Click here to switch to the map view.

The map label for this gene is mcrA [H]

Identifier: 54026569

GI number: 54026569

Start: 4779136

End: 4780491

Strand: Reverse

Name: mcrA [H]

Synonym: nfa45960

Alternate gene names: 54026569

Gene position: 4780491-4779136 (Counterclockwise)

Preceding gene: 54026570

Following gene: 54026568

Centisome position: 79.39

GC content: 74.85

Gene sequence:

>1356_bases
ATGACCGTCACCCTCGAACCCTTGCGCGCACAGTGCACCCTGCACCTGCCCGGCGACCCCGGTTACGACGCCGCCCGCAT
ACCCTGGAACGCCGCCGTCGACCAGCGCCCCGCCGCCGTCGCCGTCCCCCGCACGGCCGAGGAGGTGGCGGCCGTGGTAC
GCGCCGCCGTCGCCGCGGGCCTGCGGGTGGCGCCGCAGAGCACCGGGCACGGCGCGGGCGCGCTGAGCGAGCGCTCGATG
GACGACGTCGTGCTGCTGCGGCTTTCCGAACTCACCGGGGTGACCGTGGACCCGACCGGGCGCACCGCCCGCGTCCTCGG
CGGCACCCTGTGGCAGGACGTCCTGGCCGCCACCGCACCGCACGGTCTCACCGCCCTGCACGGCAGCGCCCCCGACGTCG
CGGTCGCGGGTTACGTCCTCGGCGGCGGCCTGTCCTTCTACGGCCGCGCCCACGGCCTGGCCGTGAACTCCGTCCGCTCG
CTCGACATCGTCGGCCCCGACGGCACCCTCGTCCACGCCTCCGCGCGACAGAACCCGGATCTGTTCTGGGCCGTGCGCGG
TGGCGGCGGCAACTTCGGCGTCGTCGTCGCCCTCGAACTCGAGCTGCTGCCCTACCCCGACGTGTTCGCGGGCATGCTGC
TGTGGGACCGCGCCCGCGCCGCCGACGTCGTGCCCGCCTGGGTGGCGTGGACCCAGACCGCGCCCGAATCGGTGACCACC
GCGTTGCGGGTGATGAGTTTCCCGCCGTTGCCCGAACTCCCGCCGTTCCTGTCCGGCCGCGACGTCGTCATCGTCGACGG
CGCGATCCTGGCCACCGACGAGCACGCCGCCGAACTGCTCGCGCCGCTGCGCGCCCTCGCCCCCGAACTCGACACCTTCG
GCCGCATTCCCGCCGACGCGCTCCTACAGGTCCACATGGACCCGCCCGCCCCCACGCCCACCGTCGGCGACCACAGCGTC
CTCGGCGACCTCGACACCGCCGCCGTCACCGCCCTGCTCGACCACGTCGGCGACGGCACCACCCACGGACTGATGTTCGC
CGAACTCCGCCACATCGGCGGCGCTCTCGCCCGCCCCGCCGTCGACGGCGGGGCCCTCTCCCACATCCCCGGCACCTACG
GCCTGCTCTGCGTGGCCGTGGCCCCCACCCCGCAGGCCGCGGTCGCGGGCCGCGCCGCCGCCTTCGCGGTCGTCCGGGCG
ATGGCCCCCTGGTCCCGGCACAACCTCATCCCCACCTTCACCGAGAACCGCGTCGACAGCGGTCGCATGTTCGACGGCGA
GGACTGGGCGAAGCTGTGCCACCTGCGCGACCGGCTCGCGCCCGGCGCGGTCTTCGTCGCCAATCACGCGCTCTAG

Upstream 100 bases:

>100_bases
GCCACGCCTTCCTCGCCGTCGACCGGCTCCGCCGCATCGACCCGCCGCCCACCGGCCCCGTCCGAACCTGCTGGATCCCC
ACCCTCCGAAAGGCCCTCCG

Downstream 100 bases:

>100_bases
GAACGACTTCGAGGGGTCGGGAGGCACCGGTGTCACCGGTGCCTCCCGCAAGAGTCTTCCGGCCACCGGCGCGCCACCGG
CAGGTCCCCGTGACGGGGCC

Product: putative oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTVTLEPLRAQCTLHLPGDPGYDAARIPWNAAVDQRPAAVAVPRTAEEVAAVVRAAVAAGLRVAPQSTGHGAGALSERSM
DDVVLLRLSELTGVTVDPTGRTARVLGGTLWQDVLAATAPHGLTALHGSAPDVAVAGYVLGGGLSFYGRAHGLAVNSVRS
LDIVGPDGTLVHASARQNPDLFWAVRGGGGNFGVVVALELELLPYPDVFAGMLLWDRARAADVVPAWVAWTQTAPESVTT
ALRVMSFPPLPELPPFLSGRDVVIVDGAILATDEHAAELLAPLRALAPELDTFGRIPADALLQVHMDPPAPTPTVGDHSV
LGDLDTAAVTALLDHVGDGTTHGLMFAELRHIGGALARPAVDGGALSHIPGTYGLLCVAVAPTPQAAVAGRAAAFAVVRA
MAPWSRHNLIPTFTENRVDSGRMFDGEDWAKLCHLRDRLAPGAVFVANHAL

Sequences:

>Translated_451_residues
MTVTLEPLRAQCTLHLPGDPGYDAARIPWNAAVDQRPAAVAVPRTAEEVAAVVRAAVAAGLRVAPQSTGHGAGALSERSM
DDVVLLRLSELTGVTVDPTGRTARVLGGTLWQDVLAATAPHGLTALHGSAPDVAVAGYVLGGGLSFYGRAHGLAVNSVRS
LDIVGPDGTLVHASARQNPDLFWAVRGGGGNFGVVVALELELLPYPDVFAGMLLWDRARAADVVPAWVAWTQTAPESVTT
ALRVMSFPPLPELPPFLSGRDVVIVDGAILATDEHAAELLAPLRALAPELDTFGRIPADALLQVHMDPPAPTPTVGDHSV
LGDLDTAAVTALLDHVGDGTTHGLMFAELRHIGGALARPAVDGGALSHIPGTYGLLCVAVAPTPQAAVAGRAAAFAVVRA
MAPWSRHNLIPTFTENRVDSGRMFDGEDWAKLCHLRDRLAPGAVFVANHAL
>Mature_450_residues
TVTLEPLRAQCTLHLPGDPGYDAARIPWNAAVDQRPAAVAVPRTAEEVAAVVRAAVAAGLRVAPQSTGHGAGALSERSMD
DVVLLRLSELTGVTVDPTGRTARVLGGTLWQDVLAATAPHGLTALHGSAPDVAVAGYVLGGGLSFYGRAHGLAVNSVRSL
DIVGPDGTLVHASARQNPDLFWAVRGGGGNFGVVVALELELLPYPDVFAGMLLWDRARAADVVPAWVAWTQTAPESVTTA
LRVMSFPPLPELPPFLSGRDVVIVDGAILATDEHAAELLAPLRALAPELDTFGRIPADALLQVHMDPPAPTPTVGDHSVL
GDLDTAAVTALLDHVGDGTTHGLMFAELRHIGGALARPAVDGGALSHIPGTYGLLCVAVAPTPQAAVAGRAAAFAVVRAM
APWSRHNLIPTFTENRVDSGRMFDGEDWAKLCHLRDRLAPGAVFVANHAL

Specific function: Involved in mitomycin resistance; oxidizes reduced form of mitomycins [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012951
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016168
- InterPro:   IPR006094
- InterPro:   IPR006093 [H]

Pfam domain/function: PF08031 BBE; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 46882; Mature: 46751

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00862 OX2_COVAL_FAD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTLEPLRAQCTLHLPGDPGYDAARIPWNAAVDQRPAAVAVPRTAEEVAAVVRAAVAAG
CEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHC
LRVAPQSTGHGAGALSERSMDDVVLLRLSELTGVTVDPTGRTARVLGGTLWQDVLAATAP
CEECCCCCCCCCCCCCCCCCCCEEEEEEHHHCCEEECCCCCCHHHHHHHHHHHHHHHCCC
HGLTALHGSAPDVAVAGYVLGGGLSFYGRAHGLAVNSVRSLDIVGPDGTLVHASARQNPD
CCCEEECCCCCCCEEEEEHHCCCEEECCCCCCEEECCCCEEEEECCCCCEEEECCCCCCC
LFWAVRGGGGNFGVVVALELELLPYPDVFAGMLLWDRARAADVVPAWVAWTQTAPESVTT
EEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHH
ALRVMSFPPLPELPPFLSGRDVVIVDGAILATDEHAAELLAPLRALAPELDTFGRIPADA
HHHHHCCCCCCCCCCCCCCCCEEEECCEEEECCHHHHHHHHHHHHHCCCHHHHCCCCCCC
LLQVHMDPPAPTPTVGDHSVLGDLDTAAVTALLDHVGDGTTHGLMFAELRHIGGALARPA
EEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHCCC
VDGGALSHIPGTYGLLCVAVAPTPQAAVAGRAAAFAVVRAMAPWSRHNLIPTFTENRVDS
CCCCCHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCC
GRMFDGEDWAKLCHLRDRLAPGAVFVANHAL
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
TVTLEPLRAQCTLHLPGDPGYDAARIPWNAAVDQRPAAVAVPRTAEEVAAVVRAAVAAG
EEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHC
LRVAPQSTGHGAGALSERSMDDVVLLRLSELTGVTVDPTGRTARVLGGTLWQDVLAATAP
CEECCCCCCCCCCCCCCCCCCCEEEEEEHHHCCEEECCCCCCHHHHHHHHHHHHHHHCCC
HGLTALHGSAPDVAVAGYVLGGGLSFYGRAHGLAVNSVRSLDIVGPDGTLVHASARQNPD
CCCEEECCCCCCCEEEEEHHCCCEEECCCCCCEEECCCCEEEEECCCCCEEEECCCCCCC
LFWAVRGGGGNFGVVVALELELLPYPDVFAGMLLWDRARAADVVPAWVAWTQTAPESVTT
EEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHH
ALRVMSFPPLPELPPFLSGRDVVIVDGAILATDEHAAELLAPLRALAPELDTFGRIPADA
HHHHHCCCCCCCCCCCCCCCCEEEECCEEEECCHHHHHHHHHHHHHCCCHHHHCCCCCCC
LLQVHMDPPAPTPTVGDHSVLGDLDTAAVTALLDHVGDGTTHGLMFAELRHIGGALARPA
EEEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHCCC
VDGGALSHIPGTYGLLCVAVAPTPQAAVAGRAAAFAVVRAMAPWSRHNLIPTFTENRVDS
CCCCCHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCC
GRMFDGEDWAKLCHLRDRLAPGAVFVANHAL
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7517396 [H]