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The map label for this gene is thlA [H]

Identifier: 53718017

GI number: 53718017

Start: 409296

End: 409979

Strand: Reverse

Name: thlA [H]

Synonym: BPSL0377

Alternate gene names: 53718017

Gene position: 409979-409296 (Counterclockwise)

Preceding gene: 53718018

Following gene: 53718016

Centisome position: 10.06

GC content: 75.29

Gene sequence:

>684_bases
ATGCAGCGCATCATGTCGGCCGAGCCGATCGTGACTCTTTCCGTGGCGCGCACGCTGTCGGCCGCCATCGGGGCGGCCTT
TCGTCGAAGCGACCGCGCTTCGGCGCGTCGCGATTCGCGCGGCCGTCGAGCGTGCGCATCGGCTCGGCGCGCGTCCACGA
GGCGTAGGCCGGCTGCGCGCTGCGCGCCGAGCGCGGGGCTCGGCCGGGCGCTCGCCCGGCAGGCCGCGCCCGGCGCGGGC
CTATCGCGCTCGGTCGCGAGCGCGACCGTCAACAAGGTGCGCGGTTCGGGCATGCGGGCGATTCGCCATGCATTCGACGC
GCCCGCGAACGGCAGCGCCGACGTCGCCGCCGCGGGCGGCATGGCGCGCTCGTCGAACGGGCCGTATCGCGCGCTCGGCG
TGCGCGGCGGCTATCGCTCGGGACACGCGGCGCTCCACGATCACGTCGCGCCCGACGGGCTCGCGGACGCCGGCGATCGC
GGCACGTCGATGGGCGAATTCGGCCAACGCGGCGCGCCACGGCTTCACGCATGCCGCTCAAGACGCGTACGCGGCCGGAT
CGCTGCAATGGGCGCAGCATGCGCAACTGGCGATCGAGCTGACGTAACGCCGCTCGCCCGCGGCGGCGCGGCGCCGCGGC
AGCGGTTCCGGCGTCGCGGCGCAACGCCTTCCGACGCCGATTAA

Upstream 100 bases:

>100_bases
GGCGCTCGCTCGCGGTGCATGCGGCCGCCATGTAGCGGCATCGCGCACGACCATAATATATGCATACGCATTCAAATTCC
AACCCGCTTTTCCCAGACGC

Downstream 100 bases:

>100_bases
CGGCGAGCGCCCATTGACGGTATGCTATCCCGCTGGCGTGCGGCCGCTGCGGCGTTGCCGCCCGCCGCCGACAGAATTAC
GCCACGTGGGAGATCTCATG

Product: hypothetical protein

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MQRIMSAEPIVTLSVARTLSAAIGAAFRRSDRASARRDSRGRRACASARRASTRRRPAARCAPSAGLGRALARQAAPGAG
LSRSVASATVNKVRGSGMRAIRHAFDAPANGSADVAAAGGMARSSNGPYRALGVRGGYRSGHAALHDHVAPDGLADAGDR
GTSMGEFGQRGAPRLHACRSRRVRGRIAAMGAACATGDRADVTPLARGGAAPRQRFRRRGATPSDAD

Sequences:

>Translated_227_residues
MQRIMSAEPIVTLSVARTLSAAIGAAFRRSDRASARRDSRGRRACASARRASTRRRPAARCAPSAGLGRALARQAAPGAG
LSRSVASATVNKVRGSGMRAIRHAFDAPANGSADVAAAGGMARSSNGPYRALGVRGGYRSGHAALHDHVAPDGLADAGDR
GTSMGEFGQRGAPRLHACRSRRVRGRIAAMGAACATGDRADVTPLARGGAAPRQRFRRRGATPSDAD
>Mature_227_residues
MQRIMSAEPIVTLSVARTLSAAIGAAFRRSDRASARRDSRGRRACASARRASTRRRPAARCAPSAGLGRALARQAAPGAG
LSRSVASATVNKVRGSGMRAIRHAFDAPANGSADVAAAGGMARSSNGPYRALGVRGGYRSGHAALHDHVAPDGLADAGDR
GTSMGEFGQRGAPRLHACRSRRVRGRIAAMGAACATGDRADVTPLARGGAAPRQRFRRRGATPSDAD

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=117, Percent_Identity=39.3162393162393, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87082165, Length=94, Percent_Identity=40.4255319148936, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147385, Length=160, Percent_Identity=33.125, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6325229, Length=119, Percent_Identity=41.1764705882353, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640423, Length=119, Percent_Identity=42.0168067226891, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 23375; Mature: 23375

Theoretical pI: Translated: 12.48; Mature: 12.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRIMSAEPIVTLSVARTLSAAIGAAFRRSDRASARRDSRGRRACASARRASTRRRPAAR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
CAPSAGLGRALARQAAPGAGLSRSVASATVNKVRGSGMRAIRHAFDAPANGSADVAAAGG
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHCC
MARSSNGPYRALGVRGGYRSGHAALHDHVAPDGLADAGDRGTSMGEFGQRGAPRLHACRS
CCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHH
RRVRGRIAAMGAACATGDRADVTPLARGGAAPRQRFRRRGATPSDAD
HHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQRIMSAEPIVTLSVARTLSAAIGAAFRRSDRASARRDSRGRRACASARRASTRRRPAAR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
CAPSAGLGRALARQAAPGAGLSRSVASATVNKVRGSGMRAIRHAFDAPANGSADVAAAGG
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHCC
MARSSNGPYRALGVRGGYRSGHAALHDHVAPDGLADAGDRGTSMGEFGQRGAPRLHACRS
CCCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHH
RRVRGRIAAMGAACATGDRADVTPLARGGAAPRQRFRRRGATPSDAD
HHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]