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The map label for this gene is pkn1 [H]

Identifier: 54026860

GI number: 54026860

Start: 5099233

End: 5100573

Strand: Reverse

Name: pkn1 [H]

Synonym: nfa48860

Alternate gene names: 54026860

Gene position: 5100573-5099233 (Counterclockwise)

Preceding gene: 54026861

Following gene: 54026859

Centisome position: 84.71

GC content: 72.04

Gene sequence:

>1341_bases
GTGACGAAGTCCTTCGCCCCCTCCGACCATTCCGCCACCGACCGGCTGCGCGAGCGGATCGCCGAGGTGCTCACCACCGC
CCGAGCCCGCACCACGGCCCTCACCGCGGCCGTCGGCGAGGCCGATCTCGTCGCCCAGCACTCGCCGCTGATGAGCCCGC
TGGTCTGGGATCTCGCGCACATCGGCAATCAGGAGGAGCTGTGGCTGGTGCGCGATGTGGGCGGGCGTGAGCCGGTGCGC
GCCGACATCGACGAGCTCTACGACGCGTTCAAACACGCGCGCAAGGACCGCCCGGCCCTACCGTTGCTGAATCCCGCCGA
AGCCCGCGGTTACGTCGGCACGGTGCGGGAGAAGGTGTGGGACGTGCTCGAGCGCAGCGCGCTGCGCGGCAGCAGGCTGA
TCGAGGACGGCTTCGCCTTCGGCATGATCGCCCAGCACGAACAGCAACACGACGAGACCATGCTGGCCACCCACCAACTG
CGCGCCGGCGAGCCGGTGCTGTCGGCCGCCGCGCCGCCGCCGGCCCGCGTCCGGGTGAGCGGCGAGGTGATCGTGCCCGG
CGGCGAATTCACCATGGGCACCTCCGCCGACCCGTGGGCGCTGGACAACGAACGGCCCGCGCACCCGGTGCACGTGCCCG
CCTTCGCCATCGACGCCGCGCCGGTGACGAACGAGCAGTACCTCGCGTTCCTCGAGGACGGCGGCTACGAACGGCCCGAG
CTGTGGTCCGAACGCGGCTGGGCGCACCGGGTCTCGGCCGGTCTCACCGCGCCCCGGTTCTGGGAGCGCGACGGTGACGG
TCGATGGTGGCGCCGGGTGTTCGGCGTGCTGTCGCCGGTGCGGCCGCGGCAGCCGGTGGTGCACGTGTGCTGGTTCGAGG
CCGAGGCGTATGCCAGGTGGGCGGGCAAACGATTGCCCACCGAGGCCGAATGGGAGAAGGCGGCGCGGTTCGATCCGGCC
ACCGGCGGCTCGCGCCGCTACCCGTGGGGCGAGGACGAACCCGACGACACCAGAGCCAATCTCGGGCAACGTCACCTCGA
GCCCGCCGAGGTCGGCGCCTATCCCGCGGGCGTCTCCGCCACCGGCGCCCACCAGCTGATCGGCGATGTCTGGGAGTGGA
CGTCCTCGGGCTTCGATCCCTACCCCGGCTTCCGCGCCTTCCCCTACCGCGAGTACTCCGAGGTCTTCTTCGGTGGTGAC
TACCGGGTGCTGCGCGGCGGCTCGTTCGGCACCGACCCGGTCGCCTGCCGCGGCACCTTCCGCAACTGGGACCACCCGAT
CCGCAGGCAGATCTTCGCCGGGTTCCGGCTCGCGCGCGACCTGCGAGCGGACGAACGCTGA

Upstream 100 bases:

>100_bases
CCCACCGAGGAGCCCGCGCGCGTGCATTCCTGACCGACCGTCCCGCCGACCGATCCGCCGCGAGCCCGCTCGCGACCCTT
CTCCCCGGGAGAGCGTTACC

Downstream 100 bases:

>100_bases
TGTGCCGTCATCTCGGCTACGTGGGTGCGCCGGTCGCCGTCGGCGAACTGCTCACCCGGGGCACGCATTCGCTGCGCGAG
CAGTCCTGGGCGCCGCGGGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTKSFAPSDHSATDRLRERIAEVLTTARARTTALTAAVGEADLVAQHSPLMSPLVWDLAHIGNQEELWLVRDVGGREPVR
ADIDELYDAFKHARKDRPALPLLNPAEARGYVGTVREKVWDVLERSALRGSRLIEDGFAFGMIAQHEQQHDETMLATHQL
RAGEPVLSAAAPPPARVRVSGEVIVPGGEFTMGTSADPWALDNERPAHPVHVPAFAIDAAPVTNEQYLAFLEDGGYERPE
LWSERGWAHRVSAGLTAPRFWERDGDGRWWRRVFGVLSPVRPRQPVVHVCWFEAEAYARWAGKRLPTEAEWEKAARFDPA
TGGSRRYPWGEDEPDDTRANLGQRHLEPAEVGAYPAGVSATGAHQLIGDVWEWTSSGFDPYPGFRAFPYREYSEVFFGGD
YRVLRGGSFGTDPVACRGTFRNWDHPIRRQIFAGFRLARDLRADER

Sequences:

>Translated_446_residues
MTKSFAPSDHSATDRLRERIAEVLTTARARTTALTAAVGEADLVAQHSPLMSPLVWDLAHIGNQEELWLVRDVGGREPVR
ADIDELYDAFKHARKDRPALPLLNPAEARGYVGTVREKVWDVLERSALRGSRLIEDGFAFGMIAQHEQQHDETMLATHQL
RAGEPVLSAAAPPPARVRVSGEVIVPGGEFTMGTSADPWALDNERPAHPVHVPAFAIDAAPVTNEQYLAFLEDGGYERPE
LWSERGWAHRVSAGLTAPRFWERDGDGRWWRRVFGVLSPVRPRQPVVHVCWFEAEAYARWAGKRLPTEAEWEKAARFDPA
TGGSRRYPWGEDEPDDTRANLGQRHLEPAEVGAYPAGVSATGAHQLIGDVWEWTSSGFDPYPGFRAFPYREYSEVFFGGD
YRVLRGGSFGTDPVACRGTFRNWDHPIRRQIFAGFRLARDLRADER
>Mature_445_residues
TKSFAPSDHSATDRLRERIAEVLTTARARTTALTAAVGEADLVAQHSPLMSPLVWDLAHIGNQEELWLVRDVGGREPVRA
DIDELYDAFKHARKDRPALPLLNPAEARGYVGTVREKVWDVLERSALRGSRLIEDGFAFGMIAQHEQQHDETMLATHQLR
AGEPVLSAAAPPPARVRVSGEVIVPGGEFTMGTSADPWALDNERPAHPVHVPAFAIDAAPVTNEQYLAFLEDGGYERPEL
WSERGWAHRVSAGLTAPRFWERDGDGRWWRRVFGVLSPVRPRQPVVHVCWFEAEAYARWAGKRLPTEAEWEKAARFDPAT
GGSRRYPWGEDEPDDTRANLGQRHLEPAEVGAYPAGVSATGAHQLIGDVWEWTSSGFDPYPGFRAFPYREYSEVFFGGDY
RVLRGGSFGTDPVACRGTFRNWDHPIRRQIFAGFRLARDLRADER

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth. Phosphorylates incG, a inclusion-membrane protein required for the modification of the nascent chlamydial inclusio

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI194248088, Length=293, Percent_Identity=34.1296928327645, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI38202250, Length=292, Percent_Identity=32.1917808219178, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI257470975, Length=281, Percent_Identity=32.3843416370107, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI257470977, Length=224, Percent_Identity=34.8214285714286, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI194248087, Length=280, Percent_Identity=33.9285714285714, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194248090, Length=195, Percent_Identity=36.4102564102564, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI226437577, Length=192, Percent_Identity=36.9791666666667, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20130397, Length=234, Percent_Identity=32.0512820512821, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 49977; Mature: 49846

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSFAPSDHSATDRLRERIAEVLTTARARTTALTAAVGEADLVAQHSPLMSPLVWDLAH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHH
IGNQEELWLVRDVGGREPVRADIDELYDAFKHARKDRPALPLLNPAEARGYVGTVREKVW
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHH
DVLERSALRGSRLIEDGFAFGMIAQHEQQHDETMLATHQLRAGEPVLSAAAPPPARVRVS
HHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEC
GEVIVPGGEFTMGTSADPWALDNERPAHPVHVPAFAIDAAPVTNEQYLAFLEDGGYERPE
CEEEECCCCEEECCCCCCCCCCCCCCCCCEECCEEEECCCCCCCHHEEEEECCCCCCCCH
LWSERGWAHRVSAGLTAPRFWERDGDGRWWRRVFGVLSPVRPRQPVVHVCWFEAEAYARW
HHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHH
AGKRLPTEAEWEKAARFDPATGGSRRYPWGEDEPDDTRANLGQRHLEPAEVGAYPAGVSA
HCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCC
TGAHQLIGDVWEWTSSGFDPYPGFRAFPYREYSEVFFGGDYRVLRGGSFGTDPVACRGTF
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHEECCCEEEEECCCCCCCCEEECCCC
RNWDHPIRRQIFAGFRLARDLRADER
CCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKSFAPSDHSATDRLRERIAEVLTTARARTTALTAAVGEADLVAQHSPLMSPLVWDLAH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHH
IGNQEELWLVRDVGGREPVRADIDELYDAFKHARKDRPALPLLNPAEARGYVGTVREKVW
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHH
DVLERSALRGSRLIEDGFAFGMIAQHEQQHDETMLATHQLRAGEPVLSAAAPPPARVRVS
HHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEEC
GEVIVPGGEFTMGTSADPWALDNERPAHPVHVPAFAIDAAPVTNEQYLAFLEDGGYERPE
CEEEECCCCEEECCCCCCCCCCCCCCCCCEECCEEEECCCCCCCHHEEEEECCCCCCCCH
LWSERGWAHRVSAGLTAPRFWERDGDGRWWRRVFGVLSPVRPRQPVVHVCWFEAEAYARW
HHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHH
AGKRLPTEAEWEKAARFDPATGGSRRYPWGEDEPDDTRANLGQRHLEPAEVGAYPAGVSA
HCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCC
TGAHQLIGDVWEWTSSGFDPYPGFRAFPYREYSEVFFGGDYRVLRGGSFGTDPVACRGTF
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHEECCCEEEEECCCCCCCCEEECCCC
RNWDHPIRRQIFAGFRLARDLRADER
CCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9784136; 14500499 [H]