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The map label for this gene is glxR [H]

Identifier: 53719086

GI number: 53719086

Start: 1686162

End: 1687067

Strand: Reverse

Name: glxR [H]

Synonym: BPSL1450

Alternate gene names: 53719086

Gene position: 1687067-1686162 (Counterclockwise)

Preceding gene: 53719087

Following gene: 53719085

Centisome position: 41.41

GC content: 69.76

Gene sequence:

>906_bases
ATGGCAACGATCGGCTTCATCGGCCTCGGCATCATGGGCGCGCACATGGCGCGCAACCTGCTCAAGGGCGGCCACCGCCT
CGTCGTGAACGGCGCGTACCCGGTGCCCGCCGATCTGCGCGAGCAGACCCAAGTCGTCGCGAATTCGACGGCCGTCGCGC
AGGCGGCGGACATCGTGATCGCGATGGTGCCCGACACGCCCGACGTGCGCAACGTGCTGTTCGCCGAAGACGGCGTCGCG
AAGGGCCTGTCGGCCGGCAAGCTCGTGATCGACATGAGCTCGATCTCGCCGCTCGACACGCGCGAGTTCGCCAAGGAGAT
CAACGCGCTCGGCTGCGACTATCTCGACGCGCCCGTGTCGGGCGGCGAAGTCGGCGCGCGCGACGCGACGCTCACGATCA
TGGTGGGCGGCCCGCAGCGCGCGTTCGAGCGCGCGCAGCCGCTCTTCGCGCTGATGGGCCGGAACGTCTCGCTGATCGGC
GAGAACGGCGCGGGCCAGACCTGCAAGGTCGCGAACCAGATCATCGTCGCGCTGAACATCGAGGCGGTCGCGGAAGCGCT
TCTCTTCGCCGCGCGCTCGGGCGCCGATCCGGAGCGCGTGCGGCGCGCGCTGATGGGCGGCTTCGCGTCGTCGCGGATTC
TCGAGCTGCACGGCGAGCGCATGACAAAGCGCGCGTTCGAGCCCGGCTTCCGGATCGACCTGCATCGCAAGGACCTGAAC
CTCGCGCTCGACGGCGCGCGCCGGATGAACATCGCGTTGCCGCACACGGCGAGCGCGCAGCAGCTCTTCAGCGTGTGCGC
GGCGAACGGCGGCGGCGCGTGGGACCACTCGGCGATCGTGCGCGCGCTCGAGATCATGTCGAACTGCGAGATCGGCGAGC
CGCAAAGCGACAAGAAGGTGGCGTGA

Upstream 100 bases:

>100_bases
TGATCCGCGCACGCGTCGACGCCCGAGCTCATCCGCGCATCACTCATTCATTCCGAATTCGCGATCCACAGGATTCGCCA
GACTCACAGGAGACACTGCA

Downstream 100 bases:

>100_bases
GCGAACGCATCGGCGCGGCGTGTCGCGCCGATGCGGGGAAGCGGTGGAGTCGGCGACGGCGTGCAGTGGCGGCGTATCGG
TATGGCGCATCGATGCAGCG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MATIGFIGLGIMGAHMARNLLKGGHRLVVNGAYPVPADLREQTQVVANSTAVAQAADIVIAMVPDTPDVRNVLFAEDGVA
KGLSAGKLVIDMSSISPLDTREFAKEINALGCDYLDAPVSGGEVGARDATLTIMVGGPQRAFERAQPLFALMGRNVSLIG
ENGAGQTCKVANQIIVALNIEAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRAFEPGFRIDLHRKDLN
LALDGARRMNIALPHTASAQQLFSVCAANGGGAWDHSAIVRALEIMSNCEIGEPQSDKKVA

Sequences:

>Translated_301_residues
MATIGFIGLGIMGAHMARNLLKGGHRLVVNGAYPVPADLREQTQVVANSTAVAQAADIVIAMVPDTPDVRNVLFAEDGVA
KGLSAGKLVIDMSSISPLDTREFAKEINALGCDYLDAPVSGGEVGARDATLTIMVGGPQRAFERAQPLFALMGRNVSLIG
ENGAGQTCKVANQIIVALNIEAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRAFEPGFRIDLHRKDLN
LALDGARRMNIALPHTASAQQLFSVCAANGGGAWDHSAIVRALEIMSNCEIGEPQSDKKVA
>Mature_300_residues
ATIGFIGLGIMGAHMARNLLKGGHRLVVNGAYPVPADLREQTQVVANSTAVAQAADIVIAMVPDTPDVRNVLFAEDGVAK
GLSAGKLVIDMSSISPLDTREFAKEINALGCDYLDAPVSGGEVGARDATLTIMVGGPQRAFERAQPLFALMGRNVSLIGE
NGAGQTCKVANQIIVALNIEAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRAFEPGFRIDLHRKDLNL
ALDGARRMNIALPHTASAQQLFSVCAANGGGAWDHSAIVRALEIMSNCEIGEPQSDKKVA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=33.3333333333333, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=28.3687943262411, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=61.5916955017301, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI145693186, Length=290, Percent_Identity=42.7586206896552, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI1790315, Length=293, Percent_Identity=35.4948805460751, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=31.6901408450704, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=284, Percent_Identity=33.4507042253521, Blast_Score=133, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24655230, Length=290, Percent_Identity=31.7241379310345, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922568, Length=290, Percent_Identity=31.7241379310345, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574115, Length=283, Percent_Identity=27.5618374558304, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31778; Mature: 31647

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIGFIGLGIMGAHMARNLLKGGHRLVVNGAYPVPADLREQTQVVANSTAVAQAADIVI
CCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHEEEEE
AMVPDTPDVRNVLFAEDGVAKGLSAGKLVIDMSSISPLDTREFAKEINALGCDYLDAPVS
EECCCCCCHHHEEECCCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGARDATLTIMVGGPQRAFERAQPLFALMGRNVSLIGENGAGQTCKVANQIIVALNI
CCCCCCCCEEEEEEECCHHHHHHHHCHHHHHHCCCEEEEECCCCCCHHHHCCEEEEEEEH
EAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRAFEPGFRIDLHRKDLN
HHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
LALDGARRMNIALPHTASAQQLFSVCAANGGGAWDHSAIVRALEIMSNCEIGEPQSDKKV
EEECCCCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
A
C
>Mature Secondary Structure 
ATIGFIGLGIMGAHMARNLLKGGHRLVVNGAYPVPADLREQTQVVANSTAVAQAADIVI
CEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHEEEEE
AMVPDTPDVRNVLFAEDGVAKGLSAGKLVIDMSSISPLDTREFAKEINALGCDYLDAPVS
EECCCCCCHHHEEECCCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGARDATLTIMVGGPQRAFERAQPLFALMGRNVSLIGENGAGQTCKVANQIIVALNI
CCCCCCCCEEEEEEECCHHHHHHHHCHHHHHHCCCEEEEECCCCCCHHHHCCEEEEEEEH
EAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRAFEPGFRIDLHRKDLN
HHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
LALDGARRMNIALPHTASAQQLFSVCAANGGGAWDHSAIVRALEIMSNCEIGEPQSDKKV
EEECCCCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]