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The map label for this gene is hpd [H]

Identifier: 54027055

GI number: 54027055

Start: 5379710

End: 5380888

Strand: Reverse

Name: hpd [H]

Synonym: nfa50810

Alternate gene names: 54027055

Gene position: 5380888-5379710 (Counterclockwise)

Preceding gene: 54027057

Following gene: 54027054

Centisome position: 89.37

GC content: 69.64

Gene sequence:

>1179_bases
ATGACCCTCGAGAATCTGCCGACCGACGGCGAGTTGCGCGATCTCGTCGGGCTGGTCGACCACGACGTGAGCATCGACCC
GTTCCCGGTGATCGGCTGGGACGCGCTGGTCTGGGTCGTCGGCAACGCGACCCAGACCGCCCACTTCCTGGAATCGGCGC
TCGGCATGCTGCTGGAGGCCTACGCCGGGCCGGAGACCGGTGTACGTGATCACAAGGCGTTCGTGTTGCGCAGCGGCGCA
GCCCGTTTCGTGGTCCAGGGTGCCGTCGACCCCGACAGCCGCCTGGCCGAGCATCATCGCCGCCACGGCGACGGCGTGCT
CGACATCGCGCTGGAGGTGCCCGATGTGGACCGCTGTGTGCGCTGGGCGCGCGGGCAGGGCGCGCGCGTGCTGGCCGAAC
CGCACGACGAGCGCGACGAGTACGGTGTCGTCCGCACCGCGACCCTGGCCGCCTACGGCGCGACCAGGCACACCCTGGTG
GACCGCTCCGGCTACGACGGCCCCTACCGGCCCGGCTTCGTGCCGCGGCGCTCGGGATTCCGGCCCCGCCCCGGCAGGCC
GGCTCGGCTGTTCCAGGCCATCGACCACGTGGTCGGCAATGTCGAACTGGGCATGATGGACCACTGGGTGGAGTTCTATC
GCCGGGTCATGGGCTTCACGAACATGGCCGAGTTCGTCGGCGACGACATCGCCACCGAGTACTCGGCGCTGATGAGCAAG
GTCGTCGCCAACGGCAACCACCGGGTGAAGTTCCCGCTCAACGAACCCGCGCCCGGCCGGCGCCGCTCCCAGATCGACGA
GTTCCTCGAATTCCACCGCGGGCCCGGTGTCCAGCACATCGCCCTGGCCACCGGCGACATCCTCGCCACCGTGGACGCGA
TGCGCGCCGAGGGCGTGGAGTTCCTCGCCACCCCCGACGCCTACTACCAGGACCCCGACCTGCGCGCCCGCATCGGCCGG
GTCCGTGTCCCGGTCGAGGAACTGCGCCGCCGCGGCATCCTGGTCGACCGCGACGAGGACGGCTACCTGCTGCAGATCTT
CACCAAGCCGATCGGCGACCGCCCCACGGTGTTCTTCGAACTCATCGAACGCCACGGTTCCCTCGGTTTCGGCAAGGGCA
ACTTCAAAGCCCTCTTCGAGGCCATCGAGCGAGAACAGGCGGCCCGGGGAAACCTGTAG

Upstream 100 bases:

>100_bases
CTGCACAGCTCATCGGGGTTGTTCCTGGCCGATTGCGCCAGACTGCGCACCCGGCGGCGGCGCTGTTGCCCAGGTCACAC
CGCCGGGATTTCCTTGGACC

Downstream 100 bases:

>100_bases
CGCCGCAACGTCGCTCGTCGCGGCGCCGGCGAGACCCCGGAGGTGCTGCGCGAACCCCGGTAGAGTGCCTGGCATGCGGA
TCCCGTCGGCGCTCATCACA

Product: putative 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTLENLPTDGELRDLVGLVDHDVSIDPFPVIGWDALVWVVGNATQTAHFLESALGMLLEAYAGPETGVRDHKAFVLRSGA
ARFVVQGAVDPDSRLAEHHRRHGDGVLDIALEVPDVDRCVRWARGQGARVLAEPHDERDEYGVVRTATLAAYGATRHTLV
DRSGYDGPYRPGFVPRRSGFRPRPGRPARLFQAIDHVVGNVELGMMDHWVEFYRRVMGFTNMAEFVGDDIATEYSALMSK
VVANGNHRVKFPLNEPAPGRRRSQIDEFLEFHRGPGVQHIALATGDILATVDAMRAEGVEFLATPDAYYQDPDLRARIGR
VRVPVEELRRRGILVDRDEDGYLLQIFTKPIGDRPTVFFELIERHGSLGFGKGNFKALFEAIEREQAARGNL

Sequences:

>Translated_392_residues
MTLENLPTDGELRDLVGLVDHDVSIDPFPVIGWDALVWVVGNATQTAHFLESALGMLLEAYAGPETGVRDHKAFVLRSGA
ARFVVQGAVDPDSRLAEHHRRHGDGVLDIALEVPDVDRCVRWARGQGARVLAEPHDERDEYGVVRTATLAAYGATRHTLV
DRSGYDGPYRPGFVPRRSGFRPRPGRPARLFQAIDHVVGNVELGMMDHWVEFYRRVMGFTNMAEFVGDDIATEYSALMSK
VVANGNHRVKFPLNEPAPGRRRSQIDEFLEFHRGPGVQHIALATGDILATVDAMRAEGVEFLATPDAYYQDPDLRARIGR
VRVPVEELRRRGILVDRDEDGYLLQIFTKPIGDRPTVFFELIERHGSLGFGKGNFKALFEAIEREQAARGNL
>Mature_391_residues
TLENLPTDGELRDLVGLVDHDVSIDPFPVIGWDALVWVVGNATQTAHFLESALGMLLEAYAGPETGVRDHKAFVLRSGAA
RFVVQGAVDPDSRLAEHHRRHGDGVLDIALEVPDVDRCVRWARGQGARVLAEPHDERDEYGVVRTATLAAYGATRHTLVD
RSGYDGPYRPGFVPRRSGFRPRPGRPARLFQAIDHVVGNVELGMMDHWVEFYRRVMGFTNMAEFVGDDIATEYSALMSKV
VANGNHRVKFPLNEPAPGRRRSQIDEFLEFHRGPGVQHIALATGDILATVDAMRAEGVEFLATPDAYYQDPDLRARIGRV
RVPVEELRRRGILVDRDEDGYLLQIFTKPIGDRPTVFFELIERHGSLGFGKGNFKALFEAIEREQAARGNL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=363, Percent_Identity=43.5261707988981, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI285002264, Length=338, Percent_Identity=44.0828402366864, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI14249394, Length=334, Percent_Identity=32.0359281437126, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17555220, Length=377, Percent_Identity=42.4403183023873, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17550752, Length=364, Percent_Identity=36.5384615384615, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24667510, Length=369, Percent_Identity=43.9024390243902, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI21356105, Length=298, Percent_Identity=46.6442953020134, Blast_Score=258, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 43724; Mature: 43593

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLENLPTDGELRDLVGLVDHDVSIDPFPVIGWDALVWVVGNATQTAHFLESALGMLLEA
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECHHEEEEEECCCHHHHHHHHHHHHHHHHH
YAGPETGVRDHKAFVLRSGAARFVVQGAVDPDSRLAEHHRRHGDGVLDIALEVPDVDRCV
HCCCCCCCCCCHHEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHH
RWARGQGARVLAEPHDERDEYGVVRTATLAAYGATRHTLVDRSGYDGPYRPGFVPRRSGF
HHHCCCCCEEECCCCCCCHHCCHHHHHHHHHHCCHHHHEECCCCCCCCCCCCCCCCCCCC
RPRPGRPARLFQAIDHVVGNVELGMMDHWVEFYRRVMGFTNMAEFVGDDIATEYSALMSK
CCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHHHH
VVANGNHRVKFPLNEPAPGRRRSQIDEFLEFHRGPGVQHIALATGDILATVDAMRAEGVE
HHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCE
FLATPDAYYQDPDLRARIGRVRVPVEELRRRGILVDRDEDGYLLQIFTKPIGDRPTVFFE
EEECCCCCCCCCCHHHHHCCCCCCHHHHHHCCCEEEECCCCCEEEEEECCCCCCHHHHHH
LIERHGSLGFGKGNFKALFEAIEREQAARGNL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLENLPTDGELRDLVGLVDHDVSIDPFPVIGWDALVWVVGNATQTAHFLESALGMLLEA
CCCCCCCCCHHHHHHHHHHCCCCCCCCCEECHHEEEEEECCCHHHHHHHHHHHHHHHHH
YAGPETGVRDHKAFVLRSGAARFVVQGAVDPDSRLAEHHRRHGDGVLDIALEVPDVDRCV
HCCCCCCCCCCHHEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHH
RWARGQGARVLAEPHDERDEYGVVRTATLAAYGATRHTLVDRSGYDGPYRPGFVPRRSGF
HHHCCCCCEEECCCCCCCHHCCHHHHHHHHHHCCHHHHEECCCCCCCCCCCCCCCCCCCC
RPRPGRPARLFQAIDHVVGNVELGMMDHWVEFYRRVMGFTNMAEFVGDDIATEYSALMSK
CCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHHHH
VVANGNHRVKFPLNEPAPGRRRSQIDEFLEFHRGPGVQHIALATGDILATVDAMRAEGVE
HHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCE
FLATPDAYYQDPDLRARIGRVRVPVEELRRRGILVDRDEDGYLLQIFTKPIGDRPTVFFE
EEECCCCCCCCCCHHHHHCCCCCCHHHHHHCCCEEEECCCCCEEEEEECCCCCCHHHHHH
LIERHGSLGFGKGNFKALFEAIEREQAARGNL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]