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The map label for this gene is ung

Identifier: 54026171

GI number: 54026171

Start: 4349958

End: 4350641

Strand: Reverse

Name: ung

Synonym: nfa42000

Alternate gene names: 54026171

Gene position: 4350641-4349958 (Counterclockwise)

Preceding gene: 54026172

Following gene: 54026170

Centisome position: 72.26

GC content: 70.91

Gene sequence:

>684_bases
ATGGGCGCGAAACCACTGTCGGAAATCATGGATCCGGGCTGGGCGCAGGCGCTGGAGCCGGTGGCCGACCGCATCAGGGC
GATGGGTGATTTCCTGCGGGCCGAGAACGCGGCCGGACGCGGCTACCTGCCCGCGGGTGAGAATGTGCTGCGCGCGTTCC
AGCGGCCGTTCCGCGACGTGCGGGTGCTGATCGTCGGCCAGGACCCCTACCCGACGCCGGGGCACCCGATGGGCCTGAGT
TTCTCGGTGGCGCCGGATGTTTCGCCGATTCCACGCAGCCTGGCCAACATCTTCGCCGAACTGCACAAGGACCTCGGCCA
CCCGACACCCTCCTGCGGCGACCTCACCCCGTGGTCGGATCAGGGTGTGCTGCTGCTGAACCGGGTGCTCACGGTCTCGC
CCGGCCAGCCGGCCTCCCATCGCGGCAAGGGGTGGGAGGCGGTGACCGAGCAGGCCATCCGCGCGCTCGTCGCCCGGGAC
GAACCCCTGGTCGCGATCCTCTGGGGCCGCGACGCCGCCACCCTGAAGCCGCTGCTCACCGAGGCCGAGGTGCCCTACAT
CGAATCGGCCCATCCCTCCCCGCTGTCGGCGTCGCGGGGATTCTTCGGCTCCCGGCCGTTCTCGCGGGCCAACGAACTGC
TCGACGAACTCGGCGCCGAGCCGGTCGACTGGCGCCTGCCCTGA

Upstream 100 bases:

>100_bases
TCACCGTGGACGGGATGAGCTGGGACGGCGCCGTGGGCTGGGAATCGTTCCGTGGGGCGGAGGCTGCGCCGGGAAACGAA
CCGCGATAGGTTGTGCGGTC

Downstream 100 bases:

>100_bases
CCATCCCACCGTGTCCCGGGCGCTCCGGGGCCTGTTCCATCGCACGACACATCGATTGAGGAGCACCACCATGCAGCACA
CCACCGTTCGCGCCGGTCTG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MGAKPLSEIMDPGWAQALEPVADRIRAMGDFLRAENAAGRGYLPAGENVLRAFQRPFRDVRVLIVGQDPYPTPGHPMGLS
FSVAPDVSPIPRSLANIFAELHKDLGHPTPSCGDLTPWSDQGVLLLNRVLTVSPGQPASHRGKGWEAVTEQAIRALVARD
EPLVAILWGRDAATLKPLLTEAEVPYIESAHPSPLSASRGFFGSRPFSRANELLDELGAEPVDWRLP

Sequences:

>Translated_227_residues
MGAKPLSEIMDPGWAQALEPVADRIRAMGDFLRAENAAGRGYLPAGENVLRAFQRPFRDVRVLIVGQDPYPTPGHPMGLS
FSVAPDVSPIPRSLANIFAELHKDLGHPTPSCGDLTPWSDQGVLLLNRVLTVSPGQPASHRGKGWEAVTEQAIRALVARD
EPLVAILWGRDAATLKPLLTEAEVPYIESAHPSPLSASRGFFGSRPFSRANELLDELGAEPVDWRLP
>Mature_226_residues
GAKPLSEIMDPGWAQALEPVADRIRAMGDFLRAENAAGRGYLPAGENVLRAFQRPFRDVRVLIVGQDPYPTPGHPMGLSF
SVAPDVSPIPRSLANIFAELHKDLGHPTPSCGDLTPWSDQGVLLLNRVLTVSPGQPASHRGKGWEAVTEQAIRALVARDE
PLVAILWGRDAATLKPLLTEAEVPYIESAHPSPLSASRGFFGSRPFSRANELLDELGAEPVDWRLP

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI6224979, Length=202, Percent_Identity=42.0792079207921, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI19718751, Length=202, Percent_Identity=42.0792079207921, Blast_Score=145, Evalue=3e-35,
Organism=Escherichia coli, GI1788934, Length=193, Percent_Identity=41.9689119170984, Blast_Score=146, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=37.3271889400922, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323620, Length=216, Percent_Identity=38.8888888888889, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_NOCFA (Q5YRZ2)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_120413.1
- HSSP:   Q9RWH9
- ProteinModelPortal:   Q5YRZ2
- SMR:   Q5YRZ2
- GeneID:   3111622
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa42000
- NMPDR:   fig|247156.1.peg.4050
- HOGENOM:   HBG605450
- OMA:   VMLLNRV
- ProtClustDB:   PRK05254
- BioCyc:   NFAR247156:NFA42000-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24605; Mature: 24474

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 68-68

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAKPLSEIMDPGWAQALEPVADRIRAMGDFLRAENAAGRGYLPAGENVLRAFQRPFRDV
CCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHE
RVLIVGQDPYPTPGHPMGLSFSVAPDVSPIPRSLANIFAELHKDLGHPTPSCGDLTPWSD
EEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
QGVLLLNRVLTVSPGQPASHRGKGWEAVTEQAIRALVARDEPLVAILWGRDAATLKPLLT
CCCEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
EAEVPYIESAHPSPLSASRGFFGSRPFSRANELLDELGAEPVDWRLP
HCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GAKPLSEIMDPGWAQALEPVADRIRAMGDFLRAENAAGRGYLPAGENVLRAFQRPFRDV
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHE
RVLIVGQDPYPTPGHPMGLSFSVAPDVSPIPRSLANIFAELHKDLGHPTPSCGDLTPWSD
EEEEECCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
QGVLLLNRVLTVSPGQPASHRGKGWEAVTEQAIRALVARDEPLVAILWGRDAATLKPLLT
CCCEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
EAEVPYIESAHPSPLSASRGFFGSRPFSRANELLDELGAEPVDWRLP
HCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA