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The map label for this gene is dctA [H]

Identifier: 54026606

GI number: 54026606

Start: 4821652

End: 4823019

Strand: Reverse

Name: dctA [H]

Synonym: nfa46330

Alternate gene names: 54026606

Gene position: 4823019-4821652 (Counterclockwise)

Preceding gene: 54026609

Following gene: 54026605

Centisome position: 80.1

GC content: 69.96

Gene sequence:

>1368_bases
ATGAGCGACCCCACCCCCACCCGGCGGCGCGACCGCACCCACTGGTTGTATCTGGCCGTGCTCGTGGCCGTCGCCGCGGG
CATCCTGGTCGGCTGGCTGGCGCCCGGGGTCGGCGTCTCGCTGGCGCCGCTGGGCACACTGTTCGTCGACCTGATCAAGA
TGATGATCGCCCCGGTCATCTTCTGCACGATCGTGCTCGGCATCGGCTCGGTGCGCACCGCCGCGACCGTCGGCCGGGTC
GGCGGCTTGGCGCTCGGTTACTTCCTGGCCATGTCGACGGTGGCGCTGGGCATCGGCCTGGTCGTCGGCAACCTGCTCGA
CCCGGGCACCGGCATGAACATCGCCGAGCACGCCGGGGCGGGCGCCTCCTATGCCGACCAGGCGCACGGTGCGGGCGGTA
CCTGGGACTTCATCCACGGCATCGTGCCCACCTCGCTGCTGTCCTCGCTCACCGCGGGCAGCGTGCTGCAGGCACTGTTC
GTCGCGCTGCTGGTCGGTTTCGCGGTGCAGGCGATGGGCAGTGCGGGCGAGCCGGTGCTGCGCGGGGTGAGCGTGTTGCA
GAAGCTGGTCTTCCGCATCCTGTCGATGATCCTGTGGCTGGCGCCGGTAGGCGCGTTCGGCGCGATCGCCAACGTCGTCG
GCAAGACCGGTCTGGACGCGGTGCTGCAACTGGGCACCCTGATGGTCGCCTTCTACCTGACCTGCCTGGTGTTCGTCTTC
GGCGTGCTCGGCGTGCTGGTGCGGGTGGTCTCCGGGGTGTCGATCTTCAAGCTGGCGCGCTACCTGGCCAGGGAATACCT
GCTCATCGTCGGCACCTCGTCGTCGGAGTCGGCGCTGCCGCGGCTGATCGCCAAGATGGAACACCTCGGCGTGCAGCGCA
CCACCGTCGGCGTGGTGGTGCCCACCGGCTACTCGTTCAACCTCGACGGCACCGCGATCTACCTGACCATGGCCTCGATC
TTCATCGCCGACGCGATGGGCAACCCGCTGGGTCTGGGCGAGCAGCTGGGCCTGCTGGTGTTCATGATCGTGGCGTCCAA
GGGCGCGGCGGGCGTCACCGGCGCCGGGCTGGCCACGCTGGCGGGCGGCCTGCAGAGCCACCGTCCCGAACTGCTCGACG
GCGTGGGCCTGATCGTCGGGATCGACCGGTTCATGTCCGAGGCCCGGGCGCTGACCAACTTCTCCGGCAACGCGGTGGCC
ACCCTGCTGATCGGCACCTGGACCAAGACCGTGGACGCCGACCGCGTCGCCGCCGTGCTCGACCGGAAGCTGCCCTTCGA
CGAGAGCGTGATGGTCGACGACCACGCCGGGGACCGTCCGGCCGAGACCACCGCCGAACCCGCTCCCAAGCAGCTGGTCT
CGGCCTGA

Upstream 100 bases:

>100_bases
CGTTATGTACCAAACAGTGACCGGCGTCACGCCTGCGGCAATCATTCTCCACACGAGGCCTCGACGGCAGGCAGTTCGGC
ATCACTGCGAGGAGACGACG

Downstream 100 bases:

>100_bases
CCGAGCCAGACCGAAGGGCCCGTGGACGATCCACGGGCCCTTCGGCTGTTCTCGCGGTACCGGCCGTGGCGGCCTCGGGT
CCACTTCCCCTGTTGCGTAT

Product: putative sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSDPTPTRRRDRTHWLYLAVLVAVAAGILVGWLAPGVGVSLAPLGTLFVDLIKMMIAPVIFCTIVLGIGSVRTAATVGRV
GGLALGYFLAMSTVALGIGLVVGNLLDPGTGMNIAEHAGAGASYADQAHGAGGTWDFIHGIVPTSLLSSLTAGSVLQALF
VALLVGFAVQAMGSAGEPVLRGVSVLQKLVFRILSMILWLAPVGAFGAIANVVGKTGLDAVLQLGTLMVAFYLTCLVFVF
GVLGVLVRVVSGVSIFKLARYLAREYLLIVGTSSSESALPRLIAKMEHLGVQRTTVGVVVPTGYSFNLDGTAIYLTMASI
FIADAMGNPLGLGEQLGLLVFMIVASKGAAGVTGAGLATLAGGLQSHRPELLDGVGLIVGIDRFMSEARALTNFSGNAVA
TLLIGTWTKTVDADRVAAVLDRKLPFDESVMVDDHAGDRPAETTAEPAPKQLVSA

Sequences:

>Translated_455_residues
MSDPTPTRRRDRTHWLYLAVLVAVAAGILVGWLAPGVGVSLAPLGTLFVDLIKMMIAPVIFCTIVLGIGSVRTAATVGRV
GGLALGYFLAMSTVALGIGLVVGNLLDPGTGMNIAEHAGAGASYADQAHGAGGTWDFIHGIVPTSLLSSLTAGSVLQALF
VALLVGFAVQAMGSAGEPVLRGVSVLQKLVFRILSMILWLAPVGAFGAIANVVGKTGLDAVLQLGTLMVAFYLTCLVFVF
GVLGVLVRVVSGVSIFKLARYLAREYLLIVGTSSSESALPRLIAKMEHLGVQRTTVGVVVPTGYSFNLDGTAIYLTMASI
FIADAMGNPLGLGEQLGLLVFMIVASKGAAGVTGAGLATLAGGLQSHRPELLDGVGLIVGIDRFMSEARALTNFSGNAVA
TLLIGTWTKTVDADRVAAVLDRKLPFDESVMVDDHAGDRPAETTAEPAPKQLVSA
>Mature_454_residues
SDPTPTRRRDRTHWLYLAVLVAVAAGILVGWLAPGVGVSLAPLGTLFVDLIKMMIAPVIFCTIVLGIGSVRTAATVGRVG
GLALGYFLAMSTVALGIGLVVGNLLDPGTGMNIAEHAGAGASYADQAHGAGGTWDFIHGIVPTSLLSSLTAGSVLQALFV
ALLVGFAVQAMGSAGEPVLRGVSVLQKLVFRILSMILWLAPVGAFGAIANVVGKTGLDAVLQLGTLMVAFYLTCLVFVFG
VLGVLVRVVSGVSIFKLARYLAREYLLIVGTSSSESALPRLIAKMEHLGVQRTTVGVVVPTGYSFNLDGTAIYLTMASIF
IADAMGNPLGLGEQLGLLVFMIVASKGAAGVTGAGLATLAGGLQSHRPELLDGVGLIVGIDRFMSEARALTNFSGNAVAT
LLIGTWTKTVDADRVAAVLDRKLPFDESVMVDDHAGDRPAETTAEPAPKQLVSA

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=400, Percent_Identity=24, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI40254478, Length=495, Percent_Identity=23.2323232323232, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI169790839, Length=465, Percent_Identity=23.4408602150538, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI4827012, Length=409, Percent_Identity=26.4058679706601, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI66773030, Length=497, Percent_Identity=22.7364185110664, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI194239697, Length=255, Percent_Identity=28.6274509803922, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI5032093, Length=410, Percent_Identity=24.1463414634146, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI223468564, Length=289, Percent_Identity=25.2595155709343, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI223468566, Length=287, Percent_Identity=25.4355400696864, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789947, Length=415, Percent_Identity=48.6746987951807, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1790514, Length=432, Percent_Identity=33.5648148148148, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1788024, Length=404, Percent_Identity=24.5049504950495, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17537407, Length=494, Percent_Identity=24.0890688259109, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71983099, Length=468, Percent_Identity=24.5726495726496, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71983106, Length=468, Percent_Identity=24.5726495726496, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71996953, Length=414, Percent_Identity=25.3623188405797, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI193206654, Length=438, Percent_Identity=22.8310502283105, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI193206505, Length=509, Percent_Identity=22.7897838899804, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17541374, Length=437, Percent_Identity=22.1967963386728, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24583025, Length=412, Percent_Identity=23.5436893203883, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137668, Length=412, Percent_Identity=23.5436893203883, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583023, Length=412, Percent_Identity=23.5436893203883, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281360481, Length=396, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281360483, Length=396, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137666, Length=396, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46964; Mature: 46833

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
SDPTPTRRRDRTHWLYLAVLVAVAAGILVGWLAPGVGVSLAPLGTLFVDLIKMMIAPVI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH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HCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA