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The map label for this gene is ispA

Identifier: 53722784

GI number: 53722784

Start: 2418016

End: 2418900

Strand: Reverse

Name: ispA

Synonym: BPSS1763

Alternate gene names: 53722784

Gene position: 2418900-2418016 (Counterclockwise)

Preceding gene: 53722785

Following gene: 53722783

Centisome position: 76.23

GC content: 71.19

Gene sequence:

>885_bases
ATGACATTCGACCAATGGATGCGCTCGGTGCTCGAGCGTGTCGAGACGGCCCTCGGCCATTATTTACCGGCCGGGACTGT
GGCGCCCGCGCAACTGCACGAAGCGATGCGCTATGCGGTGCTCGGGGGCGGCAAACGCGTGCGTCCGCTGCTGTGCCATG
CGGCGGGCGAGCTCACGGGCGCGTCGGAGGCGGCGCGTGACGCGGCGTCGGCTGCGCTCGAGATGATTCACGTGTATTCG
CTCGTGCATGATGATATGCCGTGCATGGATGACGACGCGCTGCGTCGCGGCAAGCCGACCGTCCACGTCAAGTACGACGA
GCCGACCGCGCTGCTCGTCGGCGACGCGCTGCAGTCGCAGGCTTTCGTCGCGCTGACCGACGCCGCCGCGCTGCCGGCCG
ACCGGCAGGCGGCGCTCGTGCGCGAGCTCGCGCTCGCGAGCGGCTCGATCGGCATGGCGGGCGGCCAGGCGATCGATCTC
GCGAGCGTCGGCGTGGCGCTCACGCGCGACGCGCTGGAGACGATGCATCGGATGAAGACGGGCGCGCTGTTGCGCGCGTC
GGTGCGCATGGGCGCGCTCGCGGGCGAGACGCCGTCCGGCGACGCGATGCGCGCGCTCGACGCCTATGCGGCGGCCGTCG
GCCTGGCGTTCCAGGTGGTGGACGACATTCTCGACGTCACCACCGATTCCGCGACGCTCGGCAAGACGGCCGGCAAGGAC
GCGGCGAACGACAAGCCGACCTACGTGTCGATCATCGGTCTCGACGCGTCGCGCGCGCTTGCCGCGCAATTGCGCGCCGA
TGCGCACGCCGCGCTCGAGCCGTTCGGCGCGCGCGCGCAGCGCCTGGCCGAACTGGCGGACCTGGTGGTGAACCGGGTCA
GCTGA

Upstream 100 bases:

>100_bases
AATTGGAAAAAGCGGAGCAGCAGGTGCGTGTGCTCGACGGCGCCTCGCTCAAGCCGCTTTCCGCAGGAACGGCCGCCGCG
GACGGCGAAGACGACGATCT

Downstream 100 bases:

>100_bases
CGCGAAAGCCCGCCGCCGCGCCCACGCCACGGGTGGGCGCGCAAGAAGTGCGGGCGCGTTTGTTTTCCTACAATGGAACG
ACGATGTACGACTTGCTGAA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTFDQWMRSVLERVETALGHYLPAGTVAPAQLHEAMRYAVLGGGKRVRPLLCHAAGELTGASEAARDAASAALEMIHVYS
LVHDDMPCMDDDALRRGKPTVHVKYDEPTALLVGDALQSQAFVALTDAAALPADRQAALVRELALASGSIGMAGGQAIDL
ASVGVALTRDALETMHRMKTGALLRASVRMGALAGETPSGDAMRALDAYAAAVGLAFQVVDDILDVTTDSATLGKTAGKD
AANDKPTYVSIIGLDASRALAAQLRADAHAALEPFGARAQRLAELADLVVNRVS

Sequences:

>Translated_294_residues
MTFDQWMRSVLERVETALGHYLPAGTVAPAQLHEAMRYAVLGGGKRVRPLLCHAAGELTGASEAARDAASAALEMIHVYS
LVHDDMPCMDDDALRRGKPTVHVKYDEPTALLVGDALQSQAFVALTDAAALPADRQAALVRELALASGSIGMAGGQAIDL
ASVGVALTRDALETMHRMKTGALLRASVRMGALAGETPSGDAMRALDAYAAAVGLAFQVVDDILDVTTDSATLGKTAGKD
AANDKPTYVSIIGLDASRALAAQLRADAHAALEPFGARAQRLAELADLVVNRVS
>Mature_293_residues
TFDQWMRSVLERVETALGHYLPAGTVAPAQLHEAMRYAVLGGGKRVRPLLCHAAGELTGASEAARDAASAALEMIHVYSL
VHDDMPCMDDDALRRGKPTVHVKYDEPTALLVGDALQSQAFVALTDAAALPADRQAALVRELALASGSIGMAGGQAIDLA
SVGVALTRDALETMHRMKTGALLRASVRMGALAGETPSGDAMRALDAYAAAVGLAFQVVDDILDVTTDSATLGKTAGKDA
ANDKPTYVSIIGLDASRALAAQLRADAHAALEPFGARAQRLAELADLVVNRVS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=228, Percent_Identity=30.7017543859649, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786623, Length=298, Percent_Identity=45.9731543624161, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789578, Length=213, Percent_Identity=32.8638497652582, Blast_Score=101, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24651612, Length=232, Percent_Identity=27.1551724137931, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 30650; Mature: 30519

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDQWMRSVLERVETALGHYLPAGTVAPAQLHEAMRYAVLGGGKRVRPLLCHAAGELTG
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
ASEAARDAASAALEMIHVYSLVHDDMPCMDDDALRRGKPTVHVKYDEPTALLVGDALQSQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEECCCCEEEECHHHHCC
AFVALTDAAALPADRQAALVRELALASGSIGMAGGQAIDLASVGVALTRDALETMHRMKT
EEEEEECHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
GALLRASVRMGALAGETPSGDAMRALDAYAAAVGLAFQVVDDILDVTTDSATLGKTAGKD
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC
AANDKPTYVSIIGLDASRALAAQLRADAHAALEPFGARAQRLAELADLVVNRVS
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TFDQWMRSVLERVETALGHYLPAGTVAPAQLHEAMRYAVLGGGKRVRPLLCHAAGELTG
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
ASEAARDAASAALEMIHVYSLVHDDMPCMDDDALRRGKPTVHVKYDEPTALLVGDALQSQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEECCCCEEEECHHHHCC
AFVALTDAAALPADRQAALVRELALASGSIGMAGGQAIDLASVGVALTRDALETMHRMKT
EEEEEECHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
GALLRASVRMGALAGETPSGDAMRALDAYAAAVGLAFQVVDDILDVTTDSATLGKTAGKD
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC
AANDKPTYVSIIGLDASRALAAQLRADAHAALEPFGARAQRLAELADLVVNRVS
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]