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The map label for this gene is gyrB [H]

Identifier: 54292968

GI number: 54292968

Start: 4034

End: 6451

Strand: Direct

Name: gyrB [H]

Synonym: lpl0004

Alternate gene names: 54292968

Gene position: 4034-6451 (Clockwise)

Preceding gene: 54292967

Following gene: 54292973

Centisome position: 0.12

GC content: 39.54

Gene sequence:

>2418_bases
ATGAGCGTAGACGCCAGTTATGATTCAAATAATATTAAAGTCCTAAAAGGTTTAGACGCAGTAAGAAAAAGACCGGGCAT
GTACATTGGGGATACAGATGATGGGACCGGTTTGCATCATATGGTTTTTGAGGTTGTAGATAATTCAATAGATGAATCCC
TGGCAGGTTATTGCAAGGAAATTTTTGTTACCATTCATAGCGATGAATCAATTACCGTTAAGGATGATGGTCGTGGTATT
CCTGTCGATATTCATAAGGAAGAAGGAAAATCAGCTGCTGAAGTCATTATGACAGTCCTGCATGCCGGAGGTAAATTTGA
TGATAACTCTTACAAGGTATCAGGCGGTCTACATGGAGTAGGGGTATCTGTGGTGAATGCCCTTTCAGAAGAGTTGCATT
TGCTAGTGCGTAGACATGGAAAAGTGTATGAGCAACACTACAGGCATGGTGTTCCTGAATCTCCAATTGCTGAAACTGGA
GAAGCCAACTCTACTGGCACACAAATATGGTTTAAACCAAGCGCTGAAACCTTTTCTAATATTGAGTTCCATTACGACAT
TCTAGCTAAAAGATTACGTGAATTGTCATACCTGAATTCAGGCGTTTGTATTCACTTATTTGATGAAAGAACACAGAAAA
AAGACACGTTTCACTACGAAGGCGGCATCAAAGCCTTTGTTGAGCACTTAAATAAAAATAAGACACCAGTCCACCCCGTT
GTTTTCTCAATGACATCGGAAAAAGACGGTATCGTCATTGAACTGGCCATGCAATGGAATGATGGTTATCAAGAAACCAT
ATTTTGCTTTACTAACAACATCCCGCAAAGGGATGGTGGAACACATATGGCCGGCTTTAGAGCAGCATTAACGCGCACTT
TAAATAATTACATTGAAAACGAAGGGTATGCCAAAAAGGCAAAAGTATCTCCAACAGGTGATGATGCTCGCGAAGGATTA
ACAGCTGTTCTTTCAGTGAAAGTCCCTGATCCCAAGTTTTCATCGCAAACAAAAGATAAACTGGTTTCATCTGAAGTAAA
ACCAGCAGTAGAATCTTGTGTTGCTGAAAAATTTAACGACTTTCTTTTAGAAAATCCCACGGCAGCAAAATCCATCGTAG
CAAAAATTATTGATGCAGCAAGAGCTAGAGAGGCAGCGCGGCGTGCTCGTGAAATGACTCGACGTAAAGGGGCTTTGGAT
ATTGCCGGTTTACCAGGTAAATTAGCTGATTGCCAAGAAAAAGACCCATCGCTTTCCGAGTTGTATTTAGTTGAGGGTGA
CTCTGCAGGAGGCTCAGCAAAACAAGCGCGAGACAGAAAATTCCAGGCTATTTTACCTCTTAAAGGCAAGATTCTTAATG
TTGAAAAAGCCCGGTTTGACAAGATGCTTTCTTCTCAAGAAGTAGCCACTTTGATTACTGCATTAGGCTGTGGAATTGGT
CCTGAGGAATATGATCCAGATAAAGTACGTTATCATAGAATCATCATTATGACAGATGCTGATGTGGATGGGTCCCACAT
AAGAACTTTACTTCTTACCTTTTTCTATAGACAAACCAGAGAACTATTGGAACGAGGATATATTTATATTGCACAACCAC
CTTTGTATAAAGTAAAGCGTGGAAAACAGGAGCAATATGTTAAAGATGATGAAGCGTTATTTGATTATCTAACTCAGTGC
GCATTGGATGGGGCGACATTTTATCCCGCCAAAGAGGTTCCACCCATATCTGCCAAATCGCTGGAAGAATTGGTTCAACA
TTTCAGACGTGTTGAGAAGATTATAAAGCGGTACAAGAGAAGATATCCCAGCGATATACTAAAAAGAGTAGCTTATATGC
CAATGCTGCACCAAGAAGATTTTAACAATCTGCCAAAAATTGAAAACTGGTGCAGACAATTACACTTAAGCTTACAACAA
GTAGACAGTAAAACAGAACAATACAAAGTAGATATCCAAAAACTTACAGAAGGTAATCAATACACCCCAAAAATTACTGT
GTACCAGCATGGCTTGGAAAATGATATTCCAATGCAAGTTGAATTTTTCTTGTCTAAAGATTACAAAGAAATGGTTGATT
TAGGACATAAATTGTCGAATTTAATAGAGGAAGGCGCCTATATTCAGCGTGGAGATAAATCCTTGCCTGTGGAAAATTTT
GAGCAAGTACTTAATTGGCTAATGGATGAAGCAAAAAAAGGACAAACAATTCAACGCTATAAAGGTCTTGGGGAAATGAA
CCCTGAGCAGTTATGGGAAACAACCATGGATCCCGAGGTTAGACGAATGTTGCAAGTGAGCATTGAAGATGCCGTAGCTG
CGGATGAAATTTTTACCACCTTAATGGGCGACAATGTAGAACCAAGAAGAGATTTTATTGAATCGAATGCTTTAGACGCT
GAAAACATTGATATTTAA

Upstream 100 bases:

>100_bases
ATGCACAAGCGTAAAGTTCTCTACTTAAGATATAAACCAGATACAAAAGATGATATAATAGACTCATTGTTAATAGCATA
ATACGGCAAGAGGGCAGCTG

Downstream 100 bases:

>100_bases
ACAAATAGTATTGTTGAACTGGAGTGATGTTTGCCTCGCTCGAGGCAAACGCCTCTCTAGCTTATAGCTGGCTCACTCTA
TGATGATGTGTTCAAAAAAA

Product: DNA gyrase, subunit B (type II topoisomerase)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MSVDASYDSNNIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDESLAGYCKEIFVTIHSDESITVKDDGRGI
PVDIHKEEGKSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEELHLLVRRHGKVYEQHYRHGVPESPIAETG
EANSTGTQIWFKPSAETFSNIEFHYDILAKRLRELSYLNSGVCIHLFDERTQKKDTFHYEGGIKAFVEHLNKNKTPVHPV
VFSMTSEKDGIVIELAMQWNDGYQETIFCFTNNIPQRDGGTHMAGFRAALTRTLNNYIENEGYAKKAKVSPTGDDAREGL
TAVLSVKVPDPKFSSQTKDKLVSSEVKPAVESCVAEKFNDFLLENPTAAKSIVAKIIDAARAREAARRAREMTRRKGALD
IAGLPGKLADCQEKDPSLSELYLVEGDSAGGSAKQARDRKFQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG
PEEYDPDKVRYHRIIIMTDADVDGSHIRTLLLTFFYRQTRELLERGYIYIAQPPLYKVKRGKQEQYVKDDEALFDYLTQC
ALDGATFYPAKEVPPISAKSLEELVQHFRRVEKIIKRYKRRYPSDILKRVAYMPMLHQEDFNNLPKIENWCRQLHLSLQQ
VDSKTEQYKVDIQKLTEGNQYTPKITVYQHGLENDIPMQVEFFLSKDYKEMVDLGHKLSNLIEEGAYIQRGDKSLPVENF
EQVLNWLMDEAKKGQTIQRYKGLGEMNPEQLWETTMDPEVRRMLQVSIEDAVAADEIFTTLMGDNVEPRRDFIESNALDA
ENIDI

Sequences:

>Translated_805_residues
MSVDASYDSNNIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDESLAGYCKEIFVTIHSDESITVKDDGRGI
PVDIHKEEGKSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEELHLLVRRHGKVYEQHYRHGVPESPIAETG
EANSTGTQIWFKPSAETFSNIEFHYDILAKRLRELSYLNSGVCIHLFDERTQKKDTFHYEGGIKAFVEHLNKNKTPVHPV
VFSMTSEKDGIVIELAMQWNDGYQETIFCFTNNIPQRDGGTHMAGFRAALTRTLNNYIENEGYAKKAKVSPTGDDAREGL
TAVLSVKVPDPKFSSQTKDKLVSSEVKPAVESCVAEKFNDFLLENPTAAKSIVAKIIDAARAREAARRAREMTRRKGALD
IAGLPGKLADCQEKDPSLSELYLVEGDSAGGSAKQARDRKFQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG
PEEYDPDKVRYHRIIIMTDADVDGSHIRTLLLTFFYRQTRELLERGYIYIAQPPLYKVKRGKQEQYVKDDEALFDYLTQC
ALDGATFYPAKEVPPISAKSLEELVQHFRRVEKIIKRYKRRYPSDILKRVAYMPMLHQEDFNNLPKIENWCRQLHLSLQQ
VDSKTEQYKVDIQKLTEGNQYTPKITVYQHGLENDIPMQVEFFLSKDYKEMVDLGHKLSNLIEEGAYIQRGDKSLPVENF
EQVLNWLMDEAKKGQTIQRYKGLGEMNPEQLWETTMDPEVRRMLQVSIEDAVAADEIFTTLMGDNVEPRRDFIESNALDA
ENIDI
>Mature_804_residues
SVDASYDSNNIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDESLAGYCKEIFVTIHSDESITVKDDGRGIP
VDIHKEEGKSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEELHLLVRRHGKVYEQHYRHGVPESPIAETGE
ANSTGTQIWFKPSAETFSNIEFHYDILAKRLRELSYLNSGVCIHLFDERTQKKDTFHYEGGIKAFVEHLNKNKTPVHPVV
FSMTSEKDGIVIELAMQWNDGYQETIFCFTNNIPQRDGGTHMAGFRAALTRTLNNYIENEGYAKKAKVSPTGDDAREGLT
AVLSVKVPDPKFSSQTKDKLVSSEVKPAVESCVAEKFNDFLLENPTAAKSIVAKIIDAARAREAARRAREMTRRKGALDI
AGLPGKLADCQEKDPSLSELYLVEGDSAGGSAKQARDRKFQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGP
EEYDPDKVRYHRIIIMTDADVDGSHIRTLLLTFFYRQTRELLERGYIYIAQPPLYKVKRGKQEQYVKDDEALFDYLTQCA
LDGATFYPAKEVPPISAKSLEELVQHFRRVEKIIKRYKRRYPSDILKRVAYMPMLHQEDFNNLPKIENWCRQLHLSLQQV
DSKTEQYKVDIQKLTEGNQYTPKITVYQHGLENDIPMQVEFFLSKDYKEMVDLGHKLSNLIEEGAYIQRGDKSLPVENFE
QVLNWLMDEAKKGQTIQRYKGLGEMNPEQLWETTMDPEVRRMLQVSIEDAVAADEIFTTLMGDNVEPRRDFIESNALDAE
NIDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=548, Percent_Identity=25.3649635036496, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI19913406, Length=550, Percent_Identity=25.0909090909091, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI48994957, Length=801, Percent_Identity=69.4132334581773, Blast_Score=1144, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=551, Percent_Identity=40.6533575317604, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=531, Percent_Identity=24.105461393597, Blast_Score=132, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI212645845, Length=501, Percent_Identity=24.5508982035928, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324241, Length=599, Percent_Identity=25.542570951586, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI17136538, Length=490, Percent_Identity=25.5102040816327, Blast_Score=137, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 90997; Mature: 90866

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDASYDSNNIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDESLAGYCKE
CCCCCCCCCCCEEEECCHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IFVTIHSDESITVKDDGRGIPVDIHKEEGKSAAEVIMTVLHAGGKFDDNSYKVSGGLHGV
HEEEEECCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCHH
GVSVVNALSEELHLLVRRHGKVYEQHYRHGVPESPIAETGEANSTGTQIWFKPSAETFSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHC
IEFHYDILAKRLRELSYLNSGVCIHLFDERTQKKDTFHYEGGIKAFVEHLNKNKTPVHPV
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHCCCCCCCCCE
VFSMTSEKDGIVIELAMQWNDGYQETIFCFTNNIPQRDGGTHMAGFRAALTRTLNNYIEN
EEEECCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHC
EGYAKKAKVSPTGDDAREGLTAVLSVKVPDPKFSSQTKDKLVSSEVKPAVESCVAEKFND
CCCCCCCCCCCCCCHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLLENPTAAKSIVAKIIDAARAREAARRAREMTRRKGALDIAGLPGKLADCQEKDPSLSE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCE
LYLVEGDSAGGSAKQARDRKFQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG
EEEEECCCCCCCHHHHHHCCCEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEEYDPDKVRYHRIIIMTDADVDGSHIRTLLLTFFYRQTRELLERGYIYIAQPPLYKVKR
CCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHC
GKQEQYVKDDEALFDYLTQCALDGATFYPAKEVPPISAKSLEELVQHFRRVEKIIKRYKR
CCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RYPSDILKRVAYMPMLHQEDFNNLPKIENWCRQLHLSLQQVDSKTEQYKVDIQKLTEGNQ
HCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
YTPKITVYQHGLENDIPMQVEFFLSKDYKEMVDLGHKLSNLIEEGAYIQRGDKSLPVENF
CCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHH
EQVLNWLMDEAKKGQTIQRYKGLGEMNPEQLWETTMDPEVRRMLQVSIEDAVAADEIFTT
HHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LMGDNVEPRRDFIESNALDAENIDI
HHCCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SVDASYDSNNIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDESLAGYCKE
CCCCCCCCCCEEEECCHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IFVTIHSDESITVKDDGRGIPVDIHKEEGKSAAEVIMTVLHAGGKFDDNSYKVSGGLHGV
HEEEEECCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCHH
GVSVVNALSEELHLLVRRHGKVYEQHYRHGVPESPIAETGEANSTGTQIWFKPSAETFSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHC
IEFHYDILAKRLRELSYLNSGVCIHLFDERTQKKDTFHYEGGIKAFVEHLNKNKTPVHPV
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHCCCCCCCCCE
VFSMTSEKDGIVIELAMQWNDGYQETIFCFTNNIPQRDGGTHMAGFRAALTRTLNNYIEN
EEEECCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHC
EGYAKKAKVSPTGDDAREGLTAVLSVKVPDPKFSSQTKDKLVSSEVKPAVESCVAEKFND
CCCCCCCCCCCCCCHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLLENPTAAKSIVAKIIDAARAREAARRAREMTRRKGALDIAGLPGKLADCQEKDPSLSE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCE
LYLVEGDSAGGSAKQARDRKFQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIG
EEEEECCCCCCCHHHHHHCCCEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEEYDPDKVRYHRIIIMTDADVDGSHIRTLLLTFFYRQTRELLERGYIYIAQPPLYKVKR
CCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHC
GKQEQYVKDDEALFDYLTQCALDGATFYPAKEVPPISAKSLEELVQHFRRVEKIIKRYKR
CCHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RYPSDILKRVAYMPMLHQEDFNNLPKIENWCRQLHLSLQQVDSKTEQYKVDIQKLTEGNQ
HCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
YTPKITVYQHGLENDIPMQVEFFLSKDYKEMVDLGHKLSNLIEEGAYIQRGDKSLPVENF
CCCEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHH
EQVLNWLMDEAKKGQTIQRYKGLGEMNPEQLWETTMDPEVRRMLQVSIEDAVAADEIFTT
HHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LMGDNVEPRRDFIESNALDAENIDI
HHCCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]