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The map label for this gene is tlrC [H]

Identifier: 54025509

GI number: 54025509

Start: 3748811

End: 3750490

Strand: Reverse

Name: tlrC [H]

Synonym: nfa35390

Alternate gene names: 54025509

Gene position: 3750490-3748811 (Counterclockwise)

Preceding gene: 54025511

Following gene: 54025501

Centisome position: 62.29

GC content: 75.48

Gene sequence:

>1680_bases
GTGTCTGCTTCCTCCACGGGCCGTTGCGGCCTGTCCACCTCCGATGCCCCTGCCGCCCCCGGCGACCCGCTACCTGCCGG
CGCGGGCGCGCACCTGCGAGCCACCTCGATCCACGTCACCCTCGGGGCGCGGACCGTGCTGGCCGACGTGTCGGTCACCG
TGTCCGCGCGCTCCCGGCTGGCCGTGGTCGGTGAGAACGGGCGCGGCAAGAGCACGCTGCTGCACGTGCTCGCCGGGCTG
CGCGCGCCCGACAGCGGAACCGTCACCAGGGCCGGCACCGTCGGTGTCGCCCGGCAGGCGATCCCGTTCCGCGCGGGCCA
GACCGTGGGCGATCTCGTCGCCGAGACCATCGCCCCGGCGCAGCGGGCGCTGCGCGACCTCGACGCCGCGACCGCGGCGC
TCGCCGCCGGCACAGCGGGTGCCGACGATGCCTACGGCGCGGCGCTGGATGCCGCGACCCGGCTGGACGCCTGGGACGCG
GAGCGACGCGTCGACATCGCCCTGGCCGCGCTGCGCGCCTGCACCGACCGGGCGCGGCCACTGGCGACACTGTCGGTGGG
ACAACGCCATCGGGTCCGGCTCGGCTGCCTGCTCGGCGCCGCCCACGACATCCTGCTGCTGGACGAGCCGACCAACCACC
TGGACCGCGACGGCCTGGATTTCCTCACCGAACGCCTGCGCGCCCATCCCGGCGGGTTCGCCGTCGTCAGCCACGATCGG
GCACTGCTGCGCGCGGTCGCCGAGGAATTCCTCGACCTCGACCCCAGCCGGGACGGGCGGCCGCAATTGTTCGCGGGCGG
CTACGCCGGGTGGCAGGAGGGTCGCCGCCGCGCCCGCGAGCGCTGGGAACACGACCACGAGGAACAACTCGCCGAGCGGG
CGCGGCTGCGCGAGGCCGTCGCCGGTGCGCGCGAGCGGCTGAGCACCGGGTGGCGACCCGACAAAGGCCACGGCAAGCAT
CAGCGGCAGTCCCGCGCGCCCGGCGTGGTGCAGGCGCTGCGGCGCCGCGAGGCCGAACTGGACGCCCATGTCGTCACCGT
GCCCGAACCGCCGCTGCGCCTGCGGTTCCCGGAACTGCCCGCCCGCGCGGGCACTCCGCTGCTGCGGGCCGACGAAGTCG
CGGTCGCGGGGCGGACGGCCCGGCCGGTCACGCTCGCGCTCGCGGCGGGGGAGCGGTTGCTGGTGACCGGACGTAACGGC
GCAGGCAAATCGACCCTGCTGGCCGTGCTCGCCGGCGAGCTGGCGCCGACCACCGGCGACGTCCGGCATCACGCGACGGC
GCGGGTGGCGCTGGTCGGTCAGGAAGTGCCGGACTGGGATCCCGAGCCGACCGCGCAGGAGCTCTACGAGCGCCACGTGC
GCGGTCTCGAGCTGAACGACGGCATCGCGCCCTTGCCGCTGGCCGCGACCGGTCTGCTCGAGAAAGGCGCACGGCACACC
CCGGTCGGGCGGTTGTCGCAGGGGCAACAGCGTCGGCTCCACCTGGCCGTGCGGCTCGCCGCCCGGCCCAACGTGCTGCT
GTTCGACGAGCCGACCAATCACATGTCGGCGGCGCTGGTGGACGAGCTGACCGCCGCGCTGCGCGAGACCGCGGCGGTGG
TGGTGGTGGCGACCCACGATCGGCAGCTGCTCGCCGATCTGGCGCGGTGGCCGCACCTTCGGCTCCCCTCGGACGGGTAG

Upstream 100 bases:

