Click here to switch to the map view.

The map label for this gene is trpS

Identifier: 54020621

GI number: 54020621

Start: 761687

End: 762670

Strand: Reverse

Name: trpS

Synonym: mhp609

Alternate gene names: 54020621

Gene position: 762670-761687 (Counterclockwise)

Preceding gene: 54020622

Following gene: 54020620

Centisome position: 85.43

GC content: 31.2

Gene sequence:

>984_bases
ATGAAAAAAAGATTGGTTACTGGCATTACGGCAACAGGAAAATTAACGCTTGGAAATTATTTAGGATCGATAAAACCTAG
TCTTGATCTGCAAAATGAATACGAAAATTTTATTTTCGTTGCTGACCTTCACGCGCTTACTTTGCCAATTGATCCAAAAG
AATTAGCTGAAAATCGTAAAAGTATTTTTGCTTTTTATCTTGCATGCGGATTTGATCCAGAAAAAACAGTGCTTTTTTTT
CAATCTGAAATTAGTCAACATTCTGAATTATTTTGACTTTTACAGTCTGAAACTACAATTGGCGAACTTTCAAGAATGAC
CCAATTTAAAGACAAAGCGCGTTTAAAACAGGATAATAATACTGAAAAAATTCCCACCGGACTTTTAACTTATCCAATTT
TGATGGCTGCAGATATTCTTTTGTATAACCCAGATTTTGTAACAGTTGGCGCTGATCAGTTGCAACATCTTGAATTAGTG
CGGAAAATCGCCCAAAGATTTAATAAAATTTATAAAACCGACTTTAAAATTCCAAGAACAATAATTTCTGAAAGAACACA
GAAAATTATGTCGCTAACTGATCCAGAAAAAAAGATGTCCAAATCTACTCAATCAAAAAATTCGACTATTTTTTTAACAG
ACAGTCCTGATGAGGCATATCAAAAAATCCAAAAAGCACAAACAGATTCTTATAATGAAGTTAATTTTAATTTTGCAAAA
CCCGGAGTTGCCAATCTTTTAAACATTTTTATGGGACTTACTGGAATACCAGTTGATGAAACTCAGGCGTTTTTTGATGG
AAAATCTTACCAGTTTTTAAAACAAAAAGTTGGTAGAGTAGTTGCTGAATTTTTAAGAGATTTACAAGAAAAATATCAAA
AAAATCTCGATTTAGTCGAGATTTATGCAAAAAAAGGCGCTAAAAAAGCAAAAGAAGTTGCTGTTTCTAACTTTGGAAAA
ATCAAAGAAAAAATAGGATTATAA

Upstream 100 bases:

>100_bases
GAAAAAAATAAATGATTTTAGAAACTAATTTCATAATTATGTTTTAAATTATACTTATTTTTAAAACTTTTTATATAAAT
TATGTTAAAATTTTTTAATT

Downstream 100 bases:

>100_bases
TTTATGGACTTAAAAATTGACTATAAATTAAATCATTCAAGTTCACACCTCTTAGCATTAGCAATTAAAATTCTTTATCC
GGATGTAAAATTTGGAATTG

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKKRLVTGITATGKLTLGNYLGSIKPSLDLQNEYENFIFVADLHALTLPIDPKELAENRKSIFAFYLACGFDPEKTVLFF
QSEISQHSELFWLLQSETTIGELSRMTQFKDKARLKQDNNTEKIPTGLLTYPILMAADILLYNPDFVTVGADQLQHLELV
RKIAQRFNKIYKTDFKIPRTIISERTQKIMSLTDPEKKMSKSTQSKNSTIFLTDSPDEAYQKIQKAQTDSYNEVNFNFAK
PGVANLLNIFMGLTGIPVDETQAFFDGKSYQFLKQKVGRVVAEFLRDLQEKYQKNLDLVEIYAKKGAKKAKEVAVSNFGK
IKEKIGL

Sequences:

>Translated_327_residues
MKKRLVTGITATGKLTLGNYLGSIKPSLDLQNEYENFIFVADLHALTLPIDPKELAENRKSIFAFYLACGFDPEKTVLFF
QSEISQHSELF*LLQSETTIGELSRMTQFKDKARLKQDNNTEKIPTGLLTYPILMAADILLYNPDFVTVGADQLQHLELV
RKIAQRFNKIYKTDFKIPRTIISERTQKIMSLTDPEKKMSKSTQSKNSTIFLTDSPDEAYQKIQKAQTDSYNEVNFNFAK
PGVANLLNIFMGLTGIPVDETQAFFDGKSYQFLKQKVGRVVAEFLRDLQEKYQKNLDLVEIYAKKGAKKAKEVAVSNFGK
IKEKIGL
>Mature_327_residues
MKKRLVTGITATGKLTLGNYLGSIKPSLDLQNEYENFIFVADLHALTLPIDPKELAENRKSIFAFYLACGFDPEKTVLFF
QSEISQHSELF*LLQSETTIGELSRMTQFKDKARLKQDNNTEKIPTGLLTYPILMAADILLYNPDFVTVGADQLQHLELV
RKIAQRFNKIYKTDFKIPRTIISERTQKIMSLTDPEKKMSKSTQSKNSTIFLTDSPDEAYQKIQKAQTDSYNEVNFNFAK
PGVANLLNIFMGLTGIPVDETQAFFDGKSYQFLKQKVGRVVAEFLRDLQEKYQKNLDLVEIYAKKGAKKAKEVAVSNFGK
IKEKIGL

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=330, Percent_Identity=39.6969696969697, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI41352700, Length=183, Percent_Identity=44.8087431693989, Blast_Score=163, Evalue=2e-40,
Organism=Escherichia coli, GI1789786, Length=334, Percent_Identity=41.3173652694611, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71982800, Length=330, Percent_Identity=37.5757575757576, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI71982793, Length=330, Percent_Identity=37.5757575757576, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320474, Length=340, Percent_Identity=39.4117647058824, Blast_Score=209, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24666151, Length=338, Percent_Identity=38.1656804733728, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 37034; Mature: 37034

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRLVTGITATGKLTLGNYLGSIKPSLDLQNEYENFIFVADLHALTLPIDPKELAENRK
CCCCEEECCCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHH
SIFAFYLACGFDPEKTVLFFQSEISQHSELFLLQSETTIGELSRMTQFKDKARLKQDNNT
HHHHHHHHHCCCCCCEEEEEHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
EKIPTGLLTYPILMAADILLYNPDFVTVGADQLQHLELVRKIAQRFNKIYKTDFKIPRTI
CCCCCHHHHHHHHHHHHHHEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ISERTQKIMSLTDPEKKMSKSTQSKNSTIFLTDSPDEAYQKIQKAQTDSYNEVNFNFAKP
HHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCEECCC
GVANLLNIFMGLTGIPVDETQAFFDGKSYQFLKQKVGRVVAEFLRDLQEKYQKNLDLVEI
CHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
YAKKGAKKAKEVAVSNFGKIKEKIGL
HHHHCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKRLVTGITATGKLTLGNYLGSIKPSLDLQNEYENFIFVADLHALTLPIDPKELAENRK
CCCCEEECCCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHH
SIFAFYLACGFDPEKTVLFFQSEISQHSELFLLQSETTIGELSRMTQFKDKARLKQDNNT
HHHHHHHHHCCCCCCEEEEEHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
EKIPTGLLTYPILMAADILLYNPDFVTVGADQLQHLELVRKIAQRFNKIYKTDFKIPRTI
CCCCCHHHHHHHHHHHHHHEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ISERTQKIMSLTDPEKKMSKSTQSKNSTIFLTDSPDEAYQKIQKAQTDSYNEVNFNFAKP
HHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCEECCC
GVANLLNIFMGLTGIPVDETQAFFDGKSYQFLKQKVGRVVAEFLRDLQEKYQKNLDLVEI
CHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
YAKKGAKKAKEVAVSNFGKIKEKIGL
HHHHCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]