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The map label for this gene is mvaB [H]

Identifier: 53717974

GI number: 53717974

Start: 355727

End: 356662

Strand: Reverse

Name: mvaB [H]

Synonym: BPSL0333

Alternate gene names: 53717974

Gene position: 356662-355727 (Counterclockwise)

Preceding gene: 53717975

Following gene: 53717973

Centisome position: 8.75

GC content: 70.19

Gene sequence:

>936_bases
ATGACGCTCCCCCAATCCGTGAAGATCGTCGAAGTCGGCCCGCGCGACGGGCTGCAGAACGAGCAAACGTTCGTGCCGAC
CGGCGTGAAGATCGAGCTCGTGAACCGGCTGTCGCAAGCCGGTTTTCGCAACGTCGAGGCGGCGTCGTTCGTGTCGCCGA
AATGGGTGCCGCAGATGGCCGACGGCGCCGACGTGATGGCCGGCATCGCGCGCCGCGCGGGCACGATCTACTCGGCGCTC
ACGCCGAACCTGAAAGGCGTCGAAAACGCGCTCGCCGCGCGCGCCGACGAAGTCGTGATTTTCGGCGCGGCGAGCGAGGC
GTTCTCCCGGCGCAACATCAACTGCAGCATCGCCGAGAGCATCGCGCGCTTCGAACCGGTCGCGCGCGCGGCGAAGGATG
CGGGCGTGCGGCTGCGCGCGAGCGTGTCGTGCGCGCTCGGCTGCCCGTATCAGGGCGACGTGCCTCTCGAAGCGGTCGTC
GACGTCGTCGAGCGCCTCGCCGCGCTCGGCTGCGACGAGATCGACATCGCCGATACGATCGGCGTCGGCACGCCGGGCCG
CACGCGCGCGGTGCTCGACGCGGTCGCGAAGGCGTTTCCGCGCGAGCGGCTGTCGGGCCACTTCCACGACACCTACGGGC
AGGCGCTCGCGAACATCTATGCGGCGCTCCTCGAAGGCATCGCGATCTTCCATGCGTCGGTCGCGGGCCTCGGCGGCTGC
CCGTACGCGAAAGGCGCGACGGGCAACGTCGCGACGGAAGACGTGCTGTACATGATGCGCGGGCTGAACATCGAGACGGG
GGTCGACCTCGATCAGGTCGTCGCCGCCGGCGATTTCATCTCGAACGCGATCGGCCGCGCGAACATCTCGCGCGCGGGGC
GCGCGCTGCTCGCGAAGCAACGCGCGGCCGCCGAGCCGCCGTCCGCCTGCGCGTGA

Upstream 100 bases:

>100_bases
GATCGCGGCTACTGACCGCGGCCCGCGAACGCGCGCCGCACGAGCCCATGCGCCGCAACAGCCGTTACGTTCATCAGAAA
ACAGGAATCAGGAGACTCGG

Downstream 100 bases:

>100_bases
CGCGCGCGGCCCCTTTCATCTTTCACCCCACCCAGCGAGGAGACGAAGCGCACCCATGGCTACCCCCGCCCCCATCGACA
AGCTTCCCGATTCCGCTCGC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTLPQSVKIVEVGPRDGLQNEQTFVPTGVKIELVNRLSQAGFRNVEAASFVSPKWVPQMADGADVMAGIARRAGTIYSAL
TPNLKGVENALAARADEVVIFGAASEAFSRRNINCSIAESIARFEPVARAAKDAGVRLRASVSCALGCPYQGDVPLEAVV
DVVERLAALGCDEIDIADTIGVGTPGRTRAVLDAVAKAFPRERLSGHFHDTYGQALANIYAALLEGIAIFHASVAGLGGC
PYAKGATGNVATEDVLYMMRGLNIETGVDLDQVVAAGDFISNAIGRANISRAGRALLAKQRAAAEPPSACA

Sequences:

>Translated_311_residues
MTLPQSVKIVEVGPRDGLQNEQTFVPTGVKIELVNRLSQAGFRNVEAASFVSPKWVPQMADGADVMAGIARRAGTIYSAL
TPNLKGVENALAARADEVVIFGAASEAFSRRNINCSIAESIARFEPVARAAKDAGVRLRASVSCALGCPYQGDVPLEAVV
DVVERLAALGCDEIDIADTIGVGTPGRTRAVLDAVAKAFPRERLSGHFHDTYGQALANIYAALLEGIAIFHASVAGLGGC
PYAKGATGNVATEDVLYMMRGLNIETGVDLDQVVAAGDFISNAIGRANISRAGRALLAKQRAAAEPPSACA
>Mature_310_residues
TLPQSVKIVEVGPRDGLQNEQTFVPTGVKIELVNRLSQAGFRNVEAASFVSPKWVPQMADGADVMAGIARRAGTIYSALT
PNLKGVENALAARADEVVIFGAASEAFSRRNINCSIAESIARFEPVARAAKDAGVRLRASVSCALGCPYQGDVPLEAVVD
VVERLAALGCDEIDIADTIGVGTPGRTRAVLDAVAKAFPRERLSGHFHDTYGQALANIYAALLEGIAIFHASVAGLGGCP
YAKGATGNVATEDVLYMMRGLNIETGVDLDQVVAAGDFISNAIGRANISRAGRALLAKQRAAAEPPSACA

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=55.6313993174061, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=55.6313993174061, Blast_Score=349, Evalue=1e-96,
Organism=Homo sapiens, GI62198232, Length=294, Percent_Identity=55.4421768707483, Blast_Score=345, Evalue=3e-95,
Organism=Homo sapiens, GI260654708, Length=134, Percent_Identity=51.4925373134328, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17510563, Length=294, Percent_Identity=50, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24582381, Length=296, Percent_Identity=55.7432432432432, Blast_Score=346, Evalue=9e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32434; Mature: 32303

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPQSVKIVEVGPRDGLQNEQTFVPTGVKIELVNRLSQAGFRNVEAASFVSPKWVPQMA
CCCCCCEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCC
DGADVMAGIARRAGTIYSALTPNLKGVENALAARADEVVIFGAASEAFSRRNINCSIAES
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHHHHCCCCHHHHHH
IARFEPVARAAKDAGVRLRASVSCALGCPYQGDVPLEAVVDVVERLAALGCDEIDIADTI
HHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTPGRTRAVLDAVAKAFPRERLSGHFHDTYGQALANIYAALLEGIAIFHASVAGLGGC
CCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYMMRGLNIETGVDLDQVVAAGDFISNAIGRANISRAGRALLAKQ
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAAEPPSACA
HHCCCCCCCCC
>Mature Secondary Structure 
TLPQSVKIVEVGPRDGLQNEQTFVPTGVKIELVNRLSQAGFRNVEAASFVSPKWVPQMA
CCCCCEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCC
DGADVMAGIARRAGTIYSALTPNLKGVENALAARADEVVIFGAASEAFSRRNINCSIAES
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHHHHCCCCHHHHHH
IARFEPVARAAKDAGVRLRASVSCALGCPYQGDVPLEAVVDVVERLAALGCDEIDIADTI
HHHHHHHHHHHHHCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHC
GVGTPGRTRAVLDAVAKAFPRERLSGHFHDTYGQALANIYAALLEGIAIFHASVAGLGGC
CCCCCCHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYAKGATGNVATEDVLYMMRGLNIETGVDLDQVVAAGDFISNAIGRANISRAGRALLAKQ
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAAEPPSACA
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]