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The map label for this gene is hemC

Identifier: 54027143

GI number: 54027143

Start: 5467534

End: 5468574

Strand: Reverse

Name: hemC

Synonym: nfa51690

Alternate gene names: 54027143

Gene position: 5468574-5467534 (Counterclockwise)

Preceding gene: 54027144

Following gene: 54027142

Centisome position: 90.82

GC content: 75.5

Gene sequence:

>1041_bases
GTGGGCGCCGCGGCGACGGGTACGCCGTTGCGGATCGGCACCCGCGGCAGCCTGCTGGCGATGACCCAGGCGGGCACGGT
CCGCGATGCGCTCATCGCGGCCGGCCGCCCGGCCGAACTGGTGGTGGTCAAAACGCCCGGCGACATGTCGTCGGACCCGG
TGCAGAAGATCGGCGTCGGGGTGTTCACCTCGGCGCTGCGCGACGAACTCGCGGCGGGCACCATCGACCTCGCGGTGCAC
TCCTACAAGGACCTGCCGACCGCGCCGGACCCGCGGTTCGTCATCGCCGCGATCCCTCCGCGCGAGGACCCGCGCGACGC
GCTGGTCGCCCGGGACGGCCTGGTGCTCGGTGAACTGCCCGCGGGCGCGAAGGTCGGCACCTCGGCCCCGCGCCGGGTGG
CTCAGCTGCGCGCGCTCGGGCTCGGCCTGGACATCGTGCCGCTGCGCGGCAACCTCGACAGCAGACTCGCCCGGGTCACC
GACGGTGAGCTGGACGCCGTCGTGGTGGCCCGCGCGGGCCTGTCCAGGATCGGGCGGACCGCGGTGATCACCGAGGCGCT
CGAACCCGTGCAGATGCTGCCCGCGCCCGCCCAGGGCGCGCTCGCGGTGGAGTGCCGCAGCGAGGACGCCGCCCTCATCG
AGGCGCTGGCCGAGCTCGACGACGCGGCGACCAGAGCCGCCGTGGTGGCCGAGCGCGCGTTGCTCGCCGAACTGGAGGCC
GGCTGCACCGCCCCCGTCGGCGCGCTGGCCGAGGTCGTCGAATCGCTCGACGACGACGGCAGGATCGTCGAGGAGCTCTC
GCTGCGCGGCTGCGCCGCCGCGGTGGACGGCTCGGAGGTGCTGCGCGCCTCGGTGGTCGGCGATCCGGAGCGGGCGGCCG
AGCTCGGCCGCGCGCTGGCCCGCGAACTGCTGGAACTCGGCGCGCGCGAGCTGCTCGTCGAGGTGGCGGCCACGGAGCCG
GGCGCGCGCTCCGGGACCGGCGCGGTGCGCCCGCCAGAGACAGACCTCAGCAATCCCAGTCCGATGGAGAACCCCCAATG
A

Upstream 100 bases:

>100_bases
GACTGGCCGACGACTTCACCCCGGGCCACCGCCTGGATTTCGAGCAGCACCTCGGCGAGGAGGGAAAGCCGGCATGATCG
TCGCGCAGGAACAGGGCAAC

Downstream 100 bases:

>100_bases
GCCGAGCCACCAAGAAGCACCCCGGTCGGATCCTGTTCGTCGGGTCGGGTCCCGGGGACCCGGCGCTGCTCACCGTGCGC
GCGCGGGAGGTGCTCGGCCG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MGAAATGTPLRIGTRGSLLAMTQAGTVRDALIAAGRPAELVVVKTPGDMSSDPVQKIGVGVFTSALRDELAAGTIDLAVH
SYKDLPTAPDPRFVIAAIPPREDPRDALVARDGLVLGELPAGAKVGTSAPRRVAQLRALGLGLDIVPLRGNLDSRLARVT
DGELDAVVVARAGLSRIGRTAVITEALEPVQMLPAPAQGALAVECRSEDAALIEALAELDDAATRAAVVAERALLAELEA
GCTAPVGALAEVVESLDDDGRIVEELSLRGCAAAVDGSEVLRASVVGDPERAAELGRALARELLELGARELLVEVAATEP
GARSGTGAVRPPETDLSNPSPMENPQ

Sequences:

>Translated_346_residues
MGAAATGTPLRIGTRGSLLAMTQAGTVRDALIAAGRPAELVVVKTPGDMSSDPVQKIGVGVFTSALRDELAAGTIDLAVH
SYKDLPTAPDPRFVIAAIPPREDPRDALVARDGLVLGELPAGAKVGTSAPRRVAQLRALGLGLDIVPLRGNLDSRLARVT
DGELDAVVVARAGLSRIGRTAVITEALEPVQMLPAPAQGALAVECRSEDAALIEALAELDDAATRAAVVAERALLAELEA
GCTAPVGALAEVVESLDDDGRIVEELSLRGCAAAVDGSEVLRASVVGDPERAAELGRALARELLELGARELLVEVAATEP
GARSGTGAVRPPETDLSNPSPMENPQ
>Mature_345_residues
GAAATGTPLRIGTRGSLLAMTQAGTVRDALIAAGRPAELVVVKTPGDMSSDPVQKIGVGVFTSALRDELAAGTIDLAVHS
YKDLPTAPDPRFVIAAIPPREDPRDALVARDGLVLGELPAGAKVGTSAPRRVAQLRALGLGLDIVPLRGNLDSRLARVTD
GELDAVVVARAGLSRIGRTAVITEALEPVQMLPAPAQGALAVECRSEDAALIEALAELDDAATRAAVVAERALLAELEAG
CTAPVGALAEVVESLDDDGRIVEELSLRGCAAAVDGSEVLRASVVGDPERAAELGRALARELLELGARELLVEVAATEPG
ARSGTGAVRPPETDLSNPSPMENPQ

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=284, Percent_Identity=37.6760563380282, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI66933009, Length=284, Percent_Identity=37.6760563380282, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI48994974, Length=310, Percent_Identity=42.9032258064516, Blast_Score=198, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6319996, Length=324, Percent_Identity=31.7901234567901, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI20130425, Length=335, Percent_Identity=35.5223880597015, Blast_Score=164, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_NOCFA (Q5YP70)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_121385.1
- ProteinModelPortal:   Q5YP70
- SMR:   Q5YP70
- GeneID:   3109559
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa51690
- NMPDR:   fig|247156.1.peg.4967
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- BioCyc:   NFAR247156:NFA51690-MONOMER
- BRENDA:   2.5.1.61
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 35450; Mature: 35319

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAAATGTPLRIGTRGSLLAMTQAGTVRDALIAAGRPAELVVVKTPGDMSSDPVQKIGVG
CCCCCCCCCEEECCCCCEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHH
VFTSALRDELAAGTIDLAVHSYKDLPTAPDPRFVIAAIPPREDPRDALVARDGLVLGELP
HHHHHHHHHHHCCHHHEEHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCEEEECCC
AGAKVGTSAPRRVAQLRALGLGLDIVPLRGNLDSRLARVTDGELDAVVVARAGLSRIGRT
CCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCH
AVITEALEPVQMLPAPAQGALAVECRSEDAALIEALAELDDAATRAAVVAERALLAELEA
HHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GCTAPVGALAEVVESLDDDGRIVEELSLRGCAAAVDGSEVLRASVVGDPERAAELGRALA
CCCCCHHHHHHHHHHCCCCCHHHHHHHHCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH
RELLELGARELLVEVAATEPGARSGTGAVRPPETDLSNPSPMENPQ
HHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GAAATGTPLRIGTRGSLLAMTQAGTVRDALIAAGRPAELVVVKTPGDMSSDPVQKIGVG
CCCCCCCCEEECCCCCEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHH
VFTSALRDELAAGTIDLAVHSYKDLPTAPDPRFVIAAIPPREDPRDALVARDGLVLGELP
HHHHHHHHHHHCCHHHEEHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCEEEECCC
AGAKVGTSAPRRVAQLRALGLGLDIVPLRGNLDSRLARVTDGELDAVVVARAGLSRIGRT
CCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCH
AVITEALEPVQMLPAPAQGALAVECRSEDAALIEALAELDDAATRAAVVAERALLAELEA
HHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GCTAPVGALAEVVESLDDDGRIVEELSLRGCAAAVDGSEVLRASVVGDPERAAELGRALA
CCCCCHHHHHHHHHHCCCCCHHHHHHHHCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH
RELLELGARELLVEVAATEPGARSGTGAVRPPETDLSNPSPMENPQ
HHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA