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The map label for this gene is adhC [H]

Identifier: 53717834

GI number: 53717834

Start: 198655

End: 199719

Strand: Reverse

Name: adhC [H]

Synonym: BPSL0192

Alternate gene names: 53717834

Gene position: 199719-198655 (Counterclockwise)

Preceding gene: 53717836

Following gene: 53717828

Centisome position: 4.9

GC content: 65.82

Gene sequence:

>1065_bases
ATGAGCACGACTTATGCTTACGCGGCAACGAGCGCCACCACGCCGCTCGCGCCGTTCGAATTTGCGCGCCGCGCGCTGCG
CGATCTCGATGTGCAGATCGAGATCCTTTACTGCGGCGTTTGCCACTCCGATCTCCACCAGGCCCGCAACGAGTGGAAGA
ACACGACTTATCCGGTCGTGCCGGGCCATGAAATCGTCGGCCGCGTGACGGCGGTCGGCGCGCAGGTCACGCGCTTCGAA
GCGGGCGAGCTCGTCGGCGTGGGCTGCCTCGTCGATTCGTGCCGCACGTGCCCGAGCTGCGCGCAAGGGCTCGAGCAGTA
TTGCGAGAACGGTTTCGTCGGCACCTACAACGGCCGCGACCGCGCAACCGGCGACATCACGTACGGCGGCTATTCGACGC
AGATCGTCGTCGATGAAGCGTTCGTGCTGCGCGTGCCCGACACGCTCGACCCGGCGGGCGCGGCGCCCCTTCTCTGCGCG
GGCATCACGACGTATTCGCCGCTGCGCCAGTGGGGCGCCGGGCCCGGCAAGAAGATCGGCATCGTCGGCCTGGGCGGCCT
GGGCCACATGGGCGTGAAGCTCGCACGCGCGATGGGCGCGCACGTCGTGCTGTTCACGACGTCGCCGTCGAAGATCGAGG
ACGGCAAGCGGCTCGGCGCGCACGAGGTCGTGATCTCGAAGGACGACGCGCAGATGAACGCGCATCTGAACAGCTTCGAC
TTCATCCTGAACACGGTCGCCGCGCAGCACGATCTGAATCCGTTCATCGGCCTGCTGAAGCTCGACGGCACGATGACGCT
CGTCGGCGCGCCGGAGCACGATCATCCGTCGCCGCGCGTGTTCAACCTGATCTACAAGCGCCGCCGCCTCGCGGGATCGC
TGATCGGCGGGATTGCCGAGACACAGGAAATGCTCGATTTCTGCGCGCAGCACGGCATCACGTCGGACATCGAAGTGATT
CCGATGTCGCAGATCAACGCGGCCTACGAGCGGATGCTGACGAGCGACGTGAAATATCGGTTCGTGATCGACATCGGATC
GATCAGGCCGCAGCGCGCGGCGTGA

Upstream 100 bases:

>100_bases
CAGGTATTCCGGGCATCCCGCCGCGTGCTTAGGATGGCTTCCGTCGCCGCGCCGCATTCCGTGGCCGCGCGCGGCACCCG
TTTTCGAGTCAGGAGCCTTC

Downstream 100 bases:

>100_bases
CGGGCGGCGCGCCGCCCGGCCGCGGATGTTTCGATGTGCCGGGCGCGAAGCGTTGTGCGTCGGGCGTCAGGCGTCAGGCG
TCAGGCGTCAGGCGTCAGGC

Product: NADP-dependent alcohol dehydrogenase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSTTYAYAATSATTPLAPFEFARRALRDLDVQIEILYCGVCHSDLHQARNEWKNTTYPVVPGHEIVGRVTAVGAQVTRFE
AGELVGVGCLVDSCRTCPSCAQGLEQYCENGFVGTYNGRDRATGDITYGGYSTQIVVDEAFVLRVPDTLDPAGAAPLLCA
GITTYSPLRQWGAGPGKKIGIVGLGGLGHMGVKLARAMGAHVVLFTTSPSKIEDGKRLGAHEVVISKDDAQMNAHLNSFD
FILNTVAAQHDLNPFIGLLKLDGTMTLVGAPEHDHPSPRVFNLIYKRRRLAGSLIGGIAETQEMLDFCAQHGITSDIEVI
PMSQINAAYERMLTSDVKYRFVIDIGSIRPQRAA

Sequences:

>Translated_354_residues
MSTTYAYAATSATTPLAPFEFARRALRDLDVQIEILYCGVCHSDLHQARNEWKNTTYPVVPGHEIVGRVTAVGAQVTRFE
AGELVGVGCLVDSCRTCPSCAQGLEQYCENGFVGTYNGRDRATGDITYGGYSTQIVVDEAFVLRVPDTLDPAGAAPLLCA
GITTYSPLRQWGAGPGKKIGIVGLGGLGHMGVKLARAMGAHVVLFTTSPSKIEDGKRLGAHEVVISKDDAQMNAHLNSFD
FILNTVAAQHDLNPFIGLLKLDGTMTLVGAPEHDHPSPRVFNLIYKRRRLAGSLIGGIAETQEMLDFCAQHGITSDIEVI
PMSQINAAYERMLTSDVKYRFVIDIGSIRPQRAA
>Mature_353_residues
STTYAYAATSATTPLAPFEFARRALRDLDVQIEILYCGVCHSDLHQARNEWKNTTYPVVPGHEIVGRVTAVGAQVTRFEA
GELVGVGCLVDSCRTCPSCAQGLEQYCENGFVGTYNGRDRATGDITYGGYSTQIVVDEAFVLRVPDTLDPAGAAPLLCAG
ITTYSPLRQWGAGPGKKIGIVGLGGLGHMGVKLARAMGAHVVLFTTSPSKIEDGKRLGAHEVVISKDDAQMNAHLNSFDF
ILNTVAAQHDLNPFIGLLKLDGTMTLVGAPEHDHPSPRVFNLIYKRRRLAGSLIGGIAETQEMLDFCAQHGITSDIEVIP
MSQINAAYERMLTSDVKYRFVIDIGSIRPQRAA

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI262073058, Length=361, Percent_Identity=22.9916897506925, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI71743840, Length=361, Percent_Identity=22.9916897506925, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4501933, Length=349, Percent_Identity=25.214899713467, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI34577061, Length=353, Percent_Identity=25.2124645892351, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786518, Length=340, Percent_Identity=65.2941176470588, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI87082401, Length=345, Percent_Identity=35.9420289855072, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI87081918, Length=333, Percent_Identity=26.7267267267267, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI226510992, Length=248, Percent_Identity=29.0322580645161, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788407, Length=272, Percent_Identity=27.9411764705882, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788073, Length=205, Percent_Identity=26.8292682926829, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=319, Percent_Identity=26.0188087774295, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17562582, Length=351, Percent_Identity=27.9202279202279, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17562584, Length=337, Percent_Identity=25.8160237388724, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71997431, Length=243, Percent_Identity=30.0411522633745, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=241, Percent_Identity=29.8755186721992, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=331, Percent_Identity=35.6495468277946, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6319949, Length=334, Percent_Identity=35.3293413173653, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6323961, Length=323, Percent_Identity=33.4365325077399, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324486, Length=323, Percent_Identity=31.8885448916409, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319621, Length=323, Percent_Identity=30.3405572755418, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6323729, Length=322, Percent_Identity=28.8819875776398, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319258, Length=313, Percent_Identity=24.9201277955272, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=25.4098360655738, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=24.9329758713137, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 38198; Mature: 38067

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTYAYAATSATTPLAPFEFARRALRDLDVQIEILYCGVCHSDLHQARNEWKNTTYPVV
CCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHCCCCCCCC
PGHEIVGRVTAVGAQVTRFEAGELVGVGCLVDSCRTCPSCAQGLEQYCENGFVGTYNGRD
CCHHHHHHHHHHCCHHEEECCCCEEEHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCC
RATGDITYGGYSTQIVVDEAFVLRVPDTLDPAGAAPLLCAGITTYSPLRQWGAGPGKKIG
CCCCEEEECCEEEEEEEECEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCEEE
IVGLGGLGHMGVKLARAMGAHVVLFTTSPSKIEDGKRLGAHEVVISKDDAQMNAHLNSFD
EEEECCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHCCCCHHH
FILNTVAAQHDLNPFIGLLKLDGTMTLVGAPEHDHPSPRVFNLIYKRRRLAGSLIGGIAE
HHHHHHHHHCCCCHHEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TQEMLDFCAQHGITSDIEVIPMSQINAAYERMLTSDVKYRFVIDIGSIRPQRAA
HHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
STTYAYAATSATTPLAPFEFARRALRDLDVQIEILYCGVCHSDLHQARNEWKNTTYPVV
CCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHCCCCCCCC
PGHEIVGRVTAVGAQVTRFEAGELVGVGCLVDSCRTCPSCAQGLEQYCENGFVGTYNGRD
CCHHHHHHHHHHCCHHEEECCCCEEEHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCC
RATGDITYGGYSTQIVVDEAFVLRVPDTLDPAGAAPLLCAGITTYSPLRQWGAGPGKKIG
CCCCEEEECCEEEEEEEECEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCEEE
IVGLGGLGHMGVKLARAMGAHVVLFTTSPSKIEDGKRLGAHEVVISKDDAQMNAHLNSFD
EEEECCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHCCCCHHH
FILNTVAAQHDLNPFIGLLKLDGTMTLVGAPEHDHPSPRVFNLIYKRRRLAGSLIGGIAE
HHHHHHHHHCCCCHHEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TQEMLDFCAQHGITSDIEVIPMSQINAAYERMLTSDVKYRFVIDIGSIRPQRAA
HHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]