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The map label for this gene is gyaR [H]

Identifier: 53720065

GI number: 53720065

Start: 2964859

End: 2965848

Strand: Reverse

Name: gyaR [H]

Synonym: BPSL2459

Alternate gene names: 53720065

Gene position: 2965848-2964859 (Counterclockwise)

Preceding gene: 53720066

Following gene: 53720064

Centisome position: 72.79

GC content: 70.71

Gene sequence:

>990_bases
ATGCAGAAAATCCTGGTCGCGCGCCCGATCTTTCCGGACGTGATCGAGCGGCTCAAGCAGTATTTCGACGTCGACTGGAA
CGACGGCGACGCGCTCGCCCCCGATGCGCTGAAGGCGCGCCTCGCGGACAAGGACGGCGCGCTGACGGCGGGCGACATGA
TCGACGCGTCGGTGCTCGCGGCCGCGCCGCGGCTGCGCGTCGTGTCGAACATGGCAGTCGGCTACAACAACTTCGACATC
GGCGCGTTCGACGCCGCGCACGTGCTCGGCACCAACACGCCCGACGTGCTGACCGAGACGACGGCCGATTTCGGCTGGGC
GCTGATGATGGCGGCCGCGCGGCGGATCACCGAATCCGAGCACTGGCTGCGCGCGGGGCAATGGCGCAAGTGGTCGTACG
ACAGCTTTCTCGGCGCGGACATTCACGGCGCGACGCTCGGCGTGCTCGGCATGGGCCGCATCGGCCAGGCGCTCGCGCGC
CGCGCGCGCGGCTTCGGCATGCGCGTGATCTATCACAACCGCTCGCGCGTCGCGCCCGAGATCGAGGCCGCGCTCAACGC
CGAATACGTGCCGAAGGCGGCGCTGCTCGCGCAAGCCGATCACGTCGTGCTCGTGCTGCCGTACTCGGCGCAAAGTCATC
ACACGATCGGCGCGGCCGAGCTCGCGCTGATGAAGCCGAGCGCGACGCTCACGAACATCGCGCGCGGCGGGATCGTCGAC
GACGCGGCGCTCGCCGACGCGCTGCGCGAGAAGCGGATCGCGGCGGCGGGCCTCGACGTGTTCGAAGGCGAGCCGAGCGT
GCATCCGGCGCTGCTCGACGTGCCGAACGTCGTGCTGACGCCGCACATCGCGAGCGCGAGCGAAGGCACGCGCCGCGCGA
TGGCGAATCTCGCGGCGGACAACCTGATCGCGGCGCTCGGCGCGGGCCCGCGCGCGGGCCGCCCGCCGAATCCGATCAAT
CCCGGCGTGCTGGGGAAGGCTCGCATATGA

Upstream 100 bases:

>100_bases
CGTGGGTGTTCTTCAGCGCTCAGGCGGCGCAATGACGGCCGCACGGGCGATGCGCGGCGCGATGCGCGCGCGCCGCCCGC
GCGGCGCAACGGAGACGGCA

Downstream 100 bases:

>100_bases
CCGAAACCTTGTTGCTGGCCGCGATCGTCGCGCTCGCGGTGGCGCTCGTCGTCGCGCTCGTCATGCTGTTGCGCGGCGGC
CCGCGCGGCGGTGGCCTCGA

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALKARLADKDGALTAGDMIDASVLAAAPRLRVVSNMAVGYNNFDI
GAFDAAHVLGTNTPDVLTETTADFGWALMMAAARRITESEHWLRAGQWRKWSYDSFLGADIHGATLGVLGMGRIGQALAR
RARGFGMRVIYHNRSRVAPEIEAALNAEYVPKAALLAQADHVVLVLPYSAQSHHTIGAAELALMKPSATLTNIARGGIVD
DAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNVVLTPHIASASEGTRRAMANLAADNLIAALGAGPRAGRPPNPIN
PGVLGKARI

Sequences:

>Translated_329_residues
MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALKARLADKDGALTAGDMIDASVLAAAPRLRVVSNMAVGYNNFDI
GAFDAAHVLGTNTPDVLTETTADFGWALMMAAARRITESEHWLRAGQWRKWSYDSFLGADIHGATLGVLGMGRIGQALAR
RARGFGMRVIYHNRSRVAPEIEAALNAEYVPKAALLAQADHVVLVLPYSAQSHHTIGAAELALMKPSATLTNIARGGIVD
DAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNVVLTPHIASASEGTRRAMANLAADNLIAALGAGPRAGRPPNPIN
PGVLGKARI
>Mature_329_residues
MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALKARLADKDGALTAGDMIDASVLAAAPRLRVVSNMAVGYNNFDI
GAFDAAHVLGTNTPDVLTETTADFGWALMMAAARRITESEHWLRAGQWRKWSYDSFLGADIHGATLGVLGMGRIGQALAR
RARGFGMRVIYHNRSRVAPEIEAALNAEYVPKAALLAQADHVVLVLPYSAQSHHTIGAAELALMKPSATLTNIARGGIVD
DAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNVVLTPHIASASEGTRRAMANLAADNLIAALGAGPRAGRPPNPIN
PGVLGKARI

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=290, Percent_Identity=34.8275862068965, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI23308577, Length=302, Percent_Identity=30.1324503311258, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=37.6, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=37.6, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4557497, Length=268, Percent_Identity=35.4477611940299, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI61743967, Length=268, Percent_Identity=35.4477611940299, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=37.6, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=41.5384615384615, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1789279, Length=309, Percent_Identity=28.4789644012945, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787645, Length=251, Percent_Identity=29.0836653386454, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=31.1475409836066, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=26.3779527559055, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=34.9593495934959, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=279, Percent_Identity=26.5232974910394, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=25.0764525993884, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6325144, Length=144, Percent_Identity=31.9444444444444, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=169, Percent_Identity=30.1775147928994, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=36.1022364217252, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=36.1022364217252, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=36.1022364217252, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=36.1022364217252, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=36.1022364217252, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28574286, Length=262, Percent_Identity=38.5496183206107, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28571528, Length=310, Percent_Identity=36.1290322580645, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24585516, Length=260, Percent_Identity=33.8461538461538, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19921140, Length=316, Percent_Identity=30.0632911392405, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24646446, Length=252, Percent_Identity=34.5238095238095, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24646448, Length=252, Percent_Identity=34.5238095238095, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24646452, Length=252, Percent_Identity=34.5238095238095, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24646450, Length=252, Percent_Identity=34.5238095238095, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI62472511, Length=252, Percent_Identity=34.5238095238095, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34948; Mature: 34948

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALKARLADKDGALTAGDMIDASVLA
CCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEECHHHHHHHHH
AAPRLRVVSNMAVGYNNFDIGAFDAAHVLGTNTPDVLTETTADFGWALMMAAARRITESE
HCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HWLRAGQWRKWSYDSFLGADIHGATLGVLGMGRIGQALARRARGFGMRVIYHNRSRVAPE
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCCHH
IEAALNAEYVPKAALLAQADHVVLVLPYSAQSHHTIGAAELALMKPSATLTNIARGGIVD
HHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCHHHEEEECCCHHHHHHHCCCCCC
DAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNVVLTPHIASASEGTRRAMANLAAD
HHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHCCCCEEECCCCCCCCCHHHHHHHHHHHH
NLIAALGAGPRAGRPPNPINPGVLGKARI
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKILVARPIFPDVIERLKQYFDVDWNDGDALAPDALKARLADKDGALTAGDMIDASVLA
CCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEECHHHHHHHHH
AAPRLRVVSNMAVGYNNFDIGAFDAAHVLGTNTPDVLTETTADFGWALMMAAARRITESE
HCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HWLRAGQWRKWSYDSFLGADIHGATLGVLGMGRIGQALARRARGFGMRVIYHNRSRVAPE
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCCHH
IEAALNAEYVPKAALLAQADHVVLVLPYSAQSHHTIGAAELALMKPSATLTNIARGGIVD
HHHHCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCHHHEEEECCCHHHHHHHCCCCCC
DAALADALREKRIAAAGLDVFEGEPSVHPALLDVPNVVLTPHIASASEGTRRAMANLAAD
HHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHCCCCEEECCCCCCCCCHHHHHHHHHHHH
NLIAALGAGPRAGRPPNPINPGVLGKARI
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA