| Definition | Burkholderia pseudomallei K96243 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_006350 |
| Length | 4,074,542 |
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The map label for this gene is alaS [H]
Identifier: 53719621
GI number: 53719621
Start: 2395633
End: 2398257
Strand: Reverse
Name: alaS [H]
Synonym: BPSL2009
Alternate gene names: 53719621
Gene position: 2398257-2395633 (Counterclockwise)
Preceding gene: 53719623
Following gene: 53719619
Centisome position: 58.86
GC content: 68.38
Gene sequence:
>2625_bases ATGAAAGCCGCCGAAATCCGCGAGAAATTCCTCAAGTTCTTCGAATCGAAGGGCCACACGATCGTCCGCTCGTCGAGCCT CGTGCCCGGCAACGACCCCACGCTGCTCTTCACCAATTCGGGAATGGTGCAGTTCAAGGACGTGTTCCTCGGCGCGGAGA CGCGCCCGTATTCCCGCGCGACCACCGCGCAGCGCAGCGTGCGCGCGGGCGGCAAGCACAACGATCTCGAGAACGTCGGC TACACCGCGCGTCACCATACGTTCTTCGAGATGCTCGGCAACTTCTCGTTCGGCGATTACTTCAAGCGCGACGCGATCCA TTACGCGTGGGAGCTGCTGACGAGCGTCTACAAGCTGCCCGCCGACAAGCTCTGGGTCACCGTCTACCATGACGACGACG AAGCCTATGACATCTGGGCGAAGGAAGTCGGCGTGCCTGCCGAGCGGATCATCCGGATCGGCGACAACAAGGGCGCGCGC TACGCGTCGGACAACTTCTGGCAGATGGGCGACACCGGCCCGTGCGGCCCGTGCTCGGAAATCTTCTACGACCACGGCCC GGACGTGTGGGGCGGCCCGCCCGGATCGCCCGAGGAAGACGGCGACCGCTACATCGAGATCTGGAACCTCGTGTTCATGC AGTTCAACCGCGACGCGCAGGGCAACATGACGCGCCTGCCGAAGCCGTGCGTCGACACCGGCATGGGCCTCGAGCGGATC GCGGCCGTGCTGCAGCACGTGCACAGCAACTACGAGATCGATCTGTTCCAGCAGTTGATCAAGGCGTCGGCGCGCGAGAC GGGCGTCGCCGATCTCGCGAACAACTCGCTGAAGGTGATCGCCGATCACATCCGCGCGTGCTCGTTCCTGATCGTCGACG GCGTGATCCCCGGCAACGAAGGCCGCGGCTACGTGCTGCGCCGGATCGTGCGCCGCGCGATCCGCCACGGCTACAAGCTC GGCCGCAAGGCGCCGTTCTTCCACAAGCTCGTGGCCGACCTCGTCGCCGAGATGGGCGCCGCCTATCCGGAGCTGAAGGA AGCCGAGCCGCGCGTGACCGACGTGCTGCGCCAGGAGGAGGAGCGCTTCTTCGAGACGATCGAGCACGGGATGTCGATTC TCGAGGCGGCGCTCGCCGAACTGGACGCCGCGGGCGGCAAGACGCTCGACGGCGAGCTCGCGTTCAAGCTGCACGACACG TACGGCTTCCCGCTCGATCTGACGGCCGACGTGTGCCGCGAGCGCGGTGTGACGGTCGACGAGCCGGCGTTCGACGACGC GATGGCGCGCCAGCGCGAGCAGGCGCGCGCGGCGGGCAAGTTCAAGGCGACGCAGGGCCTCGAATACACGGGCGCGAAGA CGACGTTCCACGGCTACGAGGAAATCGCGTTCGACGACGCGAAGGTCGTCGCGCTGTACGTCGAAGGCGCGTCGGTCGGC GAAGTGAAGGCGGGCGAGAGCGCGGTGGTGGTGCTCGACCACACGCCGTTCTACGCGGAATCGGGTGGCCAGGTCGGCGA CCAGGGCGTGCTCGCGAACGCGGCCACGCGTTTTGCGGTCGGCGATACGCTGAAGGTCCAGGCCGACGTGATCGGCCACC ACGGCGAGCTCGAGCAGGGCACGCTGAAGGTGGGCGACGTGGTCCGCGCGGAGATCGACGCCGCGCGCCGCGCGCGCACT GCGCGCAACCACTCGGCGACGCACCTGATGCACAAGGCGCTGCGCGACGTGCTCGGCTCGCACGTGCAGCAGAAGGGCTC GCTCGTCGACGCGGACAAGACCCGCTTCGACTTCGCGCACAACGCGCCGCTGACCGACGACGAAATCCGCCGCGTCGAGG CCATCGTCAACGAGCAGGTGCTTGCGAACGCGCCGGGCATCGTGCGCGTGATGCCGTACGACGACGCGGTGAAGGGCGGC GCGATGGCGCTCTTCGGCGAGAAGTACGGCGACGAGGTGCGCGTGCTCGATCTCGGCTTCTCGCGCGAGCTGTGCGGCGG CACGCACGTGCACCGCACGGGCGACATCGGCCTGTTCAAGATCGTCGCGGAAGGCGGCGTCGCGGCGGGCATTCGCCGCG TCGAGGCGATCACGGGCGATAACGCGGTGCGCTATGTGCAGGCGCTCGACGCGCGCGTGAACGCGGCGGCCGCCGCGCTG AAGGCGCAGCCGTCCGAGCTGCTGCAGCGCATCGGCCAGGTGCAGGATCAGGTCAAGTCGCTCGAGAAGGAGCTGGGCGC GCTGAAGTCGAAGCTCGCGTCGAGCCAGGGCGACGAGCTCGCGCAGCAGGCGGTCGAAGTGGGCGGCGTGCACGTGCTTG CCGCGACGCTCGACGGCGCCGATGCGAAGACGCTGCGCGAAACCGTCGACAAGCTGAAGGACAAGCTCAAGAGCGCGGCG ATCGTGCTCGCGGCGGTCGACGGCGGCAAGGTGAGCCTGATCGCCGGCGTCACGGCGGATGCAAGCAAGAAAGTGAAGGC GGGCGAGCTCGTGAACTTCGTCGCGCAGCAGGTGGGCGGCAAGGGCGGCGGCCGGCCGGACATGGCGCAGGCGGGCGGCA CGGAGCCGGCGAAGCTGCCGGCGGCGCTCGCGGGCGTCAAGGGCTGGGTCGAGGCGCGGCTGTAA
Upstream 100 bases:
>100_bases TCTATCCCGTATAATCGATTGTTTCAGAAACCCGCCGCCGCCCGCCTGAGCCGCAGCGGCAGGCGTTCAACCCAGTTTGG CCCGACCGTCCCCGCACGCT
Downstream 100 bases:
>100_bases CGCGGCCGGGCCGCGGCGCGCCCGGAATCGGCGCGCCGCGTTTGCGCTGTTTTGCATCCGCAGCCAGGTGGCTGCTGTTA CGTGACTGCTGTTTCGTGAT
Product: alanyl-tRNA synthetase
Products: NA
Alternate protein names: Alanine--tRNA ligase; AlaRS [H]
Number of amino acids: Translated: 874; Mature: 874
Protein sequence:
>874_residues MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLLFTNSGMVQFKDVFLGAETRPYSRATTAQRSVRAGGKHNDLENVG YTARHHTFFEMLGNFSFGDYFKRDAIHYAWELLTSVYKLPADKLWVTVYHDDDEAYDIWAKEVGVPAERIIRIGDNKGAR YASDNFWQMGDTGPCGPCSEIFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKPCVDTGMGLERI AAVLQHVHSNYEIDLFQQLIKASARETGVADLANNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKL GRKAPFFHKLVADLVAEMGAAYPELKEAEPRVTDVLRQEEERFFETIEHGMSILEAALAELDAAGGKTLDGELAFKLHDT YGFPLDLTADVCRERGVTVDEPAFDDAMARQREQARAAGKFKATQGLEYTGAKTTFHGYEEIAFDDAKVVALYVEGASVG EVKAGESAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVGDTLKVQADVIGHHGELEQGTLKVGDVVRAEIDAARRART ARNHSATHLMHKALRDVLGSHVQQKGSLVDADKTRFDFAHNAPLTDDEIRRVEAIVNEQVLANAPGIVRVMPYDDAVKGG AMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGLFKIVAEGGVAAGIRRVEAITGDNAVRYVQALDARVNAAAAAL KAQPSELLQRIGQVQDQVKSLEKELGALKSKLASSQGDELAQQAVEVGGVHVLAATLDGADAKTLRETVDKLKDKLKSAA IVLAAVDGGKVSLIAGVTADASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPAKLPAALAGVKGWVEARL
Sequences:
>Translated_874_residues MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLLFTNSGMVQFKDVFLGAETRPYSRATTAQRSVRAGGKHNDLENVG YTARHHTFFEMLGNFSFGDYFKRDAIHYAWELLTSVYKLPADKLWVTVYHDDDEAYDIWAKEVGVPAERIIRIGDNKGAR YASDNFWQMGDTGPCGPCSEIFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKPCVDTGMGLERI AAVLQHVHSNYEIDLFQQLIKASARETGVADLANNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKL GRKAPFFHKLVADLVAEMGAAYPELKEAEPRVTDVLRQEEERFFETIEHGMSILEAALAELDAAGGKTLDGELAFKLHDT YGFPLDLTADVCRERGVTVDEPAFDDAMARQREQARAAGKFKATQGLEYTGAKTTFHGYEEIAFDDAKVVALYVEGASVG EVKAGESAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVGDTLKVQADVIGHHGELEQGTLKVGDVVRAEIDAARRART ARNHSATHLMHKALRDVLGSHVQQKGSLVDADKTRFDFAHNAPLTDDEIRRVEAIVNEQVLANAPGIVRVMPYDDAVKGG AMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGLFKIVAEGGVAAGIRRVEAITGDNAVRYVQALDARVNAAAAAL KAQPSELLQRIGQVQDQVKSLEKELGALKSKLASSQGDELAQQAVEVGGVHVLAATLDGADAKTLRETVDKLKDKLKSAA IVLAAVDGGKVSLIAGVTADASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPAKLPAALAGVKGWVEARL >Mature_874_residues MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLLFTNSGMVQFKDVFLGAETRPYSRATTAQRSVRAGGKHNDLENVG YTARHHTFFEMLGNFSFGDYFKRDAIHYAWELLTSVYKLPADKLWVTVYHDDDEAYDIWAKEVGVPAERIIRIGDNKGAR YASDNFWQMGDTGPCGPCSEIFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKPCVDTGMGLERI AAVLQHVHSNYEIDLFQQLIKASARETGVADLANNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKL GRKAPFFHKLVADLVAEMGAAYPELKEAEPRVTDVLRQEEERFFETIEHGMSILEAALAELDAAGGKTLDGELAFKLHDT YGFPLDLTADVCRERGVTVDEPAFDDAMARQREQARAAGKFKATQGLEYTGAKTTFHGYEEIAFDDAKVVALYVEGASVG EVKAGESAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVGDTLKVQADVIGHHGELEQGTLKVGDVVRAEIDAARRART ARNHSATHLMHKALRDVLGSHVQQKGSLVDADKTRFDFAHNAPLTDDEIRRVEAIVNEQVLANAPGIVRVMPYDDAVKGG AMALFGEKYGDEVRVLDLGFSRELCGGTHVHRTGDIGLFKIVAEGGVAAGIRRVEAITGDNAVRYVQALDARVNAAAAAL KAQPSELLQRIGQVQDQVKSLEKELGALKSKLASSQGDELAQQAVEVGGVHVLAATLDGADAKTLRETVDKLKDKLKSAA IVLAAVDGGKVSLIAGVTADASKKVKAGELVNFVAQQVGGKGGGRPDMAQAGGTEPAKLPAALAGVKGWVEARL
Specific function: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction:alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editin
COG id: COG0013
COG function: function code J; Alanyl-tRNA synthetase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]
Homologues:
Organism=Homo sapiens, GI109148542, Length=977, Percent_Identity=37.6663254861822, Blast_Score=533, Evalue=1e-151, Organism=Homo sapiens, GI38569417, Length=961, Percent_Identity=33.5067637877211, Blast_Score=452, Evalue=1e-127, Organism=Homo sapiens, GI217416402, Length=395, Percent_Identity=22.7848101265823, Blast_Score=67, Evalue=8e-11, Organism=Escherichia coli, GI1789048, Length=875, Percent_Identity=62.8571428571429, Blast_Score=1093, Evalue=0.0, Organism=Caenorhabditis elegans, GI17506981, Length=975, Percent_Identity=36.5128205128205, Blast_Score=536, Evalue=1e-152, Organism=Caenorhabditis elegans, GI17536681, Length=747, Percent_Identity=32.6639892904953, Blast_Score=367, Evalue=1e-101, Organism=Saccharomyces cerevisiae, GI6324911, Length=970, Percent_Identity=36.3917525773196, Blast_Score=549, Evalue=1e-157, Organism=Drosophila melanogaster, GI24582809, Length=978, Percent_Identity=35.6850715746421, Blast_Score=538, Evalue=1e-153, Organism=Drosophila melanogaster, GI45552267, Length=978, Percent_Identity=35.6850715746421, Blast_Score=538, Evalue=1e-153, Organism=Drosophila melanogaster, GI24658214, Length=858, Percent_Identity=29.95337995338, Blast_Score=341, Evalue=1e-93,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002318 - InterPro: IPR018162 - InterPro: IPR018165 - InterPro: IPR018164 - InterPro: IPR023033 - InterPro: IPR003156 - InterPro: IPR018163 - InterPro: IPR012947 [H]
Pfam domain/function: PF02272 DHHA1; PF01411 tRNA-synt_2c; PF07973 tRNA_SAD [H]
EC number: =6.1.1.7 [H]
Molecular weight: Translated: 94696; Mature: 94696
Theoretical pI: Translated: 6.14; Mature: 6.14
Prosite motif: PS00087 SOD_CU_ZN_1 ; PS50860 AA_TRNA_LIGASE_II_ALA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLLFTNSGMVQFKDVFLGAETRPYSRA CCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCCEEEEHEEECCCCCCCCHH TTAQRSVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAIHYAWELLTSVYKLP HHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC ADKLWVTVYHDDDEAYDIWAKEVGVPAERIIRIGDNKGARYASDNFWQMGDTGPCGPCSE CCCEEEEEEECCCCHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCEECCCCCCCCCHHH IFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKPCVDTGMGLERI HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHH AAVLQHVHSNYEIDLFQQLIKASARETGVADLANNSLKVIADHIRACSFLIVDGVIPGNE HHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHEEEECCCCCCC GRGYVLRRIVRRAIRHGYKLGRKAPFFHKLVADLVAEMGAAYPELKEAEPRVTDVLRQEE CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHH ERFFETIEHGMSILEAALAELDAAGGKTLDGELAFKLHDTYGFPLDLTADVCRERGVTVD HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCC EPAFDDAMARQREQARAAGKFKATQGLEYTGAKTTFHGYEEIAFDDAKVVALYVEGASVG CCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEECCHHHHHCCCCEEEEEEEECCCCC EVKAGESAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVGDTLKVQADVIGHHGELEQG CCCCCCCEEEEEECCCCEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC TLKVGDVVRAEIDAARRARTARNHSATHLMHKALRDVLGSHVQQKGSLVDADKTRFDFAH CEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCC NAPLTDDEIRRVEAIVNEQVLANAPGIVRVMPYDDAVKGGAMALFGEKYGDEVRVLDLGF CCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCEEEEEECCC SRELCGGTHVHRTGDIGLFKIVAEGGVAAGIRRVEAITGDNAVRYVQALDARVNAAAAAL CHHHCCCCCEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH KAQPSELLQRIGQVQDQVKSLEKELGALKSKLASSQGDELAQQAVEVGGVHVLAATLDGA HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEECCCC DAKTLRETVDKLKDKLKSAAIVLAAVDGGKVSLIAGVTADASKKVKAGELVNFVAQQVGG CHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCC KGGGRPDMAQAGGTEPAKLPAALAGVKGWVEARL CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLLFTNSGMVQFKDVFLGAETRPYSRA CCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCCEEEEHEEECCCCCCCCHH TTAQRSVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAIHYAWELLTSVYKLP HHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC ADKLWVTVYHDDDEAYDIWAKEVGVPAERIIRIGDNKGARYASDNFWQMGDTGPCGPCSE CCCEEEEEEECCCCHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCEECCCCCCCCCHHH IFYDHGPDVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKPCVDTGMGLERI HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHH AAVLQHVHSNYEIDLFQQLIKASARETGVADLANNSLKVIADHIRACSFLIVDGVIPGNE HHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHEEEECCCCCCC GRGYVLRRIVRRAIRHGYKLGRKAPFFHKLVADLVAEMGAAYPELKEAEPRVTDVLRQEE CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHH ERFFETIEHGMSILEAALAELDAAGGKTLDGELAFKLHDTYGFPLDLTADVCRERGVTVD HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCC EPAFDDAMARQREQARAAGKFKATQGLEYTGAKTTFHGYEEIAFDDAKVVALYVEGASVG CCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEECCHHHHHCCCCEEEEEEEECCCCC EVKAGESAVVVLDHTPFYAESGGQVGDQGVLANAATRFAVGDTLKVQADVIGHHGELEQG CCCCCCCEEEEEECCCCEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC TLKVGDVVRAEIDAARRARTARNHSATHLMHKALRDVLGSHVQQKGSLVDADKTRFDFAH CEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCC NAPLTDDEIRRVEAIVNEQVLANAPGIVRVMPYDDAVKGGAMALFGEKYGDEVRVLDLGF CCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCEEEEEECCC SRELCGGTHVHRTGDIGLFKIVAEGGVAAGIRRVEAITGDNAVRYVQALDARVNAAAAAL CHHHCCCCCEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH KAQPSELLQRIGQVQDQVKSLEKELGALKSKLASSQGDELAQQAVEVGGVHVLAATLDGA HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEECCCC DAKTLRETVDKLKDKLKSAAIVLAAVDGGKVSLIAGVTADASKKVKAGELVNFVAQQVGG CHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCC KGGGRPDMAQAGGTEPAKLPAALAGVKGWVEARL CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA