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The map label for this gene is ilvC [H]

Identifier: 54026201

GI number: 54026201

Start: 4377375

End: 4378388

Strand: Reverse

Name: ilvC [H]

Synonym: nfa42300

Alternate gene names: 54026201

Gene position: 4378388-4377375 (Counterclockwise)

Preceding gene: 54026202

Following gene: 54026200

Centisome position: 72.72

GC content: 66.37

Gene sequence:

>1014_bases
GTGGCAGTCGAGATGTTCTATGACGACGACGCCGATCTGTCGATCATCCAGGGCCGTAAGGTCGCGGTGATCGGCTACGG
CAGCCAGGGGCACGCGCACTCGCTGAGCCTGCGCGACTCCGGTGTCGAGGTCCGGGTCGGTCTGGCCGAGGGCTCGAAGT
CGCGTCCGAAGGCCGAGGAGGCCGGGCTGACCGTCGGCACTCCGGCCGAGGTCTCGGCGTGGGCCGATGTGATCATGCTG
CTGGCGCCCGACACCGCGCAGGCGTCGATCTTCACCAACGACATCGAGCCGAACCTGAAGGACGGCGACGCGCTGTTCTT
CGGCCACGGCCTCAACATCCACTTCGGCCTGATCAAGCCTCCGGCGAATGTCACCATCGGCATGGTCGCCCCGAAGGGCC
CTGGCCACCTGGTGCGTCGTCAGTTCGTCGACGGCAAGGGCGTGCCCGCCCTGATCGCGATCGACCAGGACCCCAAGGGT
GAGGGCCAGGCGCTGGCGCTGTCCTACGCCAAGGGCATCGGCGGCACCCGCGCGGGTGTCATCAAGACCACCTTCAAGGA
AGAGACCGAGACCGACCTGTTCGGTGAGCAGGCCGTGCTGTGCGGTGGCACCGAGGAACTGGTCAAGACCGGTTTCGAGG
TCATGGTCGAGGCCGGCTACGCCCCGGAGATGGCCTACTTCGAGGTGCTGCACGAGCTCAAGCTGATCGTGGACCTGATG
TACGAGGGCGGCATCGCCCGGATGAACTACTCGGTCTCCGACACCGCCGAATTCGGTGGCTACCTGTCGGGCCCGCGCGT
CATCGACGCCGGCACCAAGGAGCGGATGAAGGAGATCCTGAAGGACATCCAGGACGGCACCTTCGTCAAGCGTCTGGTCG
CCAACGTCGAGGGCGGCAACAAGGAGCTCGAGGGTCTGCGCAAGCAGAACGCCGAGCACCCGATCGAGGTCACCGGCGCC
AAGCTGCGCGGTCTGATGAGCTGGGTCGACCGGCCCATCACCGAAACCGCCTGA

Upstream 100 bases:

>100_bases
CTGAGTACCGAATATCCACCCGTCACCGGCGTCAGCACGGTGCTCCCCGTTCCGGCGGGGCCAGATTTCACAAGCTGTTT
CTTCAGAAAGGAAACCACTA

Downstream 100 bases:

>100_bases
TCCGTATCGCGCAGAAGGGCCGTCCGCACCCCGCGGGCGGCCCTTCGCGCGTCGTGGGACCGGCGGTCGAATGCGGCGTA
CCGCCCCGATCCGACTGCCT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAVEMFYDDDADLSIIQGRKVAVIGYGSQGHAHSLSLRDSGVEVRVGLAEGSKSRPKAEEAGLTVGTPAEVSAWADVIML
LAPDTAQASIFTNDIEPNLKDGDALFFGHGLNIHFGLIKPPANVTIGMVAPKGPGHLVRRQFVDGKGVPALIAIDQDPKG
EGQALALSYAKGIGGTRAGVIKTTFKEETETDLFGEQAVLCGGTEELVKTGFEVMVEAGYAPEMAYFEVLHELKLIVDLM
YEGGIARMNYSVSDTAEFGGYLSGPRVIDAGTKERMKEILKDIQDGTFVKRLVANVEGGNKELEGLRKQNAEHPIEVTGA
KLRGLMSWVDRPITETA

Sequences:

>Translated_337_residues
MAVEMFYDDDADLSIIQGRKVAVIGYGSQGHAHSLSLRDSGVEVRVGLAEGSKSRPKAEEAGLTVGTPAEVSAWADVIML
LAPDTAQASIFTNDIEPNLKDGDALFFGHGLNIHFGLIKPPANVTIGMVAPKGPGHLVRRQFVDGKGVPALIAIDQDPKG
EGQALALSYAKGIGGTRAGVIKTTFKEETETDLFGEQAVLCGGTEELVKTGFEVMVEAGYAPEMAYFEVLHELKLIVDLM
YEGGIARMNYSVSDTAEFGGYLSGPRVIDAGTKERMKEILKDIQDGTFVKRLVANVEGGNKELEGLRKQNAEHPIEVTGA
KLRGLMSWVDRPITETA
>Mature_336_residues
AVEMFYDDDADLSIIQGRKVAVIGYGSQGHAHSLSLRDSGVEVRVGLAEGSKSRPKAEEAGLTVGTPAEVSAWADVIMLL
APDTAQASIFTNDIEPNLKDGDALFFGHGLNIHFGLIKPPANVTIGMVAPKGPGHLVRRQFVDGKGVPALIAIDQDPKGE
GQALALSYAKGIGGTRAGVIKTTFKEETETDLFGEQAVLCGGTEELVKTGFEVMVEAGYAPEMAYFEVLHELKLIVDLMY
EGGIARMNYSVSDTAEFGGYLSGPRVIDAGTKERMKEILKDIQDGTFVKRLVANVEGGNKELEGLRKQNAEHPIEVTGAK
LRGLMSWVDRPITETA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=328, Percent_Identity=35.9756097560976, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323387, Length=287, Percent_Identity=30.6620209059233, Blast_Score=106, Evalue=5e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36104; Mature: 35972

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVEMFYDDDADLSIIQGRKVAVIGYGSQGHAHSLSLRDSGVEVRVGLAEGSKSRPKAEE
CEEEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHH
AGLTVGTPAEVSAWADVIMLLAPDTAQASIFTNDIEPNLKDGDALFFGHGLNIHFGLIKP
CCEECCCCCHHHHHHEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEEECC
PANVTIGMVAPKGPGHLVRRQFVDGKGVPALIAIDQDPKGEGQALALSYAKGIGGTRAGV
CCCEEEEEECCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEEEHHCCCCCCCCE
IKTTFKEETETDLFGEQAVLCGGTEELVKTGFEVMVEAGYAPEMAYFEVLHELKLIVDLM
EEEHHCCCCHHHHCCCCEEEECCHHHHHHCCHHEEEECCCCCHHHHHHHHHHHHHHHHHH
YEGGIARMNYSVSDTAEFGGYLSGPRVIDAGTKERMKEILKDIQDGTFVKRLVANVEGGN
HCCCEEEEECCCCCHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCCCC
KELEGLRKQNAEHPIEVTGAKLRGLMSWVDRPITETA
HHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AVEMFYDDDADLSIIQGRKVAVIGYGSQGHAHSLSLRDSGVEVRVGLAEGSKSRPKAEE
EEEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHH
AGLTVGTPAEVSAWADVIMLLAPDTAQASIFTNDIEPNLKDGDALFFGHGLNIHFGLIKP
CCEECCCCCHHHHHHEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEEECC
PANVTIGMVAPKGPGHLVRRQFVDGKGVPALIAIDQDPKGEGQALALSYAKGIGGTRAGV
CCCEEEEEECCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEEEHHCCCCCCCCE
IKTTFKEETETDLFGEQAVLCGGTEELVKTGFEVMVEAGYAPEMAYFEVLHELKLIVDLM
EEEHHCCCCHHHHCCCCEEEECCHHHHHHCCHHEEEECCCCCHHHHHHHHHHHHHHHHHH
YEGGIARMNYSVSDTAEFGGYLSGPRVIDAGTKERMKEILKDIQDGTFVKRLVANVEGGN
HCCCEEEEECCCCCHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCCCC
KELEGLRKQNAEHPIEVTGAKLRGLMSWVDRPITETA
HHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA