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The map label for this gene is map [H]

Identifier: 54293175

GI number: 54293175

Start: 249131

End: 249892

Strand: Reverse

Name: map [H]

Synonym: lpl0221

Alternate gene names: 54293175

Gene position: 249892-249131 (Counterclockwise)

Preceding gene: 54293176

Following gene: 54293174

Centisome position: 7.47

GC content: 43.31

Gene sequence:

>762_bases
ATGTTAGTGAAGACGCCTGAAGCAATAGAAAAAATGCGCGTTGCGGGGCAGTTGGCTGCATCCGTACTTGAAATGATAGA
ACCTTATGTCATTGCAGGTGCCAGTACCAAGGAGCTTGAACAAATTTGTCGTCAGTATATTGTCGAGGATTTGAAAGCGA
TTCCCTCGACGTTAAACCACTATGGGTTTCCCGCATGCATTTGCACTTCCATAAATCACGTGGTATGCCATGGCATCCCC
TCAGAGAAAAAGCTTAAAAATGGCGACATCATTAATATTGATGTGACTGTGCAAAAGGACGGTTATATTGGGGATACCAG
CAAAATGTTTCTCGTTGGCAACATAAAGCCATTTGCTAAAAAGTTAGTAGAAGTTACCCAGGAATGCCTATACAAAGCTA
TTTCAATAGTCCGCCCAGGGGCTCACCTCGGAGACATCGGAAACATAATCCAGACACACGCAGAACAACATGGATATTCA
ATAGTACGAGAGTTTGGTGGGCATGGAATTGGTAAATCCATGTGGGAAGATCCTCACATTATGCACTTCGGTAAACCAAA
TACCGGATTACGATTACAAGCAGGAATGACTTTCACTATCGAGCCAATGCTCAATTTGGGCCGTAAAGAGGTCAAGACTT
TAGGCGATGGTTGGACGGTTGTCACAAAAGACCATAAATTATCTGCACAATGGGAGCATACCATTTTAGTGACCGATAAT
GGACATGAAATACTGACCTTAAGAGCAGACGAGCACCTATAG

Upstream 100 bases:

>100_bases
TGGATTAGAGTAGGAAAATTGGCAGAAGAAAACCCCTCTATTACCTATACTGACATTCTTAAAATTTTAGTCCATCAAGC
ATCACTAGGTGAAATATACG

Downstream 100 bases:

>100_bases
ACGTCTCTCCTCTTGCTTGGTAATTACGGTTCCTCCAAGCCTCGCAACGGAAAACATATACTATAATCAAACTAAAGGAA
ACCCAGTCAATCAAGGGAAA

Product: hypothetical protein

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MLVKTPEAIEKMRVAGQLAASVLEMIEPYVIAGASTKELEQICRQYIVEDLKAIPSTLNHYGFPACICTSINHVVCHGIP
SEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAKKLVEVTQECLYKAISIVRPGAHLGDIGNIIQTHAEQHGYS
IVREFGGHGIGKSMWEDPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTILVTDN
GHEILTLRADEHL

Sequences:

>Translated_253_residues
MLVKTPEAIEKMRVAGQLAASVLEMIEPYVIAGASTKELEQICRQYIVEDLKAIPSTLNHYGFPACICTSINHVVCHGIP
SEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAKKLVEVTQECLYKAISIVRPGAHLGDIGNIIQTHAEQHGYS
IVREFGGHGIGKSMWEDPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTILVTDN
GHEILTLRADEHL
>Mature_253_residues
MLVKTPEAIEKMRVAGQLAASVLEMIEPYVIAGASTKELEQICRQYIVEDLKAIPSTLNHYGFPACICTSINHVVCHGIP
SEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAKKLVEVTQECLYKAISIVRPGAHLGDIGNIIQTHAEQHGYS
IVREFGGHGIGKSMWEDPHIMHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTILVTDN
GHEILTLRADEHL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=246, Percent_Identity=44.3089430894309, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI40385867, Length=244, Percent_Identity=44.2622950819672, Blast_Score=202, Evalue=2e-52,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=58.4, Blast_Score=305, Evalue=1e-84,
Organism=Escherichia coli, GI1788728, Length=256, Percent_Identity=26.5625, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=43.7246963562753, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323273, Length=243, Percent_Identity=42.3868312757202, Blast_Score=197, Evalue=9e-52,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=44.7154471544715, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24583427, Length=244, Percent_Identity=44.672131147541, Blast_Score=216, Evalue=2e-56,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28015; Mature: 28015

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVKTPEAIEKMRVAGQLAASVLEMIEPYVIAGASTKELEQICRQYIVEDLKAIPSTLNH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
YGFPACICTSINHVVCHGIPSEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAK
CCCHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCCHHHH
KLVEVTQECLYKAISIVRPGAHLGDIGNIIQTHAEQHGYSIVREFGGHGIGKSMWEDPHI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCE
MHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTILVTDN
EEECCCCCCEEEECCCEEEEHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECC
GHEILTLRADEHL
CCEEEEEECCCCC
>Mature Secondary Structure
MLVKTPEAIEKMRVAGQLAASVLEMIEPYVIAGASTKELEQICRQYIVEDLKAIPSTLNH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
YGFPACICTSINHVVCHGIPSEKKLKNGDIINIDVTVQKDGYIGDTSKMFLVGNIKPFAK
CCCHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEECCCHHHH
KLVEVTQECLYKAISIVRPGAHLGDIGNIIQTHAEQHGYSIVREFGGHGIGKSMWEDPHI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCE
MHFGKPNTGLRLQAGMTFTIEPMLNLGRKEVKTLGDGWTVVTKDHKLSAQWEHTILVTDN
EEECCCCCCEEEECCCEEEEHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECC
GHEILTLRADEHL
CCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]