Click here to switch to the map view.

The map label for this gene is tyrS

Identifier: 54020016

GI number: 54020016

Start: 77817

End: 79061

Strand: Direct

Name: tyrS

Synonym: mhp066

Alternate gene names: 54020016

Gene position: 77817-79061 (Clockwise)

Preceding gene: 54020015

Following gene: 54020017

Centisome position: 8.72

GC content: 28.43

Gene sequence:

>1245_bases
ATGTCATATATAGAAAAGCAAGAATTTCTCACTGAATTAAAAACAAGAAATATTCTAAAGGATATCAGCAGTCCTGAAAA
ATTTTTTAATCTAAAACCTGACCAAGGAATTTATATCGGGTTTGATCCAACAGCTACTTCTCTGCATTTAGGAAACTATA
TTTCAATTAGTCTACTTAAAAGATTACAAAAAATAGGGATAAAAGTACTTGCAGTTATTGGTGGGGCTACTGGAATGATT
GGTGATCCATCTTTTAGTTCAAAAGAGCGAAAACTACTTGATTTTAAGACACTTAATGCCAATAAAGAGAAAATTAAAAA
ACAGTTAGAGTCCTTTGGTTTGCCAGTTTTTGATAATTTTGAGATATATAAAAATATGAATATTCTTGATTTTTTGCGTG
ATGTCGGGAAAAATATCAATATTTCTTATCTTTTAGCCAAAGAATCAGTGGCTTCGCGGATCGAAGTTGGTCTTTCTTTT
ACAGAATTTTCCTACCAGTTGATTCAAGGCTGAGATTTTAAATTTTTAGCAGAAAATTATCAAATAATCGGTCAAGCTGG
TGGTTCTGATCAATGAGGGAATATGGTTACTGGCCTTGATTTTATCAAAAAATCAAATTTAGTCCAAAAAGATGAAGCTT
TTGTGTTTACAACTAATTTATTAACCGACGAAAACGGCCAAAAATTTGGCAAAAGTTTAGGAAAACCAATCTGGCTTGAT
CCAGAAATGTATTCGCCATTTCATTTGTACCAATTTTTATTAAATCAAAACGATGAGCAAGCCGAAAAAATTATGTTGTG
GTTATCTTTTTTAGATCTAAAAGTAATAAATGAGCTAATTTTCAAGCATAAAAATGATAAAAAACAACGTATTTTACAGT
ATAATTTAGCACAAGAGGTTGTTTTTAATATCCATGGAGACAAAGGCCTAAAGATAGCTAAAAAAATTACAAAAATTTTA
TTTGAAAAACTAGATTATACAGAAATAACATTTAAAGATAAGTTAGAACTAAAAAAAATTATCCCGTATTTTAAAGTATC
TTTTTTCAATGCCAATCAAATAATCGACCTTGGAATATTTAAATCAAAGCGTGAATTAAATGAATTTATTTCTCATAAAG
CTCTTGAAATTAATGGATCTAAAATCTCAAATATTGGTGATATAACTGAAGAACTAAAAGATAAAAGCAATTTATTTTTG
CTTAGAAAAGGCAAAAAATACTTTTTTATCATAGAACTTATTTAG

Upstream 100 bases:

>100_bases
ATTCCTAAAATTTTAGAGACACCTTATGTTGATAATAAGCCTATTTATGATCAGGAAATTGCGCTTTTATTAAAAAAAGT
TTAAAATTTAAAGGTTTTTT

Downstream 100 bases:

>100_bases
TGTTTTTTTCTAAAAAAACATTTATAATATTCATACATATTTTGAAAAAAGTATTTTTTTTAAGGAAATTTTATGGAAGT
TGATAGTGTTTATGAAAATC

Product: tyrosyl tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSYIEKQEFLTELKTRNILKDISSPEKFFNLKPDQGIYIGFDPTATSLHLGNYISISLLKRLQKIGIKVLAVIGGATGMI
GDPSFSSKERKLLDFKTLNANKEKIKKQLESFGLPVFDNFEIYKNMNILDFLRDVGKNINISYLLAKESVASRIEVGLSF
TEFSYQLIQGWDFKFLAENYQIIGQAGGSDQWGNMVTGLDFIKKSNLVQKDEAFVFTTNLLTDENGQKFGKSLGKPIWLD
PEMYSPFHLYQFLLNQNDEQAEKIMLWLSFLDLKVINELIFKHKNDKKQRILQYNLAQEVVFNIHGDKGLKIAKKITKIL
FEKLDYTEITFKDKLELKKIIPYFKVSFFNANQIIDLGIFKSKRELNEFISHKALEINGSKISNIGDITEELKDKSNLFL
LRKGKKYFFIIELI

Sequences:

>Translated_414_residues
MSYIEKQEFLTELKTRNILKDISSPEKFFNLKPDQGIYIGFDPTATSLHLGNYISISLLKRLQKIGIKVLAVIGGATGMI
GDPSFSSKERKLLDFKTLNANKEKIKKQLESFGLPVFDNFEIYKNMNILDFLRDVGKNINISYLLAKESVASRIEVGLSF
TEFSYQLIQG*DFKFLAENYQIIGQAGGSDQ*GNMVTGLDFIKKSNLVQKDEAFVFTTNLLTDENGQKFGKSLGKPIWLD
PEMYSPFHLYQFLLNQNDEQAEKIMLWLSFLDLKVINELIFKHKNDKKQRILQYNLAQEVVFNIHGDKGLKIAKKITKIL
FEKLDYTEITFKDKLELKKIIPYFKVSFFNANQIIDLGIFKSKRELNEFISHKALEINGSKISNIGDITEELKDKSNLFL
LRKGKKYFFIIELI
>Mature_413_residues
SYIEKQEFLTELKTRNILKDISSPEKFFNLKPDQGIYIGFDPTATSLHLGNYISISLLKRLQKIGIKVLAVIGGATGMIG
DPSFSSKERKLLDFKTLNANKEKIKKQLESFGLPVFDNFEIYKNMNILDFLRDVGKNINISYLLAKESVASRIEVGLSFT
EFSYQLIQG*DFKFLAENYQIIGQAGGSDQ*GNMVTGLDFIKKSNLVQKDEAFVFTTNLLTDENGQKFGKSLGKPIWLDP
EMYSPFHLYQFLLNQNDEQAEKIMLWLSFLDLKVINELIFKHKNDKKQRILQYNLAQEVVFNIHGDKGLKIAKKITKILF
EKLDYTEITFKDKLELKKIIPYFKVSFFNANQIIDLGIFKSKRELNEFISHKALEINGSKISNIGDITEELKDKSNLFLL
RKGKKYFFIIELI

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=448, Percent_Identity=32.8125, Blast_Score=202, Evalue=6e-52,
Organism=Escherichia coli, GI1787925, Length=424, Percent_Identity=35.6132075471698, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI25145802, Length=431, Percent_Identity=32.7146171693735, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25145805, Length=307, Percent_Identity=31.9218241042345, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6325160, Length=440, Percent_Identity=30.9090909090909, Blast_Score=196, Evalue=6e-51,
Organism=Drosophila melanogaster, GI20130383, Length=444, Percent_Identity=32.8828828828829, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 47414; Mature: 47283

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYIEKQEFLTELKTRNILKDISSPEKFFNLKPDQGIYIGFDPTATSLHLGNYISISLLK
CCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEECCCCCEEECCCCHHHHHHH
RLQKIGIKVLAVIGGATGMIGDPSFSSKERKLLDFKTLNANKEKIKKQLESFGLPVFDNF
HHHHCCCEEEEEECCCCCCCCCCCCCCCHHHEEEEEECCCCHHHHHHHHHHCCCCCCCCC
EIYKNMNILDFLRDVGKNINISYLLAKESVASRIEVGLSFTEFSYQLIQGDFKFLAENYQ
HHHHCCCHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCE
IIGQAGGSDQGNMVTGLDFIKKSNLVQKDEAFVFTTNLLTDENGQKFGKSLGKPIWLDPE
EEEECCCCCCCCEEHHHHHHHHCCCCCCCCEEEEEEEEEECCCHHHHHHHHCCCEEECCC
MYSPFHLYQFLLNQNDEQAEKIMLWLSFLDLKVINELIFKHKNDKKQRILQYNLAQEVVF
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHE
NIHGDKGLKIAKKITKILFEKLDYTEITFKDKLELKKIIPYFKVSFFNANQIIDLGIFKS
EECCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCHHHEEEEECCCCEEEEHHHHH
KRELNEFISHKALEINGSKISNIGDITEELKDKSNLFLLRKGKKYFFIIELI
HHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCEEEEEEEEC
>Mature Secondary Structure 
SYIEKQEFLTELKTRNILKDISSPEKFFNLKPDQGIYIGFDPTATSLHLGNYISISLLK
CCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEECCCCCEEECCCCHHHHHHH
RLQKIGIKVLAVIGGATGMIGDPSFSSKERKLLDFKTLNANKEKIKKQLESFGLPVFDNF
HHHHCCCEEEEEECCCCCCCCCCCCCCCHHHEEEEEECCCCHHHHHHHHHHCCCCCCCCC
EIYKNMNILDFLRDVGKNINISYLLAKESVASRIEVGLSFTEFSYQLIQGDFKFLAENYQ
HHHHCCCHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCE
IIGQAGGSDQGNMVTGLDFIKKSNLVQKDEAFVFTTNLLTDENGQKFGKSLGKPIWLDPE
EEEECCCCCCCCEEHHHHHHHHCCCCCCCCEEEEEEEEEECCCHHHHHHHHCCCEEECCC
MYSPFHLYQFLLNQNDEQAEKIMLWLSFLDLKVINELIFKHKNDKKQRILQYNLAQEVVF
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHE
NIHGDKGLKIAKKITKILFEKLDYTEITFKDKLELKKIIPYFKVSFFNANQIIDLGIFKS
EECCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCHHHEEEEECCCCEEEEHHHHH
KRELNEFISHKALEINGSKISNIGDITEELKDKSNLFLLRKGKKYFFIIELI
HHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA