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The map label for this gene is mtlA

Identifier: 54020588

GI number: 54020588

Start: 719028

End: 720503

Strand: Reverse

Name: mtlA

Synonym: mhp569

Alternate gene names: 54020588

Gene position: 720503-719028 (Counterclockwise)

Preceding gene: 54020589

Following gene: 54020587

Centisome position: 80.71

GC content: 32.72

Gene sequence:

>1476_bases
ATGGCTAATTTGTTCAAAATGCTTAAAACTAAAATTCAGGCATTCGGCTCACTTTTAGGCCAAATGATTATGCCAATTAT
TGGGATTTTTATAGCCTGAGGTTTGTTGACATCCTTTTTTATCCCAGCAGGTTGGACCCCAAATAAAGAACTAGCAACAA
TGGTCAAAATCGGGATTGTCTATATTATTCCAATTTTAATTTGTTTTTTAGGAGGATATAAAATTTATAAAATGCGGGGC
GGAGCAATTGCTGGTATTGTTGCAATTGCATCAGTCGCCGCTGGTCAATCAGAGACTTTTTCCCAAATCACTGGCGGAAC
CGCACCGATGCTAGTTTCAGTTATGCTTTTTGGCCCAGTTTCTGCACTTATTTTAAAACATAGCGAGAAATTTTGGATTC
ATAAAATTCCAAGTGGCTATCAAATGTTGGTGAATAATTTTTACCTTGGCATTATCGGCTTTGTTCTGCTTTTTCCAGTT
TATTATTTATCAATTTATTTTATTGGATATTTTATAAAATCACTCGGGATTCTAACAGCGAAAATGGGACAGTGAAAATT
ATACCCACTAATTGCTTTAATTGTCGAACCCGCAAAAATACTTTTTTTAAATAATGCTATAAATCACGGCGTTTTTACAA
CTTTGGGTGCAATTCAAGTCACTGAAACCGGCAAGTCAATTTTGTTTTTATTAGAATCAAATCCTGGACCTGGGTTAGGA
CTTTTGCTGTTTTATTTAATTTTTTCAAAAGAGAAAATTATTAAAGGTCAAGCAACCTCGTCAATTCCTATTCATTTTTT
AGGCGGAATTCACGAAGTTTATTTCCCTTTTGCACTTTTAAGGCCAATTTTGATTTTGGCCTTAATTGCAGGCGGGGTTT
TTGCGAATGCAATTTTCCAAATTTTTAATGTTGGTGCAGTTGCTCCTGTTTCGCCAGGTTCAATTATTGCTCAATATCTT
CAAGTTGAAAAATCAACAAATTCACTAGTTGGGCTTACAATTGGAATTTTTGGCTCTGCGGCAGCGACTTTAGTTGCCGC
TTGAGGAGTTAATTTTTTGGCTAAGTTGATTAATAGAAAAAAAACAAAAAAAGAAACTTTTGCCTTAGAAAGTGCCAAAA
AATTAGTAGAAAGTGAAAAAATAAAACTAAAAAAACCAACTGAAAATAATCTAAATTGAAAACAAATTGTTTTTGCTTGC
GATGCAGGAATGGGTTCTTCAGTGATGGCGGCCTCAATTTTTCGAAAAATTTTAAAGGAAAATGGAATTAGAAATGTTGA
AATTACTAATTTAGCAATTGCAGATTTAACAGGGGCTGAAGAAATTATCATCACAATTCAAAGTCTTGAGGATCGTGTTA
AAGTGAAAAATTCAACAGCAAAAATTATTACTTTAACTCAATTTTTAGATAAAAAATCTTATGAAAATTTAGCAAAAAAA
ATTAAAAAAATACAAGAAAAAGAAGGATTTTTGTAA

Upstream 100 bases:

>100_bases
CTTTATCAATAAAATTCCGATTTTGCTTTAATAACAATGAAAGTTGATCAATTAAATTACTATTCATTTTTAAAAATTAT
ACCAAGAAAAAGGATATTTT

Downstream 100 bases:

>100_bases
TGAAAGTGGTTCATTTTGGCGCCGGAAATATCGGGCGCGGGTTGATTGCAAAACTATACCATCAAAATCAATTTGAAATT
ATTTTTGTCGATGTTAATCA

Product: PTS system, mannitol-specific IIBC component

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MANLFKMLKTKIQAFGSLLGQMIMPIIGIFIAWGLLTSFFIPAGWTPNKELATMVKIGIVYIIPILICFLGGYKIYKMRG
GAIAGIVAIASVAAGQSETFSQITGGTAPMLVSVMLFGPVSALILKHSEKFWIHKIPSGYQMLVNNFYLGIIGFVLLFPV
YYLSIYFIGYFIKSLGILTAKMGQWKLYPLIALIVEPAKILFLNNAINHGVFTTLGAIQVTETGKSILFLLESNPGPGLG
LLLFYLIFSKEKIIKGQATSSIPIHFLGGIHEVYFPFALLRPILILALIAGGVFANAIFQIFNVGAVAPVSPGSIIAQYL
QVEKSTNSLVGLTIGIFGSAAATLVAAWGVNFLAKLINRKKTKKETFALESAKKLVESEKIKLKKPTENNLNWKQIVFAC
DAGMGSSVMAASIFRKILKENGIRNVEITNLAIADLTGAEEIIITIQSLEDRVKVKNSTAKIITLTQFLDKKSYENLAKK
IKKIQEKEGFL

Sequences:

>Translated_491_residues
MANLFKMLKTKIQAFGSLLGQMIMPIIGIFIA*GLLTSFFIPAGWTPNKELATMVKIGIVYIIPILICFLGGYKIYKMRG
GAIAGIVAIASVAAGQSETFSQITGGTAPMLVSVMLFGPVSALILKHSEKFWIHKIPSGYQMLVNNFYLGIIGFVLLFPV
YYLSIYFIGYFIKSLGILTAKMGQ*KLYPLIALIVEPAKILFLNNAINHGVFTTLGAIQVTETGKSILFLLESNPGPGLG
LLLFYLIFSKEKIIKGQATSSIPIHFLGGIHEVYFPFALLRPILILALIAGGVFANAIFQIFNVGAVAPVSPGSIIAQYL
QVEKSTNSLVGLTIGIFGSAAATLVAA*GVNFLAKLINRKKTKKETFALESAKKLVESEKIKLKKPTENNLN*KQIVFAC
DAGMGSSVMAASIFRKILKENGIRNVEITNLAIADLTGAEEIIITIQSLEDRVKVKNSTAKIITLTQFLDKKSYENLAKK
IKKIQEKEGFL
>Mature_490_residues
ANLFKMLKTKIQAFGSLLGQMIMPIIGIFIA*GLLTSFFIPAGWTPNKELATMVKIGIVYIIPILICFLGGYKIYKMRGG
AIAGIVAIASVAAGQSETFSQITGGTAPMLVSVMLFGPVSALILKHSEKFWIHKIPSGYQMLVNNFYLGIIGFVLLFPVY
YLSIYFIGYFIKSLGILTAKMGQ*KLYPLIALIVEPAKILFLNNAINHGVFTTLGAIQVTETGKSILFLLESNPGPGLGL
LLFYLIFSKEKIIKGQATSSIPIHFLGGIHEVYFPFALLRPILILALIAGGVFANAIFQIFNVGAVAPVSPGSIIAQYLQ
VEKSTNSLVGLTIGIFGSAAATLVAA*GVNFLAKLINRKKTKKETFALESAKKLVESEKIKLKKPTENNLN*KQIVFACD
AGMGSSVMAASIFRKILKENGIRNVEITNLAIADLTGAEEIIITIQSLEDRVKVKNSTAKIITLTQFLDKKSYENLAKKI
KKIQEKEGFL

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=492, Percent_Identity=38.6178861788618, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI1789301, Length=474, Percent_Identity=37.1308016877637, Blast_Score=285, Evalue=6e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 52810; Mature: 52679

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLFKMLKTKIQAFGSLLGQMIMPIIGIFIAGLLTSFFIPAGWTPNKELATMVKIGIVY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
IIPILICFLGGYKIYKMRGGAIAGIVAIASVAAGQSETFSQITGGTAPMLVSVMLFGPVS
HHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHH
ALILKHSEKFWIHKIPSGYQMLVNNFYLGIIGFVLLFPVYYLSIYFIGYFIKSLGILTAK
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGQKLYPLIALIVEPAKILFLNNAINHGVFTTLGAIQVTETGKSILFLLESNPGPGLGLL
HCHHHHHHHHHHHCCHHHEEECCHHCCCHHHHHCCEEEEECCCEEEEEEECCCCCCHHHH
LFYLIFSKEKIIKGQATSSIPIHFLGGIHEVYFPFALLRPILILALIAGGVFANAIFQIF
HHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVGAVAPVSPGSIIAQYLQVEKSTNSLVGLTIGIFGSAAATLVAAGVNFLAKLINRKKTK
HCCCCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KETFALESAKKLVESEKIKLKKPTENNLNKQIVFACDAGMGSSVMAASIFRKILKENGIR
HHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
NVEITNLAIADLTGAEEIIITIQSLEDRVKVKNSTAKIITLTQFLDKKSYENLAKKIKKI
EEEEEEEEEECCCCCHHHEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QEKEGFL
HHHCCCC
>Mature Secondary Structure 
ANLFKMLKTKIQAFGSLLGQMIMPIIGIFIAGLLTSFFIPAGWTPNKELATMVKIGIVY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
IIPILICFLGGYKIYKMRGGAIAGIVAIASVAAGQSETFSQITGGTAPMLVSVMLFGPVS
HHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHH
ALILKHSEKFWIHKIPSGYQMLVNNFYLGIIGFVLLFPVYYLSIYFIGYFIKSLGILTAK
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGQKLYPLIALIVEPAKILFLNNAINHGVFTTLGAIQVTETGKSILFLLESNPGPGLGLL
HCHHHHHHHHHHHCCHHHEEECCHHCCCHHHHHCCEEEEECCCEEEEEEECCCCCCHHHH
LFYLIFSKEKIIKGQATSSIPIHFLGGIHEVYFPFALLRPILILALIAGGVFANAIFQIF
HHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVGAVAPVSPGSIIAQYLQVEKSTNSLVGLTIGIFGSAAATLVAAGVNFLAKLINRKKTK
HCCCCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KETFALESAKKLVESEKIKLKKPTENNLNKQIVFACDAGMGSSVMAASIFRKILKENGIR
HHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
NVEITNLAIADLTGAEEIIITIQSLEDRVKVKNSTAKIITLTQFLDKKSYENLAKKIKKI
EEEEEEEEEECCCCCHHHEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QEKEGFL
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]