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The map label for this gene is echA18 [H]

Identifier: 54026260

GI number: 54026260

Start: 4443170

End: 4443937

Strand: Reverse

Name: echA18 [H]

Synonym: nfa42890

Alternate gene names: 54026260

Gene position: 4443937-4443170 (Counterclockwise)

Preceding gene: 54026261

Following gene: 54026259

Centisome position: 73.8

GC content: 74.22

Gene sequence:

>768_bases
ATGGCCGAATTCGTGACCCTGGGACAGCCGGACGAGGACGGGGTCGCCGTCCTGCGCATCGCCCGCCCGCCGATGAATCA
GATCAACACCCAGGTGGCACGCGAGGTGGCCGAGGCCGCGGCGCGGGTGGCCGCCGATCCGGCGGTGGCGGCGCTCATCG
TCTACGGCGACGAGCGGGTGTTCTGCGCGGGGGACGACATGGCCGAACTCGCCGGCCTCGACCGCGACGGCGCCGCGGCC
CGGGCCGCCGATCTGCAGGACGCGCTGGAATGTCTGGCCAGGGTGCCGCAGCCGACGGTCGCCGCGATCTGCGGGTACGC
CCTGGGCGCCGGGTTGGAACTCGCGCTCGGTGCCGACCGCAGGATCATCGGCGACAACGTCAAACTCGGTCTGCCGCAGA
TCCGTGCCGGGTTGATCCCGCTCGCGGGCATCCGGCGGCTGGCGCTGTCGATCGGCCCGTCCGCGGCCAAGGATCTGGTG
TACTCCGGCCGCTTCGTCGCGGCCGACGAGGCGCGGACGCTGGGTCTGGTGGACGAGGTGGTCGCTCCCGACGACGTGTT
CGCGGCGGCGCGGCGCTGGGCCGGGCAGTTCACCGGCGGTCCGGCGCGGGCGCTGGCCGCCGCCAAGGCCGTGTTCGAGG
CCGGGCCGCACGGTCTCGACCGTGCCCGCACCGAATGGGCCGCCCTGTTCGACACCGCGGACCGGCGCATCGGCACGAGC
TCCTACGTCGCCGAAGGGCCGGGCTCGGCGGTGTTCACCGGGCGGTGA

Upstream 100 bases:

>100_bases
TCGCCGACCTGCCGGAGGCGGGCAAGCTGCGCGGTTCGGCGCGCAGCTGAGCGCCGGGCATCGCGCGGGCGCGGCTGCGC
CGGGCGGTAGGTTGCCTGGT

Downstream 100 bases:

>100_bases
CGGACCCCGGAGGCAGCCCGAGCGACCGGCTCGGGCGGGGTGTGCGGCACGATTGCGCTGATAGGAACAGGTTCTAGTTC
CGGCGGCTCTCGGTCACCTG

Product: putative enoyl-CoA hydratase/isomerase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MAEFVTLGQPDEDGVAVLRIARPPMNQINTQVAREVAEAAARVAADPAVAALIVYGDERVFCAGDDMAELAGLDRDGAAA
RAADLQDALECLARVPQPTVAAICGYALGAGLELALGADRRIIGDNVKLGLPQIRAGLIPLAGIRRLALSIGPSAAKDLV
YSGRFVAADEARTLGLVDEVVAPDDVFAAARRWAGQFTGGPARALAAAKAVFEAGPHGLDRARTEWAALFDTADRRIGTS
SYVAEGPGSAVFTGR

Sequences:

>Translated_255_residues
MAEFVTLGQPDEDGVAVLRIARPPMNQINTQVAREVAEAAARVAADPAVAALIVYGDERVFCAGDDMAELAGLDRDGAAA
RAADLQDALECLARVPQPTVAAICGYALGAGLELALGADRRIIGDNVKLGLPQIRAGLIPLAGIRRLALSIGPSAAKDLV
YSGRFVAADEARTLGLVDEVVAPDDVFAAARRWAGQFTGGPARALAAAKAVFEAGPHGLDRARTEWAALFDTADRRIGTS
SYVAEGPGSAVFTGR
>Mature_254_residues
AEFVTLGQPDEDGVAVLRIARPPMNQINTQVAREVAEAAARVAADPAVAALIVYGDERVFCAGDDMAELAGLDRDGAAAR
AADLQDALECLARVPQPTVAAICGYALGAGLELALGADRRIIGDNVKLGLPQIRAGLIPLAGIRRLALSIGPSAAKDLVY
SGRFVAADEARTLGLVDEVVAPDDVFAAARRWAGQFTGGPARALAAAKAVFEAGPHGLDRARTEWAALFDTADRRIGTSS
YVAEGPGSAVFTGR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI68989263, Length=194, Percent_Identity=37.6288659793814, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI194097323, Length=240, Percent_Identity=28.75, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI20127408, Length=176, Percent_Identity=34.0909090909091, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI157694516, Length=208, Percent_Identity=26.9230769230769, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI213417737, Length=208, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4502327, Length=189, Percent_Identity=32.2751322751323, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI62530384, Length=212, Percent_Identity=28.7735849056604, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI261878539, Length=86, Percent_Identity=47.6744186046512, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787659, Length=256, Percent_Identity=32.421875, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI221142681, Length=200, Percent_Identity=31.5, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790281, Length=185, Percent_Identity=29.7297297297297, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788682, Length=191, Percent_Identity=31.9371727748691, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788597, Length=212, Percent_Identity=26.4150943396226, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=239, Percent_Identity=30.1255230125523, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25145438, Length=237, Percent_Identity=28.6919831223629, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=178, Percent_Identity=32.5842696629214, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17558304, Length=179, Percent_Identity=32.4022346368715, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=158, Percent_Identity=31.0126582278481, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=185, Percent_Identity=27.5675675675676, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=181, Percent_Identity=27.6243093922652, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI20129971, Length=250, Percent_Identity=32, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653477, Length=250, Percent_Identity=32, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24653139, Length=165, Percent_Identity=34.5454545454545, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24583165, Length=180, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24650670, Length=160, Percent_Identity=34.375, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357171, Length=208, Percent_Identity=29.8076923076923, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19921018, Length=185, Percent_Identity=26.4864864864865, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583077, Length=179, Percent_Identity=34.6368715083799, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583079, Length=179, Percent_Identity=34.6368715083799, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921000, Length=179, Percent_Identity=32.4022346368715, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550169, Length=180, Percent_Identity=23.8888888888889, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 26387; Mature: 26256

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFVTLGQPDEDGVAVLRIARPPMNQINTQVAREVAEAAARVAADPAVAALIVYGDERV
CCCEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEE
FCAGDDMAELAGLDRDGAAARAADLQDALECLARVPQPTVAAICGYALGAGLELALGADR
EECCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCC
RIIGDNVKLGLPQIRAGLIPLAGIRRLALSIGPSAAKDLVYSGRFVAADEARTLGLVDEV
EEECCCCEECCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCHHHHHHHHH
VAPDDVFAAARRWAGQFTGGPARALAAAKAVFEAGPHGLDRARTEWAALFDTADRRIGTS
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
SYVAEGPGSAVFTGR
CCCCCCCCCEEECCC
>Mature Secondary Structure 
AEFVTLGQPDEDGVAVLRIARPPMNQINTQVAREVAEAAARVAADPAVAALIVYGDERV
CCEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEE
FCAGDDMAELAGLDRDGAAARAADLQDALECLARVPQPTVAAICGYALGAGLELALGADR
EECCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCC
RIIGDNVKLGLPQIRAGLIPLAGIRRLALSIGPSAAKDLVYSGRFVAADEARTLGLVDEV
EEECCCCEECCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCHHHHHHHHH
VAPDDVFAAARRWAGQFTGGPARALAAAKAVFEAGPHGLDRARTEWAALFDTADRRIGTS
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
SYVAEGPGSAVFTGR
CCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]