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The map label for this gene is lpd [H]

Identifier: 54027239

GI number: 54027239

Start: 5564727

End: 5566130

Strand: Reverse

Name: lpd [H]

Synonym: nfa52650

Alternate gene names: 54027239

Gene position: 5566130-5564727 (Counterclockwise)

Preceding gene: 54027242

Following gene: 54027238

Centisome position: 92.44

GC content: 66.03

Gene sequence:

>1404_bases
GTGACTTCCCACTACGATGTCGTCGTTCTCGGTGCTGGTCCCGGCGGTTACGTCGCCGCGATCCGGTCCGCGCAACTCGG
CCTGCGAACAGCGGTTGTCGAGCAGAAATACTGGGGTGGTGTGTGCCTGAACGTTGGCTGCATCCCGTCGAAGGCGCTGC
TGCGCAATGCGGAGCTCGCGCACATCTTCCACAAGGAAGCCAAGACGTTCGGAATCTCCGGCGACGTCAGCTTCGACTTC
GGCGCGGCGTTCGACCGCAGCCGCAAGGTCGCCGACGGCCGCGTCAAGGGCGTCCACTTCCTGATGAAGAAGAACAAGAT
CGACGAGTTCGACGGCAAGGGCACGTTCGTCGACGCCAACACCCTCTCGGTGGAACTGAGCAAGGGCGGCACCGAGTCGA
TCACCTTCGACAACGTCATCATCGCCACGGGCACCGTCACCAAGCTGCTGCCCGGCACCTCCCGCAGCGCCAACGTGGTC
ACCTACGAAGAGCAGATCATGACCCGTGACCTGCCGGGTTCGATCCTCATCGTCGGCGCGGGCGCCATCGGCATGGAGTT
CGGCTACGTCCTGAAGAACTACGGCGTGGACGTGCGCATCGTGGAGTTCCTCGACCGCGCGCTGCCCAACGAGGACGCCG
ACGTCTCCAAGGAGATCACCAAGGCCTACAAGAAGCTCGGCATCACCATCACCACCGGTGCCGCCGTGCAGTCCATCGAC
GACGACGGCACCAAGGTGACCGTCGCCATCAAGGACAACAAGTCCGGTTCGGTGGAGACCGTCACCGTGGACAAGGTGCT
GCAGGCCGTCGGCTTCGCGCCCCGGGTGGAGGGCTACGGCCTGGAGAACACCGGTGTCGCGCTCACCGACCGCGGCGCGA
TCGCCATCGACGACAACATGCGCACCAACGTCCCGCACATCTACGCCATCGGTGACGTCACCGCCAAGCTGCAGCTGGCC
CACGTCGCCGAGGCGCAGGGCGTCGTCGCGGCCGAGACCATCGCCGGCGCGCCGACGCTCACCCTGGGCGACTACCGGAT
GATGCCGCGCGCGACCTTCTGCCAGCCGCAGGTCGCCAGCTTCGGCCTCACCGAGGAGCAGGCGCGGGCCGAGGGCTACG
ACGTGAAGGTCGCGACCTTCCCGTTCACCGCCAACGGCAAGGCGCACGGCCTCGGCGATCCCACCGGTTTCGTCAAGCTC
ATCTCCGACGTCCGCTACGGCGAGCTCCTCGGCGGCCACCTCATCGGCCCGGATGTCTCCGAGCTGTTGCCGGAGCTGAC
GCTGGCCCAGAAGTGGGATCTCACCGTCAACGAGCTCACCCGCAACGTGCACACCCACCCGACCCTCAGTGAGGCACTGC
AGGAGGCCTTCCACGGCCTGGCCGGGCACATGATCAACTTCTGA

Upstream 100 bases:

>100_bases
CGGCGCGGCAGGCGTGGACGCCGCCGCGGCTGTGGCCTGGATCTCACCGAGGCGGGGGCACGGTGGGTGAACCGAGCGCG
GCAGCGTTAGGCTCGCAGAC

Downstream 100 bases:

>100_bases
TCGCCGGACCCGCTCGACGGCGCCCGTGGCCGGACGGCCCGGGCGCCGTCGTCGTAGCAGGCGGGTTGCCCCACCGCGCG
GTGCCGGATCGAATCGCGCT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of alpha keto acid dehydrogenase complexes [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTSHYDVVVLGAGPGGYVAAIRSAQLGLRTAVVEQKYWGGVCLNVGCIPSKALLRNAELAHIFHKEAKTFGISGDVSFDF
GAAFDRSRKVADGRVKGVHFLMKKNKIDEFDGKGTFVDANTLSVELSKGGTESITFDNVIIATGTVTKLLPGTSRSANVV
TYEEQIMTRDLPGSILIVGAGAIGMEFGYVLKNYGVDVRIVEFLDRALPNEDADVSKEITKAYKKLGITITTGAAVQSID
DDGTKVTVAIKDNKSGSVETVTVDKVLQAVGFAPRVEGYGLENTGVALTDRGAIAIDDNMRTNVPHIYAIGDVTAKLQLA
HVAEAQGVVAAETIAGAPTLTLGDYRMMPRATFCQPQVASFGLTEEQARAEGYDVKVATFPFTANGKAHGLGDPTGFVKL
ISDVRYGELLGGHLIGPDVSELLPELTLAQKWDLTVNELTRNVHTHPTLSEALQEAFHGLAGHMINF

Sequences:

>Translated_467_residues
MTSHYDVVVLGAGPGGYVAAIRSAQLGLRTAVVEQKYWGGVCLNVGCIPSKALLRNAELAHIFHKEAKTFGISGDVSFDF
GAAFDRSRKVADGRVKGVHFLMKKNKIDEFDGKGTFVDANTLSVELSKGGTESITFDNVIIATGTVTKLLPGTSRSANVV
TYEEQIMTRDLPGSILIVGAGAIGMEFGYVLKNYGVDVRIVEFLDRALPNEDADVSKEITKAYKKLGITITTGAAVQSID
DDGTKVTVAIKDNKSGSVETVTVDKVLQAVGFAPRVEGYGLENTGVALTDRGAIAIDDNMRTNVPHIYAIGDVTAKLQLA
HVAEAQGVVAAETIAGAPTLTLGDYRMMPRATFCQPQVASFGLTEEQARAEGYDVKVATFPFTANGKAHGLGDPTGFVKL
ISDVRYGELLGGHLIGPDVSELLPELTLAQKWDLTVNELTRNVHTHPTLSEALQEAFHGLAGHMINF
>Mature_466_residues
TSHYDVVVLGAGPGGYVAAIRSAQLGLRTAVVEQKYWGGVCLNVGCIPSKALLRNAELAHIFHKEAKTFGISGDVSFDFG
AAFDRSRKVADGRVKGVHFLMKKNKIDEFDGKGTFVDANTLSVELSKGGTESITFDNVIIATGTVTKLLPGTSRSANVVT
YEEQIMTRDLPGSILIVGAGAIGMEFGYVLKNYGVDVRIVEFLDRALPNEDADVSKEITKAYKKLGITITTGAAVQSIDD
DGTKVTVAIKDNKSGSVETVTVDKVLQAVGFAPRVEGYGLENTGVALTDRGAIAIDDNMRTNVPHIYAIGDVTAKLQLAH
VAEAQGVVAAETIAGAPTLTLGDYRMMPRATFCQPQVASFGLTEEQARAEGYDVKVATFPFTANGKAHGLGDPTGFVKLI
SDVRYGELLGGHLIGPDVSELLPELTLAQKWDLTVNELTRNVHTHPTLSEALQEAFHGLAGHMINF

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=473, Percent_Identity=36.9978858350951, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=27.8617710583153, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI22035672, Length=482, Percent_Identity=29.8755186721992, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI148277065, Length=437, Percent_Identity=24.4851258581236, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519430, Length=437, Percent_Identity=24.4851258581236, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI33519428, Length=437, Percent_Identity=24.4851258581236, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI33519426, Length=437, Percent_Identity=24.4851258581236, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI148277071, Length=437, Percent_Identity=24.4851258581236, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI291045266, Length=431, Percent_Identity=24.5939675174014, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI291045268, Length=427, Percent_Identity=22.4824355971897, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1786307, Length=463, Percent_Identity=37.5809935205184, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=30.5676855895196, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1789915, Length=458, Percent_Identity=29.2576419213974, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI87082354, Length=471, Percent_Identity=27.1762208067941, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=469, Percent_Identity=36.8869936034115, Blast_Score=308, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17557007, Length=478, Percent_Identity=26.3598326359833, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=353, Percent_Identity=26.9121813031161, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71983419, Length=353, Percent_Identity=26.9121813031161, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=24.948024948025, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17559934, Length=249, Percent_Identity=28.9156626506024, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=37.2340425531915, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=26.1052631578947, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=472, Percent_Identity=29.0254237288136, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21358499, Length=472, Percent_Identity=39.6186440677966, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24640551, Length=480, Percent_Identity=28.75, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24640553, Length=478, Percent_Identity=28.6610878661088, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24640549, Length=478, Percent_Identity=28.6610878661088, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17737741, Length=487, Percent_Identity=27.7207392197125, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49784; Mature: 49653

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSHYDVVVLGAGPGGYVAAIRSAQLGLRTAVVEQKYWGGVCLNVGCIPSKALLRNAELA
CCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCHHH
HIFHKEAKTFGISGDVSFDFGAAFDRSRKVADGRVKGVHFLMKKNKIDEFDGKGTFVDAN
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECC
TLSVELSKGGTESITFDNVIIATGTVTKLLPGTSRSANVVTYEEQIMTRDLPGSILIVGA
EEEEEECCCCCCCEEECCEEEECCCHHHHCCCCCCCCEEEEEHHHHHHCCCCCCEEEEEC
GAIGMEFGYVLKNYGVDVRIVEFLDRALPNEDADVSKEITKAYKKLGITITTGAAVQSID
CHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEECCCEEECCC
DDGTKVTVAIKDNKSGSVETVTVDKVLQAVGFAPRVEGYGLENTGVALTDRGAIAIDDNM
CCCCEEEEEEECCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEECCCC
RTNVPHIYAIGDVTAKLQLAHVAEAQGVVAAETIAGAPTLTLGDYRMMPRATFCQPQVAS
CCCCCEEEEECCCEEEEEEEEHHHHCCCEEEHHHCCCCEEEECCEECCCCCCCCCCHHHH
FGLTEEQARAEGYDVKVATFPFTANGKAHGLGDPTGFVKLISDVRYGELLGGHLIGPDVS
CCCCHHHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCHH
ELLPELTLAQKWDLTVNELTRNVHTHPTLSEALQEAFHGLAGHMINF
HHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSHYDVVVLGAGPGGYVAAIRSAQLGLRTAVVEQKYWGGVCLNVGCIPSKALLRNAELA
CCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCCHHH
HIFHKEAKTFGISGDVSFDFGAAFDRSRKVADGRVKGVHFLMKKNKIDEFDGKGTFVDAN
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECC
TLSVELSKGGTESITFDNVIIATGTVTKLLPGTSRSANVVTYEEQIMTRDLPGSILIVGA
EEEEEECCCCCCCEEECCEEEECCCHHHHCCCCCCCCEEEEEHHHHHHCCCCCCEEEEEC
GAIGMEFGYVLKNYGVDVRIVEFLDRALPNEDADVSKEITKAYKKLGITITTGAAVQSID
CHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEECCCEEECCC
DDGTKVTVAIKDNKSGSVETVTVDKVLQAVGFAPRVEGYGLENTGVALTDRGAIAIDDNM
CCCCEEEEEEECCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEECCCC
RTNVPHIYAIGDVTAKLQLAHVAEAQGVVAAETIAGAPTLTLGDYRMMPRATFCQPQVAS
CCCCCEEEEECCCEEEEEEEEHHHHCCCEEEHHHCCCCEEEECCEECCCCCCCCCCHHHH
FGLTEEQARAEGYDVKVATFPFTANGKAHGLGDPTGFVKLISDVRYGELLGGHLIGPDVS
CCCCHHHHHCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCCCHH
ELLPELTLAQKWDLTVNELTRNVHTHPTLSEALQEAFHGLAGHMINF
HHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]