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The map label for this gene is glxR [H]

Identifier: 53719720

GI number: 53719720

Start: 2534521

End: 2535408

Strand: Reverse

Name: glxR [H]

Synonym: BPSL2109

Alternate gene names: 53719720

Gene position: 2535408-2534521 (Counterclockwise)

Preceding gene: 53719723

Following gene: 53719715

Centisome position: 62.23

GC content: 73.99

Gene sequence:

>888_bases
GTGGACGTGGGATTTTGCGGACCGGGGTTGATGGGCGCGCCGATGATCCGGCATCTGCTGACGGCGGGCCATCGGGTGCA
CGTATGGAACCGCACGCGGGCGAAGGCCGATGCGCTTGCCGGGTGCGGCGCGCAGGTCGTCGATACGCCGGCCGAGCTCG
CCGCGCGCGCGCAGACGGTGATGCTGTGCGTGCTCGACGCGCAGGCGGTGGGCGACGTCGTGTTCGGTGCGTCCGGCGTG
CTCGCGGGGGACGCCGCGACGCGCCGCGTGCGGCGCATCGTCGATCATTCGAGCATTGCGCCCGCGGCGACGCGCGCCTA
TGCGGCGCGCGCGGCGGCGCTCGGCGTGAGCTGGATCGACGCGCCGGTGTCGGGCGGCGTGCCGGGCGCCGAGGCGGGCA
CGCTCGCGGTGATGGCGGGCGGCCCGCAAGCGGACGTCGATGCGGTGCGCGTGCTGATCGGCGCGTACGCGGCGCGCGTC
ACGCATCTCGGCGACGCGGGCGCGGGGCAGACGGCAAAGCTGTGCAACCAGGCCATCGTCACGGCGACCGTCACGGCGAT
CGCGGAAGCGGTGGGGCTCGCGCAGGCGAGCGGCATCGACGCGGCGCGCCTTGCCGAAGCGCTGGCGGGCGGTTGGGCCG
ATTCGGTGCTGCTGCAGACGTTCGTGCCGCGGATGACGCGCGCGGGTCATCCGCCGATCGGCGCGCTGAAGACGTTTCAG
AAGGACGTCGACGCCATTGCCGATGCGGCGCGCGACGCGGGCGCGGTGATGCCCGTTGCATCGACGGTGCAGCAGGTGCT
GCGGCTCGGCGCGGCGATGGGGCTCGCGCAGGCCGATTTCGCGGCGTTCATCGACATCGTGCGGCCGCAGGCGAAGCGAG
GCGCGTGA

Upstream 100 bases:

>100_bases
AAGCAGCGCGCATCCGGCGTGCCCGCGCATGCCTTCTTGAGTGATAGGTATGATGGGCGGCAACTTCAACCGGTATTCGA
ACGAGAGGAAAGGGGAACAC

Downstream 100 bases:

>100_bases
TCGGCACGAGCGCGCGTGGGGGCTTGCGGCGCGGCGGCGGCGCGCAACTCGCCTTGCCTCATTTGCCTCATGCCTCCGCC
GCGCAATGCGCCGAAAACCC

Product: putative glyoxylate-like oxidoreductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MDVGFCGPGLMGAPMIRHLLTAGHRVHVWNRTRAKADALAGCGAQVVDTPAELAARAQTVMLCVLDAQAVGDVVFGASGV
LAGDAATRRVRRIVDHSSIAPAATRAYAARAAALGVSWIDAPVSGGVPGAEAGTLAVMAGGPQADVDAVRVLIGAYAARV
THLGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTRAGHPPIGALKTFQ
KDVDAIADAARDAGAVMPVASTVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGA

Sequences:

>Translated_295_residues
MDVGFCGPGLMGAPMIRHLLTAGHRVHVWNRTRAKADALAGCGAQVVDTPAELAARAQTVMLCVLDAQAVGDVVFGASGV
LAGDAATRRVRRIVDHSSIAPAATRAYAARAAALGVSWIDAPVSGGVPGAEAGTLAVMAGGPQADVDAVRVLIGAYAARV
THLGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTRAGHPPIGALKTFQ
KDVDAIADAARDAGAVMPVASTVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGA
>Mature_295_residues
MDVGFCGPGLMGAPMIRHLLTAGHRVHVWNRTRAKADALAGCGAQVVDTPAELAARAQTVMLCVLDAQAVGDVVFGASGV
LAGDAATRRVRRIVDHSSIAPAATRAYAARAAALGVSWIDAPVSGGVPGAEAGTLAVMAGGPQADVDAVRVLIGAYAARV
THLGDAGAGQTAKLCNQAIVTATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTRAGHPPIGALKTFQ
KDVDAIADAARDAGAVMPVASTVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=298, Percent_Identity=27.8523489932886, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=29.6819787985866, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=35.2112676056338, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI145693186, Length=284, Percent_Identity=34.8591549295775, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=27.5261324041812, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1789092, Length=246, Percent_Identity=27.6422764227642, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17557316, Length=296, Percent_Identity=27.3648648648649, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655230, Length=298, Percent_Identity=30.8724832214765, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19922568, Length=298, Percent_Identity=30.8724832214765, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=26.7857142857143, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29662; Mature: 29662

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVGFCGPGLMGAPMIRHLLTAGHRVHVWNRTRAKADALAGCGAQVVDTPAELAARAQTV
CCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCHHHCCHHHHHHHHHHH
MLCVLDAQAVGDVVFGASGVLAGDAATRRVRRIVDHSSIAPAATRAYAARAAALGVSWID
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
APVSGGVPGAEAGTLAVMAGGPQADVDAVRVLIGAYAARVTHLGDAGAGQTAKLCNQAIV
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTRAGHPPIGALKTFQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KDVDAIADAARDAGAVMPVASTVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MDVGFCGPGLMGAPMIRHLLTAGHRVHVWNRTRAKADALAGCGAQVVDTPAELAARAQTV
CCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCHHHCCHHHHHHHHHHH
MLCVLDAQAVGDVVFGASGVLAGDAATRRVRRIVDHSSIAPAATRAYAARAAALGVSWID
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
APVSGGVPGAEAGTLAVMAGGPQADVDAVRVLIGAYAARVTHLGDAGAGQTAKLCNQAIV
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TATVTAIAEAVGLAQASGIDAARLAEALAGGWADSVLLQTFVPRMTRAGHPPIGALKTFQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KDVDAIADAARDAGAVMPVASTVQQVLRLGAAMGLAQADFAAFIDIVRPQAKRGA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]