>100_bases
GGCGGCGACCCGATACCTCGATTCCCCTCAGCCGCCGTCCGGGTAGTCCCGCCGGGCGGTCTTCCGCTGTCCCGGCTCCT
TCTCGAGCTGCGGAGTTCCA

Downstream 100 bases:

>100_bases
GCGCGCCCGCGGTCAGGTGGCGGCGCCGAACCAGCGGGGCAGGTGGGCGAGCAGATCGTCCTGGTCCTCGCCCACCCACG
CGACGTGCCCGTCCGGGCGC

Product: putative ABC transporter ATP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MSASSTGRCGLSTSDAPAAPGDPLPAGAGAHLRATSIHVTLGARTVLADVSVTVSARSRLAVVGENGRGKSTLLHVLAGL
RAPDSGTVTRAGTVGVARQAIPFRAGQTVGDLVAETIAPAQRALRDLDAATAALAAGTAGADDAYGAALDAATRLDAWDA
ERRVDIALAALRACTDRARPLATLSVGQRHRVRLGCLLGAAHDILLLDEPTNHLDRDGLDFLTERLRAHPGGFAVVSHDR
ALLRAVAEEFLDLDPSRDGRPQLFAGGYAGWQEGRRRARERWEHDHEEQLAERARLREAVAGARERLSTGWRPDKGHGKH
QRQSRAPGVVQALRRREAELDAHVVTVPEPPLRLRFPELPARAGTPLLRADEVAVAGRTARPVTLALAAGERLLVTGRNG
AGKSTLLAVLAGELAPTTGDVRHHATARVALVGQEVPDWDPEPTAQELYERHVRGLELNDGIAPLPLAATGLLEKGARHT
PVGRLSQGQQRRLHLAVRLAARPNVLLFDEPTNHMSAALVDELTAALRETAAVVVVATHDRQLLADLARWPHLRLPSDG

Sequences:

>Translated_559_residues
MSASSTGRCGLSTSDAPAAPGDPLPAGAGAHLRATSIHVTLGARTVLADVSVTVSARSRLAVVGENGRGKSTLLHVLAGL
RAPDSGTVTRAGTVGVARQAIPFRAGQTVGDLVAETIAPAQRALRDLDAATAALAAGTAGADDAYGAALDAATRLDAWDA
ERRVDIALAALRACTDRARPLATLSVGQRHRVRLGCLLGAAHDILLLDEPTNHLDRDGLDFLTERLRAHPGGFAVVSHDR
ALLRAVAEEFLDLDPSRDGRPQLFAGGYAGWQEGRRRARERWEHDHEEQLAERARLREAVAGARERLSTGWRPDKGHGKH
QRQSRAPGVVQALRRREAELDAHVVTVPEPPLRLRFPELPARAGTPLLRADEVAVAGRTARPVTLALAAGERLLVTGRNG
AGKSTLLAVLAGELAPTTGDVRHHATARVALVGQEVPDWDPEPTAQELYERHVRGLELNDGIAPLPLAATGLLEKGARHT
PVGRLSQGQQRRLHLAVRLAARPNVLLFDEPTNHMSAALVDELTAALRETAAVVVVATHDRQLLADLARWPHLRLPSDG
>Mature_558_residues
SASSTGRCGLSTSDAPAAPGDPLPAGAGAHLRATSIHVTLGARTVLADVSVTVSARSRLAVVGENGRGKSTLLHVLAGLR
APDSGTVTRAGTVGVARQAIPFRAGQTVGDLVAETIAPAQRALRDLDAATAALAAGTAGADDAYGAALDAATRLDAWDAE
RRVDIALAALRACTDRARPLATLSVGQRHRVRLGCLLGAAHDILLLDEPTNHLDRDGLDFLTERLRAHPGGFAVVSHDRA
LLRAVAEEFLDLDPSRDGRPQLFAGGYAGWQEGRRRARERWEHDHEEQLAERARLREAVAGARERLSTGWRPDKGHGKHQ
RQSRAPGVVQALRRREAELDAHVVTVPEPPLRLRFPELPARAGTPLLRADEVAVAGRTARPVTLALAAGERLLVTGRNGA
GKSTLLAVLAGELAPTTGDVRHHATARVALVGQEVPDWDPEPTAQELYERHVRGLELNDGIAPLPLAATGLLEKGARHTP
VGRLSQGQQRRLHLAVRLAARPNVLLFDEPTNHMSAALVDELTAALRETAAVVVVATHDRQLLADLARWPHLRLPSDG

Specific function: Responsible for tylosin resistance, and is proposed to be a subunit of a multicomponent export system for the energy- dependent efflux of tylosin [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=547, Percent_Identity=27.9707495429616, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI10947137, Length=543, Percent_Identity=25.5985267034991, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI27881506, Length=543, Percent_Identity=25.5985267034991, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI10947135, Length=384, Percent_Identity=26.8229166666667, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI69354671, Length=384, Percent_Identity=26.8229166666667, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1789751, Length=528, Percent_Identity=29.5454545454545, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI1787041, Length=526, Percent_Identity=26.2357414448669, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI2367384, Length=526, Percent_Identity=28.7072243346008, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1787182, Length=517, Percent_Identity=26.4990328820116, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1788165, Length=188, Percent_Identity=30.3191489361702, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786703, Length=201, Percent_Identity=32.8358208955224, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87081834, Length=209, Percent_Identity=29.6650717703349, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17553372, Length=527, Percent_Identity=27.8937381404175, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17555318, Length=558, Percent_Identity=22.4014336917563, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17559834, Length=535, Percent_Identity=24.1121495327103, Blast_Score=121, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320874, Length=539, Percent_Identity=25.2319109461967, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321121, Length=577, Percent_Identity=25.4766031195841, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24641342, Length=529, Percent_Identity=26.4650283553875, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24666836, Length=549, Percent_Identity=25.6830601092896, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24642252, Length=540, Percent_Identity=25.5555555555556, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI18859989, Length=540, Percent_Identity=25.5555555555556, Blast_Score=128, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 59460; Mature: 59329

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASSTGRCGLSTSDAPAAPGDPLPAGAGAHLRATSIHVTLGARTVLADVSVTVSARSRL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCEEEEEECEEEEECCCEE
AVVGENGRGKSTLLHVLAGLRAPDSGTVTRAGTVGVARQAIPFRAGQTVGDLVAETIAPA
EEEECCCCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
QRALRDLDAATAALAAGTAGADDAYGAALDAATRLDAWDAERRVDIALAALRACTDRARP
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
LATLSVGQRHRVRLGCLLGAAHDILLLDEPTNHLDRDGLDFLTERLRAHPGGFAVVSHDR
EEEECCCCCHHEEHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCH
ALLRAVAEEFLDLDPSRDGRPQLFAGGYAGWQEGRRRARERWEHDHEEQLAERARLREAV
HHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AGARERLSTGWRPDKGHGKHQRQSRAPGVVQALRRREAELDAHVVTVPEPPLRLRFPELP
HHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCC
ARAGTPLLRADEVAVAGRTARPVTLALAAGERLLVTGRNGAGKSTLLAVLAGELAPTTGD
CCCCCCCEECCCEEECCCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCC
VRHHATARVALVGQEVPDWDPEPTAQELYERHVRGLELNDGIAPLPLAATGLLEKGARHT
HHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCC
PVGRLSQGQQRRLHLAVRLAARPNVLLFDEPTNHMSAALVDELTAALRETAAVVVVATHD
CCCCCCCCHHHEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHCEEEEEEEECC
RQLLADLARWPHLRLPSDG
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SASSTGRCGLSTSDAPAAPGDPLPAGAGAHLRATSIHVTLGARTVLADVSVTVSARSRL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCEEEEEECEEEEECCCEE
AVVGENGRGKSTLLHVLAGLRAPDSGTVTRAGTVGVARQAIPFRAGQTVGDLVAETIAPA
EEEECCCCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
QRALRDLDAATAALAAGTAGADDAYGAALDAATRLDAWDAERRVDIALAALRACTDRARP
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
LATLSVGQRHRVRLGCLLGAAHDILLLDEPTNHLDRDGLDFLTERLRAHPGGFAVVSHDR
EEEECCCCCHHEEHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEECCH
ALLRAVAEEFLDLDPSRDGRPQLFAGGYAGWQEGRRRARERWEHDHEEQLAERARLREAV
HHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AGARERLSTGWRPDKGHGKHQRQSRAPGVVQALRRREAELDAHVVTVPEPPLRLRFPELP
HHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCC
ARAGTPLLRADEVAVAGRTARPVTLALAAGERLLVTGRNGAGKSTLLAVLAGELAPTTGD
CCCCCCCEECCCEEECCCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCC
VRHHATARVALVGQEVPDWDPEPTAQELYERHVRGLELNDGIAPLPLAATGLLEKGARHT
HHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCC
PVGRLSQGQQRRLHLAVRLAARPNVLLFDEPTNHMSAALVDELTAALRETAAVVVVATHD
CCCCCCCCHHHEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHCEEEEEEEECC
RQLLADLARWPHLRLPSDG
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1864505 [H]