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The map label for this gene is guaB [H]

Identifier: 53719740

GI number: 53719740

Start: 2557817

End: 2559277

Strand: Reverse

Name: guaB [H]

Synonym: BPSL2129

Alternate gene names: 53719740

Gene position: 2559277-2557817 (Counterclockwise)

Preceding gene: 53719741

Following gene: 53719739

Centisome position: 62.81

GC content: 67.42

Gene sequence:

>1461_bases
ATGCGTCTGATCCAAAAAGCACTCACGTTCGATGACGTGCTCCTCGTCCCGGCGTTCTCCGACGTTCTGCCGCGCGACAC
CAGCCTCAAGACCCAGCTGACCCGCAACATCTCCCTGAACATGCCGCTCGTGTCCGCCGCGATGGACACGGTCACCGAAG
GCCGCCTCGCGATCGCGATGGCGCAGCAAGGCGGCGTCGGCATCGTCCACAAGAATCTCACCCCCGTCGAGCAGGCGCGC
GAGGTCGCGAAGGTCAAGCGCTTCGAATCGGGCGTCGTGCGCGATCCGATCACCGTTCCGCCGAGCATGAAGGTGCGCGA
CGTGATCGCGCTGTCGCGCCAGCATGGCATCTCGGGCTTCCCGGTCGTCGAAGGTCCGAAGCTCGTCGGCATCGTGACGA
ACCGCGACCTGCGCTTCGAAACCCGCCTCGACGAGCCGGTCAAGTCGATCATGACGCCGCGCGAGCGCCTCGTGACGGTG
GCCGAGGGCACGCCGCTCGCCGAGGCGAAGGCGCTGATGCACAGCCACCGTCTCGAGCGCGTGCTCGTCGTCAACGACGC
GTTCGAGCTGCGCGGCCTGATGACGGTCAAGGACATCACGAAGCAGACCGAGCACCCGGAAGCGTGCAAGGACGAGCACG
GCAAGCTGCGCGTCGGCGCGGCGGTCGGCGTCGGTGCGGACAACGAAGAGCGTGTCGAGCTGCTCGTGCAGGCGGGCGTC
GACGTGATCGTCGTCGATACCGCGCACGGCCACAGCAAGGGCGTGCTCGAGCGCGTGCGCTGGGTCAAGCAGAACTTCCC
GAAGGTCGAGGTGATCGGCGGCAACATCGCGACCGCGGCTGCCGCGAAGGCACTCGTCGAATACGGCGCGGACGCGGTGA
AGGTCGGCATCGGCCCGGGCTCGATCTGTACGACGCGGATCGTCGCGGGCGTCGGCGTGCCGCAGATCAGCGCGATCGCG
AACGTGTCGGATGCGCTGCGCGGCACCGGCGTGCCGTGCGTCGCCGACGGCGGCATCCGCTTCTCGGGCGACGTGTCGAA
GGCGCTCGCCGCCGGCGCGAACGCGGTGATGATGGGCAGCATGTTCGCCGGCACCGAAGAGGCGCCGGGCGACGTGTTCC
TCTACCAGGGCCGCCAGTACAAGTCGTATCGCGGCATGGGCTCGGTCGGCGCGATGAAGGACGGCGCGGCGGACCGCTAC
TTCCAGGACAACTCCGCGAACATCGACAAGCTCGTGCCGGAAGGCATCGAAGGCCGCGTCGCGTACAAGGGCTCGGTCAA
CGCGATCATCTTCCAGTTGATCGGCGGCGTGCGCGCGAGCATGGGCTACTGCGGCTGCAAGACGATCGCCGAGCTGCACG
AGAAGGCCGAGTTCGTTCAGATCACCGCAGCCGGCATGCGCGAGTCGCACGTGCACGACGTGCAGATCACGAAGGAAGCC
CCCAACTATCACGTGGACTGA

Upstream 100 bases:

>100_bases
ATCCGAACGATTCGGGGCCCAAACGGCTAAGCCGTTGTTCGTGTTGTGAAAATTAACCGGGCATCGCGTATAATTCGGTT
TTGCGCCTATAGGATTTGCC

Downstream 100 bases:

>100_bases
TCGCCGATGAAACCGTTGCTGCGCGCCGTTCTTCTGATCGATGCCGTGCTGCTCGCCGCGTTCGGCGTGCTGTTCGTGCT
GACCCCGTGGAAAGCGCTGT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTQLTRNISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPVEQAR
EVAKVKRFESGVVRDPITVPPSMKVRDVIALSRQHGISGFPVVEGPKLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
AEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPEACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPKVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSDALRGTGVPCVADGGIRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAIIFQLIGGVRASMGYCGCKTIAELHEKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD

Sequences:

>Translated_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTQLTRNISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPVEQAR
EVAKVKRFESGVVRDPITVPPSMKVRDVIALSRQHGISGFPVVEGPKLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
AEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPEACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPKVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSDALRGTGVPCVADGGIRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAIIFQLIGGVRASMGYCGCKTIAELHEKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD
>Mature_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTQLTRNISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIVHKNLTPVEQAR
EVAKVKRFESGVVRDPITVPPSMKVRDVIALSRQHGISGFPVVEGPKLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
AEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPEACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQNFPKVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSDALRGTGVPCVADGGIRFSGDVSKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAIIFQLIGGVRASMGYCGCKTIAELHEKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=41.9624217118998, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=41.9624217118998, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=41.9624217118998, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=41.9624217118998, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.4564315352697, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI217035152, Length=475, Percent_Identity=41.8947368421053, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=41.1273486430063, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=39.0396659707724, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI156104880, Length=262, Percent_Identity=36.2595419847328, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI50541956, Length=248, Percent_Identity=36.6935483870968, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=36.6935483870968, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=36.6935483870968, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=36.6935483870968, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=62.8336755646817, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1786293, Length=239, Percent_Identity=34.3096234309623, Blast_Score=142, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=38.0753138075314, Blast_Score=303, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI71994389, Length=425, Percent_Identity=39.2941176470588, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=36.8200836820084, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=38.7295081967213, Blast_Score=352, Evalue=5e-98,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=39.4628099173554, Blast_Score=350, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=39.2561983471074, Blast_Score=343, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=38.5964912280702, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6319353, Length=142, Percent_Identity=35.9154929577465, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=40.6185567010309, Blast_Score=352, Evalue=4e-97,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=40.6185567010309, Blast_Score=352, Evalue=4e-97,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=41.3092550790068, Blast_Score=318, Evalue=6e-87,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51899; Mature: 51899

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTQLTRNISLNMPLVSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHCCCEEECCCHHHHHHHHHCCCCEEEEE
AQQGGVGIVHKNLTPVEQAREVAKVKRFESGVVRDPITVPPSMKVRDVIALSRQHGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PVVEGPKLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTVAEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCEEEHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPEACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHCCCCCCHHHCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQNFPKVEVIGGNIATAAAAKALVEYGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQISAIANVSDALRGTGVPCVADGGIRFSGDVSKALAAGANAVMMGS
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCCHHHHHHCCCCEEEEEH
MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAIIFQLIGGVRASMGYCGCKTIAELHEKAEFVQITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEECC
PNYHVD
CCCCCC
>Mature Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTQLTRNISLNMPLVSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCHHHHHCCCEEECCCHHHHHHHHHCCCCEEEEE
AQQGGVGIVHKNLTPVEQAREVAKVKRFESGVVRDPITVPPSMKVRDVIALSRQHGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PVVEGPKLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTVAEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCEEEHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPEACKDEHGKLRVGAAVGVGADNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHCCCCCCHHHCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQNFPKVEVIGGNIATAAAAKALVEYGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQISAIANVSDALRGTGVPCVADGGIRFSGDVSKALAAGANAVMMGS
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCCHHHHHHCCCCEEEEEH
MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAIIFQLIGGVRASMGYCGCKTIAELHEKAEFVQITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEECC
PNYHVD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA