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The map label for this gene is hap [H]

Identifier: 54292984

GI number: 54292984

Start: 24648

End: 26324

Strand: Direct

Name: hap [H]

Synonym: lpl0020

Alternate gene names: 54292984

Gene position: 24648-26324 (Clockwise)

Preceding gene: 54292982

Following gene: 54292985

Centisome position: 0.74

GC content: 37.21

Gene sequence:

>1677_bases
ATGTTAAAAAAAACAATGTTTTTTATTTTGTCGATATTTACTTCAAGTATTTTTGCTGCTGACAATGTAGATTTATATCA
AGCCCCTCTCAATAGCATCAATAAATACCCTATACTACAAACACCAAAGAATGCGATTATTTTAAAGAGTTCTTCTGCTG
TTATTGATAATTCATTGCAAAAATTAAATCAAACCAAAGAAGACAATCAAATGATTGTTCGTTATCAGCAACTGTATAAA
GGAATACCTGTTATTGGTGCCCAAGTGATGATTACTAAAGGAACAGACTCAGGAGTGCAGTCCAATGACAATGCAGAGGT
GAACGGGCATTTATTGGATAATATAGAACTTAATACGAAACCGGCTATTAGTGCGCAACAAGCGAAGGAATATGCAAAAA
AATCCTATTTCCAATTTAGCTCCCAATCTAACATACAACAGGAAACAGCTGAATTACAGATTCGGCCAGACCATAATAAT
CAATTAAAGCTGGTTTATTTGGTTTCATTTAAAAGCGTGCAGCAGGATGGTAAACCAGACTGGCCTTTTTTTGTTATTGA
TGCTCAAACAGGAGCTTTGATTAAGCAATGGAACAATATCAAAAATTATTTGGATACAGGGCCTGGAGGTAATGAGAAAG
TTCAGGAATATTGGTATGGTAAAGATGGATTACCTGCTTTGGATGTGACTCAAAATGGCAGCCAATGCGTCATGGAAAAC
TCAAAAGTCAAGTTGGTTAATCTCCATTCTCAATGGGATTGGGAAAACACTATAAATACTCCTTTTGAATACGTTTGTAA
CAATAATATAGAAGAGAATATTAATGGAGGATTTTCTCCTGGCAATGATGCGTATTATTTCGGACATGTTATTGTTGGTA
TGTACAAAGACTGGTATGGACTCAATGCCTTACAACATTCTAATGGTGCTCCAATGCAATTGGTTATGCGAGTTCATTTT
GGGCAAAACTATGATAATGCTTTTTGGGATGGACAAGCCATGTCATTTGGAGATGGGTTGGATTTTTACCCATTGGTTTC
TTTAGATGTAGCCGGTCATGAAGTGACTCATGGTTTTACAGAGCAGCATTCTGGTCTTGAGTATCATGATCAATCAGGTG
CACTTAATGAATCCCTATCTGATATGGCAGGACAAGCGTCAAGAGCTTATCTTTTGGAAAAAAATCCTCAGTTGTATAAC
AAAGCTTACTTACAGCCCAATGAAGTCACATGGGGTATTGGTGAAACAATAGTTCGTGATTCTTATGGCAAAGCTTTGCG
ATTCATGGATTACCCATCCTCTGATGGAAGCTCTGCAGATTGTTTAGACAAAGGTATTGCTCAAAACAATGGCAGCTATT
GTGCTATCAGTTATGATGAGGTAGTAGCCTATGCCAATACACATATCGCACTTCCTCAAGAACGCCAGAGCTTCATAGTT
CATACAGCCAGTGGTGTGTTCAATAAGGCTTTTTACTTAATGTCTAAGGATATGGGTATTAAAAACGCTTATCACATCAT
GGTTGTTGCTAACACAAAATATTGGACTCCTACGACAGACTTTAAAAATGGAGCTTGCGGAGTCATTTATGCTGCCAGGG
ATTTAAATACCGATATCAATAAGGTTAAGTCCGCTTTTGGTCAAGTAGGTATTGATATAGCCGGGTGTGTTATTTAG

Upstream 100 bases:

>100_bases
AAAATTGATATGAATATGACATGAATATGAAAAAAAATATTGCATAATGTTTAATTATGTGACATTATTTGCGCCATTGT
GTATTCTGTGAGAGTTGTGT

Downstream 100 bases:

>100_bases
GGGGAGCAAAAGCTCCCGGCAAGTTTTTGCTCCAACAAACTACGGTGATCTCTTGTGGTTCATCGCGAGCTATTTTTGCT
CGCAGTGTTGTTTGCTGGGC

Product: hypothetical protein

Products: NA

Alternate protein names: HA/protease; Vibriolysin [H]

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MLKKTMFFILSIFTSSIFAADNVDLYQAPLNSINKYPILQTPKNAIILKSSSAVIDNSLQKLNQTKEDNQMIVRYQQLYK
GIPVIGAQVMITKGTDSGVQSNDNAEVNGHLLDNIELNTKPAISAQQAKEYAKKSYFQFSSQSNIQQETAELQIRPDHNN
QLKLVYLVSFKSVQQDGKPDWPFFVIDAQTGALIKQWNNIKNYLDTGPGGNEKVQEYWYGKDGLPALDVTQNGSQCVMEN
SKVKLVNLHSQWDWENTINTPFEYVCNNNIEENINGGFSPGNDAYYFGHVIVGMYKDWYGLNALQHSNGAPMQLVMRVHF
GQNYDNAFWDGQAMSFGDGLDFYPLVSLDVAGHEVTHGFTEQHSGLEYHDQSGALNESLSDMAGQASRAYLLEKNPQLYN
KAYLQPNEVTWGIGETIVRDSYGKALRFMDYPSSDGSSADCLDKGIAQNNGSYCAISYDEVVAYANTHIALPQERQSFIV
HTASGVFNKAFYLMSKDMGIKNAYHIMVVANTKYWTPTTDFKNGACGVIYAARDLNTDINKVKSAFGQVGIDIAGCVI

Sequences:

>Translated_558_residues
MLKKTMFFILSIFTSSIFAADNVDLYQAPLNSINKYPILQTPKNAIILKSSSAVIDNSLQKLNQTKEDNQMIVRYQQLYK
GIPVIGAQVMITKGTDSGVQSNDNAEVNGHLLDNIELNTKPAISAQQAKEYAKKSYFQFSSQSNIQQETAELQIRPDHNN
QLKLVYLVSFKSVQQDGKPDWPFFVIDAQTGALIKQWNNIKNYLDTGPGGNEKVQEYWYGKDGLPALDVTQNGSQCVMEN
SKVKLVNLHSQWDWENTINTPFEYVCNNNIEENINGGFSPGNDAYYFGHVIVGMYKDWYGLNALQHSNGAPMQLVMRVHF
GQNYDNAFWDGQAMSFGDGLDFYPLVSLDVAGHEVTHGFTEQHSGLEYHDQSGALNESLSDMAGQASRAYLLEKNPQLYN
KAYLQPNEVTWGIGETIVRDSYGKALRFMDYPSSDGSSADCLDKGIAQNNGSYCAISYDEVVAYANTHIALPQERQSFIV
HTASGVFNKAFYLMSKDMGIKNAYHIMVVANTKYWTPTTDFKNGACGVIYAARDLNTDINKVKSAFGQVGIDIAGCVI
>Mature_558_residues
MLKKTMFFILSIFTSSIFAADNVDLYQAPLNSINKYPILQTPKNAIILKSSSAVIDNSLQKLNQTKEDNQMIVRYQQLYK
GIPVIGAQVMITKGTDSGVQSNDNAEVNGHLLDNIELNTKPAISAQQAKEYAKKSYFQFSSQSNIQQETAELQIRPDHNN
QLKLVYLVSFKSVQQDGKPDWPFFVIDAQTGALIKQWNNIKNYLDTGPGGNEKVQEYWYGKDGLPALDVTQNGSQCVMEN
SKVKLVNLHSQWDWENTINTPFEYVCNNNIEENINGGFSPGNDAYYFGHVIVGMYKDWYGLNALQHSNGAPMQLVMRVHF
GQNYDNAFWDGQAMSFGDGLDFYPLVSLDVAGHEVTHGFTEQHSGLEYHDQSGALNESLSDMAGQASRAYLLEKNPQLYN
KAYLQPNEVTWGIGETIVRDSYGKALRFMDYPSSDGSSADCLDKGIAQNNGSYCAISYDEVVAYANTHIALPQERQSFIV
HTASGVFNKAFYLMSKDMGIKNAYHIMVVANTKYWTPTTDFKNGACGVIYAARDLNTDINKVKSAFGQVGIDIAGCVI

Specific function: May play a role in the pathogenesis of cholera. Hap nicks and activates the A subunit of cholera enterotoxin and related enterotoxins [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR007280
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C; PF04151 PPC [H]

EC number: NA

Molecular weight: Translated: 62226; Mature: 62226

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKTMFFILSIFTSSIFAADNVDLYQAPLNSINKYPILQTPKNAIILKSSSAVIDNSLQ
CCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCEECCCCEEEEECCCHHHHHHHH
KLNQTKEDNQMIVRYQQLYKGIPVIGAQVMITKGTDSGVQSNDNAEVNGHLLDNIELNTK
HHHCCCCCHHHHHHHHHHHCCCCEECEEEEEECCCCCCCCCCCCCEECCEEEECEEECCC
PAISAQQAKEYAKKSYFQFSSQSNIQQETAELQIRPDHNNQLKLVYLVSFKSVQQDGKPD
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEHHHHHCCCCC
WPFFVIDAQTGALIKQWNNIKNYLDTGPGGNEKVQEYWYGKDGLPALDVTQNGSQCVMEN
CCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEECCCCCEEEEEC
SKVKLVNLHSQWDWENTINTPFEYVCNNNIEENINGGFSPGNDAYYFGHVIVGMYKDWYG
CCEEEEEECCCCCCCCCCCCCHHHHCCCCCHHCCCCCCCCCCCCEEEEHHHHHHHHHHHC
LNALQHSNGAPMQLVMRVHFGQNYDNAFWDGQAMSFGDGLDFYPLVSLDVAGHEVTHGFT
CCCEECCCCCCCEEEEEECCCCCCCCCEECCCCEECCCCCCCCEEEEEEECCCHHHCCHH
EQHSGLEYHDQSGALNESLSDMAGQASRAYLLEKNPQLYNKAYLQPNEVTWGIGETIVRD
HHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCCEEECCCHHHHHC
SYGKALRFMDYPSSDGSSADCLDKGIAQNNGSYCAISYDEVVAYANTHIALPQERQSFIV
CCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEHHHEEEECCCEEECCCCCCEEEE
HTASGVFNKAFYLMSKDMGIKNAYHIMVVANTKYWTPTTDFKNGACGVIYAARDLNTDIN
EECCHHHHHEEEEEECCCCCCCEEEEEEEECCEECCCCCCCCCCCEEEEEEECCCCCHHH
KVKSAFGQVGIDIAGCVI
HHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MLKKTMFFILSIFTSSIFAADNVDLYQAPLNSINKYPILQTPKNAIILKSSSAVIDNSLQ
CCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCEECCCCEEEEECCCHHHHHHHH
KLNQTKEDNQMIVRYQQLYKGIPVIGAQVMITKGTDSGVQSNDNAEVNGHLLDNIELNTK
HHHCCCCCHHHHHHHHHHHCCCCEECEEEEEECCCCCCCCCCCCCEECCEEEECEEECCC
PAISAQQAKEYAKKSYFQFSSQSNIQQETAELQIRPDHNNQLKLVYLVSFKSVQQDGKPD
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEHHHHHCCCCC
WPFFVIDAQTGALIKQWNNIKNYLDTGPGGNEKVQEYWYGKDGLPALDVTQNGSQCVMEN
CCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEECCCCCEEEEEC
SKVKLVNLHSQWDWENTINTPFEYVCNNNIEENINGGFSPGNDAYYFGHVIVGMYKDWYG
CCEEEEEECCCCCCCCCCCCCHHHHCCCCCHHCCCCCCCCCCCCEEEEHHHHHHHHHHHC
LNALQHSNGAPMQLVMRVHFGQNYDNAFWDGQAMSFGDGLDFYPLVSLDVAGHEVTHGFT
CCCEECCCCCCCEEEEEECCCCCCCCCEECCCCEECCCCCCCCEEEEEEECCCHHHCCHH
EQHSGLEYHDQSGALNESLSDMAGQASRAYLLEKNPQLYNKAYLQPNEVTWGIGETIVRD
HHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCCEEECCCHHHHHC
SYGKALRFMDYPSSDGSSADCLDKGIAQNNGSYCAISYDEVVAYANTHIALPQERQSFIV
CCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEHHHEEEECCCEEECCCCCCEEEE
HTASGVFNKAFYLMSKDMGIKNAYHIMVVANTKYWTPTTDFKNGACGVIYAARDLNTDIN
EECCHHHHHEEEEEECCCCCCCEEEEEEEECCEECCCCCCCCCCCEEEEEEECCCCCHHH
KVKSAFGQVGIDIAGCVI
HHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2045361; 10952301; 2123831 [H]