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The map label for this gene is ydfI [H]

Identifier: 53722498

GI number: 53722498

Start: 2014766

End: 2016235

Strand: Reverse

Name: ydfI [H]

Synonym: BPSS1476

Alternate gene names: 53722498

Gene position: 2016235-2014766 (Counterclockwise)

Preceding gene: 53722505

Following gene: 53722497

Centisome position: 63.54

GC content: 73.33

Gene sequence:

>1470_bases
ATGCCGCTTCTTTCATCCGACCATTGCCGCGCATTGCCGCCCGAGGTGTCCCGTCCGCGCTACGACCGGCGCGCGCTGCG
CACGGGCATCGTCCATCTCGGGCTCGGTGCGTTCCACCGTGCGCACCAGGCGTGCTATACCGAGACGCTCGTCGAGCGGG
GCGACCTGCGCTGGGGCATCGCCGGCGTCGAATTGCGGCGGCGGCACACGGTCGAACGGCTCGCCGCGCAGGACCATCTC
TATTCGGTGACCGAGCGCGCGGGCGACGCGGCGCGCACGCGCGTCGTCGGCGCGGTGCATCGCACGCTGTTCGCGCCGCA
GGCGCTCGCGACGCTGCTCGGGCTGATCGCCGATCCGGCCGTGTCGATCGTCAGCCTGACCGTCACCGAGAAGGGTTATT
ACCGGCGGCCCGGCGGCGGGGGGCTCGACCTCGACGATCCCGCGATCCGCCGCGACCTCGCGCAACCGCACGCGCCGTCG
ACGACGCTCGGCGTGCTCGCGGCGGGCATCCGGCTGCGTGCGGCGCACGCGCCGCTATCGGTTCTCAGTTGCGACAACAT
GCCGTCGAACGGCGACACGCTGCGCGCGCTGCTCGCGCAATACGCGGAGCAGACCGACGGCGCGCTCGCGCGGCGGATTC
GGTGCGACGTCGCGTTTCCGAACACGATGGTCGACCGGATCGTGCCCGCCGCGACGCCCGAATCGCTCGACTGGGTGCAG
TCGCGTATCGGCGTGCGCGACGAGGCGGCGATCGTCTGCGAGCCGTTCGCGCAATGGGTGTTCGAGGACCGCTTCGCGGG
CGCACGGCCGCGCTGGGAGGACGCGGGCGCGCTCGTCGCGGCCGACGTGCGGCCGTACGAGAAGATGAAGCTGCGCCTGC
TGAACGGCTCGCACTCGGCGATCGCCTATGCCGGCCAGTTGCGTGGGCGGCGCACGGTGTCCGACGCGATGGCCGATCCG
CTGATCGACGCGCTCGCGCGCGGCGTGATGACGCGCGAGCTGCTCGCGACGCTCGACGTGCCGGCCGGCTACGACGTGCG
TGCGTATTGCGCGTCGCTGATCGAGCGTTTTCGCAACCCGGCGCTCGCGCACCGCACCGCGCAAATCGCGACGGACGGCA
CGCAGAAGGTGCCGCTGCGCTGGCTGCCGGCGCTGGCCGAGAGCGCGGCGGCGGGCGTCGAGCGGCCGTTTCTCGAGCGC
TCGCTCGCGATGTGGCTGCATTACGTCGAAGTCGCGCGCGACGAGAGCGGCCGGCCGCTCGTGCTCGAGGATCCGGGCGC
GCAGGCGCTGGCGGCACGTCTGCACGGCGCGCCGGGCGCGACCGATGCGGTGCGCGCGGCGCTCGGGCTGATCGCGTCGC
GCGATGCGGCGCGATGGCCCGAGGCGCTGACGGCGCGCGTCGGCGCGCACCTGGAGACGGTGCGCACGCGCGGCACCGAC
GCGCTGCTGCGGCCGTTGCTCGACGCTTGA

Upstream 100 bases:

>100_bases
AGAGGATGTAGCGTTTACACCGATAAAAATGCAAATGCGCTCGGAATAATCTGCTGTCGATACGTTAACTACCATGGTAC
AAACGGGTCGCTTCCTCGTC

Downstream 100 bases:

>100_bases
GCGGGCGGGGCGGCCGAGGATGCCGGCGTTCGCGGGCGCCTGCACGCGGCGGCGTCGCGCGAGCGTTCGCCCGTGCTTTC
GCCCGTGCTTTCGCGCGCGC

Product: mannitol dehydrogenase protein

Products: D-fructuronate; NADH [C]

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MPLLSSDHCRALPPEVSRPRYDRRALRTGIVHLGLGAFHRAHQACYTETLVERGDLRWGIAGVELRRRHTVERLAAQDHL
YSVTERAGDAARTRVVGAVHRTLFAPQALATLLGLIADPAVSIVSLTVTEKGYYRRPGGGGLDLDDPAIRRDLAQPHAPS
TTLGVLAAGIRLRAAHAPLSVLSCDNMPSNGDTLRALLAQYAEQTDGALARRIRCDVAFPNTMVDRIVPAATPESLDWVQ
SRIGVRDEAAIVCEPFAQWVFEDRFAGARPRWEDAGALVAADVRPYEKMKLRLLNGSHSAIAYAGQLRGRRTVSDAMADP
LIDALARGVMTRELLATLDVPAGYDVRAYCASLIERFRNPALAHRTAQIATDGTQKVPLRWLPALAESAAAGVERPFLER
SLAMWLHYVEVARDESGRPLVLEDPGAQALAARLHGAPGATDAVRAALGLIASRDAARWPEALTARVGAHLETVRTRGTD
ALLRPLLDA

Sequences:

>Translated_489_residues
MPLLSSDHCRALPPEVSRPRYDRRALRTGIVHLGLGAFHRAHQACYTETLVERGDLRWGIAGVELRRRHTVERLAAQDHL
YSVTERAGDAARTRVVGAVHRTLFAPQALATLLGLIADPAVSIVSLTVTEKGYYRRPGGGGLDLDDPAIRRDLAQPHAPS
TTLGVLAAGIRLRAAHAPLSVLSCDNMPSNGDTLRALLAQYAEQTDGALARRIRCDVAFPNTMVDRIVPAATPESLDWVQ
SRIGVRDEAAIVCEPFAQWVFEDRFAGARPRWEDAGALVAADVRPYEKMKLRLLNGSHSAIAYAGQLRGRRTVSDAMADP
LIDALARGVMTRELLATLDVPAGYDVRAYCASLIERFRNPALAHRTAQIATDGTQKVPLRWLPALAESAAAGVERPFLER
SLAMWLHYVEVARDESGRPLVLEDPGAQALAARLHGAPGATDAVRAALGLIASRDAARWPEALTARVGAHLETVRTRGTD
ALLRPLLDA
>Mature_488_residues
PLLSSDHCRALPPEVSRPRYDRRALRTGIVHLGLGAFHRAHQACYTETLVERGDLRWGIAGVELRRRHTVERLAAQDHLY
SVTERAGDAARTRVVGAVHRTLFAPQALATLLGLIADPAVSIVSLTVTEKGYYRRPGGGGLDLDDPAIRRDLAQPHAPST
TLGVLAAGIRLRAAHAPLSVLSCDNMPSNGDTLRALLAQYAEQTDGALARRIRCDVAFPNTMVDRIVPAATPESLDWVQS
RIGVRDEAAIVCEPFAQWVFEDRFAGARPRWEDAGALVAADVRPYEKMKLRLLNGSHSAIAYAGQLRGRRTVSDAMADPL
IDALARGVMTRELLATLDVPAGYDVRAYCASLIERFRNPALAHRTAQIATDGTQKVPLRWLPALAESAAAGVERPFLERS
LAMWLHYVEVARDESGRPLVLEDPGAQALAARLHGAPGATDAVRAALGLIASRDAARWPEALTARVGAHLETVRTRGTDA
LLRPLLDA

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787823, Length=418, Percent_Identity=44.4976076555024, Blast_Score=341, Evalue=6e-95,
Organism=Escherichia coli, GI1790779, Length=444, Percent_Identity=43.018018018018, Blast_Score=338, Evalue=7e-94,
Organism=Escherichia coli, GI1788497, Length=418, Percent_Identity=43.7799043062201, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI48994885, Length=370, Percent_Identity=26.2162162162162, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1790028, Length=306, Percent_Identity=27.4509803921569, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324401, Length=492, Percent_Identity=35.5691056910569, Blast_Score=302, Evalue=8e-83,
Organism=Saccharomyces cerevisiae, GI6320765, Length=492, Percent_Identity=35.5691056910569, Blast_Score=302, Evalue=8e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 53055; Mature: 52924

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLSSDHCRALPPEVSRPRYDRRALRTGIVHLGLGAFHRAHQACYTETLVERGDLRWGI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECH
AGVELRRRHTVERLAAQDHLYSVTERAGDAARTRVVGAVHRTLFAPQALATLLGLIADPA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCH
VSIVSLTVTEKGYYRRPGGGGLDLDDPAIRRDLAQPHAPSTTLGVLAAGIRLRAAHAPLS
HHEEEEEEECCCCEECCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCEE
VLSCDNMPSNGDTLRALLAQYAEQTDGALARRIRCDVAFPNTMVDRIVPAATPESLDWVQ
EEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHH
SRIGVRDEAAIVCEPFAQWVFEDRFAGARPRWEDAGALVAADVRPYEKMKLRLLNGSHSA
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHEEEEECCCCCH
IAYAGQLRGRRTVSDAMADPLIDALARGVMTRELLATLDVPAGYDVRAYCASLIERFRNP
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCH
ALAHRTAQIATDGTQKVPLRWLPALAESAAAGVERPFLERSLAMWLHYVEVARDESGRPL
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
VLEDPGAQALAARLHGAPGATDAVRAALGLIASRDAARWPEALTARVGAHLETVRTRGTD
EEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHH
ALLRPLLDA
HHHHHHHCC
>Mature Secondary Structure 
PLLSSDHCRALPPEVSRPRYDRRALRTGIVHLGLGAFHRAHQACYTETLVERGDLRWGI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECH
AGVELRRRHTVERLAAQDHLYSVTERAGDAARTRVVGAVHRTLFAPQALATLLGLIADPA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCH
VSIVSLTVTEKGYYRRPGGGGLDLDDPAIRRDLAQPHAPSTTLGVLAAGIRLRAAHAPLS
HHEEEEEEECCCCEECCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCEE
VLSCDNMPSNGDTLRALLAQYAEQTDGALARRIRCDVAFPNTMVDRIVPAATPESLDWVQ
EEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHH
SRIGVRDEAAIVCEPFAQWVFEDRFAGARPRWEDAGALVAADVRPYEKMKLRLLNGSHSA
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHEEEEECCCCCH
IAYAGQLRGRRTVSDAMADPLIDALARGVMTRELLATLDVPAGYDVRAYCASLIERFRNP
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCH
ALAHRTAQIATDGTQKVPLRWLPALAESAAAGVERPFLERSLAMWLHYVEVARDESGRPL
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
VLEDPGAQALAARLHGAPGATDAVRAALGLIASRDAARWPEALTARVGAHLETVRTRGTD
EEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHH
ALLRPLLDA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-mannonate; NAD(+) [C]

Specific reaction: D-mannonate + NAD(+) = D-fructuronate + NADH [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]