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The map label for this gene is fba [H]

Identifier: 54027356

GI number: 54027356

Start: 5689946

End: 5690980

Strand: Reverse

Name: fba [H]

Synonym: nfa53820

Alternate gene names: 54027356

Gene position: 5690980-5689946 (Counterclockwise)

Preceding gene: 54027360

Following gene: 54027355

Centisome position: 94.52

GC content: 66.38

Gene sequence:

>1035_bases
GTGCCCATCGCAACCCCCGAGGTCTACGCCGAGATGCTGGCTCGCGCCAAGCAGAACTCCTTCGCGTTCCCGGCGATCAA
CTGCACCTCGTCGGAGACCATCAACGCGGCCATCAAGGGCTTCGCCGATGCCGGCAGCGACGGCATCATCCAGTTCTCGA
CCGGCGGCGCGGAGTTCGGTTCCGGGCTCGGCGTGAAGGACATGGTCACCGGCGCGGTCGCGCTGGCCGAGTTCGCGCAC
GTGGTGGCGGCGAAGTACGACGTGACCATCGCCCTGCACACCGACCACTGCCCGAAGGACAAGCTGGACGGCTTCGTCCG
GCCGCTGATCGCCATCTCGCAGGAGCGGGTGAACGCGGGCAAGAACCCGCTGTTCCAGTCGCACATGTGGGACGGCTCGG
CCATCCCGATCGACGAAAACCTCGAGATCGCCAAGGAGCTGCTGAAGGCCACCTCGGCGGCCAACATCATCCTCGAGGTC
GAGATCGGCGTCGTCGGCGGTGAAGAGGACGGTGTCGAGGCCGAGATCAACGAGAAGCTCTACACCTCCCCGGAGGACTT
CGAGAAGACCGTCGACGCGCTGGGCACCGGCGAGAACGGCAAGTACCTGCTCGCCGCCACCTTCGGCAACGTGCACGGCG
TGTACAAGCCGGGCAACGTCAAGCTCCGCCCCGAGGTGCTCGCCGAGGGCCAGCGGGTGGCCGCGGCCAAGCTCGGCCTC
GGCGCCGACGCGCAGCCGTTCGACTTCGTCTTCCACGGCGGTTCGGGCTCGCTGAAGTCCGAGATCGACGACGCGCTGCG
CTACGGCGTGGTGAAGATGAACGTCGACACCGACACCCAGTACGCCTTCACCCGTCCCGTCGCCGGGCACATGTTCACCA
ACTACGACGGTGTGCTCAAGATCGACGGCGAGGTCGGCAACAAGAAGACCTACGACCCGCGCAGCTACCTCAAGAAGGCC
GAGGCGTCGATGTCGGAGCGCGTCGTGGAGGCGTGCAATGATCTGAAGTCCGCGGGACGGTCGATCAGCGCCTGA

Upstream 100 bases:

>100_bases
GGTCCCCTGTCGGGTGGGTCGGCGTCTCCCTTAGGCTGATCAGCAGGATCAGCACCCTTCGCGCCTGCGGGCGGCGAGCG
TCGTACATGGAGGTCTGTCA

Downstream 100 bases:

>100_bases
CCCACAACGTTCGAGGGCCCGAGCTCATGAGTCTGGATGTGCGTGTGCTCGGGCCCGTCCGGTTGTTCGTCGGTGGTGAG
CCGGTGGCGGTCGGCGGGCC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MPIATPEVYAEMLARAKQNSFAFPAINCTSSETINAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFAH
VVAAKYDVTIALHTDHCPKDKLDGFVRPLIAISQERVNAGKNPLFQSHMWDGSAIPIDENLEIAKELLKATSAANIILEV
EIGVVGGEEDGVEAEINEKLYTSPEDFEKTVDALGTGENGKYLLAATFGNVHGVYKPGNVKLRPEVLAEGQRVAAAKLGL
GADAQPFDFVFHGGSGSLKSEIDDALRYGVVKMNVDTDTQYAFTRPVAGHMFTNYDGVLKIDGEVGNKKTYDPRSYLKKA
EASMSERVVEACNDLKSAGRSISA

