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The map label for this gene is cysM [C]

Identifier: 54027125

GI number: 54027125

Start: 5452864

End: 5453949

Strand: Reverse

Name: cysM [C]

Synonym: nfa51510

Alternate gene names: 54027125

Gene position: 5453949-5452864 (Counterclockwise)

Preceding gene: 54027126

Following gene: 54027124

Centisome position: 90.58

GC content: 70.17

Gene sequence:

>1086_bases
GTGAAGTTCTGCGACCGCAGCGTCGCGCGCGACTGGGTGGACAACGCGGTGCGCCTGATCGACGCCGACGCCCAGCGCAG
CGCCGACACCCATCTGCTCCGCTACCCGCTGCCCGCGGCGTGGAACATCCAGCTGTACCTCAAGGACGAGTCCGCCCACA
TCACCGGCAGCCTGAAGCACCGGCTGGCCCGCTCGCTGTTCCTGTACGCGATCTGCAACGGCTGGGTCACCGAGGGCACC
ACGATCGTGGAGGCGTCCTCGGGGTCGACGGCGGTGAGCGAGGCGTATTTCGCCAAGCTGCTCGGACTCGATTTCGTCGC
GGTGATGCCGGCGAATACCTCGCCGCAGAAGATCGCGCTGATCGAGGCCCAGGGCGGCCGCTGTCACTTCGTGCGACGCC
CGCCGGAGATGTACACCGAGGCCGCGCGCCTGGCGGCCGAGTGCGGCGGGCACTACATGGACCAGTTCACCCACGCCGAA
CGAGCCACCGACTGGCGCGGCAACAACAACATCGCCGAGAGCATCTACCACCAGCTGCGGCTGGAGACCCATCCGGTGCC
GGAATGGATCGTGGTGGGCGCGGGCACCGGCGGAACCAGCGCCACCATCGGCCGCTACATCCGCTATCGCAGGCACGCCA
CCAAGCTGGCGGTGGTCGACCCGGAGAACTCCGCCTTCTACGGCGGCTACGAGACCGGTGACGCGGGCTATCAGACCGGG
ATGCCGTCGCGCATCGAGGGCATCGGCCGTCCGCGGGTGGAGCCGTCGTTCGTGGGGCAGGTGGTCGACCGGATGATCGA
GGTGCCCGACGCGGCCTCGATCGCGGCCATGCGCCATGCCGGCCGGGTGCTGGGGCGGCGGGTCGGCGGCTCCACCGGCA
CCAACCTGTGGGGGGTGTTCGGCCTGATCGCCGAAATGCTGGCCGAGGGCCGCTCCGGCAGTGTGGTGACGCTGCTGTGC
GACGGCGGTGACCGCTACGCCGGCACGTACTACGACGACGCGTGGGTGGCGGCCCAGGGGCTGAGCCTGGCCGAGCCCAC
GGCGGTGCTGGAGGAGTTCCACGCCACCGGCCTCTGGAAGGGCTGA

Upstream 100 bases:

>100_bases
GACATCGCGGCCGTCGACGCCAAGCGCAGGCAGGACAAGGCCCAGCTGCGGGCGCGGCTGCGCGGCGAAGGCGACGACGC
GTCGTGACCGGGGCGCGGCG

Downstream 100 bases:

>100_bases
CTGTCCCACCCTCGATGACGGCGGGGGTCGCCGCGCGCTCGCAATGTCAATTTTTCTTGACATCTGCCGTGGATGTCAAC
GAAAATTGACGCATGACGGA

Product: hypothetical protein

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKFCDRSVARDWVDNAVRLIDADAQRSADTHLLRYPLPAAWNIQLYLKDESAHITGSLKHRLARSLFLYAICNGWVTEGT
TIVEASSGSTAVSEAYFAKLLGLDFVAVMPANTSPQKIALIEAQGGRCHFVRRPPEMYTEAARLAAECGGHYMDQFTHAE
RATDWRGNNNIAESIYHQLRLETHPVPEWIVVGAGTGGTSATIGRYIRYRRHATKLAVVDPENSAFYGGYETGDAGYQTG
MPSRIEGIGRPRVEPSFVGQVVDRMIEVPDAASIAAMRHAGRVLGRRVGGSTGTNLWGVFGLIAEMLAEGRSGSVVTLLC
DGGDRYAGTYYDDAWVAAQGLSLAEPTAVLEEFHATGLWKG

Sequences:

>Translated_361_residues
MKFCDRSVARDWVDNAVRLIDADAQRSADTHLLRYPLPAAWNIQLYLKDESAHITGSLKHRLARSLFLYAICNGWVTEGT
TIVEASSGSTAVSEAYFAKLLGLDFVAVMPANTSPQKIALIEAQGGRCHFVRRPPEMYTEAARLAAECGGHYMDQFTHAE
RATDWRGNNNIAESIYHQLRLETHPVPEWIVVGAGTGGTSATIGRYIRYRRHATKLAVVDPENSAFYGGYETGDAGYQTG
MPSRIEGIGRPRVEPSFVGQVVDRMIEVPDAASIAAMRHAGRVLGRRVGGSTGTNLWGVFGLIAEMLAEGRSGSVVTLLC
DGGDRYAGTYYDDAWVAAQGLSLAEPTAVLEEFHATGLWKG
>Mature_361_residues
MKFCDRSVARDWVDNAVRLIDADAQRSADTHLLRYPLPAAWNIQLYLKDESAHITGSLKHRLARSLFLYAICNGWVTEGT
TIVEASSGSTAVSEAYFAKLLGLDFVAVMPANTSPQKIALIEAQGGRCHFVRRPPEMYTEAARLAAECGGHYMDQFTHAE
RATDWRGNNNIAESIYHQLRLETHPVPEWIVVGAGTGGTSATIGRYIRYRRHATKLAVVDPENSAFYGGYETGDAGYQTG
MPSRIEGIGRPRVEPSFVGQVVDRMIEVPDAASIAAMRHAGRVLGRRVGGSTGTNLWGVFGLIAEMLAEGRSGSVVTLLC
DGGDRYAGTYYDDAWVAAQGLSLAEPTAVLEEFHATGLWKG

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=27.0358306188925, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=27.0358306188925, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=27.0358306188925, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI2367138, Length=293, Percent_Identity=25.938566552901, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71996324, Length=356, Percent_Identity=32.3033707865169, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17539800, Length=353, Percent_Identity=30.5949008498584, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17539640, Length=354, Percent_Identity=28.8135593220339, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321594, Length=324, Percent_Identity=26.2345679012346, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321449, Length=336, Percent_Identity=27.0833333333333, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39327; Mature: 39327

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFCDRSVARDWVDNAVRLIDADAQRSADTHLLRYPLPAAWNIQLYLKDESAHITGSLKH
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEEEECCCCEEHHHHHH
RLARSLFLYAICNGWVTEGTTIVEASSGSTAVSEAYFAKLLGLDFVAVMPANTSPQKIAL
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEE
IEAQGGRCHFVRRPPEMYTEAARLAAECGGHYMDQFTHAERATDWRGNNNIAESIYHQLR
EEECCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LETHPVPEWIVVGAGTGGTSATIGRYIRYRRHATKLAVVDPENSAFYGGYETGDAGYQTG
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCEEEEECCCCCEEECCCCCCCCCCCCC
MPSRIEGIGRPRVEPSFVGQVVDRMIEVPDAASIAAMRHAGRVLGRRVGGSTGTNLWGVF
CCHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
GLIAEMLAEGRSGSVVTLLCDGGDRYAGTYYDDAWVAAQGLSLAEPTAVLEEFHATGLWK
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCC
G
C
>Mature Secondary Structure
MKFCDRSVARDWVDNAVRLIDADAQRSADTHLLRYPLPAAWNIQLYLKDESAHITGSLKH
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEEEECCCCEEHHHHHH
RLARSLFLYAICNGWVTEGTTIVEASSGSTAVSEAYFAKLLGLDFVAVMPANTSPQKIAL
HHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEE
IEAQGGRCHFVRRPPEMYTEAARLAAECGGHYMDQFTHAERATDWRGNNNIAESIYHQLR
EEECCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LETHPVPEWIVVGAGTGGTSATIGRYIRYRRHATKLAVVDPENSAFYGGYETGDAGYQTG
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCEEEEECCCCCEEECCCCCCCCCCCCC
MPSRIEGIGRPRVEPSFVGQVVDRMIEVPDAASIAAMRHAGRVLGRRVGGSTGTNLWGVF
CCHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
GLIAEMLAEGRSGSVVTLLCDGGDRYAGTYYDDAWVAAQGLSLAEPTAVLEEFHATGLWK
HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]