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The map label for this gene is acuC [H]

Identifier: 54025748

GI number: 54025748

Start: 3996889

End: 3998154

Strand: Reverse

Name: acuC [H]

Synonym: nfa37780

Alternate gene names: 54025748

Gene position: 3998154-3996889 (Counterclockwise)

Preceding gene: 54025751

Following gene: 54025747

Centisome position: 66.4

GC content: 73.3

Gene sequence:

>1266_bases
ATGGCCACTGCACCCTCGGCGACGCCGCGCGACCCGGCACCGCCCGGACGCCCGGGCACCGTCGTCTGGTCCGAGCGGTT
CCTGGACTACACCTGGACGCCCGAGCATCCGATGAAACCGGCCCGGCTGAAGTTCACGATGGCGCTGGCCGAGAGCCTCG
GAGTGCTCGACGGCGTGGAGACACTCGAGCCCGCCGCCTGCGATCGCGCCGAACTGCTGCGGATCCACACCGCCGACTAC
ATCGAGGCGGTCGAACACGCGGTGCAGCCGCCCGGGCAACCCGCCGCACCGCCCTATGGGCTCGGCTCGGCCGACAACCC
GGTGTTCCCCCGCATGCACCAGGCCGCGTCGGTGATCGTCGGCGGCACACTGGCCGCCGCCCGCGAGATCGCCGAGGGCC
GCACCCGCCGGGCGGTGAGCATCGGCGGCGGCATGCACCATGCCATGCCGTCCTCGGCCGCGGGCTTCTGCATCTACAAC
GACGCGGCGGTCGCCATCTCGTGGCTGCTGGACCACGGCTTCGACCGGATCGCCTACATCGACGTCGACGTGCACCACGG
CGACGGCGTGCAACGCGCCTTCTACACCGACCCGCGGGTGCTGACCATCTCCATCCATCAGCACCCGGCGACATTGTGGC
CCAACACCGGCTGGCCCGACGAGACCGGCCTCGGCGCGGGTGAGGGCACGGCGATCAACCTCGGGGTGCTGCCCGGCACG
CGGGACGCCCAGTGGCTGCGCGGCTTCCACGCCGTCGTCCCGGGTGCGGTCGCGGCCTTCCGGCCGCAGATCGTCGTCAG
CCAGTGCGGCGCCGACACCCATCGCGAGGATCCGTTGGCCGACCTCGCGCTCACCGTCGACGGTCAGCGCGCGTCCTACC
TGGCCATGCGCGAGCTGGCCGACCGCTACGCCGAGGGGCGTTGGCTCGCCGTGGGCGGTGGCGGATACGGGCTCGTCCGG
GTGGTCCCGCGGGCGTGGACGCATCTGCTGGCCACGGCGCTGGACCGCACCGTCGACCCGGCCACCCCGGTGCCCGCCGA
CTGGTGCGACCTGGTGCGCGCCGCCGCCCCCGCGGTCGATCCGCCCACCACCATGGGTGACGGTGGCGACGTGGCGTTCC
GGCCGTGGGACGGCCCGGGCGGCACCGTCGAGACCGGCGATCCGCGCGTGGACCGCGCGCAACGGGCCGTCGACACCGCC
GTACTGGCCACCCGCCGTGCGAGTTTCGGACTACTGGGTCTCGATCCGGAGGATCCTCGTGACTGA

Upstream 100 bases:

>100_bases
CCTGTCGGCGCGCGGCCCGCGACCGGTTGCGCTCGTGTCTTATTTCTACTGCATGACAACGGTGGACGGGGGCCGTCCCT
TCCCGCGTACCGTTGCGATC

Downstream 100 bases:

>100_bases
CCAACCCCTGCTGCCCGACAGCCCCGCCACCCCGGCCGTTCCGCCGCCTCCGCCGCAGCACTGGTTCGCCGACGTGCTCG
CCGCCGACGGGGGAGTGGTG

Product: putative acetoin dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MATAPSATPRDPAPPGRPGTVVWSERFLDYTWTPEHPMKPARLKFTMALAESLGVLDGVETLEPAACDRAELLRIHTADY
IEAVEHAVQPPGQPAAPPYGLGSADNPVFPRMHQAASVIVGGTLAAAREIAEGRTRRAVSIGGGMHHAMPSSAAGFCIYN
DAAVAISWLLDHGFDRIAYIDVDVHHGDGVQRAFYTDPRVLTISIHQHPATLWPNTGWPDETGLGAGEGTAINLGVLPGT
RDAQWLRGFHAVVPGAVAAFRPQIVVSQCGADTHREDPLADLALTVDGQRASYLAMRELADRYAEGRWLAVGGGGYGLVR
VVPRAWTHLLATALDRTVDPATPVPADWCDLVRAAAPAVDPPTTMGDGGDVAFRPWDGPGGTVETGDPRVDRAQRAVDTA
VLATRRASFGLLGLDPEDPRD

Sequences:

>Translated_421_residues
MATAPSATPRDPAPPGRPGTVVWSERFLDYTWTPEHPMKPARLKFTMALAESLGVLDGVETLEPAACDRAELLRIHTADY
IEAVEHAVQPPGQPAAPPYGLGSADNPVFPRMHQAASVIVGGTLAAAREIAEGRTRRAVSIGGGMHHAMPSSAAGFCIYN
DAAVAISWLLDHGFDRIAYIDVDVHHGDGVQRAFYTDPRVLTISIHQHPATLWPNTGWPDETGLGAGEGTAINLGVLPGT
RDAQWLRGFHAVVPGAVAAFRPQIVVSQCGADTHREDPLADLALTVDGQRASYLAMRELADRYAEGRWLAVGGGGYGLVR
VVPRAWTHLLATALDRTVDPATPVPADWCDLVRAAAPAVDPPTTMGDGGDVAFRPWDGPGGTVETGDPRVDRAQRAVDTA
VLATRRASFGLLGLDPEDPRD
>Mature_420_residues
ATAPSATPRDPAPPGRPGTVVWSERFLDYTWTPEHPMKPARLKFTMALAESLGVLDGVETLEPAACDRAELLRIHTADYI
EAVEHAVQPPGQPAAPPYGLGSADNPVFPRMHQAASVIVGGTLAAAREIAEGRTRRAVSIGGGMHHAMPSSAAGFCIYND
AAVAISWLLDHGFDRIAYIDVDVHHGDGVQRAFYTDPRVLTISIHQHPATLWPNTGWPDETGLGAGEGTAINLGVLPGTR
DAQWLRGFHAVVPGAVAAFRPQIVVSQCGADTHREDPLADLALTVDGQRASYLAMRELADRYAEGRWLAVGGGGYGLVRV
VPRAWTHLLATALDRTVDPATPVPADWCDLVRAAAPAVDPPTTMGDGGDVAFRPWDGPGGTVETGDPRVDRAQRAVDTAV
LATRRASFGLLGLDPEDPRD

Specific function: Role in growth and sporulation on acetoin or butanediol. Involved in the breakdown of these compounds used as a carbon source [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128860, Length=319, Percent_Identity=33.5423197492163, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI13128862, Length=321, Percent_Identity=31.1526479750779, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI293336691, Length=319, Percent_Identity=31.3479623824451, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI8923769, Length=346, Percent_Identity=30.9248554913295, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI262073088, Length=201, Percent_Identity=35.3233830845771, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI262073092, Length=248, Percent_Identity=30.241935483871, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI17158039, Length=294, Percent_Identity=27.2108843537415, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI30795202, Length=294, Percent_Identity=27.2108843537415, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI30795204, Length=294, Percent_Identity=27.2108843537415, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI13128864, Length=326, Percent_Identity=28.8343558282209, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI153085395, Length=235, Percent_Identity=30.6382978723404, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI169234807, Length=203, Percent_Identity=33.0049261083744, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI148539870, Length=203, Percent_Identity=33.0049261083744, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI62750347, Length=188, Percent_Identity=34.5744680851064, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI62750349, Length=188, Percent_Identity=34.5744680851064, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI20070354, Length=292, Percent_Identity=27.7397260273973, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI209862883, Length=315, Percent_Identity=23.4920634920635, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI217272877, Length=319, Percent_Identity=23.5109717868339, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI226529806, Length=293, Percent_Identity=26.2798634812287, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508561, Length=326, Percent_Identity=35.5828220858896, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17561978, Length=318, Percent_Identity=32.0754716981132, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17534739, Length=314, Percent_Identity=33.1210191082803, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI193206283, Length=302, Percent_Identity=30.794701986755, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17540334, Length=336, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17540332, Length=336, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI193209491, Length=215, Percent_Identity=32.093023255814, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25154022, Length=314, Percent_Identity=21.9745222929936, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25154020, Length=314, Percent_Identity=22.2929936305732, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537347, Length=268, Percent_Identity=24.2537313432836, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321244, Length=313, Percent_Identity=33.5463258785943, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6323999, Length=347, Percent_Identity=31.700288184438, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324307, Length=313, Percent_Identity=28.7539936102236, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6325325, Length=257, Percent_Identity=25.2918287937743, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24657891, Length=323, Percent_Identity=33.4365325077399, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24644244, Length=321, Percent_Identity=31.4641744548287, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI281360899, Length=313, Percent_Identity=26.1980830670927, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24642144, Length=313, Percent_Identity=26.1980830670927, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24642146, Length=313, Percent_Identity=26.1980830670927, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24642142, Length=313, Percent_Identity=26.1980830670927, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI281360801, Length=241, Percent_Identity=32.3651452282158, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281360799, Length=241, Percent_Identity=32.3651452282158, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24641720, Length=241, Percent_Identity=32.3651452282158, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24649807, Length=260, Percent_Identity=27.3076923076923, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003085
- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 44749; Mature: 44618

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAPSATPRDPAPPGRPGTVVWSERFLDYTWTPEHPMKPARLKFTMALAESLGVLDGVE
CCCCCCCCCCCCCCCCCCCEEEEEHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCHH
TLEPAACDRAELLRIHTADYIEAVEHAVQPPGQPAAPPYGLGSADNPVFPRMHQAASVIV
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEE
GGTLAAAREIAEGRTRRAVSIGGGMHHAMPSSAAGFCIYNDAAVAISWLLDHGFDRIAYI
CHHHHHHHHHHCCCCCEEEEECCCHHHCCCCCCCCEEEECCHHHHHHHHHHCCCCEEEEE
DVDVHHGDGVQRAFYTDPRVLTISIHQHPATLWPNTGWPDETGLGAGEGTAINLGVLPGT
EEEEECCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
RDAQWLRGFHAVVPGAVAAFRPQIVVSQCGADTHREDPLADLALTVDGQRASYLAMRELA
CCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHH
DRYAEGRWLAVGGGGYGLVRVVPRAWTHLLATALDRTVDPATPVPADWCDLVRAAAPAVD
HHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCC
PPTTMGDGGDVAFRPWDGPGGTVETGDPRVDRAQRAVDTAVLATRRASFGLLGLDPEDPR
CCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
D
C
>Mature Secondary Structure 
ATAPSATPRDPAPPGRPGTVVWSERFLDYTWTPEHPMKPARLKFTMALAESLGVLDGVE
CCCCCCCCCCCCCCCCCCEEEEEHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCHH
TLEPAACDRAELLRIHTADYIEAVEHAVQPPGQPAAPPYGLGSADNPVFPRMHQAASVIV
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEE
GGTLAAAREIAEGRTRRAVSIGGGMHHAMPSSAAGFCIYNDAAVAISWLLDHGFDRIAYI
CHHHHHHHHHHCCCCCEEEEECCCHHHCCCCCCCCEEEECCHHHHHHHHHHCCCCEEEEE
DVDVHHGDGVQRAFYTDPRVLTISIHQHPATLWPNTGWPDETGLGAGEGTAINLGVLPGT
EEEEECCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCC
RDAQWLRGFHAVVPGAVAAFRPQIVVSQCGADTHREDPLADLALTVDGQRASYLAMRELA
CCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHH
DRYAEGRWLAVGGGGYGLVRVVPRAWTHLLATALDRTVDPATPVPADWCDLVRAAAPAVD
HHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCC
PPTTMGDGGDVAFRPWDGPGGTVETGDPRVDRAQRAVDTAVLATRRASFGLLGLDPEDPR
CCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]