Sequences:

>Translated_344_residues
MPIATPEVYAEMLARAKQNSFAFPAINCTSSETINAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFAH
VVAAKYDVTIALHTDHCPKDKLDGFVRPLIAISQERVNAGKNPLFQSHMWDGSAIPIDENLEIAKELLKATSAANIILEV
EIGVVGGEEDGVEAEINEKLYTSPEDFEKTVDALGTGENGKYLLAATFGNVHGVYKPGNVKLRPEVLAEGQRVAAAKLGL
GADAQPFDFVFHGGSGSLKSEIDDALRYGVVKMNVDTDTQYAFTRPVAGHMFTNYDGVLKIDGEVGNKKTYDPRSYLKKA
EASMSERVVEACNDLKSAGRSISA
>Mature_343_residues
PIATPEVYAEMLARAKQNSFAFPAINCTSSETINAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFAHV
VAAKYDVTIALHTDHCPKDKLDGFVRPLIAISQERVNAGKNPLFQSHMWDGSAIPIDENLEIAKELLKATSAANIILEVE
IGVVGGEEDGVEAEINEKLYTSPEDFEKTVDALGTGENGKYLLAATFGNVHGVYKPGNVKLRPEVLAEGQRVAAAKLGLG
ADAQPFDFVFHGGSGSLKSEIDDALRYGVVKMNVDTDTQYAFTRPVAGHMFTNYDGVLKIDGEVGNKKTYDPRSYLKKAE
ASMSERVVEACNDLKSAGRSISA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=338, Percent_Identity=40.8284023668639, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87082041, Length=331, Percent_Identity=23.8670694864048, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789526, Length=336, Percent_Identity=27.0833333333333, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1788072, Length=266, Percent_Identity=27.4436090225564, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322790, Length=338, Percent_Identity=35.7988165680473, Blast_Score=200, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 36600; Mature: 36468

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIATPEVYAEMLARAKQNSFAFPAINCTSSETINAAIKGFADAGSDGIIQFSTGGAEFG
CCCCCHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHC
SGLGVKDMVTGAVALAEFAHVVAAKYDVTIALHTDHCPKDKLDGFVRPLIAISQERVNAG
CCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
KNPLFQSHMWDGSAIPIDENLEIAKELLKATSAANIILEVEIGVVGGEEDGVEAEINEKL
CCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCC
YTSPEDFEKTVDALGTGENGKYLLAATFGNVHGVYKPGNVKLRPEVLAEGQRVAAAKLGL
CCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHCCCCCEEHHHHCC
GADAQPFDFVFHGGSGSLKSEIDDALRYGVVKMNVDTDTQYAFTRPVAGHMFTNYDGVLK
CCCCCCCEEEEECCCCCHHHHHHHHHHHCEEEEECCCCCCEEEECCCCCCEEECCCCEEE
IDGEVGNKKTYDPRSYLKKAEASMSERVVEACNDLKSAGRSISA
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PIATPEVYAEMLARAKQNSFAFPAINCTSSETINAAIKGFADAGSDGIIQFSTGGAEFG
CCCCHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHC
SGLGVKDMVTGAVALAEFAHVVAAKYDVTIALHTDHCPKDKLDGFVRPLIAISQERVNAG
CCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
KNPLFQSHMWDGSAIPIDENLEIAKELLKATSAANIILEVEIGVVGGEEDGVEAEINEKL
CCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCCCCCCCC
YTSPEDFEKTVDALGTGENGKYLLAATFGNVHGVYKPGNVKLRPEVLAEGQRVAAAKLGL
CCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHCCCCCEEHHHHCC
GADAQPFDFVFHGGSGSLKSEIDDALRYGVVKMNVDTDTQYAFTRPVAGHMFTNYDGVLK
CCCCCCCEEEEECCCCCHHHHHHHHHHHCEEEEECCCCCCEEEECCCCCCEEECCCCEEE
IDGEVGNKKTYDPRSYLKKAEASMSERVVEACNDLKSAGRSISA
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]