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The map label for this gene is mpg1 [H]

Identifier: 54026609

GI number: 54026609

Start: 4825381

End: 4826460

Strand: Reverse

Name: mpg1 [H]

Synonym: nfa46360

Alternate gene names: 54026609

Gene position: 4826460-4825381 (Counterclockwise)

Preceding gene: 54026610

Following gene: 54026606

Centisome position: 80.16

GC content: 72.59

Gene sequence:

>1080_bases
ATGGCAGGACAGCAAGGCACCGACGCCGTGATTCTGGTCGGCGGTCAGGGGACGCGGCTGCGTCCGCTCACCCTGTCGGC
GCCCAAGCCGATGCTGCCGACGGCGGGCCTGCCGTTCCTGACGCACCTGCTGGCGCGCATCGCCGAGGCCGGTATCACGC
ACGTGGTGCTGGGCACCGCCTTCAAGGCGGAGGTGTTCGAGGAGCACTTCGGCGACGGCTCCGATCTGGGTCTCGAGATC
GAGTACGTCACCGAGTCCGAGCCGCTCGGCACCGGCGGCGGCATCCGCAACGTGCTGCCCAAGCTGCGCCACGACACGGT
CATGGTGTTCAACGGCGACGTGCTCGGCGGCACCGACCTGGGCGCGGTGCTCGACACCCACCACAGCACCGGCGCGGACG
TCACCCTGCACCTGGTGCGGGTGAGCGACCCGCGCGCGTTCGGCTGCGTGCCCACCGACGAGGAGGGGCGCGTCACCGCG
TTCCTGGAGAAGACCCAGGACCCGCCGACCGACCAGATCAACGCCGGTTGCTACGTCTTCCGCCGCGAGTACATCGAGAA
GATCCCCGCGGGCAGGCCGGTGTCGGTGGAACGCGAGGTGTTTCCGGCGCTGCTGGCCGAGGGCGCCCGCGTGCAGGGGC
ACGTGGACACCTCCTACTGGCGCGACATGGGTACTCCCGAGGACTTCGTGCGCGGCTCGGCCGACCTGGTGCGCGGGATC
GCGCCCTCGCCCGCGCTGCCGGGTCAGCGCGGCGAATCGCTGGTGCATCCCGGCGCGGGGGTCGCGCCGGGCGCGCTGTT
GATCGGCGGCACGGTGGTCGGCCGCGGTGCCGAGATCGGCGCGGGCGCGCGGCTTGACGGCGCGGTGATCTTCGACGGCG
CGTGCGTGGAGGCCGGTGCCACCGTCGAGCGGTCCATCATCGGTTTCGGCGCGCGCATCGGTCCGCGCGCGCTGGTCCGC
GACGCGGTGATCGGCGACGGCGCCAACGTCGGCGCTCGCTGCGAGCTGCTGCGCGGTGCCCGGATCTGGCCCGGCGTGGA
GATCCCCGACGGCGGCATCCGCTTCTCCACCGACGTCTAG

Upstream 100 bases:

>100_bases
GCCGGACTTGCGATCCGCTCCCGTCTTGCGGTTCGATCTGCGCTGCGCCAGCAAGCGCGCGAGCGCGGTCGGTAGTACCA
GTGTGAACAGGGGAACAACG

Downstream 100 bases:

>100_bases
CGTTTCCACACGTAACGCGTCTTCGGCCGGCCCGCGCGACCGTATTCCGACCGGCGGGTCACCAGTCCGTCCTCGGCGAG
CTTCTCCAGATACCGCCACG

Product: putative mannose-1-phosphate guanyltransferase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAGQQGTDAVILVGGQGTRLRPLTLSAPKPMLPTAGLPFLTHLLARIAEAGITHVVLGTAFKAEVFEEHFGDGSDLGLEI
EYVTESEPLGTGGGIRNVLPKLRHDTVMVFNGDVLGGTDLGAVLDTHHSTGADVTLHLVRVSDPRAFGCVPTDEEGRVTA
FLEKTQDPPTDQINAGCYVFRREYIEKIPAGRPVSVEREVFPALLAEGARVQGHVDTSYWRDMGTPEDFVRGSADLVRGI
APSPALPGQRGESLVHPGAGVAPGALLIGGTVVGRGAEIGAGARLDGAVIFDGACVEAGATVERSIIGFGARIGPRALVR
DAVIGDGANVGARCELLRGARIWPGVEIPDGGIRFSTDV

Sequences:

>Translated_359_residues
MAGQQGTDAVILVGGQGTRLRPLTLSAPKPMLPTAGLPFLTHLLARIAEAGITHVVLGTAFKAEVFEEHFGDGSDLGLEI
EYVTESEPLGTGGGIRNVLPKLRHDTVMVFNGDVLGGTDLGAVLDTHHSTGADVTLHLVRVSDPRAFGCVPTDEEGRVTA
FLEKTQDPPTDQINAGCYVFRREYIEKIPAGRPVSVEREVFPALLAEGARVQGHVDTSYWRDMGTPEDFVRGSADLVRGI
APSPALPGQRGESLVHPGAGVAPGALLIGGTVVGRGAEIGAGARLDGAVIFDGACVEAGATVERSIIGFGARIGPRALVR
DAVIGDGANVGARCELLRGARIWPGVEIPDGGIRFSTDV
>Mature_358_residues
AGQQGTDAVILVGGQGTRLRPLTLSAPKPMLPTAGLPFLTHLLARIAEAGITHVVLGTAFKAEVFEEHFGDGSDLGLEIE
YVTESEPLGTGGGIRNVLPKLRHDTVMVFNGDVLGGTDLGAVLDTHHSTGADVTLHLVRVSDPRAFGCVPTDEEGRVTAF
LEKTQDPPTDQINAGCYVFRREYIEKIPAGRPVSVEREVFPALLAEGARVQGHVDTSYWRDMGTPEDFVRGSADLVRGIA
PSPALPGQRGESLVHPGAGVAPGALLIGGTVVGRGAEIGAGARLDGAVIFDGACVEAGATVERSIIGFGARIGPRALVRD
AVIGDGANVGARCELLRGARIWPGVEIPDGGIRFSTDV

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=345, Percent_Identity=30.4347826086957, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI11761621, Length=359, Percent_Identity=30.3621169916435, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI31881779, Length=396, Percent_Identity=26.010101010101, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI45447090, Length=396, Percent_Identity=26.010101010101, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI1788351, Length=240, Percent_Identity=24.5833333333333, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789837, Length=386, Percent_Identity=22.7979274611399, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790224, Length=191, Percent_Identity=26.7015706806283, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=368, Percent_Identity=31.5217391304348, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17509979, Length=327, Percent_Identity=29.0519877675841, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17509981, Length=318, Percent_Identity=27.6729559748428, Blast_Score=118, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6320148, Length=353, Percent_Identity=29.4617563739377, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21355443, Length=349, Percent_Identity=31.8051575931232, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24644084, Length=349, Percent_Identity=31.8051575931232, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24653912, Length=368, Percent_Identity=26.3586956521739, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 37439; Mature: 37308

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGQQGTDAVILVGGQGTRLRPLTLSAPKPMLPTAGLPFLTHLLARIAEAGITHVVLGTA
CCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCH
FKAEVFEEHFGDGSDLGLEIEYVTESEPLGTGGGIRNVLPKLRHDTVMVFNGDVLGGTDL
HHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCEECCCCH
GAVLDTHHSTGADVTLHLVRVSDPRAFGCVPTDEEGRVTAFLEKTQDPPTDQINAGCYVF
HHHHCCCCCCCCCEEEEEEEECCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHH
RREYIEKIPAGRPVSVEREVFPALLAEGARVQGHVDTSYWRDMGTPEDFVRGSADLVRGI
HHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHCCCCHHHHHCCCHHHHHCC
APSPALPGQRGESLVHPGAGVAPGALLIGGTVVGRGAEIGAGARLDGAVIFDGACVEAGA
CCCCCCCCCCCCCEECCCCCCCCCEEEECCEEEECCCCCCCCCCCCCEEEECCCEECCCC
TVERSIIGFGARIGPRALVRDAVIGDGANVGARCELLRGARIWPGVEIPDGGIRFSTDV
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHEECCCCCCCCCCCCCCCEEEECCC
>Mature Secondary Structure 
AGQQGTDAVILVGGQGTRLRPLTLSAPKPMLPTAGLPFLTHLLARIAEAGITHVVLGTA
CCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCH
FKAEVFEEHFGDGSDLGLEIEYVTESEPLGTGGGIRNVLPKLRHDTVMVFNGDVLGGTDL
HHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCEECCCCH
GAVLDTHHSTGADVTLHLVRVSDPRAFGCVPTDEEGRVTAFLEKTQDPPTDQINAGCYVF
HHHHCCCCCCCCCEEEEEEEECCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHH
RREYIEKIPAGRPVSVEREVFPALLAEGARVQGHVDTSYWRDMGTPEDFVRGSADLVRGI
HHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEECCCHHHHHCCCCHHHHHCCCHHHHHCC
APSPALPGQRGESLVHPGAGVAPGALLIGGTVVGRGAEIGAGARLDGAVIFDGACVEAGA
CCCCCCCCCCCCCEECCCCCCCCCEEEECCEEEECCCCCCCCCCCCCEEEECCCEECCCC
TVERSIIGFGARIGPRALVRDAVIGDGANVGARCELLRGARIWPGVEIPDGGIRFSTDV
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHEECCCCCCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]