDFNDELALKQFLSE
CEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
VDCVTIETENIPFSCAELAAQIRPFYPSTQALKITQDRLYEKNFFRTLNIPVPEFLPVES
CCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCEEEECCCCCCCCCCCC
EDELMQAISVIGMPAVLKTRRFGYDGKGQYVLRTQADISKSWGLLGSQALILEQLISFES
HHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHCCCC
EFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQIHAFKILEALNYIG
CCEEEEEECCCCCCEEEHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSSSCF
EEEEEEEECCCEEEHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHH
LLNCISNLLPLEPCLSIPGVHYHAYGKAPRPDRKVGHVTLIDTHLERYAKSKDLLLGIS
HHHHHHHHCCCCHHHCCCCCEEEECCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPNACAGQLTRLIVSDFNDELALKQFLSE
CEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
VDCVTIETENIPFSCAELAAQIRPFYPSTQALKITQDRLYEKNFFRTLNIPVPEFLPVES
CCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCEEEECCCCCCCCCCCC
EDELMQAISVIGMPAVLKTRRFGYDGKGQYVLRTQADISKSWGLLGSQALILEQLISFES
HHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHCCCC
EFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQIHAFKILEALNYIG
CCEEEEEECCCCCCEEEHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSSSCF
EEEEEEEECCCEEEHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHH
LLNCISNLLPLEPCLSIPGVHYHAYGKAPRPDRKVGHVTLIDTHLERYAKSKDLLLGIS
HHHHHHHHCCCCHHHCCCCCEEEECCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]