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The map label for this gene is ipk

Identifier: 53718162

GI number: 53718162

Start: 575258

End: 576139

Strand: Reverse

Name: ipk

Synonym: BPSL0523

Alternate gene names: 53718162

Gene position: 576139-575258 (Counterclockwise)

Preceding gene: 53718163

Following gene: 53718161

Centisome position: 14.14

GC content: 63.38

Gene sequence:

>882_bases
ATGACCGATACGACCCGCTCGCTGCGCGACTGCCTCGCCCCGGCGAAACTGAACCTGTTCCTGCACATCACGGGCCGCCG
CCCGGACGGCTATCACGCGCTGCAAAGCGTGTTCCAGCTGCTCGACTGGGGCGACCGGCTGCACTTCACGCTGCGCGACG
ACGGCAAGGTCTCGCGCGTGACGGACGTGCCGGGCGTGCCCGAGGAATCCGACCTCGTCGTGCGCGCCGCGTCGCTGCTG
AAGGCGCACGCCGGCGCGACGCTGGGCGTCGACATCGAGATCGACAAGCGGCTGCCGATGGGCGCGGGCCTGGGCGGCGG
CAGCTCGGACGCGGCGACGACGTTGCTCGCGCTCAACCGGCTATGGCGGCTCGACCTGCCGCGCACCACGCTGCAATCGC
TCGCGGTGAAGCTCGGCGCCGACGTGCCGTTCTTCGTCTTCGGAAAAAATGCGTTCGCGGAGGGTATCGGAGAAGCGCTA
CAAGCTGTAGAATTGCCGGCTCGCTGGTTCCTGGTTGTGACACCGCGGGTTCACGTGCCGACGGCAGCGATTTTTTCCGA
AAAATCGTTGACAAGAGATTCGAAACCCATCACAATTACGGACTTTCTTGCACAGCGCGGCATCGACGCAGGATGGCCAG
ACAGCTTCGGCCGGAATGACATGCAGCCGGTTGTGACAAGCAAGTACGCGGAAGTTGCAAAGGTGGTCGAATGGTTTTAT
AATCTGACCCCCGCGCGGATGACCGGCTCTGGAGCGAGCGTGTTTGCAGCGTTCAAGAGCAAGGCTGATGCAGAAGCGGC
GCAAGCCAAACTGCCTGCCGGCTGGAACAGCGCAGTTGCCGAGAGCATGAGTGAGCATCCACTCTTCGCTTTCGCGTCAT
AA

Upstream 100 bases:

>100_bases
CGTGAAGCGCATCAATCTGGCGCGGCAGACGCCGCCCCTCGACATCAAGCTCGTGCTCGACCGCTGAACGCGCGCTTTTG
CCCGACCAAGTTTGCCTAGC

Downstream 100 bases:

>100_bases
AGTTTCGCGTCATCGGATGGCCTACACTTCCGGTGGAGCTCAAAGTTAAGTGTAGGGGAGTCGCCAAGTTGGTTAAGGCA
CCGGATTTTGATTCCGGCAT

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTDTTRSLRDCLAPAKLNLFLHITGRRPDGYHALQSVFQLLDWGDRLHFTLRDDGKVSRVTDVPGVPEESDLVVRAASLL
KAHAGATLGVDIEIDKRLPMGAGLGGGSSDAATTLLALNRLWRLDLPRTTLQSLAVKLGADVPFFVFGKNAFAEGIGEAL
QAVELPARWFLVVTPRVHVPTAAIFSEKSLTRDSKPITITDFLAQRGIDAGWPDSFGRNDMQPVVTSKYAEVAKVVEWFY
NLTPARMTGSGASVFAAFKSKADAEAAQAKLPAGWNSAVAESMSEHPLFAFAS

Sequences:

>Translated_293_residues
MTDTTRSLRDCLAPAKLNLFLHITGRRPDGYHALQSVFQLLDWGDRLHFTLRDDGKVSRVTDVPGVPEESDLVVRAASLL
KAHAGATLGVDIEIDKRLPMGAGLGGGSSDAATTLLALNRLWRLDLPRTTLQSLAVKLGADVPFFVFGKNAFAEGIGEAL
QAVELPARWFLVVTPRVHVPTAAIFSEKSLTRDSKPITITDFLAQRGIDAGWPDSFGRNDMQPVVTSKYAEVAKVVEWFY
NLTPARMTGSGASVFAAFKSKADAEAAQAKLPAGWNSAVAESMSEHPLFAFAS
>Mature_292_residues
TDTTRSLRDCLAPAKLNLFLHITGRRPDGYHALQSVFQLLDWGDRLHFTLRDDGKVSRVTDVPGVPEESDLVVRAASLLK
AHAGATLGVDIEIDKRLPMGAGLGGGSSDAATTLLALNRLWRLDLPRTTLQSLAVKLGADVPFFVFGKNAFAEGIGEALQ
AVELPARWFLVVTPRVHVPTAAIFSEKSLTRDSKPITITDFLAQRGIDAGWPDSFGRNDMQPVVTSKYAEVAKVVEWFYN
LTPARMTGSGASVFAAFKSKADAEAAQAKLPAGWNSAVAESMSEHPLFAFAS

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=282, Percent_Identity=44.6808510638298, Blast_Score=218, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_BURMA (Q62FC4)

Other databases:

- EMBL:   CP000010
- RefSeq:   YP_104603.1
- ProteinModelPortal:   Q62FC4
- SMR:   Q62FC4
- GeneID:   3090198
- GenomeReviews:   CP000010_GR
- KEGG:   bma:BMA3118
- TIGR:   BMA3118
- HOGENOM:   HBG734593
- OMA:   LNLFLHV
- PhylomeDB:   Q62FC4
- ProtClustDB:   PRK00343
- BioCyc:   BMAL243160:BMA_3118-MONOMER
- BRENDA:   2.7.1.148
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 31635; Mature: 31504

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: ACT_SITE 19-19 ACT_SITE 144-144

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTTRSLRDCLAPAKLNLFLHITGRRPDGYHALQSVFQLLDWGDRLHFTLRDDGKVSRV
CCCCHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEE
TDVPGVPEESDLVVRAASLLKAHAGATLGVDIEIDKRLPMGAGLGGGSSDAATTLLALNR
ECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
LWRLDLPRTTLQSLAVKLGADVPFFVFGKNAFAEGIGEALQAVELPARWFLVVTPRVHVP
HHHCCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
TAAIFSEKSLTRDSKPITITDFLAQRGIDAGWPDSFGRNDMQPVVTSKYAEVAKVVEWFY
HHHHHCCHHCCCCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
NLTPARMTGSGASVFAAFKSKADAEAAQAKLPAGWNSAVAESMSEHPLFAFAS
CCCCCEECCCCHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHCCCEEEECC
>Mature Secondary Structure 
TDTTRSLRDCLAPAKLNLFLHITGRRPDGYHALQSVFQLLDWGDRLHFTLRDDGKVSRV
CCCHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEE
TDVPGVPEESDLVVRAASLLKAHAGATLGVDIEIDKRLPMGAGLGGGSSDAATTLLALNR
ECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
LWRLDLPRTTLQSLAVKLGADVPFFVFGKNAFAEGIGEALQAVELPARWFLVVTPRVHVP
HHHCCCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
TAAIFSEKSLTRDSKPITITDFLAQRGIDAGWPDSFGRNDMQPVVTSKYAEVAKVVEWFY
HHHHHCCHHCCCCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
NLTPARMTGSGASVFAAFKSKADAEAAQAKLPAGWNSAVAESMSEHPLFAFAS
CCCCCEECCCCHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA