Click here to switch to the map view.

The map label for this gene is fadB4 [H]

Identifier: 54025810

GI number: 54025810

Start: 4060126

End: 4061031

Strand: Reverse

Name: fadB4 [H]

Synonym: nfa38400

Alternate gene names: 54025810

Gene position: 4061031-4060126 (Counterclockwise)

Preceding gene: 54025811

Following gene: 54025805

Centisome position: 67.45

GC content: 67.55

Gene sequence:

>906_bases
ATGATGGGTGGCGTGCCGAGGCGACCGCCGTCTCGCGGAGAGGAGAACAGCATGGCCGTCGACATCAAGAAGGTGACCGT
TCTCGGGACCGGGGTGCTCGGCTCGCAGATCGCGTTCCAGACCGCCTTCCACGGGTTCGACGTCACCGCCTACGACATCA
GCGAGCAGGCGCTCGACGCGGCGCGGGAGCGTTTCGCCAAGCTCGCCGCCGCCTACCGGCAGGACGTGCCGGGGGCCACC
GAGGACAAGACCGAGGCCACCCGCTCGGGCATCACCGTCACCGCCGATCTCGCCGCCGCCGCGGCCGAGGCCGACCTGGT
GATCGAGGCAGTCCCCGAGGTGCTCGACATCAAGCGCGACACCTACCGACGCCTGGGCGAACTCGCCCCCGCCCGAACGA
TTTTCGCGACCAACTCCTCCACGCTGCTGCCCAGCGACATCAAGGACTTCACCGGCCGTCCGGACCGGTTCCTGGCCCTG
CACTTCGCCAACCAGGTGTGGAAGTTCAACACCGCCGAGGTGATGGGCACCCCCGACACCGACCCCGCGGTCTACCGAAC
GGTGGTCGAGTTCGCCGAGGCCATCGGCATGGTGCCGATCGAACTGCACAAGGAGAAGTCGGGGTACGTGCTGAACTCGC
TGCTCGTGCCGTTCCTCAACGCGGGGATGGCACTGGCCGCGGGCGGGTACGCCGAGCCCGAGGCCGTCGACAAGACCTGG
CGCATCGCCACCGGCGCCCCGATGGGCCCGTTCCAGATCCTCGACGTCATCGGTCTCACCACTCCCTACAACATCCTCGC
CCACGGCGACGCCGACACCCAGAAGCTGGCGACCTGGTTGAAGGAGAACTACATCGACAAGGGCAAGCTCGGCATCGCCA
CCGGCGAGGGCTTCTACAAGTACTAG

Upstream 100 bases:

>100_bases
CGGTCTGGATTGCCCGTATTTTGCGGAATCGTTATCGCCGTTGCCCGGTTTGCCCGTTCTCGCGCTGCCTGTCGGCGGCG
GCGCCCCCCGCGGCCGGGCC

Downstream 100 bases:

>100_bases
CTCACGGACAGATACCGGCTCACTTCTTCTCCAGGTCCATGCCCGGTGCGGCGTCGGTGATGATCGAGTCCGCGGCCAGC
ACGGCGCCACCGCCCTTGGC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MMGGVPRRPPSRGEENSMAVDIKKVTVLGTGVLGSQIAFQTAFHGFDVTAYDISEQALDAARERFAKLAAAYRQDVPGAT
EDKTEATRSGITVTADLAAAAAEADLVIEAVPEVLDIKRDTYRRLGELAPARTIFATNSSTLLPSDIKDFTGRPDRFLAL
HFANQVWKFNTAEVMGTPDTDPAVYRTVVEFAEAIGMVPIELHKEKSGYVLNSLLVPFLNAGMALAAGGYAEPEAVDKTW
RIATGAPMGPFQILDVIGLTTPYNILAHGDADTQKLATWLKENYIDKGKLGIATGEGFYKY

Sequences:

>Translated_301_residues
MMGGVPRRPPSRGEENSMAVDIKKVTVLGTGVLGSQIAFQTAFHGFDVTAYDISEQALDAARERFAKLAAAYRQDVPGAT
EDKTEATRSGITVTADLAAAAAEADLVIEAVPEVLDIKRDTYRRLGELAPARTIFATNSSTLLPSDIKDFTGRPDRFLAL
HFANQVWKFNTAEVMGTPDTDPAVYRTVVEFAEAIGMVPIELHKEKSGYVLNSLLVPFLNAGMALAAGGYAEPEAVDKTW
RIATGAPMGPFQILDVIGLTTPYNILAHGDADTQKLATWLKENYIDKGKLGIATGEGFYKY
>Mature_301_residues
MMGGVPRRPPSRGEENSMAVDIKKVTVLGTGVLGSQIAFQTAFHGFDVTAYDISEQALDAARERFAKLAAAYRQDVPGAT
EDKTEATRSGITVTADLAAAAAEADLVIEAVPEVLDIKRDTYRRLGELAPARTIFATNSSTLLPSDIKDFTGRPDRFLAL
HFANQVWKFNTAEVMGTPDTDPAVYRTVVEFAEAIGMVPIELHKEKSGYVLNSLLVPFLNAGMALAAGGYAEPEAVDKTW
RIATGAPMGPFQILDVIGLTTPYNILAHGDADTQKLATWLKENYIDKGKLGIATGEGFYKY

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=293, Percent_Identity=35.4948805460751, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI296179427, Length=310, Percent_Identity=33.8709677419355, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=25.531914893617, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI20127408, Length=290, Percent_Identity=25.8620689655172, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI261878539, Length=300, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI68989263, Length=297, Percent_Identity=24.9158249158249, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787661, Length=289, Percent_Identity=29.757785467128, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788682, Length=267, Percent_Identity=29.9625468164794, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790281, Length=300, Percent_Identity=28.6666666666667, Blast_Score=88, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=31.25, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=31.25, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=31.3793103448276, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71985923, Length=302, Percent_Identity=26.4900662251656, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71985930, Length=301, Percent_Identity=24.2524916943522, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508953, Length=293, Percent_Identity=24.5733788395904, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=293, Percent_Identity=24.5733788395904, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25144276, Length=293, Percent_Identity=24.5733788395904, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20129993, Length=242, Percent_Identity=26.4462809917355, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45549573, Length=244, Percent_Identity=27.8688524590164, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583077, Length=264, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24583079, Length=264, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921000, Length=264, Percent_Identity=24.2424242424242, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32504; Mature: 32504

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGGVPRRPPSRGEENSMAVDIKKVTVLGTGVLGSQIAFQTAFHGFDVTAYDISEQALDA
CCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCEEEECHHHHHHHH
ARERFAKLAAAYRQDVPGATEDKTEATRSGITVTADLAAAAAEADLVIEAVPEVLDIKRD
HHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHH
TYRRLGELAPARTIFATNSSTLLPSDIKDFTGRPDRFLALHFANQVWKFNTAEVMGTPDT
HHHHHHHCCCCCEEEECCCCCCCCCHHHHHCCCCCCEEEEEEHHHHHCCCCCEEECCCCC
DPAVYRTVVEFAEAIGMVPIELHKEKSGYVLNSLLVPFLNAGMALAAGGYAEPEAVDKTW
CHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHEECCCCCCCHHHCCEE
RIATGAPMGPFQILDVIGLTTPYNILAHGDADTQKLATWLKENYIDKGKLGIATGEGFYK
EEECCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCC
Y
C
>Mature Secondary Structure
MMGGVPRRPPSRGEENSMAVDIKKVTVLGTGVLGSQIAFQTAFHGFDVTAYDISEQALDA
CCCCCCCCCCCCCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCEEEECHHHHHHHH
ARERFAKLAAAYRQDVPGATEDKTEATRSGITVTADLAAAAAEADLVIEAVPEVLDIKRD
HHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCHH
TYRRLGELAPARTIFATNSSTLLPSDIKDFTGRPDRFLALHFANQVWKFNTAEVMGTPDT
HHHHHHHCCCCCEEEECCCCCCCCCHHHHHCCCCCCEEEEEEHHHHHCCCCCEEECCCCC
DPAVYRTVVEFAEAIGMVPIELHKEKSGYVLNSLLVPFLNAGMALAAGGYAEPEAVDKTW
CHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCHHEECCCCCCCHHHCCEE
RIATGAPMGPFQILDVIGLTTPYNILAHGDADTQKLATWLKENYIDKGKLGIATGEGFYK
EEECCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]