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The map label for this gene is tkt [H]

Identifier: 54293101

GI number: 54293101

Start: 169257

End: 171263

Strand: Reverse

Name: tkt [H]

Synonym: lpl0139

Alternate gene names: 54293101

Gene position: 171263-169257 (Counterclockwise)

Preceding gene: 54293105

Following gene: 54293100

Centisome position: 5.12

GC content: 45.09

Gene sequence:

>2007_bases
ATGAACAGTTTTACAGAATTAGCTAATGCGGTACGCATGTTAAGCATCGATGCAGTAAACCAGGCTCAATCAGGCCACCC
TGGCATGCCCTTGGGTATGGCTGATATTGCCACCGTTTTATGGAAAAAATTTCTAAAATTCAACCCCCAAAACCCGCACT
GGTTTAACAGAGATCGTTTTGTATTATCTAATGGCCATGGTTCCATGCTTCTCTATTCTTTACTGCATTTGACCGGATAC
AATCTGGATATTGGCGAGCTTAAAAACTTCCGCCAATTGCATTCAAAAACACCAGGACATCCGGAACATGGACATACTCC
CGGTGTTGAAACCACAACAGGGCCGTTAGGTCAAGGTTTGGCTAATTCAGTCGGGATGGCCTTAGCAGAACGTGTGCTGG
CCAGTACCTTTAACCACGACCACTTTAACCTGGTTGATCACTATACTTATACTTTTGCCGGTGATGGTTGCCTGATGGAA
GGCATTTCTCATGAAGCTTGTTCTTTAGCTGGCACTCTTGGTTTGGGAAAGCTCATTGTATTTTATGACGACAATGGGAT
ATCTATTGATGGCAAGGTGGAATCCTGGTTTACGGACGATACCACGTCTCGCTTTAAAGCCTACAACTGGCAAGTCATAG
GGCCCATCGATGGCCATGATGCAAATCAAATTGAGCACGCCATATCAGAAGCGCGCGAGAACACCACCCAACCTTCATTA
ATTATCTGTAAAACCGTCATAGGGCTTGGCTCCTCTGTAGCGGGCAGCGAAAAGGCACATGGCTCTCCATTGAGTGCCCA
GGACATAAGTAATGTTCGCGAATTTTTTAATTGGAAACATGCTTCTTTCGAAATTCCAGATTCGATATACAAGCAATGGA
ATCATAAAGAGCAGGGAGAAAAAGAAGAACAACTATGGCTGCAACTACTGCATGAATACCAACAGCAATATCCATCGGAA
CACGATGACTTTTTACGCCGTGCCAATGGTGACCTGCCTGATGATTGGCAGGAAATATCGGCTGGATTCCTGAAACAATG
CCTGAATAATGAAAAAGCTATAGCAACGCGTAAAGCGTCGCAGCAATGCATAGAATTTTTCGCGCCAATATTACCTGAAA
TGTTTGGCGGCTCGGCTGATTTGACTGGTTCCAATAATACGGACTGGTCAGGCAGCAAAGCCATCACGGCTCACAATTTT
TCCGGAAACTACCTTTATTATGGGGTGAGGGAATTCGCCATGGCAGCCATCATGAATGGGCTTGCTGTGCATGGAGGATT
CATTCCCTACGGCGGAACGTTCCTTGTTTTCGCAGATTATGCAAGAAATGCCATCCGTTTAAGCGCTTTAATGAAACAAA
GAGTGATATACGTATTGACTCATGATTCTATCGGTTTAGGGGAAGATGGCCCGACACACCAACCTGTAGAACACATCGCT
ATGTTAAGAATGACTCCTGGCATGACGGTCTGGCGTCCTGCTGATTTAATGGAAACCGCTGTTGCATGGCAACAATCGTT
AGAACATCATAATGGTCCGTCTGCCTTGTTACTCTCAAGACAAAATCTGCCCGCTTTAGCCCATGGCACCGATGCGGCTG
ACTTGATTAAGAAAGGTGGATACATTATTGCAGATTGTGAAGGGAAACCTGATGCTATCCTGATAGCCACTGGTTCAGAA
GTTCAACTGGCTATAACCGCAGCAGAAAAGGCAAAAGCAAGAGGTCTCCAGGTCAGGGTGGTATCCATGCCCTGTGCTGA
GCAGTTCCTTGCCCAGAGTGATGATTACAAAAACCAGATATTACCTGGTCAGGTTCGCACACGTATTGCGATAGAAGCAG
CTAGCAGTGCCTATTGGCACCAATTTGTTGGCTTTGACGGCGCTGTCATTGGGCTGGATTGTTTTGGGGTATCAGCTCCT
GCTACAGATGCTTTTAATTACCTTGGAATTACAGTAGAAAAAATTATCAATACTCTAGATACATTAACCAAACAAACAAT
GGTGTAA

Upstream 100 bases:

>100_bases
CTAATATTGGCATTATTTTTAACTAAAAATGATTGGTGTTCTTGCCGATTTATGCCTTCTGAGCGACAATAGTGCCTCAG
TTAAATGCATAAGAGTAGGC

Downstream 100 bases:

>100_bases
CCCATACCCCTTCTGAAGTTTCAAGAAGGCCTGTATTCAGTCTGACTGAGTATGGAGGTTACCCTAACTCGGAGAAGTAG
TATGACAATACGAGTCGCGA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPQNPHWFNRDRFVLSNGHGSMLLYSLLHLTGY
NLDIGELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLASTFNHDHFNLVDHYTYTFAGDGCLME
GISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPIDGHDANQIEHAISEARENTTQPSL
IICKTVIGLGSSVAGSEKAHGSPLSAQDISNVREFFNWKHASFEIPDSIYKQWNHKEQGEKEEQLWLQLLHEYQQQYPSE
HDDFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAITAHNF
SGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVIYVLTHDSIGLGEDGPTHQPVEHIA
MLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGTDAADLIKKGGYIIADCEGKPDAILIATGSE
VQLAITAAEKAKARGLQVRVVSMPCAEQFLAQSDDYKNQILPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFGVSAP
ATDAFNYLGITVEKIINTLDTLTKQTMV

Sequences:

>Translated_668_residues
MNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPQNPHWFNRDRFVLSNGHGSMLLYSLLHLTGY
NLDIGELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLASTFNHDHFNLVDHYTYTFAGDGCLME
GISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPIDGHDANQIEHAISEARENTTQPSL
IICKTVIGLGSSVAGSEKAHGSPLSAQDISNVREFFNWKHASFEIPDSIYKQWNHKEQGEKEEQLWLQLLHEYQQQYPSE
HDDFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAITAHNF
SGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVIYVLTHDSIGLGEDGPTHQPVEHIA
MLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGTDAADLIKKGGYIIADCEGKPDAILIATGSE
VQLAITAAEKAKARGLQVRVVSMPCAEQFLAQSDDYKNQILPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFGVSAP
ATDAFNYLGITVEKIINTLDTLTKQTMV
>Mature_668_residues
MNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPQNPHWFNRDRFVLSNGHGSMLLYSLLHLTGY
NLDIGELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGLANSVGMALAERVLASTFNHDHFNLVDHYTYTFAGDGCLME
GISHEACSLAGTLGLGKLIVFYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPIDGHDANQIEHAISEARENTTQPSL
IICKTVIGLGSSVAGSEKAHGSPLSAQDISNVREFFNWKHASFEIPDSIYKQWNHKEQGEKEEQLWLQLLHEYQQQYPSE
HDDFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKASQQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAITAHNF
SGNYLYYGVREFAMAAIMNGLAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVIYVLTHDSIGLGEDGPTHQPVEHIA
MLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGTDAADLIKKGGYIIADCEGKPDAILIATGSE
VQLAITAAEKAKARGLQVRVVSMPCAEQFLAQSDDYKNQILPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFGVSAP
ATDAFNYLGITVEKIINTLDTLTKQTMV

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=587, Percent_Identity=26.9165247018739, Blast_Score=166, Evalue=1e-40,
Organism=Homo sapiens, GI4507521, Length=587, Percent_Identity=26.9165247018739, Blast_Score=166, Evalue=1e-40,
Organism=Homo sapiens, GI133778974, Length=266, Percent_Identity=28.1954887218045, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI48994911, Length=657, Percent_Identity=58.9041095890411, Blast_Score=829, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=655, Percent_Identity=57.2519083969466, Blast_Score=804, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=593, Percent_Identity=23.7774030354132, Blast_Score=148, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=45.8893871449925, Blast_Score=571, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319593, Length=670, Percent_Identity=44.6268656716418, Blast_Score=558, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24666278, Length=284, Percent_Identity=29.5774647887324, Blast_Score=117, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45551847, Length=274, Percent_Identity=30.6569343065693, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45550715, Length=274, Percent_Identity=30.6569343065693, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24645119, Length=237, Percent_Identity=30.379746835443, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73355; Mature: 73355

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPQNPHWFNRDRF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
VLSNGHGSMLLYSLLHLTGYNLDIGELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGL
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
ANSVGMALAERVLASTFNHDHFNLVDHYTYTFAGDGCLMEGISHEACSLAGTLGLGKLIV
HHHHHHHHHHHHHHHHCCCCCCEEECCEEEEEECCCHHHHCCCHHHHHHHHHCCCCEEEE
FYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPIDGHDANQIEHAISEARENTTQPSL
EECCCCEEECCCCCCEECCCCHHHHEEECCEEECCCCCCCHHHHHHHHHHHHHCCCCCHH
IICKTVIGLGSSVAGSEKAHGSPLSAQDISNVREFFNWKHASFEIPDSIYKQWNHKEQGE
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCHHHHHHCCCCCCCC
KEEQLWLQLLHEYQQQYPSEHDDFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKAS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
QQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAITAHNFSGNYLYYGVREFAMAAIMNG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHH
LAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVIYVLTHDSIGLGEDGPTHQPVEHIA
HHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHH
MLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGTDAADLIKKGG
HHHCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHCCC
YIIADCEGKPDAILIATGSEVQLAITAAEKAKARGLQVRVVSMPCAEQFLAQSDDYKNQI
EEEEECCCCCCEEEEEECCCEEEEEEEHHHHHHCCCEEEEEECCHHHHHHHCCCCCCCCC
LPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFGVSAPATDAFNYLGITVEKIINTLD
CCCHHHHEEEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHEEHHHHHHHHH
TLTKQTMV
HHHHHHCC
>Mature Secondary Structure
MNSFTELANAVRMLSIDAVNQAQSGHPGMPLGMADIATVLWKKFLKFNPQNPHWFNRDRF
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEE
VLSNGHGSMLLYSLLHLTGYNLDIGELKNFRQLHSKTPGHPEHGHTPGVETTTGPLGQGL
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
ANSVGMALAERVLASTFNHDHFNLVDHYTYTFAGDGCLMEGISHEACSLAGTLGLGKLIV
HHHHHHHHHHHHHHHHCCCCCCEEECCEEEEEECCCHHHHCCCHHHHHHHHHCCCCEEEE
FYDDNGISIDGKVESWFTDDTTSRFKAYNWQVIGPIDGHDANQIEHAISEARENTTQPSL
EECCCCEEECCCCCCEECCCCHHHHEEECCEEECCCCCCCHHHHHHHHHHHHHCCCCCHH
IICKTVIGLGSSVAGSEKAHGSPLSAQDISNVREFFNWKHASFEIPDSIYKQWNHKEQGE
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCHHHHHHCCCCCCCC
KEEQLWLQLLHEYQQQYPSEHDDFLRRANGDLPDDWQEISAGFLKQCLNNEKAIATRKAS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
QQCIEFFAPILPEMFGGSADLTGSNNTDWSGSKAITAHNFSGNYLYYGVREFAMAAIMNG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHH
LAVHGGFIPYGGTFLVFADYARNAIRLSALMKQRVIYVLTHDSIGLGEDGPTHQPVEHIA
HHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHH
MLRMTPGMTVWRPADLMETAVAWQQSLEHHNGPSALLLSRQNLPALAHGTDAADLIKKGG
HHHCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHCCC
YIIADCEGKPDAILIATGSEVQLAITAAEKAKARGLQVRVVSMPCAEQFLAQSDDYKNQI
EEEEECCCCCCEEEEEECCCEEEEEEEHHHHHHCCCEEEEEECCHHHHHHHCCCCCCCCC
LPGQVRTRIAIEAASSAYWHQFVGFDGAVIGLDCFGVSAPATDAFNYLGITVEKIINTLD
CCCHHHHEEEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHEEHHHHHHHHH
TLTKQTMV
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]