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The map label for this gene is aphA [H]

Identifier: 53722273

GI number: 53722273

Start: 1694154

End: 1695176

Strand: Reverse

Name: aphA [H]

Synonym: BPSS1250

Alternate gene names: 53722273

Gene position: 1695176-1694154 (Counterclockwise)

Preceding gene: 53722274

Following gene: 53722271

Centisome position: 53.42

GC content: 70.48

Gene sequence:

>1023_bases
ATGCTGACATATTTTCATCCGGACCAACTGAAGCACAGTCCGCTCACTTACCTGTCGCGCGGCAAGATGCGCGCGCCGCA
CGAAGTGCCCGAGCGGGCCGTGCGGCTGCTCGGCGCGGTGACCTCGCTCGGCTTCGACGTGCGCGCGCCCGAGGATTTCG
GCGCGGCGCCGCTCGCGGCTGTGCACAGCGAGCCGTATCTGCGCTTTCTCGCCGACGCGCATCGCGAGTGGCGGCGCATC
CCGGAGGACTGGGGGCCCGAGGTGATGTCGAACATCTACGTGCGCGAGCCGAATCCGCTGCGCGGCGTGCTCGCGCAGGC
GGGGTACTATCTCGCGGACGGCAGTTGCCCGATCGGCGAGCACACGTATCGCGCCGCGTACTGGTCCGCGCAGAGCGCGC
TCGCCGGCGCGGCGGCGCTCGGCCGCGGCGCGCGCGATGCGTACGCGCTCTGCCGCCCGCCCGGCCATCATGCGTGCCGC
GACGCGGCGGGCGGCTTCTGCTATCTGAACAACGCGGCGATCGCCGCGCAGGCGTTGCGCGCGCGCCATGCGCGCGTGGC
GATCCTCGATACCGACATGCATCACGGCCAGGGCATCCAGACGCTGTTCTACGATCGCGACGACGTGCTGTACGTGTCGA
TTCACGGCGATCCGACGAACTTCTATCCGGCCGTCACCGGTTACGAAACGGAGCGCGGGGCGGGGCGCGGCGAGGGCTTC
AACGTGAACCTGCCGATGCCGCACGGCTCGCCCGAAGCGGTGTTCTTCGCGCAGCTCGAGCGCGCGAGGTCGCGCGTCGA
GCGCTTCGCGCCGGACGTGCTGGTGTTCGCGCTCGGCTTCGACGTGTATCGCGAGGACCCGCAGTCGAAGGTCGCGGTGA
CGACCGAAGGCTTCGGGCGGCTCGGCGCGCTCGTCGGCGGCCTGCGGGTGCCGACGCTGATCGTGCAGGAAGGCGGCTAT
CACCTCGAGACGCTCGAGCGCAACGCCGCCGCGCTGTTTCGCGGTTACGAGGCGGCGCGTTGA

Upstream 100 bases:

>100_bases
GCGCCCGGCGCCGGCGATGCAGGCCGCGCATTCGGGCACGGACGCGGGCACCTTCGCGCAGCCGCATTGACCGATCGATC
GTGGAGCGAAGCGACCCCGC

Downstream 100 bases:

>100_bases
TCGCGCGCGCCTGAGCGCCGGGACGGCGGCTTTTCCGCCCCGACGCCGACGGGTTTCGTTGGTTCGGCACTAGTGGCTGA
TCGAGGCTAGTGCGCCGCCC

Product: acetylpolyamine aminohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAAVHSEPYLRFLADAHREWRRI
PEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGEHTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACR
DAAGGFCYLNNAAIAAQALRARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGF
NVNLPMPHGSPEAVFFAQLERARSRVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGRLGALVGGLRVPTLIVQEGGY
HLETLERNAAALFRGYEAAR

Sequences:

>Translated_340_residues
MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAAVHSEPYLRFLADAHREWRRI
PEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGEHTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACR
DAAGGFCYLNNAAIAAQALRARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGF
NVNLPMPHGSPEAVFFAQLERARSRVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGRLGALVGGLRVPTLIVQEGGY
HLETLERNAAALFRGYEAAR
>Mature_340_residues
MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAAVHSEPYLRFLADAHREWRRI
PEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGEHTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACR
DAAGGFCYLNNAAIAAQALRARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGF
NVNLPMPHGSPEAVFFAQLERARSRVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGRLGALVGGLRVPTLIVQEGGY
HLETLERNAAALFRGYEAAR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=219, Percent_Identity=38.3561643835616, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI13128864, Length=326, Percent_Identity=30.9815950920245, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI169234807, Length=222, Percent_Identity=36.9369369369369, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI148539870, Length=222, Percent_Identity=36.9369369369369, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI13128860, Length=312, Percent_Identity=25.9615384615385, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI17158039, Length=219, Percent_Identity=34.2465753424658, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI262073088, Length=211, Percent_Identity=31.7535545023697, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI8923769, Length=213, Percent_Identity=30.5164319248826, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI30795204, Length=217, Percent_Identity=33.6405529953917, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI30795202, Length=217, Percent_Identity=33.6405529953917, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI153085395, Length=194, Percent_Identity=36.0824742268041, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI226529806, Length=218, Percent_Identity=36.2385321100917, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI293336691, Length=290, Percent_Identity=26.2068965517241, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI62750347, Length=195, Percent_Identity=37.4358974358974, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI62750349, Length=195, Percent_Identity=37.4358974358974, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13128862, Length=232, Percent_Identity=27.5862068965517, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI262073092, Length=146, Percent_Identity=31.5068493150685, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17540334, Length=203, Percent_Identity=39.4088669950739, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17540332, Length=203, Percent_Identity=39.4088669950739, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193206283, Length=203, Percent_Identity=39.4088669950739, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193209491, Length=288, Percent_Identity=30.9027777777778, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17561978, Length=307, Percent_Identity=26.7100977198697, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508561, Length=312, Percent_Identity=26.2820512820513, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17534739, Length=284, Percent_Identity=27.4647887323944, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17537347, Length=231, Percent_Identity=30.3030303030303, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25154022, Length=220, Percent_Identity=28.6363636363636, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25154020, Length=220, Percent_Identity=28.6363636363636, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=221, Percent_Identity=35.2941176470588, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323999, Length=214, Percent_Identity=30.3738317757009, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321244, Length=265, Percent_Identity=26.4150943396226, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325325, Length=152, Percent_Identity=29.6052631578947, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281360801, Length=232, Percent_Identity=38.3620689655172, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281360799, Length=232, Percent_Identity=38.3620689655172, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24641720, Length=232, Percent_Identity=38.3620689655172, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24657891, Length=315, Percent_Identity=27.3015873015873, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24644244, Length=214, Percent_Identity=32.2429906542056, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24642146, Length=241, Percent_Identity=36.9294605809129, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24642144, Length=241, Percent_Identity=36.9294605809129, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24642142, Length=241, Percent_Identity=36.9294605809129, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281360899, Length=241, Percent_Identity=36.9294605809129, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37331; Mature: 37331

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAA
CCCCCCHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VHSEPYLRFLADAHREWRRIPEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGE
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCEEEECCCHHHHHHHHCCEEEECCCCCCCC
HTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACRDAAGGFCYLNNAAIAAQALR
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHCCCCEEEECCHHHHHHHHH
ARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGF
HHCCEEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCE
NVNLPMPHGSPEAVFFAQLERARSRVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGR
EEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHCCCCCEEEEEECCHHH
LGALVGGLRVPTLIVQEGGYHLETLERNAAALFRGYEAAR
HHHHHCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAA
CCCCCCHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VHSEPYLRFLADAHREWRRIPEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGE
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCEEEECCCHHHHHHHHCCEEEECCCCCCCC
HTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACRDAAGGFCYLNNAAIAAQALR
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHCCCCEEEECCHHHHHHHHH
ARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGF
HHCCEEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCE
NVNLPMPHGSPEAVFFAQLERARSRVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGR
EEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHCCCCCEEEEEECCHHH
LGALVGGLRVPTLIVQEGGYHLETLERNAAALFRGYEAAR
HHHHHCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]